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  1. Article ; Online: CD4 derived double negative T cells prevent the development and progression of nonalcoholic steatohepatitis

    Guangyong Sun / Xinyan Zhao / Mingyang Li / Chunpan Zhang / Hua Jin / Changying Li / Liwei Liu / Yaning Wang / Wen Shi / Dan Tian / Hufeng Xu / Yue Tian / Yongle Wu / Kai Liu / Zhongtao Zhang / Dong Zhang

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 15

    Abstract: Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression ...

    Abstract Hepatic inflammation contributes to the development of nonalcoholic steatohepatitis (NASH). Here, the authors show that a transfer of ex vivo generated CD4 derived double negative T cells can prevent the development and progression of NASH by suppression of inflammatory Th17 cells and M1 macrophages in mouse models.
    Keywords Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Double negative T cells mediate Lag3-dependent antigen-specific protection in allergic asthma

    Dan Tian / Lu Yang / Song Wang / Yanbing Zhu / Wen Shi / Chunpan Zhang / Hua Jin / Yue Tian / Hufeng Xu / Guangyong Sun / Kai Liu / Zhongtao Zhang / Dong Zhang

    Nature Communications, Vol 10, Iss 1, Pp 1-

    2019  Volume 13

    Abstract: Allergic asthma symptoms may be controlled, but currently no effective therapy exist to address the underlying pathology. Here the authors show, using mouse model of adoptive cell transfer, that CD4-CD8- T cells can suppress the function of dendritic ... ...

    Abstract Allergic asthma symptoms may be controlled, but currently no effective therapy exist to address the underlying pathology. Here the authors show, using mouse model of adoptive cell transfer, that CD4-CD8- T cells can suppress the function of dendritic cells and T follicular helper cells via Lag3 to provide allergen-specific protection from asthma.
    Keywords Science ; Q
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: OX40 promotes obesity-induced adipose inflammation and insulin resistance

    Liu, Bing / Chunpan Zhang / Dan Tian / Dong Zhang / Guangyong Sun / Hengchi Yu / Hua Jin / Hufeng Xu / Jie Yin / Kai Liu / Wen Shi / Xiaojing Sun / Xinmin Li / Xu Hong

    Cellular and molecular life sciences. 2017 Oct., v. 74, no. 20

    2017  

    Abstract: Adaptive immunity plays a critical role in IR and T2DM development; however, the biological mechanisms linking T cell costimulation and glucose metabolism have not been fully elucidated. In this study, we demonstrated that the costimulatory molecule OX40 ...

    Abstract Adaptive immunity plays a critical role in IR and T2DM development; however, the biological mechanisms linking T cell costimulation and glucose metabolism have not been fully elucidated. In this study, we demonstrated that the costimulatory molecule OX40 controls T cell activation and IR development. Inflammatory cell accumulation and enhanced proinflammatory gene expression, as well as high OX40 expression levels on CD4⁺ T cells, were observed in the adipose tissues of mice with diet-induced obesity. OX40-KO mice exhibited significantly less weight gain and lower fasting glucose levels than those of WT mice, without obvious adipose tissue inflammation. The effects of OX40 on IR are mechanistically linked to the promotion of T cell activation, Th1 cell differentiation and proliferation—as well as the attenuation of Treg suppressive activity and the enhancement of proinflammatory cytokine production—in adipose tissues. Furthermore, OX40 expression on T cells was positively associated with obesity in humans, suggesting that our findings are clinically relevant. In summary, our study revealed that OX40 in CD4⁺ T cells is crucial for adipose tissue inflammation and IR development. Therefore, the OX40 signaling pathway may be a new target for preventing or treating obesity-related IR and T2DM.
    Keywords adaptive immunity ; adipose tissue ; CD4-positive T-lymphocytes ; cell differentiation ; cytokines ; gene expression ; glucose ; humans ; inflammation ; insulin resistance ; metabolism ; mice ; obesity ; signal transduction ; weight gain
    Language English
    Dates of publication 2017-10
    Size p. 3827-3840.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-017-2552-7
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: OX40 Regulates Both Innate and Adaptive Immunity and Promotes Nonalcoholic Steatohepatitis

    Guangyong Sun / Hua Jin / Chunpan Zhang / Hua Meng / Xinyan Zhao / Dan Wei / Xiaojuan Ou / Qianyi Wang / Shuxiang Li / Tianqi Wang / Xiaojing Sun / Wen Shi / Dan Tian / Kai Liu / Hufeng Xu / Yue Tian / Xinmin Li / Wei Guo / Jidong Jia /
    Zhongtao Zhang / Dong Zhang

    Cell Reports, Vol 25, Iss 13, Pp 3786-3799.e

    2018  Volume 4

    Abstract: Summary: Both innate and adaptive immune cells are involved in the pathogenesis of nonalcoholic steatohepatitis (NASH), but the crosstalk between innate and adaptive immunity is largely unknown. Here we show that compared with WT mice, OX40−/− mice ... ...

    Abstract Summary: Both innate and adaptive immune cells are involved in the pathogenesis of nonalcoholic steatohepatitis (NASH), but the crosstalk between innate and adaptive immunity is largely unknown. Here we show that compared with WT mice, OX40−/− mice exhibit decreased liver fat accumulation, lobular inflammation, and focal necrosis after feeding with diets that induce NASH. Mechanistically, OX40 deficiency suppresses Th1 and Th17 differentiation, and OX40 deficiency in T cells inhibits monocyte migration, antigen presentation, and M1 polarization. Soluble OX40 stimulation alone upregulates antigen presentation, chemokine receptor expression, and proinflammatory cytokine secretion by liver monocytes. Furthermore, plasma soluble OX40 levels are positively associated with NASH in humans, suggesting clinical relevance of the findings. In conclusion, we show a mechanism for T cell regulation of innate immune cells. OX40 is a key regulator of both intrahepatic innate and adaptive immunity, generates two-way signals, and promotes both proinflammatory monocyte and macrophage and T cell function, resulting in NASH development. : Sun et al. show that OX40 is a key molecule in the regulation of both intrahepatic innate and adaptive immunity. OX40 promotes both proinflammatory monocyte and macrophage and T cell function, resulting in NASH development and progression. These findings suggest that OX40 could serve as a diagnostic index and therapeutic target in NASH. Keywords: OX40, NAFLD, inflammation, monocyte, T cell
    Keywords Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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