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  1. Article ; Online: Effects of New Psychoactive Substance Esketamine on Behaviors and Transcription of Genes in Dopamine and GABA Pathways in Zebrafish Larvae.

    Li, Si-Ying / Shi, Wen-Jun / Ma, Dong-Dong / Zhang, Jin-Ge / Lu, Zhi-Jie / Long, Xiao-Bing / Liu, Xin / Huang, Chu-Shu / Ying, Guang-Guo

    Bulletin of environmental contamination and toxicology

    2024  Volume 112, Issue 4, Page(s) 51

    Abstract: Esketamine (ESK) is the S-enantiomer of ketamine racemate (a new psychoactive substance) that can result in illusions, and alter hearing, vision, and proprioception in human and mouse. Up to now, the neurotoxicity caused by ESK at environmental level in ... ...

    Abstract Esketamine (ESK) is the S-enantiomer of ketamine racemate (a new psychoactive substance) that can result in illusions, and alter hearing, vision, and proprioception in human and mouse. Up to now, the neurotoxicity caused by ESK at environmental level in fish is still unclear. This work studied the effects of ESK on behaviors and transcriptions of genes in dopamine and GABA pathways in zebrafish larvae at ranging from 12.4 ng L
    MeSH term(s) Humans ; Animals ; Mice ; Dopamine/metabolism ; Dopamine/pharmacology ; Zebrafish/genetics ; Zebrafish/metabolism ; Ketamine/metabolism ; Ketamine/pharmacology ; Larva ; gamma-Aminobutyric Acid/metabolism ; gamma-Aminobutyric Acid/pharmacology
    Chemical Substances Dopamine (VTD58H1Z2X) ; Esketamine (50LFG02TXD) ; Ketamine (690G0D6V8H) ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2024-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 6895-0
    ISSN 1432-0800 ; 0007-4861
    ISSN (online) 1432-0800
    ISSN 0007-4861
    DOI 10.1007/s00128-024-03883-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 75: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Ephedrine and cocaine cause developmental neurotoxicity and abnormal behavior in zebrafish.

    Ma, Dong-Dong / Shi, Wen-Jun / Li, Si-Ying / Zhang, Jin-Ge / Lu, Zhi-Jie / Long, Xiao-Bing / Liu, Xin / Huang, Chu-Shu / Ying, Guang-Guo

    Aquatic toxicology (Amsterdam, Netherlands)

    2023  Volume 265, Page(s) 106765

    Abstract: Ephedrine (EPH) and cocaine (COC) are illegal stimulant drugs, and have been frequently detected in aquatic environments. EPH and COC have negative effects on the nervous system and cause abnormal behaviors in mammals and fish at high concentrations, but ...

    Abstract Ephedrine (EPH) and cocaine (COC) are illegal stimulant drugs, and have been frequently detected in aquatic environments. EPH and COC have negative effects on the nervous system and cause abnormal behaviors in mammals and fish at high concentrations, but their mechanisms of neurotoxicity remain unclear in larvae fish at low concentrations. To address this issue, zebrafish embryos were exposed to EPH and COC for 14 days post-fertilization (dpf) at 10, 100, and 1000 ng L
    MeSH term(s) Animals ; Zebrafish/metabolism ; Ephedrine/toxicity ; Ephedrine/metabolism ; Water Pollutants, Chemical/toxicity ; Cocaine/toxicity ; Cocaine/metabolism ; Neurotransmitter Agents/metabolism ; gamma-Aminobutyric Acid/metabolism ; Larva ; Mammals/metabolism
    Chemical Substances Ephedrine (GN83C131XS) ; Water Pollutants, Chemical ; Cocaine (I5Y540LHVR) ; Neurotransmitter Agents ; gamma-Aminobutyric Acid (56-12-2)
    Language English
    Publishing date 2023-11-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 782699-0
    ISSN 1879-1514 ; 0166-445X
    ISSN (online) 1879-1514
    ISSN 0166-445X
    DOI 10.1016/j.aquatox.2023.106765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4376: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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