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Article ; Online: Optimization of n-Hexane-Acetone System for Extraction of Phosphatidylcholine and Phosphatidylethanolamine by Response Surface Methodology.

Huang, Chunling / Cao, Dong

2022 Volume 71, Issue 6, Page(s) 813–822

Abstract: Eggs are nutritious and cheap and easily available. Egg yolk is one of the sources of phosphatidylcholine (PC) and phosphatidylethanolamine (PE). PC and PE have good emulsifying properties, and they are widely used and in high demand for pharmaceutical, ... ...

Abstract	Eggs are nutritious and cheap and easily available. Egg yolk is one of the sources of phosphatidylcholine (PC) and phosphatidylethanolamine (PE). PC and PE have good emulsifying properties, and they are widely used and in high demand for pharmaceutical, feed and cosmetic applications. Red cordyceps egg yolk powder (RCEYP) was selected as the raw material to obtain high content of PC and PE by ethanol extraction and low temperature cryoprecipitation in n-hexane-acetone system (HAS), in which the process conditions of PC and PE extraction by HAS process were optimized. The phospholipids were quantified by high performance liquid chromatography (HPLC) with evaporative light scattering detector (ELSD). The effects of freezing time, material-liquid ratio, acetone washing times, solvent ratio of n-hexane to acetone and freezing temperature on the PC and PE contents and the phospholipid yield were investigated. The optimal conditions for the extraction of PC and PE from RCEYP by HAS were determined by Box-Behnken design (BBD) as follows: the solvent ratio of n-hexane to acetone was 1:6, the freezing time was 11.31 h, and the freezing temperature was -19°C. The total content of (PC+PE) in the phospholipids precipitated under these conditions amounted to 96.16%, of which 81.12% was PC and 15.04% was PE.
MeSH term(s)	Acetone ; Hexanes ; Lecithins ; Phosphatidylcholines ; Phosphatidylethanolamines ; Phospholipids/chemistry ; Solvents
Chemical Substances	Hexanes ; Lecithins ; Phosphatidylcholines ; Phosphatidylethanolamines ; Phospholipids ; Solvents ; Acetone (1364PS73AF) ; n-hexane (2DDG612ED8)
Language	English
Publishing date	2022-05-18
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2218264-0
ISSN	1347-3352 ; 1345-8957
ISSN (online)	1347-3352
ISSN	1345-8957
DOI	10.5650/jos.ess22011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Editorial: Novel therapeutic strategies for chronic kidney disease: from bench to bedside.

Huang, Chunling / Chen, Xin-Ming / Zhao, Yongli

Frontiers in cell and developmental biology

2023 Volume 11, Page(s) 1242473

Language	English
Publishing date	2023-07-06
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1242473
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Article ; Online: Platelet-Rich Plasma Intrauterine Infusion as Assisted Reproduction Technology (ART) to Combat Repeated Implantation Failure (RIF): A Systematic Review and Meta-Analysis.

Huang, Chunling / Ye, Xiaohui / Ye, Lifang / Lu, Lunyuan / Liu, Fengxiang

Iranian journal of public health

2023 Volume 52, Issue 8, Page(s) 1542–1554

Abstract: Background: Repeated implantation failure (RIF) is considered one of the major challenges facing clinician in assisted reproduction technologies (ART) despite the significant advances that have been made in this field. Platelet rich plasma (PRP), also ... ...

Abstract	Background: Repeated implantation failure (RIF) is considered one of the major challenges facing clinician in assisted reproduction technologies (ART) despite the significant advances that have been made in this field. Platelet rich plasma (PRP), also known as autologous conditioned plasma, is a protein concentrate with anti-inflammatory and pro-regenerative characteristics. The use of PRP in women undergoing ART has been studied in the past, with varying degrees of success. The goal of this trial was to see if injecting PRP into the uterus improves pregnancy outcomes in women receiving ART. Methods: PubMed, Embase, Scopus, Web of Science, and the Cochrane Database of Clinical Trials were among the databases searched (CENTRAL), from 2015 to 2021. The pooled estimates were calculated using a meta-analysis with a random-effects model. There were 14 studies with a total of 1081 individuals (549 cases and 532 controls). Results: There was no difference in miscarriage rates between women who got PRP and those who received placebo ( Conclusion: PRP may be an alternate therapeutic approach for individuals with thin endometrium and RIF, according to the findings of this comprehensive study. To determine the subgroup that would benefit the most from PRP, more prospective, big, and high-quality randomized controlled trials (RCTs) are needed.
Language	English
Publishing date	2023-09-07
Publishing country	Iran
Document type	Journal Article ; Review
ISSN	2251-6093 ; 0304-4556
ISSN (online)	2251-6093
ISSN	0304-4556
DOI	10.18502/ijph.v52i8.13394
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Article: Mesenchymal Stem Cell-Derived Exosomes: Toward Cell-Free Therapeutic Strategies in Chronic Kidney Disease.

Cao, Qinghua / Huang, Chunling / Chen, Xin-Ming / Pollock, Carol A

Frontiers in medicine

2022 Volume 9, Page(s) 816656

Abstract: Chronic kidney disease (CKD) is rising in global prevalence and has become a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease, and premature death. However, current treatments are limited to slowing rather ... ...

Abstract	Chronic kidney disease (CKD) is rising in global prevalence and has become a worldwide public health problem, with adverse outcomes of kidney failure, cardiovascular disease, and premature death. However, current treatments are limited to slowing rather than reversing disease progression or restoring functional nephrons. Hence, innovative strategies aimed at kidney tissue recovery hold promise for CKD therapy. Mesenchymal stem cells (MSCs) are commonly used for regenerative therapy due to their potential for proliferation, differentiation, and immunomodulation. Accumulating evidence suggests that the therapeutic effects of MSCs are largely mediated by paracrine secretion of extracellular vesicles (EVs), predominantly exosomes. MSC-derived exosomes (MSC-Exos) replicate the functions of their originator MSCs via delivery of various genetic and protein cargos to target cells. More recently, MSC-Exos have also been utilized as natural carriers for targeted drug delivery. Therapeutics can be effectively incorporated into exosomes and then delivered to diseased tissue. Thus, MSC-Exos have emerged as a promising cell-free therapy in CKD. In this paper, we describe the characteristics of MSC-Exos and summarize their therapeutic efficacy in preclinical animal models of CKD. We also discuss the potential challenges and strategies in the use of MSC-Exos-based therapies for CKD in the future.
Language	English
Publishing date	2022-03-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2022.816656
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Article: Corrigendum: RIPK3: A New Player in Renal Fibrosis.

Shi, Ying / Chen, Xinming / Huang, Chunling / Pollock, Carol

Frontiers in cell and developmental biology

2021 Volume 9, Page(s) 699073

Abstract: This corrects the article DOI: 10.3389/fcell.2020.00502.]. ...

Abstract	[This corrects the article DOI: 10.3389/fcell.2020.00502.].
Language	English
Publishing date	2021-06-09
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2021.699073
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Article ; Online: KCa3.1 in diabetic kidney disease.

Huang, Chunling / Chen, Xin-Ming / Pollock, Carol A

Current opinion in nephrology and hypertension

2021 Volume 31, Issue 1, Page(s) 129–134

Abstract: Purpose of review: Diabetic kidney disease (DKD) is a significant health concern. Innovative strategies to prevent or limit the progression of DKD are urgently needed due to the limitation of existing treatments. KCa3.1, a potassium channel, is involved ...

Abstract	Purpose of review: Diabetic kidney disease (DKD) is a significant health concern. Innovative strategies to prevent or limit the progression of DKD are urgently needed due to the limitation of existing treatments. KCa3.1, a potassium channel, is involved in a range of biological processes from cell survival to cell death. This review summarizes the current knowledge on the pathophysiological functions of the KCa3.1 channel, specifically its involvement in maintaining mitochondrial function. More specifically, the therapeutic potential of targeting KCa3.1 in DKD is systematically discussed in the review. Recent findings: Mitochondrial dysfunction contributes to the development and progression of DKD. Accumulating evidence indicates that KCa3.1 dysregulation plays a crucial role in mitochondrial dysfunction, in addition to driving cellular activation, proliferation and inflammation. Recent studies demonstrate that KCa3.1 deficiency improves diabetes-induced mitochondrial dysfunction in DKD, which is attributed to modulation of mitochondrial quality control through mitigating the altered mitochondrial dynamics and restoring abnormal BNIP3-mediated mitophagy. Summary: Based on its role in fibrosis, inflammation and mitochondrial dysfunction, pharmacological inhibition of KCa3.1 may offer a promising alternative for the treatment of DKD. Due to its safety profile in humans, the repurposing of senicapoc has the potential to expedite an urgently needed new drug in DKD.
MeSH term(s)	Diabetes Mellitus ; Diabetic Nephropathies/drug therapy ; Diabetic Nephropathies/etiology ; Fibrosis ; Humans ; Inflammation ; Mitochondria
Language	English
Publishing date	2021-10-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1151092-4
ISSN	1473-6543 ; 1535-3842 ; 1062-4813 ; 1062-4821
ISSN (online)	1473-6543 ; 1535-3842
ISSN	1062-4813 ; 1062-4821
DOI	10.1097/MNH.0000000000000751
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Article ; Online: Successful application of continuous renal replacement therapy in a very low birth weight neonate with acute kidney injury.

Huang, Chunling / Lu, Yang / Ma, Xu / Hu, Junkai / Yan, Guosheng / Zhu, Guizhen / Zhang, Hongtao

Artificial organs

2023 Volume 47, Issue 3, Page(s) 604–607

Abstract: Diagnosis and treatment process during hospitalization. ...

Abstract	Diagnosis and treatment process during hospitalization.
MeSH term(s)	Infant, Newborn ; Humans ; Continuous Renal Replacement Therapy ; Renal Replacement Therapy ; Retrospective Studies ; Acute Kidney Injury/therapy ; Infant, Very Low Birth Weight
Language	English
Publishing date	2023-01-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	441812-8
ISSN	1525-1594 ; 0160-564X
ISSN (online)	1525-1594
ISSN	0160-564X
DOI	10.1111/aor.14490
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Zs.A 1463: Show issues

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Article: Faecal Microbiota Transplantation and Chronic Kidney Disease

Bian, Ji / Liebert, Ann / Bicknell, Brian / Chen, Xin-Ming / Huang, Chunling / Pollock, Carol A.

Nutrients. 2022 June 17, v. 14, no. 12

2022

Abstract: Faecal microbiota transplantation (FMT) has attracted increasing attention as an intervention in many clinical conditions, including autoimmune, enteroendocrine, gastroenterological, and neurological diseases. For years, FMT has been an effective second- ... ...

Abstract	Faecal microbiota transplantation (FMT) has attracted increasing attention as an intervention in many clinical conditions, including autoimmune, enteroendocrine, gastroenterological, and neurological diseases. For years, FMT has been an effective second-line treatment for Clostridium difficile infection (CDI) with beneficial outcomes. FMT is also promising in improving bowel diseases, such as ulcerative colitis (UC). Pre-clinical and clinical studies suggest that this microbiota-based intervention may influence the development and progression of chronic kidney disease (CKD) via modifying a dysregulated gut–kidney axis. Despite the high morbidity and mortality due to CKD, there are limited options for treatment until end-stage kidney disease occurs, which results in death, dialysis, or kidney transplantation. This imposes a significant financial and health burden on the individual, their families and careers, and the health system. Recent studies have suggested that strategies to reverse gut dysbiosis using FMT are a promising therapy in CKD. This review summarises the preclinical and clinical evidence and postulates the potential therapeutic effect of FMT in the management of CKD.
Keywords	Clostridium difficile ; death ; dialysis ; digestive system ; dysbiosis ; kidney diseases ; kidney transplant ; microorganisms ; morbidity ; mortality ; ulcerative colitis
Language	English
Dates of publication	2022-0617
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14122528
Database	NAL-Catalogue (AGRICOLA)

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Article: RIPK3: A New Player in Renal Fibrosis.

Shi, Ying / Chen, Xinming / Huang, Chunling / Pollock, Carol

Frontiers in cell and developmental biology

2020 Volume 8, Page(s) 502

Abstract: Chronic kidney disease (CKD) is the end result of a plethora of renal insults, including repeated episodes of acute or toxic kidney injury, glomerular, or diabetic kidney disease. It affects a large number of the population worldwide, resulting in ... ...

Abstract	Chronic kidney disease (CKD) is the end result of a plethora of renal insults, including repeated episodes of acute or toxic kidney injury, glomerular, or diabetic kidney disease. It affects a large number of the population worldwide, resulting in significant personal morbidity and mortality and economic cost to the community. Hence it is appropriate to focus on treatment strategies that interrupt the development of kidney fibrosis, the end result of all forms of CKD, in addition to upstream factors that may be specific to certain diseases. However, the current clinical approach to prevent or manage renal fibrosis remains unsatisfactory. The rising importance of receptor-interacting serine/threonine-protein kinase (RIPK) 3 in the inflammatory response and TGF-β1 signaling is increasingly recognized. We discuss here the biological functions of RIPK3 and its role in the development of renal fibrosis.
Language	English
Publishing date	2020-06-16
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2020.00502
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Article: [Effect of Rehmanniae Radix Praeparata on energy metabolism in prefrontal cortex of rats with attention deficit hyperactivity disorder based on "static Yin and dynamic Yang" theory].

Wang, Jing / Ni, Xin-Qiang / Li, Li-Min / Liao, Ying-Zhao / Chen, Yao / Huang, Chun-Ling

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2022 Volume 47, Issue 13, Page(s) 3554–3561

Abstract: The present study investigated the effect of Rehmanniae Radix Praeparata(RRP) on the energy metabolism of prefrontal cortex(PFC) of spontaneously hypertensive rats with attention deficit hyperactivity disorder(ADHD) based on the "static Yin and dynamic ... ...

Abstract	The present study investigated the effect of Rehmanniae Radix Praeparata(RRP) on the energy metabolism of prefrontal cortex(PFC) of spontaneously hypertensive rats with attention deficit hyperactivity disorder(ADHD) based on the "static Yin and dynamic Yang" theory.Thirty spontaneously hypertensive male rats aged 3 weeks were randomly divided into a model group, a methylphenidate(MPH) group(2 mg·kg~(-1)), and an RRP group(2.4 g·kg~(-1)).Wistar-Kyoto(WKY) male rats of the same age were assigned to the normal group.Rats were treated with corresponding drugs twice per day, and those in the model group and the normal group received the same volume of 0.9% sodium carboxymethyl cellulose(CMC-Na) solution by gavage.The open-field test was performed to evaluate the spontaneous and impulsive behaviors of rats before treatment and on the 4~(th) week after treatment.Four weeks after treatment, PFC was isolated and mitochondria were prepared.The content of adenosine triphosphate(ATP), adenosine diphosphate(ADP), and adenosine monophosphate(AMP) in the PFC was determined by high-performance liquid chromatography(HPLC), and energy charge(EC) was calculated.The parameters related to mitochondrial respiratory function were measured by the Clark oxygen electrode, specifically, state 3 respiration(ST3), state 4 respiration(ST4), and respiratory control rate(RCR).Enzymatic activities of succinate dehydrogenase(SDH), cytochrome C oxidase(COX), Na~+-K~+-ATPase, and Ca~(2+)-Mg~(2+)-ATPase were measured by chemical colorimetry.Mitochondrial permeability transition pore(mPTP) opening was measured by spectrophotometry.Protein expression of glucose transporter 1(GLUT1) and GLUT3 in PFC was tested by Western blot.Compared with the results in the model group, RRP could significantly reduce the total distance of movement, vertical times, and distance in the central area in the open field test(P<0.05 or P<0.01), increase the content of ATP and EC, decrease the content of AMP(P<0.05), elevate ST3 and RCR(P<0.05), potentiate activities of SDH, COX, Na~+-K~+-ATPase, and Ca~(2+)-Mg~(2+)-ATPase(P<0.05 or P<0.01), inhibit the opening of mPTP, and increase the expression levels of GLUT1 and GLUT3 proteins(P<0.05).It was inferred that RRP could inhibit hyperacti-vity and impulsivity by improving the energy metabolism disorder in PFC of ADHD rats, and its mechanism may be related to the improvement of mitochondrial respiratory function, potentiation of Na~+-K~+-ATPase, Ca~(2+)-Mg~(2+)-ATPase, and mitochondrial respiratory enzymes, inhibition of the opening of mPTP, and up-regulation of the expression of glucose transporter proteins.This study initially reveals the biological connotation of the "static Yin and dynamic Yang" theory in ADHD.
MeSH term(s)	1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/metabolism ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/therapeutic use ; Adenosine Monophosphate ; Adenosine Triphosphatases ; Adenosine Triphosphate/pharmacology ; Animals ; Attention Deficit Disorder with Hyperactivity/drug therapy ; Energy Metabolism ; Glucose Transporter Type 1/metabolism ; Glucose Transporter Type 3/metabolism ; Male ; Methylphenidate/pharmacology ; Plant Extracts ; Prefrontal Cortex ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Rehmannia
Chemical Substances	Glucose Transporter Type 1 ; Glucose Transporter Type 3 ; Plant Extracts ; rehmannia root (1BEM3U6LQQ) ; Methylphenidate (207ZZ9QZ49) ; Adenosine Monophosphate (415SHH325A) ; Adenosine Triphosphate (8L70Q75FXE) ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (9P21XSP91P) ; Adenosine Triphosphatases (EC 3.6.1.-)
Language	Chinese
Publishing date	2022-07-18
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20220412.402
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