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Article ; Online: Progress and perspective of organoid technology in breast cancer research.

Huang, Changsheng / Jin, Hongyan

2024

Abstract: Abstract: Breast cancer, a malignant tumor with a high incidence in women, lacks in vitro research models that can represent the biological functions of breast tumors in vivo. As a new biological tool, the organoid model has unique advantages over ... ...

Abstract	Abstract: Breast cancer, a malignant tumor with a high incidence in women, lacks in vitro research models that can represent the biological functions of breast tumors in vivo. As a new biological tool, the organoid model has unique advantages over traditional methods, such as cell culture and patient-derived xenografts. Combining organoids with other emerging technologies, such as gene engineering and microfluidic chip technology, provides an effective method to compensate for the deficiencies in organoid models of breast cancer in vivo. The emergence of breast cancer organoids has provided new tools and research directions in precision medicine, personality therapy, and drug research. In this review, we summarized the merits and demerits of organoids compared to traditional biological models, explored the latest developments in the combination of new technologies and organoid models, and discussed the construction methods and application prospects of different breast organoid models.
Language	English
Publishing date	2024-01-08
Publishing country	China
Document type	Journal Article
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000002889
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Article ; Online: AOBLMOA: A Hybrid Biomimetic Optimization Algorithm for Numerical Optimization and Engineering Design Problems.

Zhao, Yanpu / Huang, Changsheng / Zhang, Mengjie / Cui, Yang

Biomimetics (Basel, Switzerland)

2023 Volume 8, Issue 4

Abstract: The Mayfly Optimization Algorithm (MOA), as a new biomimetic metaheuristic algorithm with superior algorithm framework and optimization methods, plays a remarkable role in solving optimization problems. However, there are still shortcomings of ... ...

Abstract	The Mayfly Optimization Algorithm (MOA), as a new biomimetic metaheuristic algorithm with superior algorithm framework and optimization methods, plays a remarkable role in solving optimization problems. However, there are still shortcomings of convergence speed and local optimization in this algorithm. This paper proposes a metaheuristic algorithm for continuous and constrained global optimization problems, which combines the MOA, the Aquila Optimizer (AO), and the opposition-based learning (OBL) strategy, called AOBLMOA, to overcome the shortcomings of the MOA. The proposed algorithm first fuses the high soar with vertical stoop method and the low flight with slow descent attack method in the AO into the position movement process of the male mayfly population in the MOA. Then, it incorporates the contour flight with short glide attack and the walk and grab prey methods in the AO into the positional movement of female mayfly populations in the MOA. Finally, it replaces the gene mutation behavior of offspring mayfly populations in the MOA with the OBL strategy. To verify the optimization ability of the new algorithm, we conduct three sets of experiments. In the first experiment, we apply AOBLMOA to 19 benchmark functions to test whether it is the optimal strategy among multiple combined strategies. In the second experiment, we test AOBLMOA by using 30 CEC2017 numerical optimization problems and compare it with state-of-the-art metaheuristic algorithms. In the third experiment, 10 CEC2020 real-world constrained optimization problems are used to demonstrate the applicability of AOBLMOA to engineering design problems. The experimental results show that the proposed AOBLMOA is effective and superior and is feasible in numerical optimization problems and engineering design problems.
Language	English
Publishing date	2023-08-21
Publishing country	Switzerland
Document type	Journal Article
ISSN	2313-7673
ISSN (online)	2313-7673
DOI	10.3390/biomimetics8040381
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Article: Glymphatic system: a gateway for neuroinflammation.

Zou, Kailu / Deng, Qingwei / Zhang, Hong / Huang, Changsheng

Neural regeneration research

2023 Volume 19, Issue 12, Page(s) 2661–2672

Abstract: The glymphatic system is a relatively recently identified fluid exchange and transport system in the brain. Accumulating evidence indicates that glymphatic function is impaired not only in central nervous system disorders but also in systemic diseases. ... ...

Abstract	The glymphatic system is a relatively recently identified fluid exchange and transport system in the brain. Accumulating evidence indicates that glymphatic function is impaired not only in central nervous system disorders but also in systemic diseases. Systemic diseases can trigger the inflammatory responses in the central nervous system, occasionally leading to sustained inflammation and functional disturbance of the central nervous system. This review summarizes the current knowledge on the association between glymphatic dysfunction and central nervous system inflammation. In addition, we discuss the hypothesis that disease conditions initially associated with peripheral inflammation overwhelm the performance of the glymphatic system, thereby triggering central nervous system dysfunction, chronic neuroinflammation, and neurodegeneration. Future research investigating the role of the glymphatic system in neuroinflammation may offer innovative therapeutic approaches for central nervous system disorders.
Language	English
Publishing date	2023-12-21
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.391312
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Article ; Online: Oridonin Promotes Apoptosis in Rheumatoid Arthritis Fibroblast-like Synoviocytes Through PERK/eIF2α/CHOP of Endoplasmic Reticulum Stress Pathway.

He, Shoudi / Huang, Changsheng / Tan, Ning / Zhang, Jianyong

DNA and cell biology

2023 Volume 42, Issue 12, Page(s) 711–719

Abstract: Oridonin (ORI), derived from Chinese ... ...

Abstract	Oridonin (ORI), derived from Chinese herbs
MeSH term(s)	Humans ; Synoviocytes/metabolism ; Eukaryotic Initiation Factor-2/genetics ; Eukaryotic Initiation Factor-2/metabolism ; Eukaryotic Initiation Factor-2/pharmacology ; Arthritis, Rheumatoid/genetics ; Apoptosis ; Fibroblasts/metabolism ; Endoplasmic Reticulum Stress ; Cell Proliferation ; Cells, Cultured
Chemical Substances	oridonin (0APJ98UCLQ) ; Eukaryotic Initiation Factor-2
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1024454-2
ISSN	1557-7430 ; 0198-0238 ; 1044-5498
ISSN (online)	1557-7430
ISSN	0198-0238 ; 1044-5498
DOI	10.1089/dna.2023.0244
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Article ; Online: Time-Space Simulation, Health Risk Warning and Policy Recommendations of Environmental Capacity for Heavy Metals in the Pearl River Basin, China.

Liang, Feng / Pan, Yujie / Peng, Hongxia / Zeng, Min / Huang, Changsheng

International journal of environmental research and public health

2022 Volume 19, Issue 8

Abstract: In China, the environmental capacity problem of heavy metals has long been hidden in the Pearl River Basin creating a contradiction between the economic development and environmental health. Thus, this research calculated the environmental capacity of ... ...

Abstract	In China, the environmental capacity problem of heavy metals has long been hidden in the Pearl River Basin creating a contradiction between the economic development and environmental health. Thus, this research calculated the environmental capacity of heavy metals in the agricultural land of the urban agglomeration in the Pearl River Basin, evaluated the health risk warning capacity using a comprehensive index. The results showed that the static capacity order of heavy metals in the study area was As > Pb > Zn > Cr > Hg > Cu > Ni > Cd. The dynamic capacity showed an upward trend, and it fluctuated in some cities. The remaining capacity of Cr and Ni was relatively poor, and the comprehensive soil quality index of the Pearl River Basin was 0.64. The pollution level was of grade IV, which belongs to the medium capacity, but the soil pollution risk still existed, which threaten the health of local resident. In this regard, this study also put forward some countermeasures for pollution control. Thus, studying the soil heavy metal environmental capacity can provide a reference for heavy metal pollution control and health risk early warning in the Pearl River Basin.
MeSH term(s)	China ; Environmental Monitoring ; Metals, Heavy/analysis ; Policy ; Risk Assessment ; Rivers ; Soil ; Soil Pollutants/analysis ; Space Simulation
Chemical Substances	Metals, Heavy ; Soil ; Soil Pollutants
Language	English
Publishing date	2022-04-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph19084694
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Article ; Online: Assessment of groundwater hydrochemistry, water quality, and health risk in Hainan Island, China.

Hou, Qingqin / Pan, Yujie / Zeng, Min / Wang, Simiao / Shi, Huanhuan / Huang, Changsheng / Peng, Hongxia

Scientific reports

2023 Volume 13, Issue 1, Page(s) 12104

Abstract: Groundwater is an important source of water for human sustenance. The determination of groundwater quality at island sites is an urgent priority in China, but there are lacking systematic reports relating to them. Here, 63 groups of groundwater samples ... ...

Abstract	Groundwater is an important source of water for human sustenance. The determination of groundwater quality at island sites is an urgent priority in China, but there are lacking systematic reports relating to them. Here, 63 groups of groundwater samples were collected and analyzed of Hainan Island. The groundwater in the study area is weakly alkaline, mainly comprising hard and soft freshwater. The predominant anions and cations are HCO
MeSH term(s)	Child ; Adult ; Humans ; Adolescent ; Water Quality ; Environmental Monitoring ; Water Pollutants, Chemical/analysis ; Groundwater ; China
Chemical Substances	Water Pollutants, Chemical
Language	English
Publishing date	2023-07-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-36621-3
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Article: Combined metabolomics and transcriptomics analysis of rats under neuropathic pain and pain-related depression.

Xi, Caiyun / He, Liqiong / Huang, Zhifeng / Zhang, Jianxi / Zou, Kailu / Guo, Qulian / Huang, Changsheng

Frontiers in pharmacology

2023 Volume 14, Page(s) 1320419

Abstract: Neuropathic pain often leads to negative emotions, which in turn can enhance the sensation of pain. This study aimed to investigate the molecular mechanisms mediating neuropathic pain and negative emotions. Chronic constriction injury (CCI) rats were ... ...

Abstract	Neuropathic pain often leads to negative emotions, which in turn can enhance the sensation of pain. This study aimed to investigate the molecular mechanisms mediating neuropathic pain and negative emotions. Chronic constriction injury (CCI) rats were used as model animals and behavioral tests were conducted to assess pain and negative emotions. Then, the rat anterior cingulate cortex (ACC) was analyzed using UPLC-MS/MS and subsequently integrated with our previously published transcriptome data. Metabolomics analysis revealed that 68 differentially expressed metabolites (DEMs) were identified, mainly in amino acid metabolites and fatty acyls. Combined with our previously published transcriptome data, we predicted two genes that potentially exhibited associations with these metabolites, respectively Apolipoprotein L domain containing 1 (Apold1) and WAP four-disulfide core domain 1 (Wfdc1). Taken together, our results indicated that peripheral nerve injury contributing to neuropathic pain and pain-related depression may be associated with these metabolites and genes. This research provides new insights into the molecular regulatory mechanism, which could serve as a reference for the treatment of neuropathic pain and pain-related depression.
Language	English
Publishing date	2023-12-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1320419
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Article ; Online: Poor ovarian response in assisted reproductive technology cycles is associated with anti-ovarian antibody and pro-inflammatory immune responses.

Huang, Changsheng / AlSubki, Lujain / Yamaya, Ayano / Sung, Nayoung / Kwak-Kim, Joanne

Journal of reproductive immunology

2023 Volume 160, Page(s) 104152

Abstract: Anti-ovarian antibody (AOA) could be considered an independent marker for autoimmune ovarian disease and predicting future premature ovarian failure (POF). This study aims to investigate if AOA is associated with poor ovarian response (POR) and pro- ... ...

Abstract	Anti-ovarian antibody (AOA) could be considered an independent marker for autoimmune ovarian disease and predicting future premature ovarian failure (POF). This study aims to investigate if AOA is associated with poor ovarian response (POR) and pro-inflammatory immune responses in women undergoing assisted reproductive technology (ART) cycles. Two hundred forty-eight women undergoing ART cycles were divided into four groups based on AOA test results and the presence of POR: POR(-)/AOA(-) group (N = 148), POR(+)/AOA(-) group (N = 34), POR (-)/AOA(+) group (N = 44), POR(+)/AOA(+) group (N = 22). The POR patients have a significantly higher prevalence of AOA than non-POR patients (P < 0.05). Peripheral blood CD56 + natural killer (NK) cell level (%), NK cytotoxicity, CD19 +CD5 + B-1 cell level (%), and IFN-γ/IL-10 producing T helper (Th) 1/Th2 cell ratios were significantly higher in POR(+)/AOA(+) group than those of other groups (P < 0.001, P < 0.005, P < 0.01, P < 0.05, respectively). TNF-α/IL-10 producing Th1/Th2 cell ratio of POR(+)/AOA(+) group was significantly higher than those of POR(+)/AOA(-) and POR(-)/AOA(-) groups (P < 0.05, respectively). Homocysteine and vitamin D levels of the POR(+)/AOA(+) group were significantly lower than those of other groups (P < 0.005, respectively). Plasminogen activator inhibiter-1 (PAI-1) level of POR(+)/AOA(+) group was significantly higher than that of POR(-)/AOA(-) group (P < 0.05). In the POR(+)/AOA(+) group, the prevalence of antiphospholipid antibodies was significantly higher than that of the POR(+)/AOA(-) group (P = 0.005). Women with autoimmune POR (POR(+)/AOA(+)) have dysregulated pro-inflammatory immune responses and metabolic factors. The diagnostic and therapeutic approaches for autoimmune POR should be differentiated from those for non-autoimmune POR.
MeSH term(s)	Humans ; Female ; Interleukin-10/metabolism ; Ovary ; Reproductive Techniques, Assisted ; Autoantibodies ; Autoimmune Diseases ; Immunity
Chemical Substances	Interleukin-10 (130068-27-8) ; Autoantibodies
Language	English
Publishing date	2023-09-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	424421-7
ISSN	1872-7603 ; 0165-0378
ISSN (online)	1872-7603
ISSN	0165-0378
DOI	10.1016/j.jri.2023.104152
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Article ; Online: Post-Operative Conversion Aphonia in a Pediatric Patient: A Case Report.

Zhang, Yiying / Liu, Chang / He, Xin / Tang, Zhaohui / Guo, Qulian / Huang, Changsheng

The Laryngoscope

2023 Volume 133, Issue 7, Page(s) 1737–1738

Abstract: We describe an unusual case of post-operative conversion aphonia in a pediatric patient. It indicates the importance of discussing its presentation, and amplifies the need for emotional support in the immediate post-operative period for young patients ... ...

Abstract	We describe an unusual case of post-operative conversion aphonia in a pediatric patient. It indicates the importance of discussing its presentation, and amplifies the need for emotional support in the immediate post-operative period for young patients with heightened anxiety. Laryngoscope, 133:1737-1738, 2023.
MeSH term(s)	Humans ; Child ; Aphonia ; Conversion Disorder/complications ; Conversion Disorder/psychology ; Anxiety Disorders/complications
Language	English
Publishing date	2023-02-22
Publishing country	United States
Document type	Case Reports ; Research Support, Non-U.S. Gov't
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.30615
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Book ; Online: An efficient thermal lattice Boltzmann method for simulating three-dimensional liquid-vapor phase change

Huang, Jiangxu / Wang, Lei / He, Kun / Huang, Changsheng

2022

Abstract: In this paper, a multiple-relaxation-time lattice Boltzmann (LB) approach is developed for the simulation of three-dimensional (3D) liquid-vapor phase change based on the pseudopotential model. In contrast to some existing 3D thermal LB models for liquid- ...

Abstract	In this paper, a multiple-relaxation-time lattice Boltzmann (LB) approach is developed for the simulation of three-dimensional (3D) liquid-vapor phase change based on the pseudopotential model. In contrast to some existing 3D thermal LB models for liquid-vapor phase change, the present approach has two advantages: for one thing, the current approach does not require calculating the gradient of volumetric heat capacity [i.e., $\nabla \left( {\rho {c_v}} \right)$], and for another, the current approach is constructed based on the seven discrete velocities in three dimensions (D3Q7), making the current thermal LB model more efficient and easy to implement. Also, based on the scheme proposed by Zhou and He [Phys Fluids 9:1591-1598, 1997], a pressure boundary condition for the D3Q19 lattice is proposed to model the multiphase flow in open systems. The current method is then validated by considering the temperature distribution in a 3D saturated liquid-vapor system, the $d^2$ law and the droplet evaporation on a heated surface. It is observed that the numerical results fit well with the analytical solutions, the results of the finite difference method and the experimental data. Our numerical results indicate that the present approach is reliable and efficient in dealing with the 3D liquid-vapor phase change.
Keywords	Mathematics - Numerical Analysis
Subject code	621
Publishing date	2022-06-02
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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