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Article: [Research progress on the relationship between low-density neutrophils and infectious diseases].

Li, Jiayu / Zhang, Ye / Wang, Linxu / Huang, Changxing

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2023 Volume 39, Issue 4, Page(s) 371–375

Abstract: Neutrophils play an important role in infectious diseases by clearing pathogens in the early stages of the disease and damaging the surrounding tissues along with the disease progress. Low-density neutrophils (LDNs) are a crucial and distinct ... ...

Abstract	Neutrophils play an important role in infectious diseases by clearing pathogens in the early stages of the disease and damaging the surrounding tissues along with the disease progress. Low-density neutrophils (LDNs) are a crucial and distinct subpopulation of neutrophils. They are a mixture of activated and degranulated normal mature neutrophils and a considerable number of immature neutrophils prematurely released from the bone marrow. Additionally, they may be involved in the occurrence and development of diseases through the changes in phagocytosis, the generation of reactive oxygen species (ROS), the enhancement of the ability to produce neutrophils extracellular traps and immunosuppression. We summarizes the role of LDNs in the pathogenesis and their correlation with the severity of infectious diseases such as COVID-19, severe fever with thrombocytopenia syndrome (SFTS), AIDS, and tuberculosis.
MeSH term(s)	Humans ; Neutrophils ; COVID-19/pathology ; Phagocytosis ; Extracellular Traps ; Communicable Diseases ; Reactive Oxygen Species
Chemical Substances	Reactive Oxygen Species
Language	Chinese
Publishing date	2023-04-23
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	1007-8738
ISSN	1007-8738
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Visual tracking brain-computer interface.

Huang, Changxing / Shi, Nanlin / Miao, Yining / Chen, Xiaogang / Wang, Yijun / Gao, Xiaorong

iScience

2024 Volume 27, Issue 4, Page(s) 109376

Abstract: Brain-computer interfaces (BCIs) offer a way to interact with computers without relying on physical movements. Non-invasive electroencephalography-based visual BCIs, known for efficient speed and calibration ease, face limitations in continuous tasks due ...

Abstract	Brain-computer interfaces (BCIs) offer a way to interact with computers without relying on physical movements. Non-invasive electroencephalography-based visual BCIs, known for efficient speed and calibration ease, face limitations in continuous tasks due to discrete stimulus design and decoding methods. To achieve continuous control, we implemented a novel spatial encoding stimulus paradigm and devised a corresponding projection method to enable continuous modulation of decoded velocity. Subsequently, we conducted experiments involving 17 participants and achieved Fitt's information transfer rate (ITR) of 0.55 bps for the fixed tracking task and 0.37 bps for the random tracking task. The proposed BCI with a high Fitt's ITR was then integrated into two applications, including painting and gaming. In conclusion, this study proposed a visual BCI based-control method to go beyond discrete commands, allowing natural continuous control based on neural activity.
Language	English
Publishing date	2024-03-02
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2024.109376
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Article ; Online: Neutrophils in COVID-19: recent insights and advances.

Li, Jiayu / Zhang, Kegong / Zhang, Ye / Gu, Ziyang / Huang, Changxing

Virology journal

2023 Volume 20, Issue 1, Page(s) 169

Abstract: Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure and death, posing significant ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is an acute respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which can lead to acute respiratory distress syndrome (ARDS), multi-organ failure and death, posing significant threat to human health. Studies have found that pathological mechanisms, such as cytokine storms caused by uncontrolled innate immune system activation, release of damage-associated molecular patterns during tissue injury and a high incidence of thrombotic events, are associated with the function and dysfunction of neutrophils. Specifically, the increased formation of low-density neutrophils (LDNs) and neutrophil extracellular traps (NETs) has been shown to be closely linked with the severity and poor prognosis in patients with COVID-19. Our work focuses on understanding the increased number, abnormal activation, lung tissue infiltration, and elevated neutrophil-to-lymphocyte ratio in the pathogenesis of COVID-19. We also explore the involvement of NETs and LDNs in disease progression and thrombosis formation, along with potential therapeutic strategies targeting neutrophil and NETs formation.
MeSH term(s)	Humans ; COVID-19/pathology ; Neutrophils ; SARS-CoV-2 ; Extracellular Traps ; Respiratory Distress Syndrome/pathology
Language	English
Publishing date	2023-08-02
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2160640-7
ISSN	1743-422X ; 1743-422X
ISSN (online)	1743-422X
ISSN	1743-422X
DOI	10.1186/s12985-023-02116-w
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Article ; Online: Estimating and approaching the maximum information rate of noninvasive visual brain-computer interface.

Shi, Nanlin / Miao, Yining / Huang, Changxing / Li, Xiang / Song, Yonghao / Chen, Xiaogang / Wang, Yijun / Gao, Xiaorong

NeuroImage

2024 Volume 289, Page(s) 120548

Abstract: An essential priority of visual brain-computer interfaces (BCIs) is to enhance the information transfer rate (ITR) to achieve high-speed communication. Despite notable progress, noninvasive visual BCIs have encountered a plateau in ITRs, leaving it ... ...

Abstract	An essential priority of visual brain-computer interfaces (BCIs) is to enhance the information transfer rate (ITR) to achieve high-speed communication. Despite notable progress, noninvasive visual BCIs have encountered a plateau in ITRs, leaving it uncertain whether higher ITRs are achievable. In this study, we used information theory to study the characteristics and capacity of the visual-evoked channel, which leads us to investigate whether and how we can decode higher information rates in a visual BCI system. Using information theory, we estimate the upper and lower bounds of the information rate with the white noise (WN) stimulus. Consequently, we found out that the information rate is determined by the signal-to-noise ratio (SNR) in the frequency domain, which reflects the spectrum resources of the channel. Based on this discovery, we propose a broadband WN BCI by implementing stimuli on a broader frequency band than the steady-state visual evoked potentials (SSVEPs)-based BCI. Through validation, the broadband BCI outperforms the SSVEP BCI by an impressive 7 bps, setting a record of 50 bps. The integration of information theory and the decoding analysis presented in this study offers valuable insights applicable to general sensory-evoked BCIs, providing a potential direction of next-generation human-machine interaction systems.
MeSH term(s)	Humans ; Brain-Computer Interfaces ; Evoked Potentials, Visual ; Electroencephalography ; Signal-To-Noise Ratio ; Communication ; Photic Stimulation ; Algorithms
Language	English
Publishing date	2024-02-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2024.120548
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Zs.A 3664: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 7: Show issues

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Article ; Online: Unveiling the efficient state of Pd catalyst for robust electrocatalytic hydrodechlorination.

Xu, Shuyuan / Mei, Bingbao / Li, Fengjiao / Mao, Jianing / Huang, Changxing / Yan, Yufeng / Chen, Ningning / Xu, Yinghua / Shi, Meiqin

Nanotechnology

2023 Volume 34, Issue 44

Abstract: The application of electrochemical hydrodechlorination has been impeded due to the low utilization and activity of Pd catalyst. Herein, a series of Pd catalysts were prepared via the controllable evolution of Zn state during the pyrolysis of ZIF-8 ... ...

Abstract	The application of electrochemical hydrodechlorination has been impeded due to the low utilization and activity of Pd catalyst. Herein, a series of Pd catalysts were prepared via the controllable evolution of Zn state during the pyrolysis of ZIF-8 nanosheet. Various forms of Pd with different chemical surroundings were generated upon the combined use of galvanic displacement and ion exchange process. Electrocatalytic hydrodechlorination of 4-chlorophenol was performed and the electrocatalytic hydrodechlorination efficiency of Pd/CN reaches 100% within 3 h at extra low Pd concentration. The coexistence of zero-valent Pd (Pd
Language	English
Publishing date	2023-08-16
Publishing country	England
Document type	Journal Article
ZDB-ID	1362365-5
ISSN	1361-6528 ; 0957-4484
ISSN (online)	1361-6528
ISSN	0957-4484
DOI	10.1088/1361-6528/aceb6b
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Article: [Progress in mechanism of formation of neutrophil extracellular traps: Review].

Zhang, Kegong / He, Wenchang / Guo, Xiaofeng / Zhang, Ye / Huang, Changxing

Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

2020 Volume 36, Issue 6, Page(s) 561–564

Abstract: Neutrophils play their roles via phagocytosis, degranulation and producing reactive oxygen species(ROS). Moreover, a new reaction mechanism of neutrophils producing neutrophil extracellular traps (NETs) has been reported. NETs take part in the innate ... ...

Abstract	Neutrophils play their roles via phagocytosis, degranulation and producing reactive oxygen species(ROS). Moreover, a new reaction mechanism of neutrophils producing neutrophil extracellular traps (NETs) has been reported. NETs take part in the innate immune responses. The formation of NETs is called NETosis, which belongs to programmed cell death. NETs could be formed in response to neutrophils activation by a series of processes, including ROS production, neutrophil elastase (NE) and myeloperoxidase (MPO) transportation to nucleus, histones modification, chromatin decoagulation, and membrane breakage. This process is called NADPH-dependent NETosis. In addition, peptidyl arginine deiminase 4 (PAD4) is needed for NADPH-independent NETosis. Furthermore, NETs can also be rapidly formed. Herein, we mainly reviewed the mechanism of NETosis.
MeSH term(s)	Extracellular Traps ; Neutrophil Activation ; Neutrophils ; Protein-Arginine Deiminase Type 4 ; Reactive Oxygen Species
Chemical Substances	Reactive Oxygen Species ; Protein-Arginine Deiminase Type 4 (EC 3.5.3.15)
Language	Chinese
Publishing date	2020-07-21
Publishing country	China
Document type	Journal Article ; Review
ISSN	1007-8738
ISSN	1007-8738
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Fraction spatial distributions and ecological risk assessment of heavy metals in the sediments of Baiyangdian Lake.

Ji, Zehua / Zhang, Yu / Zhang, Hao / Huang, Changxing / Pei, Yuansheng

Ecotoxicology and environmental safety

2019 Volume 174, Page(s) 417–428

Abstract: Baiyangdian Lake has been the ecological foundation of the Xiongan New Area, a newly developing economic zone in northern China since 2017, meaning that it is increasingly significant to recognize the contamination of the lake. In this work, the spatial ... ...

Abstract	Baiyangdian Lake has been the ecological foundation of the Xiongan New Area, a newly developing economic zone in northern China since 2017, meaning that it is increasingly significant to recognize the contamination of the lake. In this work, the spatial distribution and ecological risk of heavy metals in the lake sediments were examined based on field investigation, multivariate statistical analyses and X-ray diffraction techniques (XRD). The results showed that the heavy metals in sediments pose moderate to high risks in most of the sample sites. The heavily contaminated sites presented more unstable chemical (exchangeable and reducible) fractions, and the ecological risk is highly sensitive to the exchangeable fraction in highly contaminative sites. The results of statistical analyses demonstrated that metal fractions were significantly correlated with physicochemical properties, and TP, TN and TOC exhibited a strong correlation with the exchangeable fraction of As, Cd, Pb and Zn. In contrast, Fe and Mn were weakly correlated with the fractions, which due to the high proportion of the nutrient elements in the sediment. Furthermore, the results from the XRD patterns demonstrated that the mineralogy phases of the various heavy metals contributed to the different chemical fractions. Those results demonstrated that further research on metal fraction distribution and influencing factors in the sediment should be implemented to ascertain the degree of toxicity to carry out effective strategies to remediate the lake sediment.
MeSH term(s)	China ; Ecology ; Environmental Monitoring/methods ; Geologic Sediments/chemistry ; Lakes/chemistry ; Metals, Heavy/analysis ; Multivariate Analysis ; Risk Assessment ; Spatial Analysis ; Water Pollutants, Chemical/analysis
Chemical Substances	Metals, Heavy ; Water Pollutants, Chemical
Language	English
Publishing date	2019-03-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	436536-7
ISSN	1090-2414 ; 0147-6513
ISSN (online)	1090-2414
ISSN	0147-6513
DOI	10.1016/j.ecoenv.2019.02.062
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Zs.A 1418: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Book ; Online: Estimating and approaching maximum information rate of noninvasive visual brain-computer interface

Shi, Nanlin / Miao, Yining / Huang, Changxing / Li, Xiang / Song, Yonghao / Chen, Xiaogang / Wang, Yijun / Gao, Xiaorong

2023

Abstract: The mission of visual brain-computer interfaces (BCIs) is to enhance information transfer rate (ITR) to reach high speed towards real-life communication. Despite notable progress, noninvasive visual BCIs have encountered a plateau in ITRs, leaving it ... ...

Abstract	The mission of visual brain-computer interfaces (BCIs) is to enhance information transfer rate (ITR) to reach high speed towards real-life communication. Despite notable progress, noninvasive visual BCIs have encountered a plateau in ITRs, leaving it uncertain whether higher ITRs are achievable. In this study, we investigate the information rate limits of the primary visual channel to explore whether we can and how we should build visual BCI with higher information rate. Using information theory, we estimate a maximum achievable ITR of approximately 63 bits per second (bps) with a uniformly-distributed White Noise (WN) stimulus. Based on this discovery, we propose a broadband WN BCI approach that expands the utilization of stimulus bandwidth, in contrast to the current state-of-the-art visual BCI methods based on steady-state visual evoked potentials (SSVEPs). Through experimental validation, our broadband BCI outperforms the SSVEP BCI by an impressive margin of 7 bps, setting a new record of 50 bps. This achievement demonstrates the possibility of decoding 40 classes of noninvasive neural responses within a short duration of only 0.1 seconds. The information-theoretical framework introduced in this study provides valuable insights applicable to all sensory-evoked BCIs, making a significant step towards the development of next-generation human-machine interaction systems.
Keywords	Computer Science - Human-Computer Interaction ; Computer Science - Information Theory ; Electrical Engineering and Systems Science - Signal Processing ; Quantitative Biology - Neurons and Cognition
Publishing date	2023-08-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A human immunodeficiency virus-seronegative acquired immunodeficiency syndrome patient with opportunistic infections: A case report.

Zhang, Ye / Wang, Yuan-Yuan / Li, Xiao-Feng / Ma, Chun-Yan / Li, Jing / Kang, Wen / Kang, Wen-Zhen / Wang, Lin-Xu / Huang, Chang-Xing / Sun, Yong-Tao / Lian, Jian-Qi

International journal of STD & AIDS

2022 Volume 33, Issue 5, Page(s) 515–518

Abstract: Background: In rare cases, people living with chronic human immunodeficiency virus (HIV) infection do not develop antibodies despite demonstrable infection. Delayed or missed diagnosis of HIV infection leads to a lack of timely therapy, resulting in ... ...

Abstract	Background: In rare cases, people living with chronic human immunodeficiency virus (HIV) infection do not develop antibodies despite demonstrable infection. Delayed or missed diagnosis of HIV infection leads to a lack of timely therapy, resulting in rapid disease progression with opportunistic infections or malignancies. Case report: A 44-year-old Chinese man presented with sore throat, oral leukoplakia, fever, dyspnoea and diffuse ground glass-like lesions in both lungs. Serum cytomegalovirus DNA was detectable, and CD4 Conclusion: This is the third reported case of an HIV-seronegative AIDS patient in China, which are also rarely reported globally. HIV nucleic acid testing is important to screen out HIV infection, especially in those who present with severe immunodeficiency but remain HIV serogenative.
MeSH term(s)	Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/diagnosis ; Acquired Immunodeficiency Syndrome/drug therapy ; Adult ; China ; HIV ; HIV Infections/complications ; HIV Infections/diagnosis ; HIV Infections/drug therapy ; Humans ; Male ; Opportunistic Infections
Language	English
Publishing date	2022-02-28
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624221074507
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Zs.A 2829: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Small cell carcinoma of the bladder: the characteristics of molecular alterations, treatment, and follow-up.

Wang, Yanling / Li, Qijun / Wang, Jing / Tong, Mengting / Xing, Haibo / Xue, Yanan / Pan, Hongming / Huang, Changxing / Li, Da

Medical oncology (Northwood, London, England)

2019 Volume 36, Issue 12, Page(s) 98

Abstract: Small cell carcinoma of the bladder (SCCB) is a rare disease associated with high invasiveness and mortality. Histologically, SCCB is difficult to distinguish from small cell lung cancer (SCLC); however, it shares more similar molecular alterations with ... ...

Abstract	Small cell carcinoma of the bladder (SCCB) is a rare disease associated with high invasiveness and mortality. Histologically, SCCB is difficult to distinguish from small cell lung cancer (SCLC); however, it shares more similar molecular alterations with urothelial carcinoma (UC). As a result, now, the widely accepted theory about the cells of origin is that SCCB and UC probably have a common clone origin. Even the former probably comes from a preexisting UC. At present, given its rarity, early diagnoses, treatments, and follow-ups are not well established, which are vital to patients with SCCB. Inspirationally, in recent years, with the development of molecular diagnostic methods, molecular alterations of SCCB have been understood partially, which are propitious to excavate new potential therapeutic strategies and establish sound follow-ups. Therefore, the future will be light for patients with SCCB.
MeSH term(s)	Biomarkers, Tumor/genetics ; Carcinoma, Small Cell/diagnosis ; Carcinoma, Small Cell/genetics ; Carcinoma, Small Cell/therapy ; Diagnosis, Differential ; Humans ; Prognosis ; Small Cell Lung Carcinoma/diagnosis ; Small Cell Lung Carcinoma/genetics ; Small Cell Lung Carcinoma/therapy ; Telomerase/genetics ; Urinary Bladder Neoplasms/diagnosis ; Urinary Bladder Neoplasms/genetics ; Urinary Bladder Neoplasms/therapy
Chemical Substances	Biomarkers, Tumor ; TERT protein, human (EC 2.7.7.49) ; Telomerase (EC 2.7.7.49)
Language	English
Publishing date	2019-10-29
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-019-1321-x
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