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Article ; Online: Arginine-rich membrane-permeable peptides are seriously toxic.

Li, Qian / Xu, Mengchuan / Cui, Yali / Huang, Chunqian / Sun, Manji

2018 Volume 5, Issue 5

Abstract: The membrane-permeable peptides (MPP) such as undecapeptides TAT (YGRKKRRQRRR) and CTP (YGRRARRRRRR) have been receiving much attention for delivering various kinds of low membrane-permeability materials in vitro and in vivo. We have successfully used ... ...

Abstract	The membrane-permeable peptides (MPP) such as undecapeptides TAT (YGRKKRRQRRR) and CTP (YGRRARRRRRR) have been receiving much attention for delivering various kinds of low membrane-permeability materials in vitro and in vivo. We have successfully used MPP in carrying various proteins through blood-brain barrier (BBB) in treatment of many kinds of nervous diseases. However, people always concentrate their mind on the efficacy and the mechanism of permeation of the conjugates across BBB, but overlook the toxicity of the membrane-permeable peptide itself. Once we injected intravenously not very large amounts of gamma-aminobutyric acid-MPP (GABA-MPP) to the mice, to our great surprise, the mice died within seconds with seizure, whereas the GABA control mice well survived. Thus, the importance of the toxicity of MPPs and their conjugates comes into the field of our vision. The low LD
MeSH term(s)	Animals ; Arginine/chemistry ; Blood-Brain Barrier/drug effects ; Cell Membrane Permeability/drug effects ; Injections, Intravenous ; Lethal Dose 50 ; Mice ; Oligopeptides/chemistry ; Oligopeptides/metabolism ; Oligopeptides/toxicity ; Peptide Fragments/chemistry ; Peptide Fragments/toxicity ; Peptides/chemistry ; Peptides/toxicity ; Structure-Activity Relationship ; gamma-Aminobutyric Acid/administration & dosage ; tat Gene Products, Human Immunodeficiency Virus/chemistry ; tat Gene Products, Human Immunodeficiency Virus/toxicity
Chemical Substances	Oligopeptides ; Peptide Fragments ; Peptides ; R11 peptide ; tat Gene Products, Human Immunodeficiency Virus ; tat peptide (47-57), Human immunodeficiency virus 1 ; gamma-Aminobutyric Acid (56-12-2) ; Arginine (94ZLA3W45F)
Language	English
Publishing date	2018-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2740389-0
ISSN	2052-1707 ; 2052-1707
ISSN (online)	2052-1707
ISSN	2052-1707
DOI	10.1002/prp2.334
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: BBB: Permeable Conjugate of Exogenic GABA.

Li, Qian / Wang, Shuhao / Xiao, Weibin / Huang, Chunqian / Li, Hua / Sun, Manji

ACS omega

2017 Volume 2, Issue 8, Page(s) 4108–4111

Abstract: Neurotransmitters are the key factors in ameliorating the symptoms of nervous system diseases. Stroke/cerebral ischemia has been proven to be caused by the excess release of excitatory amino acid glutamate in the brain, and the inhibitory ... ...

Abstract	Neurotransmitters are the key factors in ameliorating the symptoms of nervous system diseases. Stroke/cerebral ischemia has been proven to be caused by the excess release of excitatory amino acid glutamate in the brain, and the inhibitory neurotransmitter γ-aminobutyric acid (GABA) is considered to be the best choice to counteract the action of glutamate. Here, we show that GABA conjugated to a cytoplasmic transduction peptide (YGRRARRRRRR) by means of custom chemical synthesis could penetrate through the blood-brain barrier, increasing the GABA level in the plasma of rats and mice, which, as a result, display a state of calmness and somnolence.
Language	English
Publishing date	2017-08-01
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN	2470-1343
DOI	10.1021/acsomega.7b00425
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Article: Systematic Analysis of

Zhu, Xiaoyi / Huang, Chunqian / Zhang, Liang / Liu, Hongfang / Yu, Jinhui / Hu, Zhiyong / Hua, Wei

Frontiers in plant science

2017 Volume 8, Page(s) 1174

Abstract: Drought and heat stress are major causes of lost plant crop yield. In the future, high levels of ... ...

Abstract	Drought and heat stress are major causes of lost plant crop yield. In the future, high levels of CO
Language	English
Publishing date	2017-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2711035-7
ISSN	1664-462X
ISSN	1664-462X
DOI	10.3389/fpls.2017.01174
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Article: Layer-by-layer assembly of Cu3(BTC)2 on chitosan non-woven fabrics: a promising haemostatic decontaminant composite material against sulfur mustard

Zhang, Lijuan / Sun, Junmei / Zhou, Yunshan / Zhong, Yuxu / Ying, Ying / Li, Yanqin / Liu, Yanqin / Zuhra, Zareen / Huang, Chunqian

Journal of materials chemistry B. 2017 Aug. 2, v. 5, no. 30

2017

Abstract: Cu3(BTC)2 (H3BTC = 1,3,5-benzenetricarboxylic acid) was anchored onto the surface of carboxymethylated chitosan non-woven fabrics by a controllable layer-by-layer technique in alternating solution baths of Cu(OAc)2·H2O and H3BTC solutions, and the ... ...

Abstract	Cu3(BTC)2 (H3BTC = 1,3,5-benzenetricarboxylic acid) was anchored onto the surface of carboxymethylated chitosan non-woven fabrics by a controllable layer-by-layer technique in alternating solution baths of Cu(OAc)2·H2O and H3BTC solutions, and the resulting [Cu3(BTC)2]n@chitosan non-woven fabric composite materials (n = number of alternate deposition cycles) were thoroughly characterized. The results showed that the composite materials not only exhibited excellent decontamination ability against sulfur mustard (HD), with an enhanced degradation rate of HD with increasing n, but also possessed remarkable haemostasis performance. The degradation efficiency of sulfur mustard by [Cu3(BTC)2]4@chitosan was found to be much higher than that of pristine [Cu3(BTC)2]4. The inherent haemostatic capabilities of the chitosan non-woven fabrics were not affected by the growth of Cu3(BTC)2 on the surface of chitosan. Oral and histological toxicity examinations of the pristine Cu3(BTC)2 sample showed that damage and toxicity in the viscera of mice was very low, even if the intra-gastric administration dose of Cu3(BTC)2 reached a very high level (50 mg of Cu3(BTC)2 per kg of mouse). The results have shown that the as-prepared composite can be used safely as a promising haemostatic decontaminant with good recyclability against sulfur mustard.
Keywords	animal organs ; chitosan ; composite materials ; copper ; decontamination ; hemostasis ; histology ; mice ; nonwoven fabrics ; sulfur ; toxicity
Language	English
Dates of publication	2017-0802
Size	p. 6138-6146.
Publishing place	The Royal Society of Chemistry
Document type	Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c7tb01489a
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Article ; Online: H

Li, Yanqin / Gao, Qi / Zhang, Lijuan / Zhou, Yunshan / Zhong, Yuxu / Ying, Ying / Zhang, Mingcai / Huang, Chunqian / Wang, Yong'an

Dalton transactions (Cambridge, England : 2003)

2018 Volume 47, Issue 18, Page(s) 6394–6403

Abstract: Currently extensive effort is compulsively expended to decontaminate efficiently banned chemical war agents. In this work, H5PV2Mo10O40 molecules have been encapsulated in mesoporous MIL-101(Cr), which features two types of mesoporous cages (internal ... ...

Abstract	Currently extensive effort is compulsively expended to decontaminate efficiently banned chemical war agents. In this work, H5PV2Mo10O40 molecules have been encapsulated in mesoporous MIL-101(Cr), which features two types of mesoporous cages (internal diameters of 29 Å and 34 Å) and microporous windows (diameters of 12 Å and 16 Å), leading to the formation of a new composite H5PV2Mo10O40@MIL-101(Cr) through a simple impregnation method. The composite was characterized thoroughly by elemental analysis, FT-IR spectroscopy, powder X-ray diffraction, scanning electron microscopy, energy dispersive X-ray spectroscopy, TG/DTA, and textural analysis thereby confirming the encapsulation of the H5PV2Mo10O40 into MIL-101(Cr). The decontamination efficiency of sulfur mustard (4 μL HD in 40 μL of petroleum ether) by 20 mg of the composite is found to be 97.39% in 120 min under ambient conditions. GC-MS analysis on the decontaminated products using 2-chloroethyl ethyl sulfide (CEES), which has been widely used as a simulant of sulfur mustard, showed that MIL-101(Cr) just decontaminates CEES by adsorption, while CEES can be decontaminated under ambient conditions by a synergetic combination of adsorption of MIL-101(Cr) and subsequent chemical oxidation degradation to nontoxic 2-chloroethyl ethyl sulfoxide (CEESO) due to the presence of highly dispersed H5PV2Mo10O40 within the composites.
Language	English
Publishing date	2018-05-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/c8dt00572a
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Article ; Online: Layer-by-layer assembly of Cu

Zhang, Lijuan / Sun, Junmei / Zhou, Yunshan / Zhong, Yuxu / Ying, Ying / Li, Yanqin / Liu, Yanqin / Zuhra, Zareen / Huang, Chunqian

Journal of materials chemistry. B

2017 Volume 5, Issue 30, Page(s) 6138–6146

Abstract: ... ...

Abstract	Cu
Language	English
Publishing date	2017-07-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/c7tb01489a
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Article ; Online: Important photosynthetic contribution of silique wall to seed yield-related traits in Arabidopsis thaliana.

Zhu, Xiaoyi / Zhang, Liang / Kuang, Chen / Guo, Yan / Huang, Chunqian / Deng, Linbin / Sun, Xingchao / Zhan, Gaomiao / Hu, Zhiyong / Wang, Hanzhong / Hua, Wei

Photosynthesis research

2018 Volume 137, Issue 3, Page(s) 493–501

Abstract: In plants, green non-foliar organs are able to perform photosynthesis just as leaves do, and the seed-enclosing pod acts as an essential photosynthetic organ in legume and Brassica species. To date, the contribution of pod photosynthesis to seed yield ... ...

Abstract	In plants, green non-foliar organs are able to perform photosynthesis just as leaves do, and the seed-enclosing pod acts as an essential photosynthetic organ in legume and Brassica species. To date, the contribution of pod photosynthesis to seed yield and related components still remains largely unexplored, and in Arabidopsis thaliana, the photosynthetic activity of the silique (pod) is unknown. In this study, an Arabidopsis glk1/glk2 mutant defective in both leaf and silique photosynthesis was used to create tissue-specific functional complementation lines. These lines were used to analyze the contribution of silique wall photosynthesis to seed yield and related traits, and to permit the comparison of this contribution with that of leaf photosynthesis. Our results showed that, together with leaves, the photosynthetic assimilation of the silique wall greatly contributed to total seed yield per plant. As for individual components of yield traits, leaf photosynthesis alone contributed to the seed number per silique and silique length, while silique wall photosynthesis alone contributed to thousand-seed weight. In addition, enhancing the photosynthetic capacity of the silique wall by overexpressing the photosynthesis-related RCA gene in this tissue resulted in significantly increased seed weight and oil content in the wild-type (WT) background. These results reveal that silique wall photosynthesis plays an important role in seed-related traits, and that enhancing silique photosynthesis in WT plants can further improve seed yield-related traits and oil production. This finding may have significant implications for improving the seed yield and oil production of oilseed crops and other species with pod-like organs.
MeSH term(s)	Arabidopsis/genetics ; Arabidopsis/growth & development ; Arabidopsis/physiology ; Arabidopsis Proteins/genetics ; Arabidopsis Proteins/metabolism ; Fruit/genetics ; Fruit/growth & development ; Fruit/physiology ; Mutation ; Organ Specificity ; Phenotype ; Photosynthesis ; Plant Leaves/genetics ; Plant Leaves/growth & development ; Plant Leaves/physiology ; Plant Oils/analysis ; Plant Oils/metabolism ; Seeds/genetics ; Seeds/growth & development ; Seeds/physiology ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Arabidopsis Proteins ; GLK1 protein, Arabidopsis ; GLK2 protein, Arabidopsis ; Plant Oils ; Rca protein, Arabidopsis ; Transcription Factors
Language	English
Publishing date	2018-06-29
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1475688-2
ISSN	1573-5079 ; 0166-8595
ISSN (online)	1573-5079
ISSN	0166-8595
DOI	10.1007/s11120-018-0532-x
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Article ; Online: New efficient imidazolium aldoxime reactivators for nerve agent-inhibited acetylcholinesterase.

Wei, Zhao / Liu, Yan-Qin / Zhou, Xin-Bo / Luo, Yuan / Huang, Chun-Qian / Wang, Yong-An / Zheng, Zhi-Bing / Li, Song

Bioorganic & medicinal chemistry letters

2014 Volume 24, Issue 24, Page(s) 5743–5748

Abstract: Herein, we described a new class of uncharged non-pyridinium reactivators for nerve agent-inhibited acetylcholinesterase (AChE). Based on a dual site binding strategy, we conjugated the imidazolium aldoxime to different peripheral site ligands (PSLs) of ... ...

Abstract	Herein, we described a new class of uncharged non-pyridinium reactivators for nerve agent-inhibited acetylcholinesterase (AChE). Based on a dual site binding strategy, we conjugated the imidazolium aldoxime to different peripheral site ligands (PSLs) of AChE through alkyl chains. Compared with the known quaternary pyridinium reactivators, two of the resulting conjugates (7g and 7h) were highlighted to be the first efficient non-pyridinium oxime conjugates exhibiting similar or superior ability to reactivate sarin-, VX- and tabun-inhibited AChE. Moreover, they were more broad-spectrum reactivators.
MeSH term(s)	Acetylcholinesterase/chemistry ; Acetylcholinesterase/metabolism ; Binding Sites ; Chemical Warfare Agents/chemistry ; Cholinesterase Reactivators/chemical synthesis ; Cholinesterase Reactivators/chemistry ; Cholinesterase Reactivators/metabolism ; Humans ; Imidazoles/chemistry ; Kinetics ; Ligands ; Molecular Docking Simulation ; Oximes/chemical synthesis ; Oximes/chemistry ; Oximes/metabolism ; Protein Binding ; Protein Structure, Tertiary
Chemical Substances	Chemical Warfare Agents ; Cholinesterase Reactivators ; Imidazoles ; Ligands ; Oximes ; imidazole (7GBN705NH1) ; Acetylcholinesterase (EC 3.1.1.7) ; acetaldehyde oxime (ME6U10SD7D)
Language	English
Publishing date	2014-12-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1063195-1
ISSN	1464-3405 ; 0960-894X
ISSN (online)	1464-3405
ISSN	0960-894X
DOI	10.1016/j.bmcl.2014.10.055
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Article ; Online: Novel nonquaternary reactivators showing reactivation efficiency for soman-inhibited human acetylcholinesterase.

Wei, Zhao / Liu, Yan-Qin / Wang, Yong-An / Li, Wan-Hua / Zhou, Xin-Bo / Zhao, Jian / Huang, Chun-Qian / Li, Xing-Zhou / Liu, Jia / Zheng, Zhi-Bing / Li, Song

Toxicology letters

2016 Volume 246, Page(s) 1–6

Abstract: Soman is a highly toxic nerve agent with strong inhibition of acetylcholinesterase (AChE), but of the few reactivators showing antidotal efficiency for soman-inhibited AChE presently are all permanently charged cationic oximes with poor penetration of ... ...

Abstract	Soman is a highly toxic nerve agent with strong inhibition of acetylcholinesterase (AChE), but of the few reactivators showing antidotal efficiency for soman-inhibited AChE presently are all permanently charged cationic oximes with poor penetration of the blood-brain barrier. To overcome this problem, uncharged reactivators have been designed and synthesized, but few of them were efficient for treating soman poisoning. Herein, we used a dual site biding strategy to develop more efficient uncharged reactivators. The ortho-hydroxylbenzaldoximes were chosen as reactivation ligands of AChE to prevent the secondary poisoning of AChE, and simple aromatic groups were used as peripheral site ligands of AChE, which were linked to the oximes in a similar way as that found in the reactivator HI-6. The in vitro experiment demonstrated that some of the resulting conjugates have robust activity against soman-inhibited AChE, and oxime 8b was highlighted as the most efficient one. Although not good as HI-6 in vitro, these new compounds hold promise for development of more efficient centrally acting reactivators for soman poisoning due to their novel nonquaternary structures, which are predicted to be able to cross the blood-brain barrier.
MeSH term(s)	Blood-Brain Barrier ; Cholinesterase Inhibitors/poisoning ; Cholinesterase Reactivators/chemical synthesis ; Cholinesterase Reactivators/pharmacology ; Humans ; Oximes/pharmacokinetics ; Oximes/pharmacology ; Pyridinium Compounds/pharmacokinetics ; Pyridinium Compounds/pharmacology ; Soman/poisoning
Chemical Substances	Cholinesterase Inhibitors ; Cholinesterase Reactivators ; Oximes ; Pyridinium Compounds ; Soman (96-64-0) ; asoxime chloride (HUV88P6SJS)
Language	English
Publishing date	2016-03-30
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	433788-8
ISSN	1879-3169 ; 0378-4274
ISSN (online)	1879-3169
ISSN	0378-4274
DOI	10.1016/j.toxlet.2016.01.015
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Zs.A 1367: Show issues

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Article ; Online: Monoclonal antibody, mAb 4C13, an effective detoxicant antibody against ricin poisoning.

Dong, Na / Luo, Longlong / Wu, Junhua / Jia, Peiyuan / Li, Qian / Wang, Yuxia / Gao, Zhongcai / Peng, Hui / Lv, Ming / Huang, Chunqian / Feng, Jiannan / Li, Hua / Shan, Junjie / Han, Gang / Shen, Beifen

Vaccine

2015 Volume 33, Issue 32, Page(s) 3836–3842

Abstract: Ricin is a glycoprotein produced in castor seeds and consists of two polypeptide chains named Ricin Toxin A Chain (RTA) and Ricin Toxin B Chain (RTB), linked via a disulfide bridge. Due to its high toxicity, ricin is regarded as a high terrorist risk for ...

Abstract	Ricin is a glycoprotein produced in castor seeds and consists of two polypeptide chains named Ricin Toxin A Chain (RTA) and Ricin Toxin B Chain (RTB), linked via a disulfide bridge. Due to its high toxicity, ricin is regarded as a high terrorist risk for the public. However, antibodies can play a pivotal role in neutralizing the toxin. In this research, the anti-toxicant effect of mAb 4C13, a monoclonal antibody (mAb) established using detoxicated ricin as the immunized antigen, was evaluated. Compared with mAb 4F2 and mAb 5G6, the effective mechanism of mAb 4C13 was analyzed by experiments relating to its cytotoxicity, epitope on ricin, binding kinetics with the toxin, its blockage on the protein synthesis inhibition induced by ricin and the intracelluar tracing of its complex with ricin. Our result indicated that mAb 4C13 could recognize and bind to RTA, RTB and exert its high affinity to the holotoxin. Both cytotoxicity and animal toxicity of ricin were well blocked by pre-incubating the toxin with mAb 4C13. By intravenous injection, mAb 4C13 could rescue the mouse intraperitoneally (ip) injected with a lethal dose of ricin (20μg/kg) even at 6h after the intoxication and its efficacy was dependent on its dosage. This research indicated that mAb 4C13 could be an excellent candidate for therapeutic antibodies. Its potent antitoxic efficiency was related to its recognition on the specific epitope with very high affinity and its blockage of protein synthesis inhibition in cytoplasm followed by cellular internalization with ricin.
MeSH term(s)	Animals ; Antibodies, Monoclonal/isolation & purification ; Antibodies, Monoclonal/therapeutic use ; Antitoxins/isolation & purification ; Antitoxins/therapeutic use ; Disease Models, Animal ; Mice, Inbred BALB C ; Poisoning/therapy ; Ricin/antagonists & inhibitors ; Survival Analysis
Chemical Substances	Antibodies, Monoclonal ; Antitoxins ; Ricin (9009-86-3)
Language	English
Publishing date	2015-07-31
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2015.06.096
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