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  1. Article ; Online: Copper(II)-catalyzed enantioselective hydrosilylation of halo-substituted alkyl aryl and heteroaryl ketones: asymmetric synthesis of (R)-fluoxetine and (S)-duloxetine.

    Zhou, Ji-Ning / Fang, Qiang / Hu, Yi-Hu / Yang, Li-Yao / Wu, Fei-Fei / Xie, Lin-Jie / Wu, Jing / Li, Shijun

    Organic & biomolecular chemistry

    2014  Volume 12, Issue 6, Page(s) 1009–1017

    Abstract: A set of reaction conditions has been established to facilitate the non-precious copper-catalyzed enantioselective hydrosilylation of a number of structurally diverse β-, γ- or ε-halo-substituted alkyl aryl ketones and α-, β- or γ-halo-substituted alkyl ... ...

    Abstract A set of reaction conditions has been established to facilitate the non-precious copper-catalyzed enantioselective hydrosilylation of a number of structurally diverse β-, γ- or ε-halo-substituted alkyl aryl ketones and α-, β- or γ-halo-substituted alkyl heteroaryl ketones under air to afford a broad spectrum of halo alcohols in high yields and good to excellent enantioselectivities (up to 99% ee). The developed procedure has been successfully applied to the asymmetric synthesis of antidepressant drugs (R)-fluoxetine and (S)-duloxetine, which highlighted its synthetic utility.
    MeSH term(s) Catalysis ; Copper/chemistry ; Duloxetine Hydrochloride ; Fluoxetine/chemical synthesis ; Fluoxetine/chemistry ; Ketones/chemistry ; Molecular Conformation ; Organometallic Compounds/chemistry ; Stereoisomerism ; Thiophenes/chemical synthesis ; Thiophenes/chemistry
    Chemical Substances Ketones ; Organometallic Compounds ; Thiophenes ; Fluoxetine (01K63SUP8D) ; Copper (789U1901C5) ; Duloxetine Hydrochloride (9044SC542W)
    Language English
    Publishing date 2014-02-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/c3ob42214c
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: A supramolecularly tunable chiral diphosphine ligand: application to Rh and Ir-catalyzed enantioselective hydrogenation.

    Zhang, Xi-Chang / Hu, Yi-Hu / Chen, Chuan-Fu / Fang, Qiang / Yang, Li-Yao / Lu, Ying-Bo / Xie, Lin-Jie / Wu, Jing / Li, Shijun / Fang, Wenjun

    Chemical science

    2016  Volume 7, Issue 7, Page(s) 4594–4599

    Abstract: A supramolecularly tunable chiral bisphosphine ligand bearing two pyridyl-containing crown ethers, (-) or (+)-Xyl-P16C6-Phos, was fabricated and utilized in the Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acid esters and Ir-catalyzed ... ...

    Abstract A supramolecularly tunable chiral bisphosphine ligand bearing two pyridyl-containing crown ethers, (-) or (+)-Xyl-P16C6-Phos, was fabricated and utilized in the Rh-catalyzed asymmetric hydrogenation of α-dehydroamino acid esters and Ir-catalyzed asymmetric hydrogenation of quinolines in high yields with excellent enantioselectivities (90-99% ee). Up to a 22% enhancement in enantioselectivity was achieved by the addition of certain amounts of alkali ions (Li
    Language English
    Publishing date 2016-03-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c6sc00589f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nickel(II)-dipyridylphosphine-catalyzed enantioselective hydrosilylation of ketones in air.

    Wu, Fei-Fei / Zhou, Ji-Ning / Fang, Qiang / Hu, Yi-Hu / Li, Shijun / Zhang, Xi-Chang / Chan, Albert S C / Wu, Jing

    Chemistry, an Asian journal

    2012  Volume 7, Issue 11, Page(s) 2527–2530

    Abstract: Out of thin air: Catalytic amounts of nickel(II) salt and non-racemic dipyridylphosphine ligand, as well as the stoichiometric hydride source PhSiH(3), formed an effective catalyst system for the Ni(II)-catalyzed asymmetric hydrosilylation of a diverse ... ...

    Abstract Out of thin air: Catalytic amounts of nickel(II) salt and non-racemic dipyridylphosphine ligand, as well as the stoichiometric hydride source PhSiH(3), formed an effective catalyst system for the Ni(II)-catalyzed asymmetric hydrosilylation of a diverse range of electron-deficient aryl alkyl ketones with enantioselectivities up to 90% ee. The practical potential of the protocol was evinced by its good air-stability.
    MeSH term(s) Air ; Catalysis ; Electrons ; Ketones/chemistry ; Nickel/chemistry ; Phosphines/chemistry ; Stereoisomerism
    Chemical Substances Ketones ; Phosphines ; Nickel (7OV03QG267) ; phosphine (FW6947296I)
    Language English
    Publishing date 2012-11
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1861-471X
    ISSN (online) 1861-471X
    DOI 10.1002/asia.201200512
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Luminescence investigation of Na(z)Ca(1-x-2y-z)Bi(y)MoO4 : Eu(x+y)3+, red phosphors].

    Kang, Feng-Wen / Hu, Yi-Hu / Wang, Yin-Hai / Wu, Hao-Yi / Mu, Zhong-Fei / Ju, Gui-Fang / Fu, Chu-Jun

    Guang pu xue yu guang pu fen xi = Guang pu

    2011  Volume 31, Issue 9, Page(s) 2341–2345

    Abstract: A series of red phosphors with the composition Na(z)Ca(1-x-2y-z), Bi(y) MoO4 : Eu(x+y)3+ (y, z = 0, x = 0.24, 0.26, 0.30, 0.34, 0.38; x = 0.30, y = 0.01, 0.02, 0.03, 0.03, 0.05, 0.06, 0.07; x = 0.30, y = 0.04, z = 0.38) were prepared via traditional ... ...

    Abstract A series of red phosphors with the composition Na(z)Ca(1-x-2y-z), Bi(y) MoO4 : Eu(x+y)3+ (y, z = 0, x = 0.24, 0.26, 0.30, 0.34, 0.38; x = 0.30, y = 0.01, 0.02, 0.03, 0.03, 0.05, 0.06, 0.07; x = 0.30, y = 0.04, z = 0.38) were prepared via traditional solid-state method. The crystal structures of the obtained phosphors were identified by X-ray powder diffraction (XRD) method. The photoluminescence properties of the samples were characterized by fluorescence spectrophotometer. The results indicated that the concentration of Eu3+ single doped Ca(1-x) MoO4 : Eu3+ with the maximum luminescence intensity was found to be 0.30 (namely, Ca0.70 MoO4 : Eu(0.30)3+); the photoluminescence properties with different ratio of Bi3+/Eu3+ codoped Ca0.70-2y Bi(y) MoO4 : Eu(0.30+y)3+, were also investigated, and the results showed that the charge band (CTB) reached the maximum value when the y value was equal to 0.03; for the characteristic excitation peaks of Eu3+, however, the intensity of the excitation spectral line locating at 393 nm was stronger than that at 464 nm when y < 0.03, while the intensity at 464 nm was greater than that at 393 nm when y > or = 0.03; the intensity of excitation peaks locating at 393 and 464 nm respectively both reached the maximum intensity when the y value was 0.04. The relative intensity of the excitation and emission of the above phosphor was enhanced greatly when Na2CO3 acting as charge compensation was added. The above results showed that the relative intensity between 393 and 464 nm could be changed by adjusting the ratio of Bi3+ /Eu3+ codoping concentrations.
    Language Chinese
    Publishing date 2011-09
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 1000-0593
    ISSN 1000-0593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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