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  1. Article ; Online: Prevalence, Patterns, and Clinical Severity of Long COVID among Chinese Medicine Telemedicine Service Users: Preliminary Results from a Cross-Sectional Study.

    Ho, Fai Fai / Xu, Shanshan / Kwong, Talos Ming Hong / Li, Angus Siu-Cheong / Ha, Eun Hae / Hua, Heyu / Liong, Ching / Leung, Kwan Chi / Leung, Ting Hung / Lin, Zhixiu / Wong, Samuel Yeung-Shan / Pan, Faming / Chung, Vincent Chi Ho

    International journal of environmental research and public health

    2023  Volume 20, Issue 3

    Abstract: Introduction: The emergence and persistence of symptoms after acute COVID-19 is expected to become a major burden on healthcare systems. We assessed the features of the post-COVID-19 Syndrome (Long COVID) burden in a cohort of COVID-19 patients during ... ...

    Abstract Introduction: The emergence and persistence of symptoms after acute COVID-19 is expected to become a major burden on healthcare systems. We assessed the features of the post-COVID-19 Syndrome (Long COVID) burden in a cohort of COVID-19 patients during the fifth major wave in Hong Kong.
    Methods: A cross-sectional study of 135 patients with confirmed COVID-19 from Feb to Apr 2022 who utilized traditional Chinese medicine telemedicine services was conducted. The COVID-19 Yorkshire Rehabilitation Scale was administered using an online survey 12 weeks after the COVID-19 infection. Prevalence of symptom severity and functional impairments were assessed to identify burdens and patterns. The correlation between symptom severity, functional impairments, patient characteristics, and overall health was evaluated.
    Results: The mean age was 46.8 years, with 46 (34.1%) males. Symptoms, functional impairments, and overall health worsened significantly when compared to the status prior to the infection. More than 50% reported the following sequelae 12 weeks after the acute infection: breathlessness, laryngeal or airway complications, fatigue, weakness, sleep, cognition, and anxiety. The presence of a single symptom or functional impairment significantly correlated with at least seven other problems positively, except for pain. Severity tended to be higher among vulnerable groups, including those who were chronic disease patients, older, less well educated, female, or had incomplete COVID-19 vaccinations.
    Conclusions: Long COVID is a significant healthcare burden among telemedicine users in Hong Kong, with complex needs for symptom and functional impairment management. Designing relevant health and rehabilitation services tailored to the needs of these patients is warranted.
    MeSH term(s) Male ; Humans ; Female ; Middle Aged ; Post-Acute COVID-19 Syndrome ; COVID-19/epidemiology ; Cross-Sectional Studies ; Prevalence ; Medicine, Chinese Traditional ; Telemedicine
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph20031827
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: pH-responsive polymer-drug conjugates: Design and progress.

    Pang, Xin / Jiang, Yue / Xiao, Qicai / Leung, Albert Wingnang / Hua, Heyu / Xu, Chuanshan

    Journal of controlled release : official journal of the Controlled Release Society

    2016  Volume 222, Page(s) 116–129

    Abstract: Polymer-drug conjugates are becoming established as a shining platform for drug delivery. Incorporation of pH-responsive linker between drug and polymer is expected to realize triggered release of bioactive agents from conjugates in specific sites, ... ...

    Abstract Polymer-drug conjugates are becoming established as a shining platform for drug delivery. Incorporation of pH-responsive linker between drug and polymer is expected to realize triggered release of bioactive agents from conjugates in specific sites, either in mildly acidic extracellular matrices of tumor tissues or, after cellular internalization, in acidic endosomes and lysosomes. As an emerging drug delivery system, such pH-responsive polymer-drug conjugates are able to selectively deliver and activate drug molecules while reducing their systemic side-effects. In this review, we present the recent advances in pH-responsive polymer-drug conjugates with different chemical structures and architectures, and attempt to clarify their mechanism of action, synthesis and characterization technology. Furthermore, several promising approaches for the future will also be suggested.
    MeSH term(s) Drug Delivery Systems ; Drug Design ; Hydrogen-Ion Concentration ; Pharmaceutical Preparations/chemistry ; Polymers/chemistry
    Chemical Substances Pharmaceutical Preparations ; Polymers
    Language English
    Publishing date 2016-01-28
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632533-6
    ISSN 1873-4995 ; 0168-3659
    ISSN (online) 1873-4995
    ISSN 0168-3659
    DOI 10.1016/j.jconrel.2015.12.024
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Sonodynamic action of hypocrellin B on biofilm-producing Staphylococcus epidermidis in planktonic condition.

    Wang, Xinna / Leung, Albert Wingnang / Hua, Heyu / Xu, Chuanshan / Ip, Margaret

    The Journal of the Acoustical Society of America

    2015  Volume 138, Issue 4, Page(s) 2548–2553

    Abstract: Staphylococcus epidermidis is an opportunistic pathogen causing biofilm-associated infections. To investigate sonodynamic action of hypocrellin B on biofilm-producing Staphylococcus epidermidis in planktonic culture, a biofilm-producing strain ... ...

    Abstract Staphylococcus epidermidis is an opportunistic pathogen causing biofilm-associated infections. To investigate sonodynamic action of hypocrellin B on biofilm-producing Staphylococcus epidermidis in planktonic culture, a biofilm-producing strain Staphylococcus epidermidis (ATCC 35984) was incubated with hypocrellin B and then exposed to ultrasound at intensity (ISATA) of 1.56 W/cm(2) with a frequency of 1 MHz in continuous mode for 5 min. After sonodynamic treatment of hypocrellin B, the bacterial growth was measured using the colony counting method. Bacterial membrane integrity was investigated using a flow cytometry with propidium iodide staining. Intracellular reactive oxygen species (ROS) level was measured using a flow cytometry with DCFH-DA staining. The results showed that sonodynamic action of hypocrellin B significantly induced survival reduction of Staphylococcus epidermidis in a hypocrellin B dose-dependent manner, and a 4-log reduction was observed after the combined treatment of hypcorellin B (40 μM) and ultrasound sonication with the intensity of 1.56 W/cm(2) for 5 min. Bacterial membrane integrity was notably damaged and the level of intracellular ROS level was remarkably increased after sonodynamic treatment. The findings demonstrated that sonodynamic action of hypocrellin B had significant antibacterial activity on biofilm-producing Staphylococcus epidermidis in planktonic condition probably through increasing intracellular ROS level to cause damage to bacterial membrane integrity.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Load ; Biofilms/drug effects ; Cell Membrane/drug effects ; Disinfection/methods ; Dose-Response Relationship, Drug ; Perylene/analogs & derivatives ; Perylene/pharmacology ; Quinones/pharmacology ; Random Allocation ; Reactive Oxygen Species ; Sonication/methods ; Staphylococcus epidermidis/drug effects ; Staphylococcus epidermidis/growth & development ; Suspensions ; Vancomycin/pharmacology
    Chemical Substances Anti-Bacterial Agents ; Quinones ; Reactive Oxygen Species ; Suspensions ; Perylene (5QD5427UN7) ; Vancomycin (6Q205EH1VU) ; hypocrellin B (XNP7UO129A)
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/1.4932014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Sanhuangyinchi decoction pretreatment ameliorates acute hepatic failure in rats by suppressing antioxidant stress and caspase-3 expression].

    Ma, Wenxiao / Yang, Yungao / Diao, Jianxin / Liu, Yawei / Hua, Heyu / Wen, Xiaomin

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2014  Volume 34, Issue 4, Page(s) 482–486

    Abstract: Objective: To observe the effects of Sanhuangyinchi decoction (SHYCD) pretreatment on acute hepatic failure (AHF) induced by D-galactosamine and lipopolysaccharide (LPS) in rats and explore the possible mechanisms involving antioxidant stress and cell ... ...

    Abstract Objective: To observe the effects of Sanhuangyinchi decoction (SHYCD) pretreatment on acute hepatic failure (AHF) induced by D-galactosamine and lipopolysaccharide (LPS) in rats and explore the possible mechanisms involving antioxidant stress and cell apoptosis-related protein expression.
    Methods: Forty-eight SD rats were randomized equally into control group, AHF model group, high-, medium- and low-dose SHYCD groups, and Bicyclol group. Five days after administration of the corresponding drugs, the rats were challenged with peritoneal D-galactosamine (700 mg/kg) plus LPS (10 ug/kg) injections to induce AHF acute hepatic failure except for those in the control group. At 48 h after the injections, blood samples were collected from the rats to detect the levels of ALT, AST, TBIL, PT, INR and FIB, and pathological changes and superoxide dismutase (SOD) and malondialdehyde (MDA) contents in the liver were examined; immunohistochemistry and western blotting were used to detect caspase-3 protein expression in the liver.
    Results: The levels of ALT, AST, TBIL, TP and INR in the 3 SHYCD groups and Bicyclol group significantly decreased (P<0.05) while FIB significantly increased in comparison with those in the model group. SHYCD obviously ameliorated the pathological changes, enhanced SOD activity (P<0.05), and decreased MDA levels (P<0.05) and caspase-3 expression (P<0.05) in the liver tissue. SHYCD at the medium dose produced similar effects to Bicyclol (P>0.05) and showed better effects at the high dose than Bicyclol (P<0.05).
    Conclusion: SHYCD pretreatment can dose-dependently ameliorate AHF in rats possibly by suppressing antioxidant stress and caspase-3 expression to decrease hepatic cell apoptosis.
    MeSH term(s) Animals ; Caspase 3/metabolism ; Drugs, Chinese Herbal/therapeutic use ; Liver Failure, Acute/drug therapy ; Liver Failure, Acute/metabolism ; Liver Failure, Acute/prevention & control ; Male ; Malondialdehyde/metabolism ; Oxidative Stress ; Phytotherapy ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase/metabolism
    Chemical Substances Drugs, Chinese Herbal ; Malondialdehyde (4Y8F71G49Q) ; Superoxide Dismutase (EC 1.15.1.1) ; Casp3 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language Chinese
    Publishing date 2014-04
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Corrigendum to "Neural circuitry among connecting the hippocampus, prefrontal cortex and basolateral amygdala in a mouse depression model: Associations correlations between BDNF levels and BOLD - fMRI signals" [Brain Res. Bull. 142(2018) 107-115].

    Huang, Peng / Gao, Tingting / Dong, Zhaoyang / Zhou, Chuying / Lai, Yuling / Pan, Ting / Liu, Yuan / Zhao, Xiaoshan / Sun, Xuegang / Hua, Heyu / Wen, Ge / Gao, Lei / Lv, Zhiping

    Brain research bulletin

    2019  Volume 153, Page(s) 350

    Language English
    Publishing date 2019-11-08
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 197620-5
    ISSN 1873-2747 ; 0361-9230
    ISSN (online) 1873-2747
    ISSN 0361-9230
    DOI 10.1016/j.brainresbull.2019.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Antioxidant and Antiapoptotic Polyphenols from Green Tea Extract Ameliorate CCl

    Diao, Jian-Xin / Ou, Jin-Ying / Dai, Huan / Li, Hai-Ye / Huang, Wei / Hua, He-Yu / Xie, Ting / Wang, Ming / Yang, Yun-Gao

    Chinese journal of integrative medicine

    2019  Volume 26, Issue 10, Page(s) 736–744

    Abstract: Objective: To investigate the phenolic composition, antioxidant properties, and hepatoprotective mechanisms of polyphenols from green tea extract (GTP) in carbon tetrachloride (CCl: Methods: High-performance liquid chromatography was used to analyze ... ...

    Abstract Objective: To investigate the phenolic composition, antioxidant properties, and hepatoprotective mechanisms of polyphenols from green tea extract (GTP) in carbon tetrachloride (CCl
    Methods: High-performance liquid chromatography was used to analyze the chemical composition of the extract. Antioxidant activity of GTP was assessed by O
    Results: GTP contained 98.56 µg gallic acid equivalents per milligram extract total polyphenols, including epicatechingallate, epigallocatechin gallate, epicatechin, and epigallocatechin. Compared with the model group, low-, medium-, or high doses GTP significantly decreased serum levels of alanine aminotransferase and aspartate transaminase (P<0.01). Histopathological observation confirmed that pretreatment of GTP prevented swelling and necrosis in CCl
    Conclusion: GTP achieves hepatoprotective effects by improving hepatic antioxidant status and preventing cell apoptosis through caspase-3-dependent signaling pathways.
    MeSH term(s) Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Apoptosis/drug effects ; Biomarkers/blood ; Carbon Tetrachloride/toxicity ; Caspase 3/metabolism ; Chemical and Drug Induced Liver Injury/drug therapy ; China ; Disease Models, Animal ; Male ; Mice ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Polyphenols/chemistry ; Polyphenols/pharmacology ; Tea
    Chemical Substances Antioxidants ; Biomarkers ; Plant Extracts ; Polyphenols ; Tea ; Carbon Tetrachloride (CL2T97X0V0) ; Casp3 protein, mouse (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2019-11-25
    Publishing country China
    Document type Journal Article
    ZDB-ID 2171254-2
    ISSN 1993-0402 ; 1672-0415
    ISSN (online) 1993-0402
    ISSN 1672-0415
    DOI 10.1007/s11655-019-3043-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Sonodynamic action of hypocrellin B on methicillin-resistant Staphylococcus aureus.

    Wang, Xinna / Ip, Margaret / Leung, Albert Wingnang / Wang, Pan / Zhang, Hongwei / Hua, Heyu / Xu, Chuanshan

    Ultrasonics

    2016  Volume 65, Page(s) 137–144

    Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) commonly causes refractory infections and has recently become a serious public health concern. The present study was designed to investigate sonodynamic action of hypocrellin B on MRSA. A MRSA strain ( ... ...

    Abstract Methicillin-resistant Staphylococcus aureus (MRSA) commonly causes refractory infections and has recently become a serious public health concern. The present study was designed to investigate sonodynamic action of hypocrellin B on MRSA. A MRSA strain (ATCC BAA-43) was used in the present study. The dark toxicity of hypocrellin B on MRSA and its uptake in MRSA first were measured. And then bacteria were incubated with hypocrellin B and exposed to ultrasound. After sonodynamic treatment, colony forming unit assay and bacterial viability assay were conducted. Membrane permeability assay, DNA fragmentation assay, and DNA synthesis assay were also performed to examine the underlying mechanism. The results showed that hypocrellin B at concentrations of up to 500 μM had no toxicity to MRSA in the dark. After incubation for 50 min, hypocrellin B could be maximally absorbed by MRSA, and exhibited significant sonodynamic activity in a dose-dependent manner. The 5-log reduction in colony forming unit (CFU) was observed after hypocrellin B (40 μM) treatment at an intensity of 1.38 W/cm(2) ultrasound for 5 min. Compared to the control, hypocrellin B alone and ultrasound sonication alone group, more dead cells were found and bacterial membrane integrity was notably damaged after sonodynamic treatment of hypocrellin B. However, no remarkable DNA damage was found in MRSA after sonodynamic treatment of hypocrellin B. All the findings demonstrated that hypocrellin B could serve as a potential antibacterial sonosensitizer to significantly cause damage to the membrane integrity of MRSA and inhibit its growth under ultrasound sonication.
    MeSH term(s) Cell Survival/drug effects ; Cell Survival/physiology ; Cell Survival/radiation effects ; Electrochemotherapy/methods ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/physiology ; Methicillin-Resistant Staphylococcus aureus/radiation effects ; Perylene/administration & dosage ; Perylene/analogs & derivatives ; Quinones/administration & dosage ; Radiation Dosage ; Radiation-Sensitizing Agents/administration & dosage ; Sonication/methods ; Sterilization/methods
    Chemical Substances Quinones ; Radiation-Sensitizing Agents ; Perylene (5QD5427UN7) ; hypocrellin B (XNP7UO129A)
    Language English
    Publishing date 2016-02
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 200839-7
    ISSN 1874-9968 ; 0041-624X
    ISSN (online) 1874-9968
    ISSN 0041-624X
    DOI 10.1016/j.ultras.2015.10.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: [Effect of Sanhuangyinchi decoction on liver damage and caspase-3 in rats with acute hepatic failure].

    Yang, Yun-gao / Liu, Ya-wei / Hua, He-yu / Li, Li-jie

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2010  Volume 30, Issue 11, Page(s) 2443–2445

    Abstract: Objective: To investigate effect of Sanhuangyinchi decoction (SHYCD) on liver damage and the pro-apoptotic factor caspase-3 in rats with acute hepatic failure.: Methods: SD rats were randomly divided into blank control group, model group, ... ...

    Abstract Objective: To investigate effect of Sanhuangyinchi decoction (SHYCD) on liver damage and the pro-apoptotic factor caspase-3 in rats with acute hepatic failure.
    Methods: SD rats were randomly divided into blank control group, model group, Angongniuhuang group (AGNH) and SHYCD group. Acute hepatic failure was induced in the rats by intraperitoneal injections of D-GaLN and LPS, and the death rate, ALT, TBIL, PT and caspase-3 activity was observed or tested.
    Results: At 36 h after the injections, the death rate of the rats was 74.29% (26/35) in the model group, 31.43% (11/35) in AGNH group and 28.57%(10/35) in SHYCD group. The death rate, ALT, TBIL, PT and caspase-3 activity in AGNH and SHYCD groups were significantly lower than those in the model group (P<0.01). SHYCD showed stronger effect than AGNH in depressing TBIL and the activity of caspase-3 (P<0.05).
    Conclusion: SHYCD can improve the liver function and inhibit the activity of caspase-3 in rats, which can be the possible mechanism for its therapeutic effect against acute hepatic failure.
    MeSH term(s) Animals ; Apoptosis ; Caspase 3/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver Failure, Acute/drug therapy ; Liver Failure, Acute/metabolism ; Liver Failure, Acute/pathology ; Male ; Phytotherapy ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Drugs, Chinese Herbal ; Casp3 protein, rat (EC 3.4.22.-) ; Caspase 3 (EC 3.4.22.-)
    Language Chinese
    Publishing date 2010-11
    Publishing country China
    Document type English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
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  9. Article ; Online: Neural circuitry among connecting the hippocampus, prefrontal cortex and basolateral amygdala in a mouse depression model: Associations correlations between BDNF levels and BOLD - fMRI signals.

    Huang, Peng / Gao, Tingting / Dong, Zhaoyang / Zhou, Chuying / Lai, Yuling / Pan, Ting / Liu, Yuan / Zhao, Xiaoshan / Sun, Xuegang / Hua, Heyu / Wen, Ge / Gao, Lei / Lv, Zhiping

    Brain research bulletin

    2018  Volume 142, Page(s) 107–115

    Abstract: Background: Depression is a heterogeneous disorder, but the exact neuronal mechanisms causing the disease have not yet been discovered.: Methods/materials: We have established a chronic unpredictable mild stress (CUMS) mouse model to explore the ... ...

    Abstract Background: Depression is a heterogeneous disorder, but the exact neuronal mechanisms causing the disease have not yet been discovered.
    Methods/materials: We have established a chronic unpredictable mild stress (CUMS) mouse model to explore the blood oxygen level-dependent (BOLD) activity in the hippocampus, prefrontal cortex (PFC), and basolateral amygdala (BLA) using amplitude of low-frequency fluctuations (ALFF) in functional magnetic resonance imaging (fMRI). We initially studied the relationship between brain-derived neurotrophic factor (BDNF) expression and BOLD activity using BDNF
    Results: We found that CUMS induced depressive-like behaviours and stimulated changes in brain regions expressing a different BDNF level, which was decreased in the hippocampus and PFC but increased in the BLA. In contrast, the BOLD activity was elevated in the hippocampus and PFC but reduced in the BLA after CUMS exposure, indicating that the BDNF level negatively correlated with the BOLD activity in the WT CUMS-exposed mice. Moreover, the depressive-like behaviours and region-specific BOLD activity in BDNF
    Conclusion: We surmised that critical neural circuitry connects the hippocampus, PFC and BLA in mice, which was regulated by BDNF to protect against depression. These findings suggested a potential central role of BDNF expression in functional changes in the brain.
    MeSH term(s) Animals ; Brain/diagnostic imaging ; Brain/physiopathology ; Brain Mapping ; Brain-Derived Neurotrophic Factor/metabolism ; Cerebrovascular Circulation/physiology ; Depressive Disorder/diagnostic imaging ; Depressive Disorder/physiopathology ; Disease Models, Animal ; Gene Expression ; Magnetic Resonance Imaging ; Male ; Mice, Inbred C57BL ; Mice, Transgenic ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiopathology ; Neurogenesis/physiology ; Oxygen/blood ; Random Allocation ; Stress, Psychological/diagnostic imaging ; Stress, Psychological/physiopathology
    Chemical Substances Bdnf protein, mouse ; Brain-Derived Neurotrophic Factor ; Oxygen (S88TT14065)
    Language English
    Publishing date 2018-06-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 197620-5
    ISSN 1873-2747 ; 0361-9230
    ISSN (online) 1873-2747
    ISSN 0361-9230
    DOI 10.1016/j.brainresbull.2018.06.019
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  10. Article ; Online: Voluntary wheel running ameliorates depression-like behaviors and brain blood oxygen level-dependent signals in chronic unpredictable mild stress mice.

    Huang, Peng / Dong, Zhaoyang / Huang, Weiliang / Zhou, Chuying / Zhong, Weichao / Hu, Peiqian / Wen, Ge / Sun, Xuegang / Hua, Heyu / Cao, Huihui / Gao, Lei / Lv, Zhiping

    Behavioural brain research

    2017  Volume 330, Page(s) 17–24

    Abstract: Background: Physical exercise has been long recognized for its therapeutic effects on depressive disorders, but the underlying mechanisms remain largely unknown. In the study, we investigated whether the physical exercise by voluntary wheel running (VWR) ...

    Abstract Background: Physical exercise has been long recognized for its therapeutic effects on depressive disorders, but the underlying mechanisms remain largely unknown. In the study, we investigated whether the physical exercise by voluntary wheel running (VWR) alters depression-like behaviors and its impact on brain blood oxygen level-dependent (BOLD) signals in mice.
    Methods: Adult male C57BL/6 mice were assigned to one of the following groups; (1) no exercise control (noEx), housed in a standard cage; (2) exercise (Ex), 2h/day in a running wheel apparatus; (3) chronic unpredictable mild stress (CUMS), which was imitating adult stress; and (4) CUMS+Ex. The differences in functional brain changes were determined by BOLD functional magnetic resonance imaging (fMRI).
    Results: The results showed that VWR exercise significantly reversed the CUMS-induced behavioral abnormalities. Base on the fMRI amplitude of low-frequency fluctuation (ALFF) analysis, we found that VWR exercise could restore the CUMS-induced excessive BOLD activation in parts of limbic system, such as cortex, hippocampus and corpus callosum. Furthermore, CUMS-induced BOLD suppressive regions were also partially attenuated by VWR exercise, such as amygdala, cerebellum anterior lobe, thalamus, midbrain, and pontine. Most of these regions are involved in mood-regulating circuit, suggesting dysfunction of the circuit in CUMS model of depression, and VWR exercise could adjust the mood-regulating circuit.
    Conclusions: These results suggested that VWR exercise ameliorated depression-like behaviors and brain BOLD signals in CUMS induced depression mice.
    Language English
    Publishing date 2017-07-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 449927-x
    ISSN 1872-7549 ; 0166-4328
    ISSN (online) 1872-7549
    ISSN 0166-4328
    DOI 10.1016/j.bbr.2017.05.032
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