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Article ; Online: Computed Tomography Findings and Preliminary Exploration of Pathological Analysis of Bronchiolar Adenoma

Xiaohuan PAN / Ping HE / Huai CHEN

CT Lilun yu yingyong yanjiu, Vol 33, Iss 1, Pp 56-

2023 Volume 62

Abstract: Objective: To summarize and analyze the clinical data, computed tomography (CT) signs, and pathological features of bronchiolar adenoma, and to discuss the diagnostic value of bronchiolar adenoma. Methods: In total, 18 cases of pulmonary nodules ... ...

Abstract	Objective: To summarize and analyze the clinical data, computed tomography (CT) signs, and pathological features of bronchiolar adenoma, and to discuss the diagnostic value of bronchiolar adenoma. Methods: In total, 18 cases of pulmonary nodules diagnosed as bronchiolar adenoma via postoperative pathology from January 2020 to December 2020 were retrospectively collected, and the clinical data, chest CT signs, and postoperative pathological features of pulmonary nodules were analyzed. Results: Among the 18 cases, 16 had no clinical chest symptoms, and 2 had chest pain. The patients were 18~65 years old. The mean age was 51.8 years, and the median age (25％~75％ quantile) was 52 (49~59) years; 7 patients were male (39％), and 11 were females (61％). The average maximum slice diameter of bronchiolar adenoma was 11.1 mm, and the median diameter (25％~75％ quantile) was 8 (6~15) mm. There were 15 cases with lesion distance ≤10 mm from the pleura. CT showed that 8 cases were pure ground-glass nodules (pGGN), 7 cases were part-solid nodules (PSN), and 3 cases had simple cystic space. The mean CT value of bronchiolar adenomas presenting with pGGN was −690.7 HU. The median mean CT value (25％~75％ quantiles) was −717.5 (−722~ −681) HU. A spicule sign at the nodular margin was found in 6 of the 18 cases. Pleural traction around nodules was found in 7 cases, and bronchiectasis occurred in nodules in 5 cases. The postoperative gross pathological diameter of 18 nodules was 9.1 mm, and the median diameter (25％~75％ quantile) was 7 (6~9) mm. Pathological immunohistochemical antibody CK7 was positive in 18 cases; p40, p63, CK5/6, and TTF-1 were positive in 16 cases. Conclusions: Bronchiolar adenoma often occurs in middle-aged and older women. Preoperative CT diagnosis of subpleural nodules around 10 mm could indicate the disease, and immunohistochemical antibody CK7, p40, and other indicators are qualitative methods for diagnosing bronchiolar adenoma.
Keywords	computed tomography ; lung cancer ; bronchiolar adenoma ; diagnosis ; Geophysics. Cosmic physics ; QC801-809 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Editorial Office of Computerized Tomography Theory and Application
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: “C-wetland”

Huai Chen / Zicheng Yu / Ning Wu / Yanfen Wang / Xinwei Liu

The Innovation, Vol 4, Iss 2, Pp 100403- (2023)

A new paradigm to enhance conservation of carbon-rich wetlands

2023

Keywords	Science (General) ; Q1-390
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Impacts of earthworms and their excreta on peat soil properties and bacterial community

Hui Zhang / Xinya Huang / Xuhui Chen / Haitao Wu / Huai Chen

Global Ecology and Conservation, Vol 46, Iss , Pp e02594- (2023)

2023

Abstract: Peatlands store 20–30 % of the global soil carbon (C). Earthworms simultaneously increase net C stabilization and net C mineralization. But little is known about the impact of earthworm invasion on the C cycling in peat soils. Earthworm excreta, such as ... ...

Abstract	Peatlands store 20–30 % of the global soil carbon (C). Earthworms simultaneously increase net C stabilization and net C mineralization. But little is known about the impact of earthworm invasion on the C cycling in peat soils. Earthworm excreta, such as casts and mucus, have been shown to affect soil chemistry and microbes, the former representing gut process and the latter are secretions from earthworms as they dig burrows. Therefore, this study evaluates the separate effects of the presence of earthworms, casts, and mucus on the soil chemistry, soil microbial community, and the enzymes of peat soil. The results indicated that earthworms and their casts had significantly negative effects on peat soil dissolved organic C, microbial biomass C, pH and polyphenol oxidase, and had positive effects on phenolic matters, hydrolase activity, bacterial diversity, and metabolic functions. The effects of mucus on polyphenol oxidase, phenolic matters and bacterial evenness were similar to those of earthworms, but the effects on other soil properties were different. Earthworms and their excreta selectively promote or inhibit the survival of some soil bacteria, e.g., the relative abundance of Bacteroidetes was increased and Acidobacteria and Rokubacteria was reduced after earthworm entering. This research provides evidence that earthworms change soil properties primarily through gut processes (casts), indicates the negative effect of earthworms on peat soil C, and call for the monitoring of soil fauna in degraded peatland to protecting C stocks in peatlands.
Keywords	Peatlands ; Soil organic carbon ; Soil enzyme activity ; Soil fauna ; Bacterial diversity ; Ecology ; QH540-549.5
Subject code	630
Language	English
Publishing date	2023-10-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinicopathological and CT Findings of Cystic Lung Cancer

Hongjia MENG / Xiaojuan CHEN / Junjie HUANG / Xiaoxue HE / Huai CHEN

CT Lilun yu yingyong yanjiu, Vol 32, Iss 1, Pp 97-

2023 Volume 104

Abstract: Objective: Cystic lung cancer is a rare type of lung cancer with special morphological manifestations on imaging that have not been completely recognized. This study aimed to improve the understanding and diagnosis of this lung cancer by analyzing its ... ...

Abstract	Objective: Cystic lung cancer is a rare type of lung cancer with special morphological manifestations on imaging that have not been completely recognized. This study aimed to improve the understanding and diagnosis of this lung cancer by analyzing its computed tomography (CT) features and clinicopathological findings. Methods: The clinical data, pathological types, and CT features of patients with cystic lung cancer who were diagnosed at our hospital between January 2015 and June 2021 were analyzed retrospectively. Results: We identified 44 cases (86.27%) of adenocarcinomas; these included 7 (13.73%) and 35 (68.63%) cases of microinvasive adenocarcinomas and invasive adenocarcinomas, respectively. Regarding the histological type, 11 (21.57%), 8 (15.69%), and 15 (29.41%) cases were of the adjoint, papillary, and acinar types, respectively. Two cases (3.92%) contained micropapillary components that accounted for more than 20% . Furthermore, one case (1.96%) was not classified, and in another case (1.96%), pathological examination after chemotherapy suggested an adenocarcinoma. Lymph node biopsy in one case (1.96%) suggested a metastatic lung adenocarcinoma. Squamous cell carcinoma was observed in five cases (9.80%); these included three (5.89%) and two (3.92%) cases of keratinizing and non-keratinizing squamous cell carcinomas, respectively. A large cell carcinoma and a high-grade mucoepidermoid carcinoma were observed in one case each (1.96%). A peripheral distribution was observed in 40 cases (80.30%). The mean diameter was 4.7± 2.7 cm. A cystic cavity with ground glass, cystic cavity with solid components, and cystic cavity with mixed components were observed in 20 (39.22%), 22 (43.14%), and 9 (17.65%) cases, respectively. According to the Mario classification, 24 (47.06%), 8 (15.69%), 9 (17.65%), and 10 (19.61%) cases were of types I, II, III, and IV, respectively. The cyst wall was uneven in 42 cases (82.35%); furthermore, a lobular lesion edge and the burr sign were observed in 28 (54.90%) and 14 (27.45%) ...
Keywords	computed tomography ; lung cancer ; cystic cavity ; Geophysics. Cosmic physics ; QC801-809 ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Editorial Office of Computerized Tomography Theory and Application
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Varied response of carbon dioxide emissions to warming in oxic, anoxic and transitional soil layers in a drained peatland

Liangfeng Liu / Huai Chen / Jianqing Tian

Communications Earth & Environment, Vol 3, Iss 1, Pp 1-

2022 Volume 12

Abstract: Carbon dioxide emissions from oxic-anoxic transitional soil layers in a drained peatland are less sensitive to warming than emissions from oxic surface and anoxic deep soil layers, according to a laboratory-based incubation experiment of Qinghai-Tibet ... ...

Abstract	Carbon dioxide emissions from oxic-anoxic transitional soil layers in a drained peatland are less sensitive to warming than emissions from oxic surface and anoxic deep soil layers, according to a laboratory-based incubation experiment of Qinghai-Tibet Plateau peatland soils.
Keywords	Geology ; QE1-996.5 ; Environmental sciences ; GE1-350
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effects of Freeze–Thaw Cycles on Methane Emissions From Peat Soils of a High-Altitude Peatland

Zao Yang / Dan Zhu / Liangfeng Liu / Xinwei Liu / Huai Chen

Frontiers in Earth Science, Vol

2022 Volume 10

Abstract: The Qinghai– Tibet Plateau (QTP), which embodies the largest area of permafrost at mid–low altitudes of the world, has been experiencing rapid permafrost degradation and changes in freeze–thaw processes for the past decades. However, the responses and ... ...

Abstract	The Qinghai– Tibet Plateau (QTP), which embodies the largest area of permafrost at mid–low altitudes of the world, has been experiencing rapid permafrost degradation and changes in freeze–thaw processes for the past decades. However, the responses and potential feedbacks of the methane flux from peatlands on the QTP to changing freeze–thaw cycles (FTCs) remain unknown. In this study, we collected peat soils from the Zoîgé peatlands, the largest peatland complex on the QTP, to examine methane emissions under simulated diurnal FTC scenarios. In incubation experiments of 15 days, two freeze–thaw temperature ranges of −5 to 4°C (mild) and −15 to 4°C (intense) were applied to two sets of peat soil samples, and each of them was characterized by 100% or 80% maximum water holding capacity (MWHC). The results showed that the peak of methane emission from the peat soil occurred after the first freeze–thaw cycle (FTC1), with the highest reaching a value of 0.103 mg kg soil−1·h−1. Generally, the cumulative methane emissions were elevated by FTCs, and relative higher rates of methane emissions were found for the 2nd FTC to the 15th FTC, compared with those from low-altitude peatlands. Methane emissions were significantly correlated to the export of dissolved organic carbon (DOC) and the activities of β-D-cellobiosidase and phenol oxidase in various freeze–thaw conditions. This study highlights the importance of FTCs in stimulating methane emissions and implies that methane emissions during FTCs from high-altitude peatlands would increase under a warmer climate in the future.
Keywords	methane emissions ; high-altitude peatlands ; freeze–thaw cycles ; dissolved organic carbon ; enzyme activity ; Science ; Q
Subject code	500
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Methane Emissions Regulated by Microbial Community Response to the Addition of Monensin and Fumarate in Different Substrates

Dan Xue / Huai Chen / Xiaolin Luo

Applied Sciences, Vol 11, Iss 6282, p

2021 Volume 6282

Abstract: Ruminants contribute significantly to global methane (CH 4 ) emissions. This study aimed to evaluate the in vitro effects of monensin sodium salt (MSS) and disodium fumarate (DF) on CH 4 production, rumen fermentation, and microbial community, with ... ...

Abstract	Ruminants contribute significantly to global methane (CH 4 ) emissions. This study aimed to evaluate the in vitro effects of monensin sodium salt (MSS) and disodium fumarate (DF) on CH 4 production, rumen fermentation, and microbial community, with different substrates. The addition of MSS and DF, alone and in combination, significantly reduced the concentration and production of CH 4 ( p < 0.05), and while with vinasse as substrate, the CH 4 production was higher for forage. The highest propionate production and lowest acetate and propionic ratio (A:P) values were all observed in cultures added to the combination of 14 mmol/L DF and 80 mg/kg MSS in both substrates, suggesting that these additives improved the rumen fermentation efficiency. The diversity indexes of prokaryotic microbiota with forage as the substrate were significantly higher than vinasse, and there were different effects on diversity indexes with the addition of MSS and DF depending on the incubated substrate. Supplementation with MSS and DF increased the number of starch degradation and fumarate reducing bacteria, decreased the number of methanogens, but had no significant effect on the number of fibrolytic bacteria. pH, NH 3 -N, and rumen volatile fatty acids (VFA) were the main factors influencing prokaryotic community structure. In conclusion, basal substrates (forage and vinasse) and CH 4 mitigation additives (MSS and DF) have interactions on the in vitro rumen fermentation and microbial composition.
Keywords	monensin ; disodium fumarate ; in vitro ; rumen fermentation ; microbial community ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A CT-based deep learning model

Xiaofeng Lin / Kunfeng Liu / Kunwei Li / Xiaojuan Chen / Biyun Chen / Sheng Li / Huai Chen / Li Li

iScience, Vol 27, Iss 1, Pp 108712- (2024)

visceral pleural invasion and survival prediction in clinical stage IA lung adenocarcinoma

1481

Abstract: Summary: Pathologic visceral pleural invasion (VPI) in patients with early-stage lung cancer can result in the upstaging of T1 to T2, in addition to having implications for surgical resection and prognostic outcomes. This study was designed with the goal ...

Abstract	Summary: Pathologic visceral pleural invasion (VPI) in patients with early-stage lung cancer can result in the upstaging of T1 to T2, in addition to having implications for surgical resection and prognostic outcomes. This study was designed with the goal of establishing and validating a CT-based deep learning (DL) model capable of predicting VPI status and stratifying patients based on their prognostic outcomes. In total, 2077 patients from three centers with pathologically confirmed clinical stage IA lung adenocarcinoma were enrolled. DL signatures were extracted with a 3D residual neural network. DL model was able to effectively predict VPI status. VPI predicted by the DL models, as well as pathologic VPI, was associated with shorter disease-free survival. The established deep learning signature provides a tool capable of aiding the accurate prediction of VPI in patients with clinical stage IA lung adenocarcinoma, thus enabling prognostic stratification.
Keywords	Radiology ; Bioinformatics ; Neural networks ; Cancer ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Air Warming and Drainage Influences Soil Microarthropod Communities

Hui Zhang / Xin Sun / Dong Liu / Haitao Wu / Huai Chen

Frontiers in Ecology and Evolution, Vol

2021 Volume 9

Abstract: The degradation of wetlands due to climate change is of critical concern to human beings worldwide. Little is known about the potential synergistic effects of simultaneous water level reduction and warming on the underground wetland ecosystems. We ... ...

Abstract	The degradation of wetlands due to climate change is of critical concern to human beings worldwide. Little is known about the potential synergistic effects of simultaneous water level reduction and warming on the underground wetland ecosystems. We conducted a 5-month field experiment in the Sanjiang Plain, utilizing open-top chambers and water level automatic control systems to investigate such synergistic effects. Soil springtails (Collembola) and mites (Acari) in the top (0–20 cm) soil layers were sampled to calculate their density, diversity, and to screen for indicator species. Warming significantly influenced soil springtail communities, slightly increasing the total density and total abundance under the natural water level while reducing them under a constant water level. In addition, Anurida maritima and Vertagopus laricis, two indicators for the natural water level, had the highest densities in the natural water level treatment and under the combined treatment of warming and natural water level, respectively. Cheiroseius sinicus and Malaconothrus tardus had the highest densities in warming under the 0 cm water level, significantly higher than the other three treatments. This study also revealed the importance of maintaining fluctuating water levels for microarthropod communities influenced by global warming, providing a theoretical basis for water level control in wetland restoration.
Keywords	climate change ; collembola ; mites ; indicator species ; wetland restoration ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Subject code	550
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Effect of Short-Term Low-Nitrogen Addition on Carbon, Nitrogen and Phosphorus of Vegetation-Soil in Alpine Meadow

Zhen’an Yang / Wei Zhan / Lin Jiang / Huai Chen

International Journal of Environmental Research and Public Health, Vol 18, Iss 10998, p

2021 Volume 10998

Abstract: As one of the nitrogen (N) limitation ecosystems, alpine meadows have significant effects on their structure and function. However, research on the response and linkage of vegetation-soil to short-term low-level N deposition with rhizosphere processes is ...

Abstract	As one of the nitrogen (N) limitation ecosystems, alpine meadows have significant effects on their structure and function. However, research on the response and linkage of vegetation-soil to short-term low-level N deposition with rhizosphere processes is scant. We conducted a four level N addition (0, 20, 40, and 80 kg N ha − 1 y −1 ) field experiment in an alpine meadow on the Qinghai-Tibetan Plateau (QTP) from July 2014 to August 2016. We analyzed the community characteristics, vegetation (shoots and roots), total carbon (TC), nutrients, soil (rhizosphere and bulk) properties, and the linkage between vegetation and soil under different N addition rates. Our results showed that (i) N addition significantly increased and decreased the concentration of soil nitrate nitrogen (NO 3 − -N) and ammonium nitrogen, and the soil pH, respectively; (ii) there were significant correlations between soil (rhizosphere and bulk) NO 3 − -N and total nitrogen (TN), and root TN, and there was no strong correlation between plant and soil TC, TN and total phosphorus, and their stoichiometry under different N addition rates. The results suggest that short-term low-N addition affected the plant community, vegetation, and soil TC, TN, TP, and their stoichiometry insignificantly, and that the correlation between plant and soil TC, TN, and TP, and their stoichiometry were insignificant.
Keywords	community ; rhizosphere ; bulk ; carbon ; nutrient ; stoichiometry ; Medicine ; R
Subject code	333
Language	English
Publishing date	2021-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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