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Article ; Online: In-situ measurement of the electron spin polarization by controlling its distribution in atomic ensembles.

Liu, Xuejing / Li, Yang / Zhang, Chenhui / Hu, Yanhui

2023 Volume 31, Issue 10, Page(s) 17017–17026

Abstract: The determination of electron spin polarization by controlling the atomic population distributions of ground states has been proposed. The polarization could be deduced by generating different population symmetries by polarized lights. The polarization ... ...

Abstract	The determination of electron spin polarization by controlling the atomic population distributions of ground states has been proposed. The polarization could be deduced by generating different population symmetries by polarized lights. The polarization of the atomic ensembles was decoded from optical depth in different transmissions of linearly and elliptic polarized lights. The feasibility of the method has been validated theoretically and experimentally. Moreover, the influences of relaxation and magnetic fields are analyzed. The transparency induced by high pump rates are investigated experimentally, and the influences of ellipticity of lights are also discussed. The in-situ polarization measurement was achieved without changing optical path of atomic magnetometer, which provides a new way to interrogate the performance of atomic magnetometer and in-situ monitoring the hyperpolarization of nuclear spins for atomic co-magnetometer.
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.488083
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Article ; Online: Comparison Between Drug-Coated Balloon and Stents in Large De Novo Coronary Artery Disease: A Systematic Review and Meta-Analysis of RCT Data.

Ma, Zhiqiang / Liu, Kanling / Hu, Yanhui / Hu, Xiwen / Wang, Binyu / Li, Zhengyi

Cardiovascular drugs and therapy

2024

Abstract: Purpose: Although a number of studies involving small-vessel de novo coronary disease showed clinical benefits of drug-coated balloons (DCB), the role of DCB in large vessel lesions is still unclear.: Methods: We searched main electronic databases ... ...

Abstract	Purpose: Although a number of studies involving small-vessel de novo coronary disease showed clinical benefits of drug-coated balloons (DCB), the role of DCB in large vessel lesions is still unclear. Methods: We searched main electronic databases for randomized controlled trials (RCTs) comparing DCB with stents for large vessel de novo coronary artery disease. The primary endpoint was major cardiovascular adverse events (MACE), composite cardiovascular death (CD), myocardial infarction (MI), or target lesion revascularization (TLR). Results: This study included 7 RCTs with 770 participants. DCB were associated with a marked risk reduction in MACE [Risk Ratio (RR): 0.48; 95% confidence interval [CI]: 0.24 to 0.97; P = 0.04], TLR (RR: 0.53; 95% CI: 0.25 to 1.14; P = 0.10), and late lumen loss [standard mean difference (SMD): -0.57; 95% CI: -1.09 to -0.05; P = 0.03] as compared with stents. There is no significant difference in MI (RR: 0.58; 95% CI: 0.21 to 1.54; P = 0.27), CD (RR: 0.33; 95% CI: 0.06 to 1.78; P = 0.19), and minimal lumen diameter (SMD: -0.34; 95% CI: -0.72 to 0.05; P = 0.08) between groups. In subgroup analyses, the risk reduction of MACE persisted in patients with chronic coronary syndrome (RR: 0.25; 95% CI: 0.07 to 0.89; P = 0.03), and patients receiving DCB vs. bare metal stent (RR: 0.19; 95% CI: 0.05 to 0.73; P = 0.01). In addition, there was no significant difference between the DCB group and the drug eluting stent group for MACE (RR: 0.69; 95% CI: 0.30 to 1.60; P = 0.38). Conclusion: DCB may be an effective therapeutic option in patients with large vessel de novo coronary artery disease.
Language	English
Publishing date	2024-01-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639068-7
ISSN	1573-7241 ; 0920-3206
ISSN (online)	1573-7241
ISSN	0920-3206
DOI	10.1007/s10557-024-07548-2
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Article ; Online: Finding information about uncharacterized Drosophila melanogaster genes.

Mohr, Stephanie E / Kim, Ah-Ram / Hu, Yanhui / Perrimon, Norbert

Genetics

2023 Volume 225, Issue 4

Abstract: Genes that have been identified in the genome but remain uncharacterized with regards to function offer an opportunity to uncover novel biological information. Novelty is exciting but can also be a barrier. If nothing is known, how does one start ... ...

Abstract	Genes that have been identified in the genome but remain uncharacterized with regards to function offer an opportunity to uncover novel biological information. Novelty is exciting but can also be a barrier. If nothing is known, how does one start planning and executing experiments? Here, we provide a recommended information-mining workflow and a corresponding guide to accessing information about uncharacterized Drosophila melanogaster genes, such as those assigned only a systematic coding gene identifier. The available information can provide insights into where and when the gene is expressed, what the function of the gene might be, whether there are similar genes in other species, whether there are known relationships to other genes, and whether any other features have already been determined. In addition, available information about relevant reagents can inspire and facilitate experimental studies. Altogether, mining available information can help prioritize genes for further study, as well as provide starting points for experimental assays and other analyses.
MeSH term(s)	Animals ; Drosophila melanogaster/genetics ; Genome
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/iyad187
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Article: Epithelial Ca

Petsakou, Afroditi / Liu, Yifang / Liu, Ying / Comjean, Aram / Hu, Yanhui / Perrimon, Norbert

bioRxiv : the preprint server for biology

2023

Abstract: A fundamental and unresolved question in regenerative biology is how tissues return to homeostasis after injury. Answering this question is essential for understanding the etiology of chronic disorders such as inflammatory bowel diseases and cancer. We ... ...

Abstract	A fundamental and unresolved question in regenerative biology is how tissues return to homeostasis after injury. Answering this question is essential for understanding the etiology of chronic disorders such as inflammatory bowel diseases and cancer. We used the
Language	English
Publishing date	2023-08-15
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.08.14.553227
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Article ; Online: Pooled genome-wide CRISPR activation screening for rapamycin resistance genes in

Xia, Baolong / Viswanatha, Raghuvir / Hu, Yanhui / Mohr, Stephanie E / Perrimon, Norbert

eLife

2023 Volume 12

Abstract: Loss-of-function and gain-of-function genetic perturbations provide valuable insights into gene function. ... ...

Abstract	Loss-of-function and gain-of-function genetic perturbations provide valuable insights into gene function. In
MeSH term(s)	Animals ; Drosophila/genetics ; Sirolimus ; Clustered Regularly Interspaced Short Palindromic Repeats ; CRISPR-Cas Systems ; Genome
Chemical Substances	Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2023-04-20
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.85542
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Article ; Online: Ionic liquids revolutionizing biomedicine: recent advances and emerging opportunities.

Hu, Yanhui / Xing, Yuyuan / Yue, Hua / Chen, Tong / Diao, Yanyan / Wei, Wei / Zhang, Suojiang

Chemical Society reviews

2023 Volume 52, Issue 20, Page(s) 7262–7293

Abstract: Ionic liquids (ILs), due to their inherent structural tunability, outstanding miscibility behavior, and excellent electrochemical properties, have attracted significant research attention in the biomedical field. As the application of ILs in biomedicine ... ...

Abstract	Ionic liquids (ILs), due to their inherent structural tunability, outstanding miscibility behavior, and excellent electrochemical properties, have attracted significant research attention in the biomedical field. As the application of ILs in biomedicine is a rapidly emerging field, there is still a need for systematic analyses and summaries to further advance their development. This review presents a comprehensive survey on the utilization of ILs in the biomedical field. It specifically emphasizes the diverse structures and properties of ILs with their relevance in various biomedical applications. Subsequently, we summarize the mechanisms of ILs as potential drug candidates, exploring their effects on various organisms ranging from cell membranes to organelles, proteins, and nucleic acids. Furthermore, the application of ILs as extractants and catalysts in pharmaceutical engineering is introduced. In addition, we thoroughly review and analyze the applications of ILs in disease diagnosis and delivery systems. By offering an extensive analysis of recent research, our objective is to inspire new ideas and pathways for the design of innovative biomedical technologies based on ILs.
MeSH term(s)	Ionic Liquids/chemistry ; Proteins ; Biomedical Technology ; Cell Membrane
Chemical Substances	Ionic Liquids ; Proteins
Language	English
Publishing date	2023-10-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1472875-8
ISSN	1460-4744 ; 0306-0012
ISSN (online)	1460-4744
ISSN	0306-0012
DOI	10.1039/d3cs00510k
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Article ; Online: Quality of life, household income, and dietary habits are associated with the risk of sarcopenia among the Chinese elderly.

Wan, Hua / Hu, Yan-Hui / Li, Wei-Peng / Wang, Quan / Su, Hong / Chenshu, Jun-Yan / Lu, Xiang / Gao, Wei

Aging clinical and experimental research

2024 Volume 36, Issue 1, Page(s) 29

Abstract: Background: Health-related quality of life (HRQoL), which can be influenced by various aspects, especially socioeconomic status and lifestyle, has been identified as an important predictor of the prognosis of older adults. Dietary habit, a major part of ...

Abstract	Background: Health-related quality of life (HRQoL), which can be influenced by various aspects, especially socioeconomic status and lifestyle, has been identified as an important predictor of the prognosis of older adults. Dietary habit, a major part of lifestyle, can affect the nutritional status, which is closely correlated with the development of geriatric syndromes in the elderly. Aims: The aim of the study was to examine the association of HRQoL, socioeconomic status, and lifestyle with the risk and severity of sarcopenia, a geriatric syndrome characterized by progressive loss of skeletal muscle mass, strength and function. Methods: A cross-sectional retrospective study with 2877 participants aged ≥65 years was performed. HRQoL was assessed using EuroQoL Five Dimensions questionnaire. Socioeconomic status was assessed by the educational attainment, occupation, and household income. Lifestyle was assessed using 12 items closely related to Chinese living habits. The information of daily dietary habits including tea, alcohol, type of diet, and volume of drinking water were collected. The associations of HRQoL, socioeconomic status, and lifestyle with the risk of sarcopenia were examined by multivariate regression logistical analysis. The potential causal role of age, body mass index, and waist circumference in the effect of HRQoL on sarcopenia risk was analyzed by causal mediation analysis. Results: High HRQoL [adjusted odds ratio (OR) =0.85, 95% confidence interval (CI) =0.69-0.95, P=0.034] and household income levels (adjusted OR =0.74, 95% CI =0.57-0.95, P=0.019) were inversely associated with the risk of sarcopenia. Meanwhile, more consumption of spicy food (adjusted OR =1.34, 95% CI =1.09-1.81, P =0.037) and occasionally drinking (adjusted OR =1.46, 95% CI =1.07-2.00, P =0.016, as compared to those never drinking) were associated with higher risk of sarcopenia, while skipping breakfast occasionally (adjusted OR =0.37, 95% CI =0.21-0.64, P <0.001, as compared to those eating breakfast every day) and less consumption of salt (adjusted OR =0.71, 95% CI =0.52-0.96, P =0.026, as compared to those consuming high amount of salt) were associated with lower risk of sarcopenia. Further causal mediation analysis aimed to explore how much age, body mass index, and waist circumference might explain the effect of HRQoL on the risk of sarcopenia showed that the estimated proportion that mediated the effect of HRQoL on the risk of sarcopenia by age was 28.0%. Conclusions: In summary, our findings demonstrate that low levels of HRQoL and household income, more intake of salt and spicy food, and occasional intake of alcohol are correlated with higher risk of sarcopenia, while skipping breakfast occasionally is associated with lower risk of sarcopenia in a Chinese population of older adults.
MeSH term(s)	Aged ; Humans ; Sarcopenia/epidemiology ; Sarcopenia/etiology ; Quality of Life ; Cross-Sectional Studies ; Retrospective Studies ; Feeding Behavior ; China/epidemiology
Language	English
Publishing date	2024-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2104785-6
ISSN	1720-8319 ; 1594-0667
ISSN (online)	1720-8319
ISSN	1594-0667
DOI	10.1007/s40520-023-02656-9
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Zs.A 3343: Show issues

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Article ; Online: Cholinergic neurons trigger epithelial Ca

Petsakou, Afroditi / Liu, Yifang / Liu, Ying / Comjean, Aram / Hu, Yanhui / Perrimon, Norbert

Nature

2023 Volume 623, Issue 7985, Page(s) 122–131

Abstract: A fundamental and unresolved question in regenerative biology is how tissues return to homeostasis after injury. Answering this question is essential for understanding the aetiology of chronic disorders such as inflammatory bowel diseases and ... ...

Abstract	A fundamental and unresolved question in regenerative biology is how tissues return to homeostasis after injury. Answering this question is essential for understanding the aetiology of chronic disorders such as inflammatory bowel diseases and cancer
MeSH term(s)	Animals ; Humans ; Acetylcholine/metabolism ; Acetylcholinesterase/metabolism ; Calcium/metabolism ; Calcium Signaling ; Cholinergic Neurons/metabolism ; Drosophila melanogaster/enzymology ; Drosophila melanogaster/metabolism ; Enterocytes/metabolism ; Homeostasis ; Inflammation/enzymology ; Inflammation/metabolism ; Inflammatory Bowel Diseases/metabolism ; Intestines/cytology ; Intestines/metabolism ; Receptors, Nicotinic/metabolism ; Disease Models, Animal
Chemical Substances	Acetylcholine (N9YNS0M02X) ; Acetylcholinesterase (EC 3.1.1.7) ; Calcium (SY7Q814VUP) ; egr protein, Drosophila ; inx2 protein, Drosophila ; inx7 protein, Drosophila ; Receptors, Nicotinic ; Yki protein, Drosophila
Language	English
Publishing date	2023-09-18
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-023-06627-y
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: A Retrospective Observational Study of Anlotinib in Patients with Platinum-Resistant or Platinum-Refractory Epithelial Ovarian Cancer.

Cui, Qingli / Hu, Yanhui / Ma, Dongyang / Liu, Huaimin

Drug design, development and therapy

2021 Volume 15, Page(s) 339–347

Abstract: Objective: Anlotinib, an oral small-molecular tyrosine kinase inhibitor (TKI) on tumor angiogenesis and growth, has a wide spectrum of inhibitory effects on targets such as vascular endothelial growth factor receptors 2/3 (VEGFR2/3), etc. The efficacy ... ...

Abstract	Objective: Anlotinib, an oral small-molecular tyrosine kinase inhibitor (TKI) on tumor angiogenesis and growth, has a wide spectrum of inhibitory effects on targets such as vascular endothelial growth factor receptors 2/3 (VEGFR2/3), etc. The efficacy and safety of anlotinib in the treatment of platinum-resistant or platinum-refractory ovarian cancer were evaluated. Patients and methods: Patients with platinum-resistant or platinum-refractory ovarian cancer that treated with anlotinib in the Affiliated Cancer Hospital of Zhengzhou University from May 2018 to March 2020 were included. Medical records were reviewed in terms of objective response, survival outcomes, and safety. Results: A total of 38 patients were analyzed. The median progression-free survival and the median overall survival were 7.7 months (95% CI: 6.7-8.7) and 16.5 months (95% CI: 13.3-19.7), respectively. About 17 patients received anlotinib monotherapy, and the median progression-free survival was 7.7 months (95% CI: 6.3-9.1). A total of 19 cases received anlotinib plus chemotherapy with a median progression-free survival of 8.0 months (95% CI: 4.8-11.2). A total of 2 cases received anlotinib plus anti-PD-1 antibody pembrolizumab, and 1 case had partial response, the other progressive disease. The objective response rate was 42.1% while the disease control rate was 86.8%. A total of 5 patients experienced dose reduction from 12 mg to 10 mg because of adverse effects. The most common adverse effects were hypertension (31.6%), fatigue (28.9%), anorexia (26.3%) and hand-foot syndrome (23.7%). No treatment-related deaths were recorded. Conclusion: Anlotinib produced moderate improvements in progression-free survival and overall survival in patients with platinum-resistant or platinum-refractory ovarian cancer. It indicates that anlotinib maybe a new treatment option for patients with platinum-resistant or platinum-refractory ovarian cancer.
MeSH term(s)	Administration, Oral ; Adult ; Aged ; Aged, 80 and over ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Carcinoma, Ovarian Epithelial/drug therapy ; Drug Resistance, Neoplasm/drug effects ; Female ; Humans ; Indoles/administration & dosage ; Indoles/therapeutic use ; Middle Aged ; Ovarian Neoplasms/drug therapy ; Platinum/therapeutic use ; Protein Kinase Inhibitors/administration & dosage ; Protein Kinase Inhibitors/therapeutic use ; Quinolines/administration & dosage ; Quinolines/therapeutic use
Chemical Substances	Indoles ; Protein Kinase Inhibitors ; Quinolines ; anlotinib ; Platinum (49DFR088MY)
Language	English
Publishing date	2021-01-27
Publishing country	New Zealand
Document type	Journal Article ; Observational Study
ZDB-ID	2451346-5
ISSN	1177-8881 ; 1177-8881
ISSN (online)	1177-8881
ISSN	1177-8881
DOI	10.2147/DDDT.S286529
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Article ; Online: mRNA expression profiling of the cancellous bone in patients with idiopathic osteonecrosis of the femoral head by whole-transcriptome sequencing.

Song, Da / Ha, Cheng-Zhi / Xu, Qi / Hu, Yan-Hui

Medicine

2022 Volume 101, Issue 35, Page(s) e30213

Abstract: Idiopathic osteonecrosis of the femoral head (INFH) seriously affects patients' activities and is a heavy burden to society and patients' families. Therefore, the early diagnosis and treatment of INFH is essential in reducing pain and burden. In the ... ...

Abstract	Idiopathic osteonecrosis of the femoral head (INFH) seriously affects patients' activities and is a heavy burden to society and patients' families. Therefore, the early diagnosis and treatment of INFH is essential in reducing pain and burden. In the present study, the cancellous bone under the cartilage of the femoral head was isolated from patients with INFH and femoral neck fracture (FNF). Histological examination revealed that the bone trabecular and the medullary cavity in the INFH group compared with those in the FNF group. Whole-transcriptome sequencing (WTS), a recently applied technology, plays a significant role in the screening of risk factors associated with the onset of femoral head necrosis. Herein, WTS was used to obtain the mRNA expression profile in the cancellous bone of the femoral head isolated from 5 patients with INFH and 5 patients with FNF. Compared with the FNF group, a total of 155 differentially expressed genes were identified in the INFH group. Among these genes, 96 and 59 were upregulated and downregulated, respectively. Reverse transcription-quantitative PCR and western blot analyses revealed that leucine-rich repeat-containing 17 (LRRC17) displayed the most significantly decreased mRNA and protein expression levels between the INFH and FNF groups. The expression profile of the differentially expressed genes and LRRC17 protein in the INFH and FNF groups was consistent with that obtained by WTS. LRRC17, a leucine repeat sequence, plays a significant role in regulating bone metabolism, thus indicating that LRRC17 downregulation could affect bone metabolism and could be considered a key factor in the pathogenesis of INFH.
MeSH term(s)	Cancellous Bone/pathology ; Femur Head/pathology ; Femur Head Necrosis/genetics ; Femur Head Necrosis/pathology ; Humans ; Leucine ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Transcriptome
Chemical Substances	RNA, Messenger ; Leucine (GMW67QNF9C)
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000030213
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