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  1. Article: Analysis of differentially expressed circRNAs in longissimus muscle between castrated and intact male pigs.

    Xing, Bao-Song / Wang, Jing / Chen, Jun-Feng / Ma, Qiang / Ren, Qiao-Ling / Zhang, Jia-Qing / Zhang, Hua / Hua, Liu-Shuai / Sun, Jia-Jie / Cao, Hai

    Yi chuan = Hereditas

    2021  Volume 43, Issue 11, Page(s) 1066–1077

    Abstract: Castration can reduce odor and fights in boars, but the carcass yield is reduced, and the intramuscular fat content is increased. Understanding its molecular mechanism is of great significance for production. Recent studies have shown that circular RNAs ( ...

    Abstract Castration can reduce odor and fights in boars, but the carcass yield is reduced, and the intramuscular fat content is increased. Understanding its molecular mechanism is of great significance for production. Recent studies have shown that circular RNAs (circRNAs) play an important role(s) in the regulation of muscle development. To explore the effects of circRNAs on the development of longissimus dorsi (LD) muscle after castration, six Huainan male pigs were selected and three of which were randomly castrated. Six pigs were slaughtered when their body weight reached around 130 kg, and the LD muscle samples were collected. The differentially expressed circRNAs (DECs) were screened by high-throughput sequencing and functionally analyzed using the KEGG databases. DECs-miRNAs network was constructed, and the expression profiles of candidate circRNAs and their interactions with miRNAs were verified in porcine skeletal muscle satellite cells. The results showed that a total of 5866 circRNAs were obtained, and 370 DECs were identified in LD muscle between the castrated and intact groups (| log
    MeSH term(s) Animals ; High-Throughput Nucleotide Sequencing ; Male ; MicroRNAs/genetics ; Muscle Development ; Muscles ; RNA, Circular ; Swine/genetics
    Chemical Substances MicroRNAs ; RNA, Circular
    Language English
    Publishing date 2021-10-26
    Publishing country China
    Document type Journal Article
    ISSN 0253-9772
    ISSN 0253-9772
    DOI 10.16288/j.yczz.21-162
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  2. Article: Isolation and characterization of microsatellite markers from the Chinese endemic species, Beal’s-eyed turtle (Sacalia bealei)

    Li, Wei-ye / Gong, Shi-ping / Hua, Liu-shuai

    Conservation genetic resources. 2014 June, v. 6, no. 2

    2014  

    Abstract: Beal’s-eyed turtle (Sacalia bealei) is an endangered species with important medicinal values and effective measures should be taken to protect this species. Development of molecular markers that could be used in population genetic assessment is necessary ...

    Abstract Beal’s-eyed turtle (Sacalia bealei) is an endangered species with important medicinal values and effective measures should be taken to protect this species. Development of molecular markers that could be used in population genetic assessment is necessary for the conservation of endangered species. In this investigation, we isolated 14 microsatellite DNA markers from an enriched library. The number of alleles at each locus was between 7 and 17. He and Ho ranged from 0.7958 to 0.9324 and 0.6333 to 0.9697 respectively. The PIC value ranged from 0.757 to 0.913, indicated all the loci are high polymorphism. No significant linkage disequilibrium was detected and only one locus deviated from Hardy–Weinberg equilibrium. These loci could provide useful information for the genetic analyses of S. bealei populations.
    Keywords endangered species ; genetic markers ; indigenous species ; linkage disequilibrium ; loci ; microsatellite repeats ; turtles
    Language English
    Dates of publication 2014-06
    Size p. 437-438.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2508018-0
    ISSN 1877-7260 ; 1877-7252
    ISSN (online) 1877-7260
    ISSN 1877-7252
    DOI 10.1007/s12686-013-0117-0
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  3. Article ; Online: Haplotypes in the promoter region of the CIDEC gene associated with growth traits in Nanyang cattle.

    Wang, Jing / Hua, Liu-shuai / Pan, Hong / Zhang, Liang-zhi / Li, Ming-xun / Huang, Yong-zhen / Li, Zhuan-jian / Lan, Xian-yong / Lei, Chu-zhao / Li, Cong-jun / Chen, Hong

    Scientific reports

    2015  Volume 5, Page(s) 12075

    Abstract: Cell death-inducing DFFA-like effector c (CIDEC, also known as Fsp27) has emerged as an important regulator of metabolism associated with lipodystrophy, diabetes, and hepatic steatosis. It is required for unilocular lipid droplet formation and optimal ... ...

    Abstract Cell death-inducing DFFA-like effector c (CIDEC, also known as Fsp27) has emerged as an important regulator of metabolism associated with lipodystrophy, diabetes, and hepatic steatosis. It is required for unilocular lipid droplet formation and optimal energy storage. The mechanism between this gene and livestock growth traits, however, has yet to be reported. In this study, we found ten novel single nucleotide polymorphisms (SNPs) in the 5' transcriptional region of CIDEC in Nanyang (NY) cattle, which are located in the recognition sequences (potential cis-acting elements) of 22 transcription factors, and the nine haplotypes represent nine different combinations of polymorphic potential cis-acting elements. The results indicated that individuals with the H8-H8 diplotype had heavier body weights and faster growth rates (P < 0.01) at 18th months than those with H1-H8. We evaluated the transcriptional activities of different haplotypes in vitro, the results were consistent with the association analysis. The H8 haplotype had 1.88-fold (P < 0.001) higher transcriptional activity than the H1 haplotype. We speculate that the haplotypes of the potential cis-acting elements may affect the transcriptional activity of CIDEC, thus affecting the growth traits of cattle. This information may be used in molecular marker-assisted selection of cattle breeding in the future.
    MeSH term(s) Animals ; Cattle ; Genetic Association Studies ; Genetic Loci ; Haplotypes ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Quantitative Trait, Heritable ; Regulatory Elements, Transcriptional ; Regulatory Sequences, Nucleic Acid ; Transcription, Genetic
    Language English
    Publishing date 2015-07-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep12075
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  4. Article: Two novel intronic polymorphisms of bovine FGF21 gene are associated with body weight at 18 months in Chinese cattle

    Sun, Xiao-Mei / Li, Ming-Xun / Li, Ai-Min / Lan, Xian-Yong / Lei, Chu-Zhao / Ma, Wei / Hua, Liu-shuai / Wang, Jing / Hu, Shen-Rong / Chen, Hong

    Livestock science. 2013 July, v. 155, no. 1

    2013  

    Abstract: Fibroblast growth factor 21 (FGF21) is a hepatic hormone that regulates peripheral glucose tolerance, energy balance and lipid metabolism. Prior evidence suggests that FGF21 may have the potential to favorably reduce obesity. The objective of the present ...

    Abstract Fibroblast growth factor 21 (FGF21) is a hepatic hormone that regulates peripheral glucose tolerance, energy balance and lipid metabolism. Prior evidence suggests that FGF21 may have the potential to favorably reduce obesity. The objective of the present study was to identify single nucleotide polymorphisms (SNPs) of bovine FGF21 using 1255 animals representing the five main Chinese breeds and to investigate the effect of these SNPs on economic traits in Nanyang cattle. Four significant SNPs were identified, one was a synonymous mutation and the other three were in intronic regions. The polymorphism information content (PIC) analysis showed that four beef cattle populations (NY, JX, LX and QC) had a moderate genetic diversity at the four loci while the beef and dairy population (CRS) had a low level. Additionally, allele and genotype frequencies for the beef breeds were significantly different from CRS, implying that these mutations are possibly associated with some quantitative traits. Moreover, linkage disequilibrium analysis and haplotype frequencies were also reported. Seven different haplotypes were identified and haplotype TCCC was predominant in all five cattle breeds. Association analysis suggested that SNPs g.297C>G and g.940C>T of bovine FGF21 were associated with higher body weight at 18 months within NY cattle, which would contribute to cattle breeding and genetics through marker-assisted selection (MAS).
    Keywords beef ; beef cattle ; cattle breeding ; cattle breeds ; energy balance ; genes ; genetic variation ; glucose tolerance ; haplotypes ; linkage disequilibrium ; lipid metabolism ; loci ; marker-assisted selection ; obesity ; quantitative traits ; single nucleotide polymorphism
    Language English
    Dates of publication 2013-07
    Size p. 23-29.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2226176-X
    ISSN 1871-1413
    ISSN 1871-1413
    DOI 10.1016/j.livsci.2013.03.023
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  5. Article: Isolation and characterization of microsatellite markers from the Chinese endemic species, Beal’s-eyed turtle (Sacalia bealei)

    Li, Wei-ye / Gong, Shi-ping / Hua, Liu-shuai

    Conservation genetic resources

    Volume v. 6,, Issue no. 2

    Abstract: Beal’s-eyed turtle (Sacalia bealei) is an endangered species with important medicinal values and effective measures should be taken to protect this species. Development of molecular markers that could be used in population genetic assessment is necessary ...

    Abstract Beal’s-eyed turtle (Sacalia bealei) is an endangered species with important medicinal values and effective measures should be taken to protect this species. Development of molecular markers that could be used in population genetic assessment is necessary for the conservation of endangered species. In this investigation, we isolated 14 microsatellite DNA markers from an enriched library. The number of alleles at each locus was between 7 and 17. He and Ho ranged from 0.7958 to 0.9324 and 0.6333 to 0.9697 respectively. The PIC value ranged from 0.757 to 0.913, indicated all the loci are high polymorphism. No significant linkage disequilibrium was detected and only one locus deviated from Hardy–Weinberg equilibrium. These loci could provide useful information for the genetic analyses of S. bealei populations.
    Keywords indigenous species ; linkage disequilibrium ; endangered species ; microsatellite repeats ; turtles ; loci ; genetic markers
    Language English
    Document type Article
    ISSN 1877-7252
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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    Order via subito

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    Inter-library loan at ZB MED

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  6. Article: Two novel intronic polymorphisms of bovine FGF21 gene are associated with body weight at 18 months in Chinese cattle

    Sun, Xiao-Mei / Li, Ming-Xun / Li, Ai-Min / Lan, Xian-Yong / Lei, Chu-Zhao / Ma, Wei / Hua, Liu-shuai / Wang, Jing / Hu, Shen-Rong / Chen, Hong

    Livestock science

    Volume v. 155,, Issue no. 1

    Abstract: Fibroblast growth factor 21 (FGF21) is a hepatic hormone that regulates peripheral glucose tolerance, energy balance and lipid metabolism. Prior evidence suggests that FGF21 may have the potential to favorably reduce obesity. The objective of the present ...

    Abstract Fibroblast growth factor 21 (FGF21) is a hepatic hormone that regulates peripheral glucose tolerance, energy balance and lipid metabolism. Prior evidence suggests that FGF21 may have the potential to favorably reduce obesity. The objective of the present study was to identify single nucleotide polymorphisms (SNPs) of bovine FGF21 using 1255 animals representing the five main Chinese breeds and to investigate the effect of these SNPs on economic traits in Nanyang cattle. Four significant SNPs were identified, one was a synonymous mutation and the other three were in intronic regions. The polymorphism information content (PIC) analysis showed that four beef cattle populations (NY, JX, LX and QC) had a moderate genetic diversity at the four loci while the beef and dairy population (CRS) had a low level. Additionally, allele and genotype frequencies for the beef breeds were significantly different from CRS, implying that these mutations are possibly associated with some quantitative traits. Moreover, linkage disequilibrium analysis and haplotype frequencies were also reported. Seven different haplotypes were identified and haplotype TCCC was predominant in all five cattle breeds. Association analysis suggested that SNPs g.297C>G and g.940C>T of bovine FGF21 were associated with higher body weight at 18 months within NY cattle, which would contribute to cattle breeding and genetics through marker-assisted selection (MAS).
    Keywords quantitative traits ; linkage disequilibrium ; single nucleotide polymorphism ; beef ; beef cattle ; genes ; obesity ; cattle breeding ; loci ; haplotypes ; lipid metabolism ; energy balance ; glucose tolerance ; marker-assisted selection ; cattle breeds ; genetic variation
    Language English
    Document type Article
    ISSN 1871-1413
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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