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  1. Article: IGFBP7 downregulation or overexpression effect on bovine preadipocyte differentiation

    Hu, Zhongchang / Wu, Jian / Qin, Lihong / Jin, Haiguo / Cao, Yang / Zhao, Yumin

    Animal biotechnology. 2021 Feb. 1, v. 32, no. 1

    2021  

    Abstract: The insulin-like growth factor binding-protein 7 (IGFBP7) has binding affinities to IGFs and is able to either positively or negatively regulate the IGFs signaling pathway. It also plays a crucial role in cell growth, differentiation and development in ... ...

    Abstract The insulin-like growth factor binding-protein 7 (IGFBP7) has binding affinities to IGFs and is able to either positively or negatively regulate the IGFs signaling pathway. It also plays a crucial role in cell growth, differentiation and development in an IGF-independent manner. Herein, we investigated the specific regulation of the gene encoding for IGFBP7during the differentiation process of the adipocyte cells of the Yan Yellow Cattle by interfering with or by overexpressing the IGFBP7 gene. As a result, we found that the mRNA expression levels of IGFBP7 were significantly increased during the formation of progenitor cells. In addition, the expression levels of the lipoprotein lipase (LPL) and transcription factors (PPARγ, C/EBPα) were also significantly increased. IGFBP7 gene overexpression and RNA interfering promoted and inhibited respectively the lipid accumulation and triglyceride production in mature adipocytes, and the expression of the LPL and transcription factors (PPARγ, C/EBPα). The changes in the protein expression levels of IGFBP7 and adipogenic factors were in accord with the changes observed in the mRNA levels. In conclusion, our results indicate that IGFBP7 plays an important regulatory role in the differentiation of preadipocyte cells.
    Keywords adipocytes ; biotechnology ; cattle ; cell growth ; gene overexpression ; genes ; lipoprotein lipase ; protein synthesis ; somatomedins ; triacylglycerols
    Language English
    Dates of publication 2021-0201
    Size p. 21-30.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2043243-4
    ISSN 1532-2378 ; 1049-5398
    ISSN (online) 1532-2378
    ISSN 1049-5398
    DOI 10.1080/10495398.2019.1642906
    Database NAL-Catalogue (AGRICOLA)

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  2. Article: ALDH1A1 effect on Yan Yellow Cattle preadipocyte differentiation

    Hu, Zhongchang / Wu, Jian / Qin, Lihong / Jin, Haiguo / Lv, Yang / Zhang, Ran / Xiao, Cheng / Cao, Yang / Zhao, Yumin

    Animal biotechnology. 2021 Apr. 1, v. 32, no. 2

    2021  

    Abstract: Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cytosolic enzyme that mainly catalyzes the oxidation of acetaldehyde into acetic acid and participates in the regulation of differentiation and gene expression in fat cell growth and development. However, the ... ...

    Abstract Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cytosolic enzyme that mainly catalyzes the oxidation of acetaldehyde into acetic acid and participates in the regulation of differentiation and gene expression in fat cell growth and development. However, the physiological role of ALDH1A1 in the formation of fat cell precursors in the Yan Yellow Cattle is still not clear. Herein, we investigated the specific regulation of the gene encoding for ALDH1A1 during the differentiation process of the adipocyte cells of the Yan Yellow Cattle by interfering or overexpressing the ALDH1A1 gene. As a result, we found that the mRNA expression levels of ALDH1A1 were significantly increased during the formation of progenitor cells. In addition, the expression levels of the Lipoprotein lipase (LPL) and transcription factors (PPARγ, C/EBPα) were also significantly increased. ALDH1A1 gene overexpression and RNA interfering promoted and inhibited respectively the lipid accumulation and triglyceride production in mature adipocytes, and the expression of the LPL and transcription factors (PPARγ, C/EBPα). The changes in the protein expression levels of ALDH1A1 and adipogenic factors were in accord with the changes observed in the mRNA levels. In conclusion, our results indicate that ALDH1A1 plays an important regulatory role in the differentiation of preadipocyte cells.
    Keywords acetaldehyde ; acetic acid ; adipocytes ; aldehyde dehydrogenase ; biotechnology ; cattle ; cell growth ; gene overexpression ; genes ; growth and development ; lipoprotein lipase ; oxidation ; protein synthesis ; triacylglycerols
    Language English
    Dates of publication 2021-0401
    Size p. 219-228.
    Publishing place Taylor & Francis
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 2043243-4
    ISSN 1532-2378 ; 1049-5398
    ISSN (online) 1532-2378
    ISSN 1049-5398
    DOI 10.1080/10495398.2019.1679824
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: IGFBP7 downregulation or overexpression effect on bovine preadipocyte differentiation.

    Hu, Zhongchang / Wu, Jian / Qin, Lihong / Jin, Haiguo / Cao, Yang / Zhao, Yumin

    Animal biotechnology

    2019  Volume 32, Issue 1, Page(s) 21–30

    Abstract: The insulin-like growth factor binding-protein 7 (IGFBP7) has binding affinities to IGFs and is able to either positively or negatively regulate the IGFs signaling pathway. It also plays a crucial role in cell growth, differentiation and development in ... ...

    Abstract The insulin-like growth factor binding-protein 7 (IGFBP7) has binding affinities to IGFs and is able to either positively or negatively regulate the IGFs signaling pathway. It also plays a crucial role in cell growth, differentiation and development in an IGF-independent manner. Herein, we investigated the specific regulation of the gene encoding for IGFBP7during the differentiation process of the adipocyte cells of the Yan Yellow Cattle by interfering with or by overexpressing the
    MeSH term(s) Adipocytes/metabolism ; Adipogenesis/genetics ; Animals ; Cattle ; Cells, Cultured ; Down-Regulation/genetics ; Insulin-Like Growth Factor Binding Proteins/genetics ; Insulin-Like Growth Factor Binding Proteins/metabolism ; Lipid Metabolism/genetics ; Lipoprotein Lipase/genetics ; Lipoprotein Lipase/metabolism
    Chemical Substances Insulin-Like Growth Factor Binding Proteins ; Lipoprotein Lipase (EC 3.1.1.34)
    Language English
    Publishing date 2019-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2043243-4
    ISSN 1532-2378 ; 1049-5398
    ISSN (online) 1532-2378
    ISSN 1049-5398
    DOI 10.1080/10495398.2019.1642906
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Effect of

    Lv, Yang / Cao, Yang / Gao, Yi / Yun, Jinyan / Yu, Yongsheng / Zhang, Lichun / Hu, Zhongchang / Liu, Lixiang / Xue, Jiajia / Zhang, Guoliang

    DNA and cell biology

    2019  Volume 38, Issue 9, Page(s) 945–954

    Abstract: Domestic cattle are an important type of livestock, with beef production playing a major role in the agricultural economy. Adipocyte levels and fat content are interrelated, with meat quality being highly dependent on its fat content and distribution. ... ...

    Abstract Domestic cattle are an important type of livestock, with beef production playing a major role in the agricultural economy. Adipocyte levels and fat content are interrelated, with meat quality being highly dependent on its fat content and distribution. Acyl-CoA synthetases of long-chain (ACSL) fatty acids (FAs) play an integral role in virtually every metabolic pathway in mammalian biochemistry, including complex lipid biosynthesis, protein modification, and β-oxidation processes.
    MeSH term(s) Adipocytes/cytology ; Adipocytes/metabolism ; Adipogenesis ; Animals ; CCAAT-Enhancer-Binding Protein-alpha/genetics ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; Cattle/genetics ; Cells, Cultured ; Coenzyme A Ligases/genetics ; Coenzyme A Ligases/metabolism ; PPAR gamma/genetics ; PPAR gamma/metabolism
    Chemical Substances CCAAT-Enhancer-Binding Protein-alpha ; PPAR gamma ; Coenzyme A Ligases (EC 6.2.1.-) ; long-chain-fatty-acid-CoA ligase (EC 6.2.1.3)
    Language English
    Publishing date 2019-07-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1024454-2
    ISSN 1557-7430 ; 0198-0238 ; 1044-5498
    ISSN (online) 1557-7430
    ISSN 0198-0238 ; 1044-5498
    DOI 10.1089/dna.2018.4443
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

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  5. Article ; Online: ALDH1A1

    Hu, Zhongchang / Wu, Jian / Qin, Lihong / Jin, Haiguo / Lv, Yang / Zhang, Ran / Xiao, Cheng / Cao, Yang / Zhao, Yumin

    Animal biotechnology

    2019  Volume 32, Issue 2, Page(s) 219–228

    Abstract: Aldehyde dehydrogenase 1A1 ( ...

    Abstract Aldehyde dehydrogenase 1A1 (
    MeSH term(s) Adipocytes/physiology ; Aldehyde Dehydrogenase 1 Family/genetics ; Animals ; Cattle/genetics ; Cattle/physiology ; Cell Differentiation/physiology ; Gene Expression Regulation/physiology ; Lipid Metabolism ; Retinal Dehydrogenase/genetics
    Chemical Substances Aldehyde Dehydrogenase 1 Family (EC 1.2.1) ; Retinal Dehydrogenase (EC 1.2.1.36)
    Language English
    Publishing date 2019-10-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2043243-4
    ISSN 1532-2378 ; 1049-5398
    ISSN (online) 1532-2378
    ISSN 1049-5398
    DOI 10.1080/10495398.2019.1679824
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The effect of Acot2 overexpression or downregulation on the preadipocyte differentiation in Chinese Red Steppe cattle.

    Liu, Lixiang / Wu, Jian / Gao, Yi / Lv, Yang / Xue, Jiajia / Qin, Lihong / Xiao, Cheng / Hu, Zhongchang / Zhang, Lichun / Luo, Xiaotong / Wang, Yanli / Cao, Yang / Zhang, Guoliang

    Adipocyte

    2020  Volume 9, Issue 1, Page(s) 279–289

    Abstract: The quality and nutritional value of beef is closely linked to its content of intramuscular fat (IMF). The differentiation of preadipocytes and the deposition of lipid droplets in the adipocytes are the key to regulate the IMF content. The ... ...

    Abstract The quality and nutritional value of beef is closely linked to its content of intramuscular fat (IMF). The differentiation of preadipocytes and the deposition of lipid droplets in the adipocytes are the key to regulate the IMF content. The differentiation of adipocytes is regulated by a series of transcription factors and genes. Acyl-CoA thioesterase 2 (Acot2) hydrolyzes the acyl-coenzyme A (CoA) into free fatty acids and CoA and has the potential to maintain the free fatty acids and acyl CoA at the cellular level. In this work, we detected the expression of the
    MeSH term(s) Adipocytes/cytology ; Adipocytes/metabolism ; Adipogenesis/genetics ; Animals ; Cattle ; Cell Differentiation/genetics ; Cells, Cultured ; Gene Expression ; Lipid Metabolism ; RNA Interference ; RNA, Small Interfering/genetics ; Thiolester Hydrolases/genetics
    Chemical Substances RNA, Small Interfering ; Thiolester Hydrolases (EC 3.1.2.-)
    Language English
    Publishing date 2020-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 2162-397X
    ISSN (online) 2162-397X
    DOI 10.1080/21623945.2020.1776553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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