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Article ; Online: Autologous transplantation of green tea epigallocatechin-3-gallate pretreated adipose-derived stem cells increases cardiac regenerative capability through C-X-C motif chemokine receptor 4 expression in the treatment of rats with diabetic cardiomyopathy.

Chen, Tung-Sheng / Kuo, Wei-Wen / Huang, Chih-Yang

2024

Abstract: Cardiomyopathy is one of complications related to diabetes. Stem cell transplantation shows potential in diabetic cardiomyopathy treatment. Epigallocatechin-3-gallate (EGCG) is one of the major components found in green tea. Although stem cell ... ...

Abstract	Cardiomyopathy is one of complications related to diabetes. Stem cell transplantation shows potential in diabetic cardiomyopathy treatment. Epigallocatechin-3-gallate (EGCG) is one of the major components found in green tea. Although stem cell transplantation and green tea EGCG supplementation show therapeutic effects on cardiomyopathy, the detailed cellular mechanisms in stem cell transplantation coupled with EGCG treatment remain unclear. This study investigates whether adipose-derived stem cells (ADSC) pretreated with EGCG show better protective effect on diabetic cardiomyopathy than ADSC without EGCG pretreatment. A cell model indicated that ADSC pretreated with EGCG increased cell functions including colony formation, migration and survival markers. All of these functions are blocked by small interfering C-X-C motif chemokine receptor 4 (siCXCR4) administration. These findings suggest that ADSC pretreatment with EGCG increases cell functions through CXCR4 expression. A diabetic animal model was designed to verify the above findings, including Sham, DM (diabetic rats), DM+ADSC (DM rats receiving autologous transplantation of ADSC) and DM+E-ADSC (DM rats receiving EGCG pretreated ADSC). Compared to the Sham, we found that all of pathophysiological signalings were activated in the DM group, including functional changes (decrease in ejection fraction and fractional shortening), structural changes (disarray and fibrosis) and molecular changes (increases in apoptotic, fibrotic, hypertrophic markers and decreases in survival and longevity markers). E-ADSC (DM+E-ADSC) transplantation shows significant improvement in the above pathophysiological signalings greater than ADSC (DM+ADSC). Therefore, ADSC pretreated with EGCG may contribute to clinical applications for diabetic patients with cardiomyopathy.
Language	English
Publishing date	2024-03-07
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2088228-2
ISSN	1881-7122 ; 1341-1357 ; 0007-5124
ISSN (online)	1881-7122
ISSN	1341-1357 ; 0007-5124
DOI	10.1538/expanim.23-0109
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Zs.B 1653: Show issues

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Article ; Online: Boosting NAD+ levels through fasting to aid in COVID-19 recovery.

Dongoran, Rachmad Anres / Mardiana, Meity / Huang, Chih-Yang / Situmorang, Jiro Hasegawa

Frontiers in immunology

2024 Volume 15, Page(s) 1319106

MeSH term(s)	Humans ; NAD ; COVID-19 ; Fasting
Chemical Substances	NAD (0U46U6E8UK)
Language	English
Publishing date	2024-02-14
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1319106
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Article ; Online: Comparison of two hepatocyte differentiation protocols in human umbilical cord mesenchymal stem cells: In vitro study.

Shibu, Marthandam Asokan / Huang, Chih-Yang / Ding, Dah-Ching

Tissue & cell

2023 Volume 83, Page(s) 102153

Abstract: Human umbilical cord mesenchymal stromal cells (HUCMSCs) are an emerging source of cell therapy due to their self-renew and differentiation ability. They can differentiate into three germ layers, including the potential to generate hepatocytes. This ... ...

Abstract	Human umbilical cord mesenchymal stromal cells (HUCMSCs) are an emerging source of cell therapy due to their self-renew and differentiation ability. They can differentiate into three germ layers, including the potential to generate hepatocytes. This study determined the transplantation efficiency and suitability of HUCMSCs-derived hepatocyte-like cells (HLCs) for their therapeutic application for liver diseases. This study aims to formulate ideal conditions to induce HUCMSCs into the hepatic lineage and investigate the efficiency of the differentiated HLCs based on their expression characteristics and capacity to integrate into the damaged liver of CCl4-challenged mice. Hepatocyte growth factor (HGF) and Activin A, Wnt3a were found to optimally promote the endodermal expansion of HUCMSCs, which showed phenomenal expression of hepatic markers upon differentiation in the presence of oncostatin M and dexamethasone. HUCMSCs expressed MSC-related surface markers and could undergo tri-lineage differentiations. Two hepatogenic differentiation protocols (differentiated hepatocyte protocol 1 [DHC1]: 32 days and DHC2: 15 days) were experimented with. The proliferation rate was faster in DHC2 than in DHC1 on day 7 of differentiation. The migration capability was the same in both DHC1 and DHC2. Hepatic markers like CK18, CK19, ALB, and AFP were upregulated. The mRNA levels of albumin, α1AT, αFP, CK18, TDO2, CYP3A4, CYP7A1, HNF4A, CEBPA, PPARA, and PAH were even higher in the HUCMSCs-derived HCLs than in the primary hepatocytes. Western blot confirmed HNF3B and CK18 protein expression in a step-wise manner differentiated from HUCMSCs. The metabolic function of differentiated hepatocytes was evident by increasing PAS staining and urea production. Pre-treating HUCMSCs with a hepatic differentiation medium containing HGF can drive their differentiation towards endodermal and hepatic lineages, enabling efficient integration into the damaged liver. This approach represents a potential alternative protocol for cell-based therapy that could enhance the integration potential of HUCMSC-derived HLCs.
MeSH term(s)	Humans ; Mice ; Animals ; Liver ; Hepatocytes/metabolism ; Cell Differentiation ; Mesenchymal Stem Cells ; Umbilical Cord
Language	English
Publishing date	2023-06-30
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2023.102153
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Zs.A 1016: Show issues

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Article: Effects of Nutrient Source, Temperature, and Salinity on the Growth and Survival of Three Giant Clam Species (Tridacnidae).

Lee, Rod Ping-Tsan / Lin, Yu-Ru / Huang, Chih-Yang / Nan, Fan-Hua

Animals : an open access journal from MDPI

2024 Volume 14, Issue 7

Abstract: The habitats of giant clams are undergoing environmental changes, and giant clam populations are declining. The present study was conducted to facilitate clam conservation. We conducted three 18-week trials to investigate the effects of nutrient, ... ...

Abstract	The habitats of giant clams are undergoing environmental changes, and giant clam populations are declining. The present study was conducted to facilitate clam conservation. We conducted three 18-week trials to investigate the effects of nutrient, temperature, and salinity on the growth performance and survival rates (SRs) of juvenile
Language	English
Publishing date	2024-03-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani14071054
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Article ; Online: An innovation percutaneous needle knife use for trigger finger: A retrospective cohort study.

Velmurugan, Bharath Kumar / Huang, Chih-Yang / Ding, Dah-Ching / Wu, Kun-Chi

Tzu chi medical journal

2023 Volume 35, Issue 3, Page(s) 242–246

Abstract: Objectives: This study retrospectively evaluated the effectiveness of percutaneous pulley release by our newly designed needle knife in terms of cure, relapse, and complication rates.: Materials and methods: Two hundred and fifty-seven patients were ... ...

Abstract	Objectives: This study retrospectively evaluated the effectiveness of percutaneous pulley release by our newly designed needle knife in terms of cure, relapse, and complication rates. Materials and methods: Two hundred and fifty-seven patients were allocated into male and female groups between October 2014 and September 2021. We included patients >15 years of age with a trigger finger (TF) (types II-VI). The primary outcome was the absence of a TF and pain-free movement. In contrast, the secondary outcome included second-time surgery and the number of complications such as infection and admission for antibiotics. Results: One hundred patients were male, and 157 patients were female. Males and females had mean ages of 62.45 ± 11.76 and 61.50 ± 8.57 years, respectively. The operative time was significantly longer in males than in females (7.88 ± 6.02 vs. 6.52 ± 3.74 min in males and females, respectively, Conclusion: The percutaneous methods with our needle knife displayed effectiveness. The cure rate was high, and the relapse rate was low. Further large-scale clinical trials comparing percutaneous needle to open surgery for releasing the TF will be needed to confirm our results.
Language	English
Publishing date	2023-05-02
Publishing country	India
Document type	Journal Article
ZDB-ID	2452925-4
ISSN	2223-8956 ; 2223-8956
ISSN (online)	2223-8956
ISSN	2223-8956
DOI	10.4103/tcmj.tcmj_277_22
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Article: A retrospective cohort study on outcome and interactions among prognostic factors of endodontic microsurgery.

Lai, Po-Tang / Wu, Shang-Liang / Huang, Chih-Yang / Yang, Shue-Fen

Journal of the Formosan Medical Association = Taiwan yi zhi

2022 Volume 121, Issue 11, Page(s) 2220–2226

Abstract: Background/purpose: Endodontic microsurgery (EMS) is a reliable treatment for teeth with non-healing apical periodontitis. This study evaluated the outcome of EMS with mineral trioxide aggregate as the retrograde filling material and identified ... ...

Abstract	Background/purpose: Endodontic microsurgery (EMS) is a reliable treatment for teeth with non-healing apical periodontitis. This study evaluated the outcome of EMS with mineral trioxide aggregate as the retrograde filling material and identified potential prognostic factors associated with the EMS outcome. Methods: Consecutive clinical and radiographic records of EMS performed in a teaching hospital from 2013 to 2017 were reviewed. Cases of root fracture, cemental tear, re-surgery, and incomplete records were excluded. After selection, 268 EMS-treated teeth with the follow-up period more than one year were included. Surgical outcome as success or failure was evaluated according to Molven's criteria. For analysis of potential prognostic factors, multivariate logistic regression was performed followed by bivariate chi-square tests. Stratified analysis was performed to understand the interactions between two prognostic factors. Results: The overall EMS success rate was 89.9% in this study. Tooth type (anteriors vs. molars, odds ratio (OR) = 6.83, P = 0.001, anteriors vs. premolars, OR = 4.27, P = 0.010) and endodontic-periodontal (endo-perio) communicating defects (with vs. without, OR = 4.92, P = 0.005) both had a significant influence on the EMS outcome. The negative impact of endo-perio communicating defects was closely associated with tooth type. Premolars with endo-perio communicating defects had significantly higher rates of failure. Conclusion: The EMS outcome is significantly affected by the tooth type and endo-perio communicating defect. The presence of endo-perio communicating defects has a greater negative influence on the success rate for premolars than for anteriors and molars.
MeSH term(s)	Humans ; Microsurgery ; Prognosis ; Retrospective Studies ; Root Canal Filling Materials/therapeutic use ; Treatment Outcome
Chemical Substances	Root Canal Filling Materials
Language	English
Publishing date	2022-04-19
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2096659-3
ISSN	1876-0821 ; 0929-6646
ISSN (online)	1876-0821
ISSN	0929-6646
DOI	10.1016/j.jfma.2022.04.005
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Zs.B 1041: Show issues

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Article ; Online: Neferine attenuates doxorubicin-induced fibrosis and hypertrophy in H9c2 cells.

Lohanathan, Bharathi Priya / Rathinasamy, Baskaran / Huang, Chih-Yang / Viswanadha, Vijaya Padma

Journal of biochemical and molecular toxicology

2022 Volume 36, Issue 7, Page(s) e23054

Abstract: Doxorubicin (DOX), an anthracycline antineoplastic candidate is used to treat various malignancies. Around 41% of patients undergoing DOX treatment develop acute cardiotoxicity. Preventing DOX-induced cardiac fibrosis and hypertrophy helps in evading ... ...

Abstract	Doxorubicin (DOX), an anthracycline antineoplastic candidate is used to treat various malignancies. Around 41% of patients undergoing DOX treatment develop acute cardiotoxicity. Preventing DOX-induced cardiac fibrosis and hypertrophy helps in evading cardiac remodeling leading to cardiomyopathy and heart failure. Neferine, an alkaloid from the lotus has numerous pharmacological activities. The present study was designed to evaluate the protective effect of neferine on DOX-mediated fibrosis and hypertrophy. DOX-induced fibrosis involves activation of transforming growth factor-β1 (TGF-β1), matrix metalloproteinase 2 (MMP-2), and MMP-9 with concomitant downregulation of tissue inhibitors of MMPs (TIMP)-1 and TIMP-2 expressions in H9c2 cardiomyoblasts. Furthermore, DOX treatment also resulted in hypertrophy with the increased cell volume and overexpression of hypertrophy markers calcineurin, brain natriuretic peptide, and atrial natriuretic peptide. Finally, DOX treatment resulted in apoptosis through activation of p53. Pretreatment with neferine markedly activated SIRT1 expression and modulated the expression levels of TGF-β1 and p53, thereby significantly reducing DOX-induced fibrosis, hypertrophy, and apoptosis in H9c2 cardiomyoblasts.
MeSH term(s)	Antibiotics, Antineoplastic/pharmacology ; Apoptosis ; Benzylisoquinolines ; Cardiotoxicity/metabolism ; Doxorubicin/adverse effects ; Fibrosis ; Humans ; Hypertrophy/metabolism ; Hypertrophy/pathology ; Matrix Metalloproteinase 2/metabolism ; Myocytes, Cardiac/metabolism ; Transforming Growth Factor beta1/metabolism ; Tumor Suppressor Protein p53/metabolism
Chemical Substances	Antibiotics, Antineoplastic ; Benzylisoquinolines ; Transforming Growth Factor beta1 ; Tumor Suppressor Protein p53 ; neferine (2292-16-2) ; Doxorubicin (80168379AG) ; Matrix Metalloproteinase 2 (EC 3.4.24.24)
Language	English
Publishing date	2022-03-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.23054
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Zs.A 2201: Show issues

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Article ; Online: Diallyl trisulfide (DATS) protects cardiac cells against advanced glycation end-product-induced apoptosis by enhancing FoxO3A-dependent upregulation of miRNA-210.

Lin, Kuan-Ho / Ng, Shang-Chuan / Lu, Shang-Yeh / Lin, Yueh-Min / Lin, Shu-Hui / Su, Tzu-Cheng / Huang, Chih-Yang / Kuo, Wei-Wen

The Journal of nutritional biochemistry

2024 Volume 125, Page(s) 109567

Abstract: Diabetic cardiomyopathy is a common complication of diabetes, resulting in cardiac hypertrophy and heart failure associated with excessive reactive oxygen species and mitochondria-mediated apoptosis generation. Mitogen-activated protein kinase-c-Jun N- ... ...

Abstract	Diabetic cardiomyopathy is a common complication of diabetes, resulting in cardiac hypertrophy and heart failure associated with excessive reactive oxygen species and mitochondria-mediated apoptosis generation. Mitogen-activated protein kinase-c-Jun N-terminal kinase (MAPK-JNK), regulated by microRNA (miR)-210, affects mitochondrial function and is activated by advanced glycation end-products (AGE) in cardiac cells. Diallyl trisulfide (DATS), an antioxidant in garlic oil, inhibits stress-induced cardiac apoptosis. This study examined whether DATS enhances miR-210 expression to attenuate cardiac apoptosis. We investigated the DATS-mediated attenuation mechanism of AGE-enhanced cardiac apoptosis by modulating miR-210 and its upstream transcriptional regulator, FoxO3a. We found FoxO3a binding sites in the miR-210 promoter region. Our results indicated that DATS treatment inhibited AGE-induced JNK activation, phosphoprotein c-Jun nuclear transactivation, and cardiac apoptosis and reversed the AGE-induced reduction in cardiac miR-210 levels. The luciferase activity after DATS treatment was significantly lower than that of the control and was reversed following AGE treatment. We also showed that FoxO3a, upregulated by DATS treatment, may bind to the miR-210 promoter to enhance its expression and downregulates JNK expression to attenuate AGE-induced cardiac apoptosis. Oral administration of DATS enhanced FoxO3a expression in the heart and reduced diabetes-induced heart apoptosis. Our findings indicate that DATS mediates AGE-induced cardiac cell apoptosis attenuation by promoting FoxO3a nuclear transactivation to enhance miR-210 expression and regulate JNK activation. Our results suggest that DATS can be used as a cardioprotective agent, and miR-210 is a critical regulator in inhibiting diabetic cardiomyopathy.
MeSH term(s)	Humans ; Up-Regulation ; Diabetic Cardiomyopathies/prevention & control ; Glycation End Products, Advanced ; Maillard Reaction ; Sulfides/pharmacology ; Apoptosis ; Cell Line, Tumor ; Mitogen-Activated Protein Kinase Kinases ; MicroRNAs/genetics ; Allyl Compounds
Chemical Substances	diallyl trisulfide (0ZO1U5A3XX) ; Glycation End Products, Advanced ; Sulfides ; Mitogen-Activated Protein Kinase Kinases (EC 2.7.12.2) ; MicroRNAs ; MIRN210 microRNA, human ; Allyl Compounds
Language	English
Publishing date	2024-01-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1014929-6
ISSN	1873-4847 ; 0955-2863
ISSN (online)	1873-4847
ISSN	0955-2863
DOI	10.1016/j.jnutbio.2024.109567
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Zs.A 2838: Show issues

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Article: DNA oxidation after exercise: a systematic review and meta-analysis.

Ye, Mengxin / Dewi, Luthfia / Liao, Yu-Chieh / Nicholls, Andrew / Huang, Chih-Yang / Kuo, Chia-Hua

Frontiers in physiology

2023 Volume 14, Page(s) 1275867

Abstract: Purpose: ...

Abstract	Purpose:
Language	English
Publishing date	2023-10-31
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.1275867
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Article ; Online: Epibiont Cohabitation in Freshwater Shrimp Neocaridina davidi with the Description of Two Species New to Science, Cladogonium kumaki sp. nov. and Monodiscus kumaki sp. nov., and Redescription of Scutariella japonica and Holtodrilus truncatus

Maciaszek, Rafał / Świderek, Wiesław / Prati, Sebastian / Huang, Chih-Yang / Karaban, Kamil / Kaliszewicz, Anita / Jablonska, Alejandra

Animals. 2023 May 12, v. 13, no. 10

2023

Abstract: This contribution presents the occurrence of epibiotic species associated with Neocaridina davidi shrimp collected in the wild, aquaculture ponds, and aquaria. A total of 900 shrimp are imported from Taiwan, three-quarters of which host at least one of ... ...

Abstract	This contribution presents the occurrence of epibiotic species associated with Neocaridina davidi shrimp collected in the wild, aquaculture ponds, and aquaria. A total of 900 shrimp are imported from Taiwan, three-quarters of which host at least one of the recorded epibionts. Among those epibionts, two species new to science are discovered, Cladogonium kumaki sp. nov. and Monodiscus kumaki sp. nov., while the other two, Holtodrilus truncatus and Scutariella japonica, are redescribed. The largest number of epibionts is found in shrimp collected from aquaculture ponds and the lowest in individuals from aquaria. Epibiont occurrence differs across designated microhabitats. The epibionts may be introduced alongside their host outside their native range, and their presence may affect shrimp breeding rates. Thus, more control over them should be provided. Their spread can be limited by removal from the host during molting or manually, as well as by using interspecies interactions.
Keywords	aquaculture ; epibionts ; redescriptions ; shrimp ; Taiwan
Language	English
Dates of publication	2023-0512
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2606558-7
ISSN	2076-2615
ISSN	2076-2615
DOI	10.3390/ani13101616
Database	NAL-Catalogue (AGRICOLA)

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