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  1. AU="Hu, Yizhong"
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  30. AU=Gerhardy A
  31. AU="Qi, Huixin"
  32. AU="Dobosiewicz, May"
  33. AU="Srivastava, Rakesh"
  34. AU="Grevtsov K.I."

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  1. Artikel ; Online: Individual trabecula segmentation validation in first- and second-generation high-resolution peripheral computed tomography compared to micro-computed tomography in the distal radius and tibia.

    Dinescu, Andreea Teodora / Zhou, Bin / Hu, Yizhong Jenny / Agarwal, Sanchita / Shane, Elizabeth / Guo, Xiang-Dong Edward

    JBMR plus

    2024  Band 8, Heft 3, Seite(n) ziae007

    Abstract: High-resolution peripheral quantitative computed tomography (HR-pQCT) has been used for in vivo 3D visualization of trabecular microstructure. Second-generation HR-pQCT (HR-pQCT II) has been shown to have good agreement with first generation HR-pQCT (HR- ... ...

    Abstract High-resolution peripheral quantitative computed tomography (HR-pQCT) has been used for in vivo 3D visualization of trabecular microstructure. Second-generation HR-pQCT (HR-pQCT II) has been shown to have good agreement with first generation HR-pQCT (HR-pQCT I). Advanced Individual Trabecula Segmentation (ITS) decomposes the trabecula network into individual plates and rods. ITS based on HR-pQCT I showed a strong correlation to ITS based on micro-computed tomography (μCT) and identified trabecular changes in metabolic bone diseases. ITS based on HR-pQCT II has new potential because of the enhanced resolution but has yet to be validated. The objective of this study was to assess the agreement between ITS based on HR-pQCT I, HR-pQCT II, and μCT to assess the capability of ITS on HR-pQCT images as a tool for studying bone structure. Freshly frozen tibia and radius bones were scanned in the distal region using HR-pQCT I at 82 μm, HR-pQCT II at 60.7 μm, and μCT at 37 μm. Images were registered, binarized, and ITS analysis was performed. Bone volume fraction (pBV/TV, rBV/TV), number density (pTb.N, rTb.N), thickness (pTb.Th, rTb.Th), and plate-to-rod (PR) ratio (pBV/rBV) of trabecular plates and rods were obtained. Paired Student's
    Sprache Englisch
    Erscheinungsdatum 2024-01-04
    Erscheinungsland England
    Dokumenttyp Journal Article
    ISSN 2473-4039
    ISSN (online) 2473-4039
    DOI 10.1093/jbmrpl/ziae007
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  2. Artikel ; Online: Association between serum galectin-3 and chronic obstructive pulmonary disease: A meta-analysis.

    Zhao, Xiangyu / Han, Bo / Tang, Wentao / Ji, Shanshan / Wang, Lie / Huang, Jinbao / Hu, Yizhong / Li, Jie

    Biomolecules & biomedicine

    2024  

    Abstract: Chronic obstructive pulmonary disease (COPD) is a significant public health issue characterized by progressive and irreversible airflow limitation. The aim of this meta-analysis was to determine the association between changes in serum galectin-3 levels ... ...

    Abstract Chronic obstructive pulmonary disease (COPD) is a significant public health issue characterized by progressive and irreversible airflow limitation. The aim of this meta-analysis was to determine the association between changes in serum galectin-3 levels and COPD and to assess the relationship between serum galectin-3 levels and acute exacerbations of COPD (AECOPD). Relevant observational studies were retrieved from electronic databases, including PubMed, Web of Science, Embase, Wanfang, and China National Knowledge Infrastructure (CNKI). A random-effects model was used to combine the data, incorporating the influence of between-study heterogeneity. Twelve case-control studies were included. The pooled results showed a significantly higher serum level of galectin-3 in patients with COPD compared to controls (standardized mean difference [SMD] 0.60; 95% confidence interval [CI] 0.40 - 0.80; P < 0.001; I2 = 68%). Further meta-analysis suggested higher levels of serum galectin-3 in patients with AECOPD compared to those with stable COPD (SMD 0.33; 95% CI 0.20 - 0.46; P < 0.001; I2 = 0%). Subgroup analyses according to the mean age of the participants, the proportion of males, and study quality scores did not significantly change the results (P for subgroup differences all > 0.05). In conclusion, patients with COPD were found to have higher serum levels of galectin-3, with levels further elevated in patients with AECOPD compared to those with stable COPD.
    Sprache Englisch
    Erscheinungsdatum 2024-05-26
    Erscheinungsland Bosnia and Herzegovina
    Dokumenttyp Meta-Analysis
    ISSN 2831-090X
    ISSN (online) 2831-090X
    DOI 10.17305/bb.2024.10527
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Yap controls notochord formation and neural tube patterning by integrating mechanotransduction with

    Cheng, Caiqi / Cong, Qian / Liu, Yuchen / Hu, Yizhong / Liang, Guoyan / Dioneda, Kevin Marc Manquiquis / Yang, Yingzi

    Science advances

    2023  Band 9, Heft 24, Seite(n) eadf6927

    Abstract: Correct notochord and neural tube (NT) formation is crucial to the development of the central nervous system and midline structures. Integrated biochemical and biophysical signaling controls embryonic growth and patterning; however, the underlying ... ...

    Abstract Correct notochord and neural tube (NT) formation is crucial to the development of the central nervous system and midline structures. Integrated biochemical and biophysical signaling controls embryonic growth and patterning; however, the underlying mechanisms remain poorly understood. Here, we took the opportunities of marked morphological changes during notochord and NT formation and identified both necessary and sufficient roles of Yap, a key mechanosensor and mechanotransducer, in biochemical signaling activation during formation of notochord and floor plate, the ventral signaling centers that pattern the dorsal-ventral axis of NT and the surrounding tissues. We showed that Yap activation by a gradient of mechanical stress and tissue stiffness in the notochord and ventral NT induces
    Mesh-Begriff(e) Central Nervous System/embryology ; Embryonic Development ; Hedgehog Proteins ; Mechanotransduction, Cellular ; Neural Tube/embryology ; YAP-Signaling Proteins ; Hepatocyte Nuclear Factor 3-beta
    Chemische Substanzen Hedgehog Proteins ; YAP-Signaling Proteins ; Hepatocyte Nuclear Factor 3-beta (135845-92-0)
    Sprache Englisch
    Erscheinungsdatum 2023-06-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adf6927
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Amygdalin Improves Allergic Asthma via the Thymic Stromal Lymphopoietin-dendritic Cell-OX40 Ligand Axis in a Mouse Model.

    Cui, Wen / Zhou, Huan / Liu, Ya-Zun / Yang, Yan / Hu, Yi-Zhong / Han, Zhao-Peng / Yu, Jian-Er / Xue, Zheng

    Iranian journal of allergy, asthma, and immunology

    2023  Band 22, Heft 5, Seite(n) 430–439

    Abstract: Asthma, characterized by persistent inflammation and increased sensitivity of the airway, is the most common chronic condition among children. Novel, safe, and reliable treatment strategies are the focus of current research on pediatric asthma. Amygdalin, ...

    Abstract Asthma, characterized by persistent inflammation and increased sensitivity of the airway, is the most common chronic condition among children. Novel, safe, and reliable treatment strategies are the focus of current research on pediatric asthma. Amygdalin, mainly present in bitter almonds, has anti-inflammatory and immunoregulatory potential, but its effect on asthma remains uninvestigated. Here, the impact of amygdalin on the thymic stromal lymphopoietin (TSLP)-dendritic cell (DC)-OX40L axis was investigated. A BALB/c mouse model for allergic asthma was established using the ovalbumin-sensitization method. Amygdalin treatment was administered between days 21 and 27 of the protocol. Cell numbers and hematoxylin and eosin (H&E) staining in bronchoalveolar lavage fluid (BALF) were used to observe the impact of amygdalin on airway inflammation. TSLP, IL-4, IL-5, IL-13, and IFN-γ concentrations were determined via Enzyme-linked immunosorbent assay (ELISA). TSLP, GATA-3, and T-bet proteins were measured using western blotting. Cell-surface receptor expression on DCs (MHC II, CD80, and CD86) was assessed via flow cytometry. OX40L mRNA and protein levels were detected using western blotting and qRT-PCR, respectively. Amygdalin treatment attenuated airway inflammation decreased BALF TSLP levels, inhibited DC maturation, restrained TSLP-induced DC surface marker expression (MHCII, CD80, and CD86), and further decreased OX40L levels in activated DCs. This occurred together with decreased Th2 cytokine levels (IL-4, IL-5, and IL-13) and GATA3 expression, whereas Th1 cytokine (IFN-γ) levels and T-bet expression increased. Amygdalin thus regulates the Th1/Th2 balance through the TSLP-DC-OX40L axis to participate in inflammation development in the airways, providing a basis for potential allergic asthma treatments.
    Mesh-Begriff(e) Mice ; Animals ; Child ; Humans ; Thymic Stromal Lymphopoietin ; Interleukin-13/metabolism ; Interleukin-13/pharmacology ; Amygdalin/pharmacology ; Amygdalin/therapeutic use ; Amygdalin/metabolism ; OX40 Ligand/metabolism ; OX40 Ligand/pharmacology ; Interleukin-4/metabolism ; Interleukin-5/metabolism ; Interleukin-5/pharmacology ; Cytokines/metabolism ; Asthma/metabolism ; Disease Models, Animal ; Inflammation/metabolism ; Th2 Cells/metabolism ; Dendritic Cells/metabolism ; Mice, Inbred BALB C
    Chemische Substanzen Thymic Stromal Lymphopoietin (GT0IL38SP4) ; Interleukin-13 ; Amygdalin (214UUQ9N0H) ; OX40 Ligand ; Interleukin-4 (207137-56-2) ; Interleukin-5 ; Cytokines
    Sprache Englisch
    Erscheinungsdatum 2023-10-29
    Erscheinungsland Iran
    Dokumenttyp Journal Article
    ZDB-ID 2488724-9
    ISSN 1735-5249 ; 1735-1502
    ISSN (online) 1735-5249
    ISSN 1735-1502
    DOI 10.18502/ijaai.v22i5.13993
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Professor HUANG Sheng-Kai.

    Hu, Yi-Zhong / Gao, Ling

    Acta pharmacologica Sinica

    2016  Band 37, Heft 12, Seite(n) 1645

    Mesh-Begriff(e) China ; History, 20th Century ; History, 21st Century ; Pharmacokinetics ; Pharmacology/education ; Pharmacology/history
    Sprache Englisch
    Erscheinungsdatum 2016-11
    Erscheinungsland United States
    Dokumenttyp Biography ; Historical Article ; Journal Article
    ZDB-ID 1360774-1
    ISSN 1745-7254 ; 0253-9756 ; 1671-4083
    ISSN (online) 1745-7254
    ISSN 0253-9756 ; 1671-4083
    DOI 10.1038/aps.2016.132
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  6. Artikel ; Online: Microstructure Determines Apparent-Level Mechanics Despite Tissue-Level Anisotropy and Heterogeneity of Individual Plates and Rods in Normal Human Trabecular Bone.

    Yu, Y Eric / Hu, Yizhong Jenny / Zhou, Bin / Wang, Ji / Guo, X Edward

    Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research

    2021  Band 36, Heft 9, Seite(n) 1796–1807

    Abstract: Trabecular plates and rods determine apparent elastic modulus and yield strength of trabecular bone, serving as important indicators of bone's mechanical integrity in health and disease. Although trabecular bone's apparent-level mechanical properties ... ...

    Abstract Trabecular plates and rods determine apparent elastic modulus and yield strength of trabecular bone, serving as important indicators of bone's mechanical integrity in health and disease. Although trabecular bone's apparent-level mechanical properties have been widely reported, tissue mechanical properties of individual trabeculae have not been fully characterized. We systematically measured tissue mineral density (TMD)-dependent elastic modulus of individual trabeculae using microindentation and characterized its anisotropy as a function of trabecular type (plate or rod), trabecular orientation in the global coordinate (longitudinal, oblique, or transverse along the anatomic loading axis), and indentation direction along the local trabecular coordinate (axial or lateral). Human trabecular bone samples were scanned by micro-computed tomography for TMD and microstructural measurements. Individual trabecula segmentation was used to decompose trabecular network into individual trabeculae, where trabecular type and orientation were determined. We performed precise, selective indentation of trabeculae in each category using a custom-built, microscope-coupled microindentation device. Co-localization of TMD at each indentation site was performed to obtain TMD-to-modulus correlations. We found significantly higher TMD and tissue modulus in trabecular plates than rods. Regardless of trabecular type and orientation, axial tissue modulus was consistently higher than lateral tissue modulus, with ratios ranging from 1.13 to 1.41. Correlations between TMD and tissue modulus measured from axial and lateral indentations were strong but distinct: axial correlation predicted higher tissue modulus than lateral correlation at the same TMD level. To assess the contribution of experimentally measured anisotropic tissue properties of individual trabeculae to apparent-level mechanics, we constructed non-linear micro-finite element models using a new set of trabecular bone samples and compared model predictions to mechanical testing measurements. Heterogeneous anisotropic models accurately predicted apparent elastic modulus but were no better than a simple homogeneous isotropic model. Variances in tissue-level properties may therefore contribute nominally to apparent-level mechanics in normal human trabecular bone. © 2021 American Society for Bone and Mineral Research (ASBMR).
    Mesh-Begriff(e) Anisotropy ; Biomechanical Phenomena ; Bone and Bones/diagnostic imaging ; Cancellous Bone/diagnostic imaging ; Elastic Modulus ; Humans ; X-Ray Microtomography
    Sprache Englisch
    Erscheinungsdatum 2021-06-03
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 632783-7
    ISSN 1523-4681 ; 0884-0431
    ISSN (online) 1523-4681
    ISSN 0884-0431
    DOI 10.1002/jbmr.4338
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  7. Artikel ; Online: The effect of denosumab and alendronate on trabecular plate and rod microstructure at the distal tibia and radius: A post-hoc HR-pQCT study.

    Hu, Yizhong Jenny / Chines, Arkadi / Shi, Yifei / Seeman, Ego / Guo, X Edward

    Bone

    2021  Band 154, Seite(n) 116187

    Abstract: Background: Age-related trabecular microstructural deterioration and conversion from plate-like trabeculae to rod-like trabeculae occur because of unbalanced rapid remodeling. As denosumab achieves greater remodeling suppression and lower cortical ... ...

    Abstract Background: Age-related trabecular microstructural deterioration and conversion from plate-like trabeculae to rod-like trabeculae occur because of unbalanced rapid remodeling. As denosumab achieves greater remodeling suppression and lower cortical porosity than alendronate, we hypothesized that denosumab might also preserve trabecular plate microstructure, bone stiffness and strength more effectively than alendronate.
    Methods: In this post hoc analysis of a phase 2 study, postmenopausal women randomized to placebo (P, n = 74), denosumab (D, n = 72), or alendronate (A, n = 68). HR-pQCT scans of the distal radius and tibia were performed at baseline and Month-12 (M12). Trabecular compartment was subjected to Individual Trabecula Segmentation while finite element analysis was performed to estimate stiffness and strength. Percent change from baseline at M12 of each parameter was compared between patient groups.
    Results: At the distal tibia, in the placebo group, plate surface area (pTb.S, -1.3%) decreased while rod bone volume fraction (rBV/TV, +4.5%) and number (rTb.N, +2.1%) increased. These changes were prevented by denosumab but persisted despite alendronate therapy (pTb.S: -1.7%; rBV/TV: +6.9%; rTb.N: +3.0%). Both treatments improved whole bone stiffness (D: +3.1%; A: +1.8%) and failure load (D: +3.0%; A: +2.2%); improvements using denosumab was significant compared to placebo (stiffness: p = 0.004; failure load: p = 0.003). At the distal radius, denosumab increased total trabecular bone volume fraction (BV/TV, +3.4%) and whole bone failure load (+4.0%), significantly different from placebo (BV/TV: p = 0.044; failure load: p = 0.046). Significantly different effects of either drug on plate and rod microstructure were not detected.
    Conclusions: Denosumab preserved trabecular plate microstructure. Alendronate did not. However, estimated strength did not differ between denosumab and alendronate treated groups.
    Mesh-Begriff(e) Alendronate/pharmacology ; Alendronate/therapeutic use ; Bone Density ; Denosumab/pharmacology ; Denosumab/therapeutic use ; Female ; Humans ; Radius/diagnostic imaging ; Tibia/diagnostic imaging
    Chemische Substanzen Denosumab (4EQZ6YO2HI) ; Alendronate (X1J18R4W8P)
    Sprache Englisch
    Erscheinungsdatum 2021-09-14
    Erscheinungsland United States
    Dokumenttyp Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2021.116187
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  8. Artikel ; Online: Early zoledronate treatment inhibits subchondral bone microstructural changes in skeletally-mature, ACL-transected canine knees.

    Xu, Lei / Hu, Yizhong Jenny / Peng, Ying / Wang, Zexi / Wang, Jingyi / Lu, W William / Tang, Bin / Guo, X Edward

    Bone

    2022  Band 167, Seite(n) 116638

    Abstract: Anterior cruciate ligament (ACL) tear leads to post-traumatic osteoarthritis (PTOA), a significant clinical burden worldwide that currently has no cure. Recent studies suggest a role of subchondral bone adaptations in the development of PTOA. ... ...

    Abstract Anterior cruciate ligament (ACL) tear leads to post-traumatic osteoarthritis (PTOA), a significant clinical burden worldwide that currently has no cure. Recent studies suggest a role of subchondral bone adaptations in the development of PTOA. Particularly, microstructural changes in the rod-and-plate microstructure of subchondral bone may precede and contribute to OA progression. In this study, we quantified microstructural changes in subchondral trabecular rods and plates after ACL-transection for the first time in the well-established preclinical canine model of PTOA and investigated the therapeutic potentials of a bisphosphonate (zoledronate) and NSAID treatment (meloxicam). Unilateral hindlimb ACL transection was performed on skeletally-mature (2-year-old, N = 20) and juvenile (10-month-old, N = 20) male beagles. Animals were assigned to 4 groups (N = 5): ACLT, un-operated control, ACLT with zoledronate, and ACLT with meloxicam treatment. Subchondral bone microstructure was evaluated by micro-computed tomography and cartilage integrity was evaluated histologically. We found that ACL-induced subchondral bone changes depended on skeletal maturity of animals. In mature animals, significant loss of trabecular plates that resulted in reduced PR ratio occurred at Month 1 and persisted until Month 8. Zoledronate treatment prevented trabecular plate loss while meloxicam treatment did not. Whether cartilage degeneration is also attenuated warrants further investigation. In juvenile animals that have not reached skeletal maturity, transient changes in trabecular plate and rod microstructure occurred at Month 3 but not Month 9. Neither zoledronate nor meloxicam treatment attenuated bone microstructural changes or cartilage damages. Findings from this study suggest that early inhibition of bone resorption by bisphosphonate after injury may be a promising therapeutic approach to prevent alterations in subchondral bone microstructure associated with PTOA. Our results further demonstrate that pathogenesis of PTOA may differ between adolescent and adult patients and therefore require distinct management strategies.
    Mesh-Begriff(e) Animals ; Male ; Dogs ; Zoledronic Acid/pharmacology ; Zoledronic Acid/therapeutic use ; X-Ray Microtomography ; Meloxicam/pharmacology ; Meloxicam/therapeutic use ; Bone and Bones/pathology ; Osteoarthritis/pathology ; Anterior Cruciate Ligament Injuries/drug therapy ; Anterior Cruciate Ligament Injuries/complications ; Cartilage, Articular/pathology ; Disease Models, Animal
    Chemische Substanzen Zoledronic Acid (6XC1PAD3KF) ; Meloxicam (VG2QF83CGL)
    Sprache Englisch
    Erscheinungsdatum 2022-12-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 632515-4
    ISSN 1873-2763 ; 8756-3282
    ISSN (online) 1873-2763
    ISSN 8756-3282
    DOI 10.1016/j.bone.2022.116638
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Fabrication of Self-Cleaning Superhydrophobic Surfaces with Improved Corrosion Resistance on 6061 Aluminum Alloys.

    Dong, Xiaojuan / Meng, Jianbing / Hu, Yizhong / Wei, Xiuting / Luan, Xiaosheng / Zhou, Haian

    Micromachines

    2020  Band 11, Heft 2

    Abstract: Aluminum alloys are widely used, but they are prone to contamination or damage under harsh working environments. In this paper, a self-cleaning superhydrophobic aluminum alloy surface with good corrosion resistance was successfully fabricated via the ... ...

    Abstract Aluminum alloys are widely used, but they are prone to contamination or damage under harsh working environments. In this paper, a self-cleaning superhydrophobic aluminum alloy surface with good corrosion resistance was successfully fabricated via the combination of sand peening and electrochemical oxidation, and it was subsequently covered with a fluoroalkylsilane (FAS) film. The surface morphology, surface wettability, and corrosion resistance were investigated using a scanning electron microscope (SEM), an optical contact angle measurement, and an electrochemical workstation. The results show that binary rough structures and an FAS film with a low surface energy on the Al alloy surfaces confer good superhydrophobicity with a water contact angle of 167.5 ± 1.1° and a sliding angle of 2.5 ± 0.7°. Meanwhile, the potentiodynamic polarization curve shows that the corrosion potential has a positively shifted trend, and the corrosion current density decreases by three orders of magnitude compared with that of the original aluminum alloy sample. In addition, the chemical stability of the as-prepared superhydrophobic surface was evaluated by dripping test using solutions with different pH values for different immersion time. It indicates that the superhydrophobic surface could provide long-term corrosion protection for aluminum alloys. Consequently, the as-prepared superhydrophobic surface has excellent contamination resistance and self-cleaning efficacy, which are important for practical applications.
    Sprache Englisch
    Erscheinungsdatum 2020-02-01
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11020159
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Experimental Investigation on Ultrasonic Atomization Assisted Turning of Titanium Alloy.

    Meng, Jianbing / Huang, Bingqi / Dong, Xiaojuan / Hu, Yizhong / Zhao, Yugang / Wei, Xiuting / Luan, Xiaosheng

    Micromachines

    2020  Band 11, Heft 2

    Abstract: There are high cutting temperatures, large tool wear, and poor tool life in conventional machining, owing to the superior strength and low thermal conductivity of titanium alloy. In this work, ultrasonic atomization assisted turning (UAAT) of Ti6Al4V was ...

    Abstract There are high cutting temperatures, large tool wear, and poor tool life in conventional machining, owing to the superior strength and low thermal conductivity of titanium alloy. In this work, ultrasonic atomization assisted turning (UAAT) of Ti6Al4V was performed with a mixed water-soluble oil-based cutting fluid, dispersed into tiny droplets by the high frequency vibration of a piezoelectric crystal. Different cutting speeds and two machining environments, dry and ultrasonic atomization assisted machining, were considered in the investigation of tool life, tool wear morphology, surface roughness, and chip morphology. In comparison with dry machining, UAAT shows lower tool wear and longer tool life due to the advantages of cooling and lubrication. Furthermore, better surface roughness, smoother chip edges, and shorter tool-chip contact length were obtained with UAAT.
    Sprache Englisch
    Erscheinungsdatum 2020-02-05
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi11020168
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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