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  1. Article ; Online: Visible Light-Driven Micromotors in Fuel-Free Environment with Promoted Ion Tolerance

    Huaide Jiang / Xiaoli He / Ming Yang / Chengzhi Hu

    Nanomaterials, Vol 13, Iss 1827, p

    2023  Volume 1827

    Abstract: Light-driven electrophoretic micromotors have gained significant attention recently for applications in drug delivery, targeted therapy, biosensing, and environmental remediation. Micromotors that possess good biocompatibility and the ability to adapt to ...

    Abstract Light-driven electrophoretic micromotors have gained significant attention recently for applications in drug delivery, targeted therapy, biosensing, and environmental remediation. Micromotors that possess good biocompatibility and the ability to adapt to complex external environments are particularly attractive. In this study, we have fabricated visible light-driven micromotors that could swim in an environment with relatively high salinity. To achieve this, we first tuned the energy bandgap of rutile TiO 2 that was hydrothermally synthesized, enabling it to generate photogenerated electron-hole pairs under visible light rather than solely under UV. Next, platinum nanoparticles and polyaniline were decorated onto the surface of TiO 2 microspheres to facilitate the micromotors swimming in ion-rich environments. Our micromotors exhibited electrophoretic swimming in NaCl solutions with concentrations as high as 0.1 M, achieving a velocity of 0.47 μm/s without the need for additional chemical fuels. The micromotors’ propulsion was generated solely by splitting water under visible light illumination, therefore offering several advantages over traditional micromotors, such as biocompatibility and the ability to operate in environments with high ionic strength. These results demonstrated high biocompatibility of photophoretic micromotors and high potential for practical applications in various fields.
    Keywords micromotors ; visible light ; ion-tolerant ; biocompatibility ; Chemistry ; QD1-999
    Subject code 535
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article: Chronic lead exposure enhances the sympathoexcitatory response associated with P2X4 receptor in rat stellate ganglia

    Zhu, Gaochun / Bo Dai / Chaoran Zheng / Guilin Li / Huaide Jiang / Jingjing Guo / Shangdong Liang / Xuan Sheng / Yu Dan / Yurong Xu / Zhenying Chen

    Environmental toxicology. 2018 June, v. 33, no. 6

    2018  

    Abstract: Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 ... ...

    Abstract Chronic lead exposure causes peripheral sympathetic nerve stimulation, including increased blood pressure and heart rate. Purinergic receptors are involved in the sympathoexcitatory response induced by myocardial ischemia injury. However, whether P2X4 receptor participates in sympathoexcitatory response induced by chronic lead exposure and the possible mechanisms are still unknown. The aim of this study was to explore the change of the sympathoexcitatory response induced by chronic lead exposure via the P2X4 receptor in the stellate ganglion (SG). Rats were given lead acetate through drinking water freely at doses of 0 g/L (control group), 0.5 g/L (low lead group), and 2 g/L (high lead group) for 1 year. Our results demonstrated that lead exposure caused autonomic nervous dysfunction, including blood pressure and heart rate increased and heart rate variability (HRV) decreased. Western blotting results indicated that after lead exposure, the protein expression levels in the SG of P2X4 receptor, IL‐1β and Cx43 were up‐regulated, the phosphorylation of p38 mitogen‐activated protein kinase (MAPK) was activated. Real‐time PCR results showed that the mRNA expression of P2X4 receptor in the SG was higher in lead exposure group than that in the control group. Double‐labeled immunofluorescence results showed that P2X4 receptor was co‐expressed with glutamine synthetase (GS), the marker of satellite glial cells (SGCs). These changes were positively correlated with the dose of lead exposure. The up‐regulated expression of P2X4 receptor in SGCs of the SG maybe enhance the sympathoexcitatory response induced by chronic lead exposure.
    Keywords blood pressure ; correlation ; drinking water ; fluorescent antibody technique ; ganglia ; gene expression ; glutamate-ammonia ligase ; heart rate ; interleukin-1beta ; lead ; lead acetate ; messenger RNA ; mitogen-activated protein kinase ; myocardial ischemia ; nerve tissue ; neuroglia ; phosphorylation ; protein synthesis ; purinergic receptors ; quantitative polymerase chain reaction ; rats ; Western blotting
    Language English
    Dates of publication 2018-06
    Size p. 631-639.
    Publishing place John Wiley & Sons, Ltd
    Document type Article
    Note JOURNAL ARTICLE
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.22547
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: The role of adrenergic activation on murine luteal cell viability and progesterone production

    Wang, Jing / Bing Wu / Chuan Hu / Chunping Zhang / Gang Li / Huaide Jiang / Li Xiao / Min Tang / Qiming Dong / Riqiang Bao / Wei Cai

    Theriogenology. 2016 Sept. 15, v. 86, no. 5

    2016  

    Abstract: Sympathetic innervations exist in mammalian CL. The action of catecholaminergic system on luteal cells has been the focus of a variety of studies. Norepinephrine (NE) increased progesterone secretion of cattle luteal cells by activating β-adrenoceptors. ... ...

    Abstract Sympathetic innervations exist in mammalian CL. The action of catecholaminergic system on luteal cells has been the focus of a variety of studies. Norepinephrine (NE) increased progesterone secretion of cattle luteal cells by activating β-adrenoceptors. In this study, murine luteal cells were treated with NE and isoprenaline (ISO). We found that NE increased the viability of murine luteal cells and ISO decreased the viability of luteal cells. Both NE and ISO promoted the progesterone production. Nonselective β-adrenergic antagonist, propranolol reversed the effect of ISO on cell viability but did not reverse the effect of NE on cell viability. Propranolol blocked the influence of NE and ISO on progesterone production. These results reveal that the increase of luteal cell viability induced by NE is not dependent on β-adrenergic activation. α-Adrenergic activation possibly contributes to it. Both NE and ISO increased progesterone production through activating β-adrenergic receptor. Further study showed that CyclinD2 is involved in the increase of luteal cell induced by NE. 3β-Hydroxysteroid dehydrogenase, LHR, steroidogenic acute regulatory protein (StAR), and PGF2α contribute to the progesterone production induced by NE and ISO.
    Keywords antagonists ; beta adrenergic receptors ; beta-adrenergic antagonists ; cattle ; cell viability ; isoprenaline ; luteal cells ; mice ; norepinephrine ; progesterone ; propranolol ; regulatory proteins ; secretion
    Language English
    Dates of publication 2016-0915
    Size p. 1182-1188.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2016.04.008
    Database NAL-Catalogue (AGRICOLA)

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