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Article ; Online: Cyro-EM structure of human mGlus

Huan Xiao / Qiu Sun

Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

leading therapeutic potential to neurological diseases

2021 Volume 2

Keywords	Medicine ; R ; Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Nature Publishing Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: [Retracted] Cardioprotective effect of epigallocatechin‑3‑gallate against myocardial infarction in hypercholesterolemic rats.

Zhong, Wei / Huan, Xiao-Dong / Cao, Qian / Yang, Jun

Experimental and therapeutic medicine

2024 Volume 27, Issue 3, Page(s) 108

Abstract: This retracts the article DOI: 10.3892/etm.2014.2135.]. ...

Abstract	[This retracts the article DOI: 10.3892/etm.2014.2135.].
Language	English
Publishing date	2024-01-22
Publishing country	Greece
Document type	Retraction of Publication
ZDB-ID	2683844-8
ISSN	1792-1015 ; 1792-0981
ISSN (online)	1792-1015
ISSN	1792-0981
DOI	10.3892/etm.2024.12396
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Effect of Magnetized Water on the Stability and Consolidation Compressive Strength of Cement Grout.

Hu, Huan-Xiao / Deng, Chao

Materials (Basel, Switzerland)

2021 Volume 14, Issue 2

Abstract: In this study, tap water is magnetized by a self-developed device. The conductivity and evaporation of magnetized water (MW) at different temperatures are tested to demonstrate the magnetization mechanism. The results show that the conductivity and ... ...

Abstract	In this study, tap water is magnetized by a self-developed device. The conductivity and evaporation of magnetized water (MW) at different temperatures are tested to demonstrate the magnetization mechanism. The results show that the conductivity and evaporation of the magnetized water increase to different degrees compared with regular tap water (RW). The maximum increase in conductivity is 10.6%, and the maximum increase in evaporation is 25.6% and 16.7% at 50 and 80 °C, respectively. Cement grout samples with water-cement ratios (
Language	English
Publishing date	2021-01-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma14020275
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Article ; Online: Spatial-temporal pattern evolution and geological influence factors analysis of ecological vulnerability in Western Sichuan mountain region

Huan Xiao / Huaiyong Shao / Jiamei Long / Shuhui Zhang / Shan He / Dun Wang

Ecological Indicators, Vol 155, Iss , Pp 110980- (2023)

2023

Abstract: Compared to plains, hills and basins, mountainous areas with complex topography are more prone to ecological and environment vulnerability to climate change, human interference and geological disasters. This type of region is usually located in abrupt ... ...

Abstract	Compared to plains, hills and basins, mountainous areas with complex topography are more prone to ecological and environment vulnerability to climate change, human interference and geological disasters. This type of region is usually located in abrupt transitional zones, which marked by active neotectonic movements, high-incidence mountain disasters, abundant available resources, slower economic development, diverse eco-environment and insufficient cultivated land resources. Therefore, it is of great significance to determ the vulnerability status and spatial–temporal change process of the eco-environment in mountainous area with complex topography. In this study, data derived from vegetation, topography, soil, meteorological and human social factors were used to develop an evaluation index system that can reflect the characteristics of the eco-environment in the mountain area. Employing the Genetic Projection Tracing Model (RAGA-PPM), we developed a framework for assessing the vulnerability of mountainous areas with complex terrains and applied it to the western Sichuan mountain region, China. In addition, the relationship between the geological factors and the vulnerability of eco-environment was quantitatively analyzed by using the geographic detector. The results indicate that (1) The overall vulnerability was medium and the spatial distribution was higher in the central and eastern parts and lower in the surrounding areas. The area with high vulnerability accounted for 27.9%. (2) The overall degree of vulnerability increased from2010 to 2020, the eco-environment experienced a rapid deterioration from 2010 to 2015, followed by a slower improvement from 2015 to 2020. (3) Correlations were minimal between vulnerability results and fault density and earthquake dynamic peak acceleration, the influence of other geological factors ranged from 10% to 25.8%, indicating a nonlinear correlation. (4) This study reveals that the ecological vulnerability of mountain areas was the effect of multiple human and natural ...
Keywords	Ecological vulnerability ; Geological factors ; Projection Pursuit Model ; Western Sichuan ; Mountainous area ; Ecology ; QH540-549.5
Subject code	910
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Identification of prognostic immune genes in laryngeal cancer

Huan Xiao / Qi-sheng Su / Chao-qian Li

Journal of International Medical Research, Vol

2020 Volume 48

Abstract: Objective In this study, we aimed to identify prognostic immune-related genes and establish a prognostic model for laryngeal cancer based on these genes. Methods Transcriptome profiles and clinical data of patients with laryngeal cancer were downloaded ... ...

Abstract	Objective In this study, we aimed to identify prognostic immune-related genes and establish a prognostic model for laryngeal cancer based on these genes. Methods Transcriptome profiles and clinical data of patients with laryngeal cancer were downloaded from The Cancer Genome Atlas database. Integrated bioinformatics analyses were performed to identify genes associated with prognosis. Results Thirty prognostic immune-related genes for laryngeal cancer were identified. We constructed a regulatory network of prognosis comprising transcription factors and immune-related genes. Multivariate Cox regression analyses identified 15 immune-related genes in the network that were used to establish the prognostic model. The model exhibited excellent prognostic prediction ability with a high area under the curve value (0.916). The calculated risk score based on expression of the 15 immune-related genes was shown to be an independent prognostic factor for laryngeal cancer. Conclusion We identified prognostic immune-related genes and established a prognostic model for laryngeal cancer, which might help identify novel predictive biomarkers and therapeutic targets of laryngeal cancer.
Keywords	Medicine (General) ; R5-920
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	SAGE Publishing
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Type II transmembrane serine proteases 4 (TMPRSS4) promotes proliferation, invasion and epithelial–mesenchymal transition in endometrial carcinoma cells (HEC1A and Ishikawa) via activation of MAPK and AKT

Huan Xiao / Zhian Zhang / Dan Peng / Chunqing Wei / Benling Ma

Animal Cells and Systems, Vol 25, Iss 4, Pp 211-

2021 Volume 218

Abstract: Endometrial cancer is the most common gynecological cancer in the developed countries. Type II transmembrane serine proteases 4 (TMPRSS4) is a newly discovered transmembrane protein, which may be related to the invasion, metastasis of the tumor and the ... ...

Abstract	Endometrial cancer is the most common gynecological cancer in the developed countries. Type II transmembrane serine proteases 4 (TMPRSS4) is a newly discovered transmembrane protein, which may be related to the invasion, metastasis of the tumor and the poor prognosis. This study aims to investigate the role of TMPRSS4 in endometrial cancer and the detailed molecular mechanism. The results showed that TMPRSS4 was highly expressed in human endometrial cancer cells (HEC1A and Ishikawa). TMPRSS4 knockdown inhibited proliferation of endometrial cancer cells. In TMPRSS4 knockdown cells, the invasion of cells was significantly supressed. The expression of E-cadherin was significantly enhanced, while the levels of fibronectin and vimentin decreased in TMPRSS4 knockdown cells, which indicated thatTMPRSS4 knockdown attenuated the EMT of cancer cells. TMPRSS4 positively regulated the activation of MAPK and AKT signaling pathways in endometrial cancer. In conclusion, this study indicated that TMPRSS4 may be associated with the progression of endometrial cancer through promoting proliferation, invasion and EMT via activation of MAPK and AKT in endometrial cancer cells. TMPRSS4 may be a new and more effective target or therapeutic strategy for treating endometrial cancer.
Keywords	type ii transmembrane serine proteases 4 (tmprss4) ; endometrial cancer ; epithelial–mesenchymal transition ; mapk ; akt ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: The Effect of Routine Management Combined with Case Management Model on Social Support, Self-Efficacy, Self-Management Ability, and Psychological Flexibility of AIDS Patients

Li Liu / Jing Zhou / Huan Xiao / Yanhe Luo / Yan Zeng / Li Fan / Chen Zheng

Computational and Mathematical Methods in Medicine, Vol

2022 Volume 2022

Abstract: Objective. To explore the influence of conventional management combined with case management on social support and self-efficacy of AIDS patients. Methods. The clinical case data of 120 AIDS patients who were treated and nursed in our hospital from June ... ...

Abstract	Objective. To explore the influence of conventional management combined with case management on social support and self-efficacy of AIDS patients. Methods. The clinical case data of 120 AIDS patients who were treated and nursed in our hospital from June 2019 to June 2021 were selected as the research objects and were divided into the control group and the observation group according to the digital table method, with 60 cases each. The control group implements routine management, and the observation group implements case-based nursing management on this basis and compares the effects of self-efficacy, self-management ability, nursing ability, social support, and psychological flexibility of the two groups of patients. Results. Before the intervention, the quality of life scores of the two groups was not statistically significant (P>0.05). After the intervention, the physical function score, pain management score, and symptom response score of the observation group were significantly higher than those of the control group, and statistics showed that the difference was statistically significant (P<0.05). Before the intervention, the self-management ability of the two groups of patients was not statistically significant (P>0.05). After the intervention, the observation group’s symptom management, emotional cognition management, social support and assistance, daily life management, disease knowledge management, and treatment compliance management were significantly higher than those of the control group. Statistics show that this difference is statistically significant (P<0.05). Before the intervention, there was no significant difference in the nursing ability and psychological flexibility between the two groups of patients (P>0.05). After the intervention, the observation group’s health knowledge level, self-care skills, self-care responsibility, self-concept, and mental flexibility (resilience, strength, optimism) indicators were higher than the control group, while the depression mood disorder ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7
Subject code	796
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Serum cytokines profile changes in amyotrophic lateral sclerosis.

Xu, Chun-Zuan / Huan, Xiao / Luo, Su-Shan / Zhong, Hua-Hua / Zhao, Chong-Bo / Chen, Yan / Zou, Zhang-Yu / Chen, Sheng

Heliyon

2024 Volume 10, Issue 7, Page(s) e28553

Abstract: Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder, characterized by progressive limb weakness, dysphagia, dysphonia, and respiratory failure due to degeneration of upper and lower motor neurons. The pathogenesis ...

Abstract	Background: Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder, characterized by progressive limb weakness, dysphagia, dysphonia, and respiratory failure due to degeneration of upper and lower motor neurons. The pathogenesis of ALS is still unclear. Neuroinflammation has been found to be involved in its development and progression. Cytokines play a significant role in the inflammatory process. This study aims to identify novel biomarkers that may assist in the diagnosis of ALS. Methods: In Fujian Medical University Union Hospital and Huashan Hospital Fudan University, two independent centers, we prospectively recruited 50 ALS patients, and 41 healthy controls (25 ALS and 26 controls in the first stage and 25 ALS and 15 controls in the validation stage). An 18-plex Luminex kit was used to screen the serum cytokines levels in the first stage. Commercial ELISA kits were used to measure the levels of target cytokines in the validation stage. A single-molecule array HD-X platform was applied to assess the levels of serum neurofilament light chain (NFL). Results: The levels of serum IL-18 were markedly increased in patients with ALS in the first stage ( Conclusion: In this study, we identified systemic cytokine profile changes in the serum of ALS patients, especially the elevated IL-18, as well as the decreased IL-21 in elder patients. These changes in serum cytokine profiles may shed new light on an in-depth understanding of the immunopathogenic characteristics of ALS.
Language	English
Publishing date	2024-03-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e28553
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Article ; Online: Global trends and performances in diabetic retinopathy studies

Huan Xiao / Jinfan Tang / Feng Zhang / Luping Liu / Jing Zhou / Meiqi Chen / Mengyue Li / Xiaoxiao Wu / Yingying Nie / Junguo Duan

Frontiers in Public Health, Vol

A bibliometric analysis

2023 Volume 11

Abstract: ObjectiveThe objective of this study is to conduct a comprehensive bibliometric analysis to identify and evaluate global trends in diabetic retinopathy (DR) research and visualize the focus and frontiers of this field.MethodsDiabetic retinopathy-related ... ...

Abstract	ObjectiveThe objective of this study is to conduct a comprehensive bibliometric analysis to identify and evaluate global trends in diabetic retinopathy (DR) research and visualize the focus and frontiers of this field.MethodsDiabetic retinopathy-related publications from the establishment of the Web of Science (WOS) through 1 November 2022 were retrieved for qualitative and quantitative analyses. This study analyzed annual publication counts, prolific countries, institutions, journals, and the top 10 most cited literature. The findings were presented through descriptive statistics. VOSviewer 1.6.17 was used to exhibit keywords with high frequency and national cooperation networks, while CiteSpace 5.5.R2 displayed the timeline and burst keywords for each term.ResultsA total of 10,709 references were analyzed, and the number of publications continuously increased over the investigated period. America had the highest h-index and citation frequency, contributing to the most influence. China was the most prolific country, producing 3,168 articles. The University of London had the highest productivity. The top three productive journals were from America, and Investigative Ophthalmology Visual Science had the highest number of publications. The article from Gulshan et al. (2016; co-citation counts, 2,897) served as the representative and symbolic reference. The main research topics in this area were incidence, pathogenesis, treatment, and artificial intelligence (AI). Deep learning, models, biomarkers, and optical coherence tomography angiography (OCTA) of DR were frontier hotspots.ConclusionBibliometric analysis in this study provided valuable insights into global trends in DR research frontiers. Four key study directions and three research frontiers were extracted from the extensive DR-related literature. As the incidence of DR continues to increase, DR prevention and treatment have become a pressing public health concern and a significant area of research interest. In addition, the development of AI technologies and ...
Keywords	diabetic retinopathy ; CiteSpace ; VOSviewer ; public health ; bibliometric analysis ; Public aspects of medicine ; RA1-1270
Subject code	001
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Peripheral immune landscape for hypercytokinemia in myasthenic crisis utilizing single-cell transcriptomics.

Zhong, Huahua / Huan, Xiao / Zhao, Rui / Su, Manqiqige / Yan, Chong / Song, Jie / Xi, Jianying / Zhao, Chongbo / Luo, Feifei / Luo, Sushan

Journal of translational medicine

2023 Volume 21, Issue 1, Page(s) 564

Abstract: Background: Myasthenia gravis (MG) is the most prevalent autoimmune disorder affecting the neuromuscular junction. A rapid deterioration in respiratory muscle can lead to a myasthenic crisis (MC), which represents a life-threatening condition with high ... ...

Abstract	Background: Myasthenia gravis (MG) is the most prevalent autoimmune disorder affecting the neuromuscular junction. A rapid deterioration in respiratory muscle can lead to a myasthenic crisis (MC), which represents a life-threatening condition with high mortality in MG. Multiple CD4 Methods: We conducted single-cell transcriptomic and immune repertoire sequencing on 33,577 peripheral blood mononuclear cells (PBMCs) from two acetylcholine receptor antibody-positive (AChR +) MG patients during MC and again three months post-MC. We followed the Scanpy workflow for quality control, dimension reduction, and clustering of the single-cell data. Subsequently, we annotated high-resolution cell types utilizing transfer-learning models derived from publicly available single-cell immune datasets. RNA velocity calculations from unspliced and spliced mRNAs were applied to infer cellular state progression. We analyzed cell communication and MG-relevant cytokines and chemokines to identify potential inflammation initiators. Results: We identified a unique subset of monocytes, termed monocytes 3 (FCGR3B Conclusions: In summary, our integrated analysis of single-cell transcriptomics and TCR/BCR sequencing has underscored the role of innate immune activation which is associated with hypercytokinemia in MC. The identification of a specific monocyte cluster that dominates the peripheral immune profile may provide some hints into the etiology and pathology of MC. However, future functional studies are required to explore causality.
MeSH term(s)	Humans ; Cytokine Release Syndrome ; Transcriptome/genetics ; CD8-Positive T-Lymphocytes ; Leukocytes, Mononuclear ; Myasthenia Gravis/genetics
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2118570-0
ISSN	1479-5876 ; 1479-5876
ISSN (online)	1479-5876
ISSN	1479-5876
DOI	10.1186/s12967-023-04421-y
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