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Article ; Online: Theoretical Insights into the Dynamics of Gas-Phase Bimolecular Reactions with Submerged Barriers

Hongwei Song / Hua Guo

ACS Physical Chemistry Au, Vol 3, Iss 5, Pp 406-

2023 Volume 418

Keywords	Physical and theoretical chemistry ; QD450-801
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	American Chemical Society
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Evinacumab for Homozygous Familial Hypercholesterolemia.

Xu, Hua-Guo

The New England journal of medicine

2021 Volume 384, Issue 6, Page(s) e17

MeSH term(s)	Antibodies, Monoclonal/therapeutic use ; Homozygote ; Humans ; Hyperlipoproteinemia Type II/drug therapy ; Hyperlipoproteinemia Type II/genetics
Chemical Substances	Antibodies, Monoclonal ; evinacumab (T8B2ORP1DW)
Language	English
Publishing date	2021-02-05
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMc2033612
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Article: Analysis of clinical research publication patterns to characterize the cooperation among China's "double first-class" construction medical universities: based on social network analysis.

Jing, Xue / Hua, Guo

Annals of translational medicine

2022 Volume 10, Issue 6, Page(s) 320

Abstract: Background: The "Double First-Class" refers to world first-class university and first-class academic discipline construction proposed by China government. The "Double First-Class" construction medical universities have made many clinical research ... ...

Abstract	Background: The "Double First-Class" refers to world first-class university and first-class academic discipline construction proposed by China government. The "Double First-Class" construction medical universities have made many clinical research achievements, but the analysis and evaluation of research collaboration networks in the field of clinical research are still lacking. Methods: Clinical research papers by 23 "Double First-Class" construction medical universities in China from 2000 to 2019 indexed in the databases of the China National Knowledge Infrastructure and Web of Science (WoS) databases were collected. Through the social network analysis (SNA) method and Ucinet software, the interuniversity research cooperation networks of domestic and international publications were comparatively analyzed at the overall, individual, and group levels in terms of number of publications, cooperation network matrix, centrality analysis, cohesive subgroup analysis, and core-periphery structure to understand the developmental status of the cooperative network of clinical research publications among China's "Double First-Class" construction medical universities. Results: The cooperation among China's "Double First-Class" construction universities showed certain regional distribution characteristics, and they showed closer cooperation in publishing papers in international journals than in domestic ones. The overall density of the domestic-journal research collaboration network of the universities was 0.4229, mainly centered on Beijing University of Traditional Chinese Medicine and Shanghai University of Traditional Chinese Medicine. In contrast, the overall density of international-journal research collaboration network was 0.9052, mainly centered on Peking University, Central South University, and Zhengzhou University, with large differences in subgroup density and low integration. Conclusions: To promote the development of clinical research, it is necessary to improve the construction of the interuniversity clinical research collaboration system, build a national clinical research network with a multilevel structure and sophisticated functions, and expand resource sharing as well as collaborative innovation capacity.
Language	English
Publishing date	2022-03-30
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-516
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Article ; Online: Advances in polysaccharides of natural source of anti-diabetes effect and mechanism.

Yang, Mao-Hui / Yang, Yan / Zhou, Xin / Chen, Hua-Guo

Molecular biology reports

2024 Volume 51, Issue 1, Page(s) 101

Abstract: Purpose: Diabetes is a chronic disease in metabolic disorder, and the pathology is characterized by insulin resistance and insulin secretion disorder in blood. In current, many studies have revealed that polysaccharides extracted from natural sources ... ...

Abstract	Purpose: Diabetes is a chronic disease in metabolic disorder, and the pathology is characterized by insulin resistance and insulin secretion disorder in blood. In current, many studies have revealed that polysaccharides extracted from natural sources with significant anti-diabetic effects. Natural polysaccharides can ameliorate diabetes through different action mechanisms. All these polysaccharides are expected to have an important role in the clinic. Methods: Existing polysaccharides for the treatment of diabetes are reviewed, and the mechanism of polysaccharides in the treatment of diabetes and its structural characteristics are described in detail. Results: This article introduced the natural polysaccharide through different mechanisms of action in the treatment of diabetes, including oxidative stress, apoptosis, inflammatory response and regulation of intestinal bacteria. Natural polysaccharides can treat of diabetes by regulating signaling pathways is also a research hotspot. In addition, the structural characteristics of polysaccharides were explored. There are some structure-activity relationships between natural polysaccharides and the treatment of diabetes.
MeSH term(s)	Humans ; Hypoglycemic Agents/pharmacology ; Hypoglycemic Agents/therapeutic use ; Hypoglycemic Agents/chemistry ; Diabetes Mellitus/drug therapy ; Polysaccharides/pharmacology ; Polysaccharides/therapeutic use ; Polysaccharides/chemistry ; Oxidative Stress ; Insulin Resistance
Chemical Substances	Hypoglycemic Agents ; Polysaccharides
Language	English
Publishing date	2024-01-13
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-09081-1
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Article: Lipidomic investigation of the protective effects of Polygonum perfoliatum against chemical liver injury in mice.

Peng, Lei / Chen, Hua-Guo / Zhou, Xin

Journal of integrative medicine

2023 Volume 21, Issue 3, Page(s) 289–301

Abstract: Objective: Recent investigations have demonstrated that Polygonum perfoliatum L. can protect against chemical liver injury, but the mechanism behind its efficacy is still unclear. Therefore, we studied the pharmacological mechanism at work in P. ... ...

Abstract	Objective: Recent investigations have demonstrated that Polygonum perfoliatum L. can protect against chemical liver injury, but the mechanism behind its efficacy is still unclear. Therefore, we studied the pharmacological mechanism at work in P. perfoliatum protection against chemical liver injury. Methods: To evaluate the activity of P. perfoliatum against chemical liver injury, levels of alanine transaminase, lactic dehydrogenase, aspartate transaminase, superoxide dismutase, glutathione peroxidase and malondialdehyde were measured, alongside histological assessments of the liver, heart and kidney tissue. A nontargeted lipidomics strategy based on ultra-performance liquid chromatography quadrupole-orbitrap high-resolution mass spectrometry method was used to obtain the lipid profiles of mice with chemical liver injury and following treatment with P. perfoliatum; these profiles were used to understand the possible mechanisms behind P. perfoliatum's protective activity. Results: Lipidomic studies indicated that P. perfoliatum protected against chemical liver injury, and the results were consistent between histological and physiological analyses. By comparing the profiles of liver lipids in model and control mice, we found that the levels of 89 lipids were significantly changed. In animals receiving P. perfoliatum treatment, the levels of 8 lipids were significantly improved, relative to the model animals. The results showed that P. perfoliatum extract could effectively reverse the chemical liver injury and significantly improve the abnormal liver lipid metabolism of mice with chemical liver injury, especially glycerophospholipid metabolism. Conclusion: Regulation of enzyme activity related to the glycerophospholipid metabolism pathway may be involved in the mechanism of P. perfoliatum's protection against liver injury. Please cite this article as: Peng L, Chen HG, Zhou X. Lipidomic investigation of the protective effects of Polygonum perfoliatum against chemical liver injury in mice. J Integr Med. 2023; 21(3): 289-301.
MeSH term(s)	Animals ; Mice ; Polygonum/chemistry ; Lipidomics ; Liver ; Lipids/pharmacology ; Glycerophospholipids/metabolism ; Glycerophospholipids/pharmacology ; Chemical and Drug Induced Liver Injury/drug therapy ; Chemical and Drug Induced Liver Injury/prevention & control ; Chemical and Drug Induced Liver Injury/metabolism
Chemical Substances	Lipids ; Glycerophospholipids
Language	English
Publishing date	2023-03-09
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2705612-0
ISSN	2095-4964
ISSN	2095-4964
DOI	10.1016/j.joim.2023.03.002
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Article ; Online: Single atom catalysis poised to transition from an academic curiosity to an industrially relevant technology

Abhaya K. Datye / Hua Guo

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 3

Abstract: During the past decade, initial skepticism rapidly changed into widespread recognition of the role of single atoms in heterogeneous catalysts. The next decade could usher in the era of industrial applications as manufacturing of durable single atom ... ...

Abstract	During the past decade, initial skepticism rapidly changed into widespread recognition of the role of single atoms in heterogeneous catalysts. The next decade could usher in the era of industrial applications as manufacturing of durable single atom catalysts is perfected.
Keywords	Science ; Q
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Frustrated Lewis Pairs in Heterogeneous Catalysis

Qiang Wan / Sen Lin / Hua Guo

Molecules, Vol 27, Iss 3734, p

Theoretical Insights

2022 Volume 3734

Abstract: Frustrated Lewis pair (FLP) catalysts have attracted much recent interest because of their exceptional ability to activate small molecules in homogeneous catalysis. In the past ten years, this unique catalysis concept has been extended to heterogeneous ... ...

Abstract	Frustrated Lewis pair (FLP) catalysts have attracted much recent interest because of their exceptional ability to activate small molecules in homogeneous catalysis. In the past ten years, this unique catalysis concept has been extended to heterogeneous catalysis, with much success. Herein, we review the recent theoretical advances in understanding FLP-based heterogeneous catalysis in several applications, including metal oxides, functionalized surfaces, and two-dimensional materials. A better understanding of the details of the catalytic mechanism can help in the experimental design of novel heterogeneous FLP catalysts.
Keywords	heterogeneous catalysis ; frustrated Lewis pairs ; hydrogen dissociation ; alkynes hydrogenation ; density functional theory ; Organic chemistry ; QD241-441
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cryptanalysis of a white‐box SM4 implementation based on collision attack

Rusi Wang / Hua Guo / Jiqiang Lu / Jianwei Liu

IET Information Security, Vol 16, Iss 1, Pp 18-

2022 Volume 27

Abstract: Abstract White‐box cryptography is to primarily protect the key of a cipher from being extracted in a white‐box scenario, where an adversary has full access to the execution environment of software implementation. Since the introduction of white‐box ... ...

Abstract	Abstract White‐box cryptography is to primarily protect the key of a cipher from being extracted in a white‐box scenario, where an adversary has full access to the execution environment of software implementation. Since the introduction of white‐box cryptography, a number of white‐box implementations of the Chinese SM4 block cipher standard have been proposed, and all of them have been attacked based on Billet et al.’s attack. In this study, we show that collision‐based attack can work more efficiently on Shi et al.’s white‐box SM4 implementation than the previously published attacks, by devising an attack with a time complexity of 223, significantly reducing the previously known time complexity of 249 to a very practical level. Our attack can also be similarly applied to some other white‐box SM4 implementations.
Keywords	computational complexity ; Computer engineering. Computer hardware ; TK7885-7895 ; Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: [Comparison on biological activities of Lycium barbarum polysaccharides extracted with five methods].

Wang, Sheng-Lin / Zai, Qing-Yong / Chen, Hua-Guo / Li, Jia-Wen / Zhou, Xin

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2024 Volume 49, Issue 1, Page(s) 110–122

Abstract: Studying the physicochemical properties and biological activities of Lycium barbarum polysaccharides(LBPs) is of great significance. The previous study had extracted LBPs(LBP-1, LBP-2, LBP-3, LBP-4, and LBP-5) by five different methods(cold water ... ...

Abstract	Studying the physicochemical properties and biological activities of Lycium barbarum polysaccharides(LBPs) is of great significance. The previous study had extracted LBPs(LBP-1, LBP-2, LBP-3, LBP-4, and LBP-5) by five different methods(cold water extraction, boiling water reflux extraction of the residue after cold water extraction, ultrasonic extraction with 50% ethanol, ultrasonic extraction with 25% ethanol of the residue after 50% ethanol extraction, and hot water extraction). In this study, the structures of the obtained five LBPs were characterized by UV spectroscopy, thermogravimetric analysis, and scanning electron microscopy. Furthermore, the antioxidant, blood lipid-lowering, nitrosation-inhibting, acetylcholinesterase-inhibiting, and tyrosinase-inhibiting activities of the five LBPs were measured in vitro. The results showed that high-temperature extraction destroyed the polysaccharide structure, while ultrasound-assisted extraction ensured the structural integrity. The thermal stability and degradation behaviors differed among the five LBPs. However, the UV spectroscopic results of the five LBPs did not show significant differences, and all of the five LBPs showed the characteristic absorption peaks of proteins. LBP-3 and LBP-4 exhibited strong antioxidant activity, while LBP-3 had the strongest blood lipid-lowering activity. In addition, LBP-3 outperformed other LBPs in inhibiting nitrosation and acetylcholineste-rase, and LBP-2 showed the strongest inhibitory effect on tyrosinase. This study explored the effects of different extraction methods on the physicochemical properties and biological activities of LBPs, with a view to providing a basis for the selection of suitable extraction methods to obtain LBPs with ideal biological activities.
MeSH term(s)	Lycium/chemistry ; Monophenol Monooxygenase ; Acetylcholinesterase ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/chemistry ; Polysaccharides/pharmacology ; Polysaccharides/chemistry ; Lipids ; Ethanol ; Water
Chemical Substances	Monophenol Monooxygenase (EC 1.14.18.1) ; Acetylcholinesterase (EC 3.1.1.7) ; Antioxidants ; Drugs, Chinese Herbal ; Polysaccharides ; Lipids ; Ethanol (3K9958V90M) ; Water (059QF0KO0R)
Language	Chinese
Publishing date	2024-02-25
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20231025.301
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Article ; Online: Dynamics Analysis of a Stochastic Hybrid Logistic Model with Delay and Two-Pulse Perturbations

Haokun Qi / Hua Guo

Complexity, Vol

2020 Volume 2020

Abstract: In this paper, we propose and discuss a stochastic logistic model with delay, Markovian switching, Lévy jump, and two-pulse perturbations. First, sufficient criteria for extinction, nonpersistence in the mean, weak persistence, persistence in the mean, ... ...

Abstract	In this paper, we propose and discuss a stochastic logistic model with delay, Markovian switching, Lévy jump, and two-pulse perturbations. First, sufficient criteria for extinction, nonpersistence in the mean, weak persistence, persistence in the mean, and stochastic permanence of the solution are gained. Then, we investigate the lower (upper) growth rate of the solutions. At last, we make use of Matlab to illustrate the main results and give an explanation of biological implications: the large stochastic disturbances are disadvantageous for the persistence of the population; excessive impulsive harvesting or toxin input can lead to extinction of the population.
Keywords	Electronic computers. Computer science ; QA75.5-76.95
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Hindawi-Wiley
Document type	Article ; Online
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