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Article ; Online: Thermodynamic Model for Calculation the Position of Quitting Surface of Supersonic Beam Based on Speed Measurements.

Huang, Chuanfu

The journal of physical chemistry. A

2018 Volume 122, Issue 46, Page(s) 8998–9000

Abstract: For a nozzle jet beam, one fascinating fact is where a transition occurs from continuous to discontinuous beam during the expansion, which is typically known as the quitting surface. In our previous work, we applied a pickup method to investigate the ... ...

Abstract	For a nozzle jet beam, one fascinating fact is where a transition occurs from continuous to discontinuous beam during the expansion, which is typically known as the quitting surface. In our previous work, we applied a pickup method to investigate the fragmentation properties of water cluster during electron ionization, and we roughly estimated the possible quitting surface position (∼1 to 1.5 mm in front of the nozzle) to make sure the dopants were not accelerated by the beam expansion. Thus, the momentum conservation law can be applied to evaluate the possible fragmented water molecules. In this work, we applied a simple thermodynamic method to more accurately calculate the position of quitting surface of supersonic beam based on speed measurements. From our calculation in this paper, the quitting surface should be exactly located 1 mm in front of the nozzle, and this paper can further support our previous work.
Language	English
Publishing date	2018-11-08
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.8b09149
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Article ; Online: A simple derivation of the shell polarizability formula and investigation of the plasmonic behavior of aluminum nanoshells with the Mie theory.

Huang, Chuanfu / Zhang, Heng

Physical chemistry chemical physics : PCCP

2021 Volume 23, Issue 41, Page(s) 23501–23507

Abstract: In this paper, we found that the formula of shell polarizability in existing popular monographs is not uniform, which may lead to misuse of this expression in research. To avoid potential misuse, a detailed derivation has been supplemented in this work ... ...

Abstract	In this paper, we found that the formula of shell polarizability in existing popular monographs is not uniform, which may lead to misuse of this expression in research. To avoid potential misuse, a detailed derivation has been supplemented in this work to clarify this formula. Using the attained correct shell polarizability, we questioned the conclusion of the surface plasmon resonances of aluminum metal nanoshells that could be tuned into the near-infrared region in previous research. More importantly, the new reliable parameters are successfully searched to achieve controllable surface plasmon resonances of aluminum nanoshells, such as tuning into the near-infrared regime, based on the Mie theory.
Language	English
Publishing date	2021-10-27
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d1cp01699g
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Article ; Online: Note: Contamination-free loading of lithium metal into a nozzle source.

Huang, Chuanfu / Kresin, Vitaly V

The Review of scientific instruments

2016 Volume 87, Issue 6, Page(s) 66105

Abstract: This note describes a system for transferring a load of high purity lithium metal into a molecular or cluster beam source. A hot loading vessel is thoroughly baked out while empty and overpressured with argon. A clean Li rod is then dropped in through a ... ...

Abstract	This note describes a system for transferring a load of high purity lithium metal into a molecular or cluster beam source. A hot loading vessel is thoroughly baked out while empty and overpressured with argon. A clean Li rod is then dropped in through a long narrow tube. The thoroughly degassed interior of the vessel and the rapid melting of the inserted rod facilitate contamination-free transfer of the highly reactive liquid metal into the source oven.
Language	English
Publishing date	2016-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/1.4953918
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Article ; Online: Destructive Extraction and Enhanced Diffusion of Phospholipids on Lipid Membranes by Phosphorene Oxide Nanosheets.

Chen, Yezhe / Zhang, Wei / Huang, Chuanfu / Feng, Mei / Yang, Yunqiu / Gou, Yuanyuan

The journal of physical chemistry. B

2021 Volume 125, Issue 10, Page(s) 2636–2643

Abstract: Phosphorene is a novel two-dimensional nanomaterial with a puckered surface morphology, which has broad potential application prospects in the fields of biology and medicine. Phosphorene nanosheets are easily oxidized and form phosphorene oxide (PO) in ... ...

Abstract	Phosphorene is a novel two-dimensional nanomaterial with a puckered surface morphology, which has broad potential application prospects in the fields of biology and medicine. Phosphorene nanosheets are easily oxidized and form phosphorene oxide (PO) in an aerobic environment, whose biological effect remains unknown. In this paper, using large-scale molecular dynamics simulations, we show that the PO nanosheets can penetrate into and destructively extract large amounts of phospholipids from the lipid membrane. The PO nanosheets with a higher oxidation concentration have less extraction of phospholipids, while its oxidation mode has no effect on the extraction of phospholipids. Moreover, inserting PO nanosheets into the lipid membrane can enhance the diffusion of phospholipids on the membrane. These findings can shed light on understanding/designing the membrane-nanomaterial interactions.
Language	English
Publishing date	2021-01-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.0c07476
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Article: A Pathophysiological Approach to Reduce Peritumoral Edema with Gamma Knife Radiosurgery for Large Incidental Meningiomas.

Chang, Cheng-Siu / Huang, Cheng-Wei / Chou, Hsi-Hsien / Tu, Hsien-Tang / Lee, Ming-Tsung / Huang, Chuan-Fu

Life (Basel, Switzerland)

2022 Volume 12, Issue 11

Abstract: Background: Peritumoral edema may be a prohibitive side effect in treating large incidental meningiomas with stereotactic radiosurgery. An approach that limits peritumoral edema and achieves tumor control with SRS would be an attractive management ... ...

Abstract	Background: Peritumoral edema may be a prohibitive side effect in treating large incidental meningiomas with stereotactic radiosurgery. An approach that limits peritumoral edema and achieves tumor control with SRS would be an attractive management option for large incidental meningiomas. Methods: This is a retrospective cohort study of patients with large incidental meningiomas (≥2 mL in volume and/or 2 cm in diameter) treated with gamma knife radiosurgery (GKRS) between 2000 and 2019 in Taiwan and followed up for 5 years. The outcomes of a pathophysiological approach targeting the dural feeding artery site with a higher marginal dose (18-20 Gy) to enhance vascular damage and the parenchymal margin of the tumor with a lower dose (9-11 Gy) to reduce parenchymal damage were compared with those of a conventional approach targeting the tumor center with a higher dose and tumor margin with a lower dose (12-14 Gy). Results: A total of 53 incidental meningiomas were identified, of which 23 (43.4%) were treated with a pathophysiological approach (4 cases underwent a two-stage approach) and 30 (56.7%) were treated with a conventional approach. During a median follow-up of 3.5 (range 1-5) years, tumor control was achieved in 19 (100%) incidental meningiomas that underwent a single-stage pathophysiological approach compared with 29 (96.7%) incidental meningiomas that underwent a conventional approach (log-rank test: Conclusions: Treatment of large incidental meningiomas with a pathophysiological approach with GKRS achieves similar rates of tumor control and reduces the risk of peritumoral edema. GKRS with a pathophysiological approach may be a reasonable management strategy for large incidental meningiomas.
Language	English
Publishing date	2022-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life12111683
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Article ; Online: Outcome of Gamma Knife radiosurgery for trigeminal neuralgia associated with neurovascular compression.

Chang, Cheng-Siu / Huang, Cheng-Wei / Chou, His-Hsien / Lin, Long-Yau / Huang, Chuan-Fu

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia

2018 Volume 47, Page(s) 174–177

Abstract: We reviewed 130 patients from 1999 to 2012 to evaluate whether neurovascular compression (NVC) has prognostic value for pain relief in idiopathic trigeminal neuralgia (TN) treated by Gamma Knife radiosurgery (GKRS). Patients were assigned to one of the ... ...

Abstract	We reviewed 130 patients from 1999 to 2012 to evaluate whether neurovascular compression (NVC) has prognostic value for pain relief in idiopathic trigeminal neuralgia (TN) treated by Gamma Knife radiosurgery (GKRS). Patients were assigned to one of the following groups based on NVC identified by MRI: no NVC, small vessel NVC, and large vessel (defined as part of the vertebrobasilar arterial system) NVC. Follow-up ranged from 4 to 14years. Primary outcome was pain graded by the Barrow Neurological Institute (BNI) pain scale. Successful pain control was defined asa score within Grade I-IIIb. Among the 130 patients, 53 had no neurovascular compression (group 1), 60 had a small vessel NVC (group 2), and 17 had a large vessel NVC (group 3). Successful pain control was 85% in group 1, 75% in group 2, and 88% in group 3 (X
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Pain/etiology ; Pain Management ; Pain Measurement ; Prognosis ; Radiosurgery/methods ; Retrospective Studies ; Treatment Outcome ; Trigeminal Neuralgia/etiology ; Trigeminal Neuralgia/surgery
Language	English
Publishing date	2018-01
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	1193674-5
ISSN	1532-2653 ; 0967-5868
ISSN (online)	1532-2653
ISSN	0967-5868
DOI	10.1016/j.jocn.2017.09.016
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Article ; Online: Water cluster fragmentation probed by pickup experiments.

Huang, Chuanfu / Kresin, Vitaly V / Pysanenko, Andriy / Fárník, Michal

The Journal of chemical physics

2016 Volume 145, Issue 10, Page(s) 104304

Abstract: Electron ionization is a common tool for the mass spectrometry of atomic and molecular clusters. Any cluster can be ionized efficiently by sufficiently energetic electrons, but concomitant fragmentation can seriously obstruct the goal of size-resolved ... ...

Abstract	Electron ionization is a common tool for the mass spectrometry of atomic and molecular clusters. Any cluster can be ionized efficiently by sufficiently energetic electrons, but concomitant fragmentation can seriously obstruct the goal of size-resolved detection. We present a new general method to assess the original neutral population of the cluster beam. Clusters undergo a sticking collision with a molecule from a crossed beam, and the velocities of neat and doped cluster ion peaks are measured and compared. By making use of longitudinal momentum conservation, one can reconstruct the sizes of the neutral precursors. Here this method is applied to H2O and D2O clusters in the detected ion size range of 3-10. It is found that water clusters do fragment significantly upon electron impact: the deduced neutral precursor size is ∼3-5 times larger than the observed cluster ions. This conclusion agrees with beam size characterization by another experimental technique: photoionization after Na-doping. Abundant post-ionization fragmentation of water clusters must therefore be an important factor in the interpretation of experimental data; interestingly, there is at present no detailed microscopic understanding of the underlying fragmentation dynamics.
Language	English
Publishing date	2016-09-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/1.4962220
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Article ; Online: Wastewater surveillance and an automated robot: effectively tracking SARS-CoV-2 transmission in the post-epidemic era.

Ou, Guanyong / Tang, Yuxuan / Niu, Shiyu / Wu, Liwen / Li, Shaxi / Yang, Yang / Wang, Jun / Peng, Yun / Huang, Chuanfu / Hu, Wei / Hu, Qinghua / Li, Yinghui / Ping, Yang / Lin, Chao / Yu, Boping / Han, Qi / Hao, Yabin / Luo, Zhiguang / Tian, Wende /

Zhang, Han / Liu, Yingxia

National science review

2023 Volume 10, Issue 6, Page(s) nwad089

Abstract: Wastewater-based epidemiology (WBE) has exhibited great utility in the early and rapid identification of SARS-CoV-2. However, the efficacy of wastewater surveillance under China's previous strict epidemic prevention policy remains to be described. We ... ...

Abstract	Wastewater-based epidemiology (WBE) has exhibited great utility in the early and rapid identification of SARS-CoV-2. However, the efficacy of wastewater surveillance under China's previous strict epidemic prevention policy remains to be described. We collected the WBE data of wastewater treatment plants (WWTPs) in the Third People's Hospital of Shenzhen and several communities to determine the significant effectiveness of routine wastewater surveillance in monitoring the local spread of SARS-CoV-2 under tight containment of the epidemic. The results of 1 month of continuous wastewater surveillance showed that positive signals for SARS-CoV-2 RNA were detected in the wastewater samples, and a significant positive correlation was observed between the virus concentration and the number of daily cases. In addition, the community's domestic wastewater surveillance results were confirmed even 3 days before, or simultaneously with, the infected patient being confirmed as having the virus. Meanwhile, an automated sewage virus detection robot, ShenNong No.1 robot, was developed, showing a high degree of agreement with experimental data, offering the possibility of large-scale multi-point surveillance. Overall, our results illustrated the clear indicative role of wastewater surveillance in combating COVID-19 and provided a practical basis for rapidly expanding the feasibility and value of routine wastewater surveillance for future emerging infectious diseases.
Language	English
Publishing date	2023-03-31
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwad089
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Article ; Online: Gamma Knife radiosurgery for large vestibular schwannomas greater than 3 cm in diameter.

Huang, Cheng-Wei / Tu, Hsien-Tang / Chuang, Chun-Yi / Chang, Cheng-Siu / Chou, Hsi-Hsien / Lee, Ming-Tsung / Huang, Chuan-Fu

Journal of neurosurgery

2017 Volume 128, Issue 5, Page(s) 1380–1387

Abstract: OBJECTIVE Stereotactic radiosurgery (SRS) is an important alternative management option for patients with small- and medium-sized vestibular schwannomas (VSs). Its use in the treatment of large tumors, however, is still being debated. The authors ... ...

Abstract	OBJECTIVE Stereotactic radiosurgery (SRS) is an important alternative management option for patients with small- and medium-sized vestibular schwannomas (VSs). Its use in the treatment of large tumors, however, is still being debated. The authors reviewed their recent experience to assess the potential role of SRS in larger-sized VSs. METHODS Between 2000 and 2014, 35 patients with large VSs, defined as having both a single dimension > 3 cm and a volume > 10 cm
MeSH term(s)	Adult ; Aged ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neuroma, Acoustic/diagnostic imaging ; Neuroma, Acoustic/epidemiology ; Neuroma, Acoustic/pathology ; Neuroma, Acoustic/radiotherapy ; Radiosurgery/adverse effects ; Radiotherapy Dosage ; Retreatment ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; Tumor Burden ; Young Adult
Language	English
Publishing date	2017-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2016.12.JNS161530
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Article ; Online: Comparison of active sites of butyrylcholinesterase and acetylcholinesterase based on inhibition by geometric isomers of benzene-di-N-substituted carbamates.

Chiou, Shyh-Ying / Huang, Chuan-Fu / Hwang, Mei-Ting / Lin, Gialih

Journal of biochemical and molecular toxicology

2009 Volume 23, Issue 5, Page(s) 303–308

Abstract: We have reported that benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates (1-15) are characterized as the conformationally constrained inhibitors of acetylcholinesterase and mimic gauche, eclipsed, and anti-conformations of acetylcholine, ... ...

Abstract	We have reported that benzene-1,2-, 1,3-, and 1,4-di-N-substituted carbamates (1-15) are characterized as the conformationally constrained inhibitors of acetylcholinesterase and mimic gauche, eclipsed, and anti-conformations of acetylcholine, respectively (J Biochem Mol Toxicol 2007;21:348-353). We further report the inhibition of butyrylcholinesterase by these inhibitors. Carbamates 1-15 are also characterized as the pseudosubstrate inhibitors of butyrylcholinesterase as in the acetylcholinesterase catalysis. Benzene-1,4-di-N-n-hexylcarbamate (12) and benzene-1,4-di-N-n-octylcarbamate (13) are the two most potent inhibitors of butyrylcholinesterase among inhibitors 1-15. These two para compounds, with the angle of 180 degrees between two C(benzene)--O bonds, mimic the preferable anti C--O/C--N conformers for the choline ethylene backbone of butyrylcholine during the butyrylcholinesterase catalysis. The second n-hexylcarbamyl or n-octylcarbamyl moiety of inhibitors 12 and 13 is proposed to bind tightly to the peripheral anionic site of butyrylcholinesterase from molecular modeling. Butyrylcholinesterase prefers para-carbamates to ortho- and meta-carbamates, whereas acetylcholinesterase prefers para- and meta-carbamates to ortho-carbamates. This result implies that the anionic site of butyrylcholinesterase is relatively smaller than that of acetylcholinesterase because meta-carbamates, which may bind to the anionic sites of both enzymes, are not potent inhibitors of butyrylcholinesterase.
MeSH term(s)	Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Benzene/chemistry ; Binding Sites ; Butyrylcholinesterase/chemistry ; Butyrylcholinesterase/metabolism ; Carbamates/chemistry ; Carbamates/metabolism ; Cholinesterase Inhibitors/pharmacology ; Isomerism ; Kinetics ; Models, Chemical ; Molecular Conformation ; Molecular Structure ; Structure-Activity Relationship ; Substrate Specificity/drug effects
Chemical Substances	Carbamates ; Cholinesterase Inhibitors ; Acetylcholinesterase (EC 3.1.1.7) ; Butyrylcholinesterase (EC 3.1.1.8) ; Benzene (J64922108F)
Language	English
Publishing date	2009-09
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1410020-4
ISSN	1099-0461 ; 1095-6670
ISSN (online)	1099-0461
ISSN	1095-6670
DOI	10.1002/jbt.20286
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