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  1. Article ; Online: Longitudinal Invariance and Construct Validity of the Chinese Version of the Mini-Mental State Examination Across 10 Years in the Elderly Population.

    Huan, Guo / Heyong, Shen

    Journal of nursing measurement

    2024  Volume 32, Issue 1, Page(s) 4–17

    Abstract: Background and Purpose: ...

    Abstract Background and Purpose:
    MeSH term(s) Humans ; Aged ; Reproducibility of Results ; China ; Factor Analysis, Statistical ; Psychometrics
    Language English
    Publishing date 2024-03-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1180408-7
    ISSN 1945-7049 ; 1061-3749
    ISSN (online) 1945-7049
    ISSN 1061-3749
    DOI 10.1891/JNM-2021-0102
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Multifactor Stock Selection Strategy Based on Machine Learning

    Jieying Gao / Huan Guo / Xin Xu

    Complexity, Vol

    Evidence from China

    2022  Volume 2022

    Abstract: Machine learning methods have been used in multifactor stock strategy for years. This paper uses three machine learning methods and linear regression method to find the most appropriate approach. First, a framework is established and 10 style factors and ...

    Abstract Machine learning methods have been used in multifactor stock strategy for years. This paper uses three machine learning methods and linear regression method to find the most appropriate approach. First, a framework is established and 10 style factors and 30 industry factors are chosen. Second, four methods are used to forecast portfolio returns and compared by predicting returns, successful rate, and Sharpe ratio. Finally, this paper draws conclusion. The main findings are as follows: the support vector regression has the most stable successful rate for predicting, while ridge regression and linear regression have the most unstable successful rate with more extreme cases; algorithm of support vector regression fitting higher-degree polynomials in Chinese A-share market is optimized, compared with the traditional linear regression both in terms of stock return and retracement control; the results of support vector regression significantly outperforming the CSI 500 index prove further.
    Keywords Electronic computers. Computer science ; QA75.5-76.95
    Subject code 310
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Hindawi-Wiley
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: TaSYP137 and TaVAMP723, the SNAREs Proteins from Wheat, Reduce Resistance to Blumeria graminis f. sp. tritici

    Guanghao Wang / Xiangyu Zhang / Huan Guo / Chenxu Zhao / Hong Zhang / Chunhuan Chen / Wanquan Ji

    International Journal of Molecular Sciences, Vol 24, Iss 4830, p

    2023  Volume 4830

    Abstract: SNARE protein is an essential factor driving vesicle fusion in eukaryotes. Several SNAREs have been shown to play a crucial role in protecting against powdery mildew and other pathogens. In our previous study, we identified SNARE family members and ... ...

    Abstract SNARE protein is an essential factor driving vesicle fusion in eukaryotes. Several SNAREs have been shown to play a crucial role in protecting against powdery mildew and other pathogens. In our previous study, we identified SNARE family members and analyzed their expression pattern in response to powdery mildew infection. Based on quantitative expression and RNA-seq results, we focused on TaSYP137 / TaVAMP723 and hypothesized that they play an important role in the interaction between wheat and Blumeria graminis f. sp. Tritici ( Bgt ). In this study, we measured the expression patterns of TaSYP132 / TaVAMP723 genes in wheat post-infection with Bgt and found that the expression pattern of TaSYP137 / TaVAMP723 was opposite in resistant and susceptible wheat samples infected by Bgt . The overexpression of TaSYP137 / TaVAMP723 disrupted wheat’s defense against Bgt infection, while silencing these genes enhanced its resistance to Bgt . Subcellular localization studies revealed that TaSYP137/TaVAMP723 are present in both the plasma membrane and nucleus. The interaction between TaSYP137 and TaVAMP723 was confirmed using the yeast two-hybrid (Y2H) system. This study offers novel insights into the involvement of SNARE proteins in the resistance of wheat against Bgt , thereby enhancing our comprehension of the role of the SNARE family in the pathways related to plant disease resistance.
    Keywords wheat ; powdery mildew resistance ; TaVAMP723 ; TaSYP137 ; gene function ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 570
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: The Emerging Role of Long Non-Coding RNAs in Plant Defense Against Fungal Stress

    Hong Zhang / Huan Guo / Weiguo Hu / Wanquan Ji

    International Journal of Molecular Sciences, Vol 21, Iss 2659, p

    2020  Volume 2659

    Abstract: Growing interest and recent evidence have identified long non-coding RNA (lncRNA) as the potential regulatory elements for eukaryotes. LncRNAs can activate various transcriptional and post-transcriptional events that impact cellular functions though ... ...

    Abstract Growing interest and recent evidence have identified long non-coding RNA (lncRNA) as the potential regulatory elements for eukaryotes. LncRNAs can activate various transcriptional and post-transcriptional events that impact cellular functions though multiple regulatory functions. Recently, a large number of lncRNAs have also been identified in higher plants, and an understanding of their functional role in plant resistance to infection is just emerging. Here, we focus on their identification in crop plant, and discuss their potential regulatory functions and lncRNA-miRNA-mRNA network in plant pathogen stress responses, referring to possible examples in a model plant. The knowledge gained from a deeper understanding of this colossal special group of plant lncRNAs will help in the biotechnological improvement of crops.
    Keywords lncRNAs ; plant immunity ; transcriptional regulation ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 580
    Language English
    Publishing date 2020-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Damage behavior of the KKV direct hit against fluid-filled submunition payload

    Yang Zan / Hai-fu Wang / Yuan-feng Zheng / Huan-guo Guo

    Defence Technology, Vol 18, Iss 11, Pp 2052-

    2022  Volume 2064

    Abstract: The damage effects of fluid-filled submunition payload impacted by the kinetic kill vehicle (KKV) are investigated by simulations and ground-based experiments. Numerical simulations showed that the damage level and number of submunitions were ... ...

    Abstract The damage effects of fluid-filled submunition payload impacted by the kinetic kill vehicle (KKV) are investigated by simulations and ground-based experiments. Numerical simulations showed that the damage level and number of submunitions were significantly influenced by the diameter of the KKV compared with its length. Based on that, a high velocity penetrator formed by shaped charge explosion was used to simulate the direct hit experiment of a KKV impacting submunition payload. Experimental results demonstrated that the damage modes of submunitions mainly included the slight damage, perforation and total smash, showing a good agreement with the simulations. To understand the multiple damage modes of submunitions, the damage behavior of the submunitions in direct hit process were analyzed based on the AUTODYN-3D code. Numerical results presented that increased KKV diameter can increase the crater diameter and expand the damage volume, which will achieve a higher direct hit lethality. Further analysis indicated that there were other mechanical behaviors can enhance the damage to submunitions not lying in the KKV flight path, such as secondary debris kill, neighboring submunitions collision with each other, and high-speed fluid injection effect.
    Keywords Kinetic kill vehicle ; Tactical ballistic missiles ; Submunition payload ; Direct hit ; Damage behavior ; Military Science ; U
    Subject code 621
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Prenatal diagnosis of fetuses conceived by assisted reproductive technology by karyotyping and chromosomal microarray analysis

    Huan Guo / Rui Sheng / Xiu Zhang / Xuemei Jin / Wenjing Gu / Ting Liu / Haixin Dong / Ran Jia

    PeerJ, Vol 11, p e

    2023  Volume 14678

    Abstract: Background Invasive prenatal evaluation by chromosomal microarray analysis (CMA) and karyotyping might represent an important option in pregnant women, but limited reports have applied CMA and karyotyping of fetuses conceived by assisted reproductive ... ...

    Abstract Background Invasive prenatal evaluation by chromosomal microarray analysis (CMA) and karyotyping might represent an important option in pregnant women, but limited reports have applied CMA and karyotyping of fetuses conceived by assisted reproductive technology (ART). This study aimed to examine the value of CMA and karyotyping in prenatal diagnosis after ART. Methods This retrospective study included all singleton fetuses conceived by ART from January 2015 to December 2021. Anomalies prenatally diagnosed based on karyotyping and CMA were analyzed. Prevalence rates for various CMA and karyotyping results were stratified based on specific testing indications including isolated—and non-isolated ART groups. The rates of CMA findings with clinical significance (pathogenic/likely pathogenic) and karyotype anomalies were assessed and compared to those of local control individuals with naturally conceived pregnancies and without medical indications. Results In total, 224 subjects were assessed by karyotyping and CMA. In the examined patients, chromosomal and karyotype abnormality rates were 3.57% (8/224) and 8.93% (20/224), respectively. This finding indicated a 5.35% (12/224)-incremental rate of abnormal CMA was obtained over karyotype analysis (p = 0.019). The risk of CMA with pathogenic findings for all pregnancies conceived by ART (5.80%, 13/224) was markedly elevated in comparison with the background value obtained in control individuals (1.47%, 9/612; p = 0.001). In addition, risk of CMA with clinically pathogenic results in isolated ART groups was significant higher compared to the background risk reported in the control cohort (p = 0.037). Conclusions Prenatal diagnosis including karyotyping and CMA is recommended for fetuses conceived by ART, with or without ultrasound findings.
    Keywords Assisted reproductive technology ; Prenatal diagnosis ; Karyotyping ; Chromosomal microarray analysis ; DNA copy number variation ; Medicine ; R ; Biology (General) ; QH301-705.5
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher PeerJ Inc.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Physiological and Transcriptional Analyses Provide Insight into Maintaining Ion Homeostasis of Sweet Sorghum under Salt Stress

    Huan Guo / Chun-Ya Nie / Zhen Li / Jie Kang / Xiao-Long Wang / Yan-Nong Cui

    International Journal of Molecular Sciences, Vol 24, Iss 11045, p

    2023  Volume 11045

    Abstract: Sweet sorghum is an important bioenergy grass and valuable forage with a strong adaptability to saline environments. However, little is known about the mechanisms of sweet sorghum coping with ion toxicity under salt stresses. Here, we first evaluated the ...

    Abstract Sweet sorghum is an important bioenergy grass and valuable forage with a strong adaptability to saline environments. However, little is known about the mechanisms of sweet sorghum coping with ion toxicity under salt stresses. Here, we first evaluated the salt tolerance of a sweet sorghum cultivar “Lvjuren” and determined its ion accumulation traits under NaCl treatments; then, we explored key genes involved in Na + , Cl − , K + and NO 3 − transport using transcriptome profiling and the qRT-PCR method. The results showed that growth and photosynthesis of sweet sorghum were unaffected by 50 and 100 mM NaCl treatments, indicative of a strong salt tolerance of this species. Under NaCl treatments, sweet sorghum could efficiently exclude Na + from shoots and accumulate Cl − in leaf sheaths to avoid their overaccumulation in leaf blades; meanwhile, it possessed a prominent ability to sustain NO 3 − homeostasis in leaf blades. Transcriptome profiling identified several differentially expressed genes associated with Na + , Cl − , K + and NO 3 − transport in roots, leaf sheaths and leaf blades after 200 mM NaCl treatment for 6 and 48 h. Moreover, transcriptome data and qRT-PCR results indicated that HKT1;5 , CLCc and NPF7.3-1 should be key genes involved in Na + retention in roots, Cl − accumulation in leaf sheaths and maintenance of NO 3 − homeostasis in leaf blades, respectively. Many TFs were also identified after NaCl treatment, which should play important regulatory roles in salt tolerance of sweet sorghum. In addition, GO analysis identified candidate genes involved in maintaining membrane stability and photosynthetic capacity under salt stresses. This work lays a preliminary foundation for clarifying the molecular basis underlying the adaptation of sweet sorghum to adverse environments.
    Keywords soil salinity ; sodium ; chloride ; ion transporters ; transcription factors ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Manganese(II) Oxidizing Bacteria as Whole-Cell Catalyst for β-Keto Ester Oxidation

    Juan Guo / Huan Guo / Jin Liu / Fangrui Zhong / Yuzhou Wu

    International Journal of Molecular Sciences, Vol 21, Iss 5, p

    2020  Volume 1709

    Abstract: Manganese oxidizing bacteria can produce biogenic manganese oxides (BMO) on their cell surface and have been applied in the fields of agriculture, bioremediation, and drinking water treatment to remove toxic contaminants based on their remarkable ... ...

    Abstract Manganese oxidizing bacteria can produce biogenic manganese oxides (BMO) on their cell surface and have been applied in the fields of agriculture, bioremediation, and drinking water treatment to remove toxic contaminants based on their remarkable chemical reactivity. Herein, we report for the first time the synthetic application of the manganese oxidizing bacteria, Pseudomonas putida MnB1 as a whole-cell biocatalyst for the effective oxidation of β-keto ester with excellent yield. Differing from known chemical protocols toward this transformation that generally necessitate the use of organic solvents, stoichiometric oxygenating agents and complex chemical catalysts, our strategy can accomplish it simply under aqueous and mild conditions with higher efficiency than that provided by chemical manganese oxides. Moreover, the live MnB1 bacteria are capable of continuous catalysis for this C-O bond forming reaction for several cycles and remain proliferating, highlighting the favorable merits of this novel protocol for sustainable chemistry and green synthesis.
    Keywords pseudomonas putida mnb1 ; biogenic manganese oxides ; abiotic manganese oxides ; α-hydroxy-β-keto esters ; whole-cell biocatalysis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 540
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Force chains based mesoscale simulation on the dynamic response of Al-PTFE granular composites

    Le Tang / Chao Ge / Huan-guo Guo / Qing-bo Yu / Hai-fu Wang

    Defence Technology, Vol 17, Iss 1, Pp 56-

    2021  Volume 63

    Abstract: Force chains based mesoscale simulation is conducted to investigate the response behavior of aluminum-polytetrafluoroethylene (Al-PTFE) granular composites under a low-velocity impact. A two-dimensional model followed the randomly normal distribution of ... ...

    Abstract Force chains based mesoscale simulation is conducted to investigate the response behavior of aluminum-polytetrafluoroethylene (Al-PTFE) granular composites under a low-velocity impact. A two-dimensional model followed the randomly normal distribution of real Al particles size is developed. The dynamic compressive process of Al-PTFE composites with varied Al mass fraction is simulated and validated against the experiments. The results indicate that, force chains behavior governed by the number and the size of agglomerated Al particles, significantly affects the impact response of the material. The failure mode of the material evolves from shear failure of matrix to debonding failure of particles with increasing density. A high crack area of the material is critical mechanism to arouse the initiation reaction. The damage maintained by force chains during large plastic strain builds up more local stresses concentration to enhance a possible reaction performance. In addition, simulation is performed with identical mass fraction but various Al size distribution to explore the effects of size centralization and dispersion on the mechanical properties of materials. It is found that smaller sized Al particle of composites are more preferred than its bulky material in ultimate strength. Increasing dispersed degree is facilitated to create stable force chains in samples with comparable particle number. The simulation studies provide further insights into the plastic deformation, failure mechanism, and possible energy release capacity for Al-PTFE composites, which is helpful for further design and application of reactive materials.
    Keywords Al-PTFE ; Granular composites ; Mesoscale simulation ; Dynamic response ; Force chains ; Military Science ; U
    Subject code 620
    Language English
    Publishing date 2021-02-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Experimental investigation on enhanced damage to fuel tanks by reactive projectiles impact

    Hai-fu Wang / Jian-wen Xie / Chao Ge / Huan-guo Guo / Yuan-feng Zheng

    Defence Technology, Vol 17, Iss 2, Pp 599-

    2021  Volume 608

    Abstract: Enhanced damage to the full-filled fuel tank, impacted by the cold pressed and sintered PTFE/Al/W reactive material projectile (RMP) with a density of 7.8 g/cm3, is investigated experimentally and theoretically. The fuel tank is a rectangular structure, ... ...

    Abstract Enhanced damage to the full-filled fuel tank, impacted by the cold pressed and sintered PTFE/Al/W reactive material projectile (RMP) with a density of 7.8 g/cm3, is investigated experimentally and theoretically. The fuel tank is a rectangular structure, welded by six pieces of 2024 aluminum plate with a thickness of 6 mm, and filled with RP-3 aviation kerosene. Experimental results show that the kerosene is ignited by the RMP impact at a velocity above 1062 m/s, and a novel interior ignition phenomenon which is closely related to the rupture effect of the fuel tank is observed. However, the traditional steel projectile with the same mass and dimension requires a velocity up to 1649 m/s to ignite the kerosene. Based on the experimental results, the radial pressure field is considered to be the main reason for the shear failure of weld. For mechanism considerations, the chemical energy released by the RMP enhances the hydrodynamic ram (HRAM) effect and provides additional ignition sources inside the fuel tank, thereby enhancing both rupture and ignition effects. Moreover, to further understand the enhanced ignition effect of RMP, the reactive debris temperature inside the kerosene is analyzed theoretically. The initiated reactive debris with high temperature provides effective interior ignition sources to ignite the kerosene, resulting in the enhanced ignition of the kerosene.
    Keywords Reactive material projectile ; Fuel tank ; Enhanced damage effect ; Enhanced ignition mechanism ; Impact behavior ; Military Science ; U
    Subject code 660
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher KeAi Communications Co., Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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