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  1. Article: A Hypoxia-Related miRNA-mRNA Signature for Predicting the Response and Prognosis of Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma.

    Zong, Shaoqi / Huang, Guokai / Pan, Bo / Zhao, Shasha / Ling, Changquan / Cheng, Binbin

    Journal of hepatocellular carcinoma

    2024  Volume 11, Page(s) 525–542

    Abstract: Purpose: Transcatheter arterial chemoembolization (TACE) is commonly used in the treatment of hepatocellular carcinoma (HCC). However, not all patients respond to this treatment. TACE typically leads to hypoxia in the tumor microenvironment. Therefore, ... ...

    Abstract Purpose: Transcatheter arterial chemoembolization (TACE) is commonly used in the treatment of hepatocellular carcinoma (HCC). However, not all patients respond to this treatment. TACE typically leads to hypoxia in the tumor microenvironment. Therefore, we aimed to construct a prognostic model based on hypoxia-related differentially expressed microRNA (miRNAs) in hepatocellular carcinoma (HCC) and to investigate the potential target mRNAs for predicting TACE response.
    Methods: The hypoxia-related miRNAs (HRMs) were identified in liver cancer cells, then global test was performed to further select the miRNAs which were associated with recurrence and vascular invasion. A prognostic model was constructed based on multivariate Cox regression analysis; qRT-PCR analysis was used to validate the differentially expressed miRNAs in HCC cell lines under hypoxic condition. We further identified the putative target genes of the miRNAs and investigate the relationship between the target genes and TACE response, immune cells infiltration.
    Results: We established a HRMs prognostic model for HCC patients, containing two miRNAs (miR-638, miR-501-5p), the patients with high-HRMs score showed worse survival in discovery and validation cohort; qRT-PCR analysis confirmed that these two miRNAs are up-regulated in hepatoma cells under hypoxic condition. Furthermore, four putative target genes of these two miRNAs were identified (ADH1B, CTH, FTCD, RCL1), which were significantly associated with TACE response, immune score, immunosuppressive immune cells infiltration, PDCD1 and CTLA4.
    Conclusion: The HCC-HRMs signature may be utilized as a promising prognostic factor and may have implications for guiding TACE and immune therapy.
    Language English
    Publishing date 2024-03-12
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2780784-8
    ISSN 2253-5969
    ISSN 2253-5969
    DOI 10.2147/JHC.S454698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The therapeutic principle of combined clearing heat and resolving toxin plus TACE on primary liver cancer: A systematic review and meta-analysis.

    Wang, Yuyao / Lin, Wanfu / Huang, Guokai / Nie, Shuchang / Yu, Qin / Hou, Fenggang / Zong, Shaoqi

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 1, Page(s) 117072

    Abstract: Ethnopharmacological relevance: Transcatheter arterial chemoembolization (TACE) is recommended as the first-line therapy for unresected primary liver cancer (PLC), but only partial patients could benefit from TACE due to the serious adverse reactions. ... ...

    Abstract Ethnopharmacological relevance: Transcatheter arterial chemoembolization (TACE) is recommended as the first-line therapy for unresected primary liver cancer (PLC), but only partial patients could benefit from TACE due to the serious adverse reactions. Clearing heat and resolving toxin (CHRT), one of most critical traditional Chinese medicine (TCM) therapeutic principles, has been widely used in the treatment of PLC patients especially after TACE. However, there is no enough clinical evidence to confirm the efficacy and safety of the combined therapy.
    Aim of the study: To comprehensively evaluate the efficacy and safety of the combined CHRT-CHF with TACE in the treatment of PLC.
    Materials and methods: 7 databases were searched from their inception until February 1, 2023. The primary outcomes included survival rate (1-, 2-year), objective response rate (ORR) and disease control rate (DCR), liver function indicators (AST, ALT), adverse reactions including fever, upper digestive tract side and myelosuppression, AFP were selected as the secondary outcomes. RevMan5.4 software was used to evaluate the quality of included studies; meta-analysis, subgroup analysis, meta-regression analysis, publication bias and trial sequential analyses (TSA) was conducted by Stata software 12.0.
    Results: There were 40 RCTs involving 3649 patients. Patients treated with TACE plus CHRT-CHF showed significantly better 1-, 2-year survival (respectively: OR, 2.23 [1.67-2.97]; OR, 2.13 [1.56-2.92]), ORR (OR, 2.14 [1.82-2.52]), DCR (OR, 2.13 [1.73-2.62]) compared with TACE alone. There was a decreased incidence of aspartate transaminase (AST), alanine transaminase (ALT), alpha-fetoprotein (AFP) and postembolization syndrome (PES) in patients receiving the combined TACE with CHRT-CHF compared with TACE alone. Subgroup analysis found that lower proportion (20-30%) of CHRT-CHF significantly enhanced survival rate and DCR, higher proportion (≥40%) of CHRT-CHF reduced PES after TACE treatment.
    Conclusion: The efficacy and safety of the combined CHRT-CHF with TACE were validated in this meta-analysis, the optimal proportion of CHRT-CHF in enhancing the efficacy may be 20-30%; Additionally, higher proportion (≥40%) of CHRT-CHF appears to reduce PES after TACE treatment. The potential role of combined relative proportion of CHRT-CHF with TACE should be emphasized in clinic.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/etiology ; Liver Neoplasms/drug therapy ; alpha-Fetoproteins ; Chemoembolization, Therapeutic/adverse effects ; Hot Temperature ; Treatment Outcome
    Chemical Substances alpha-Fetoproteins
    Language English
    Publishing date 2023-08-23
    Publishing country Ireland
    Document type Meta-Analysis ; Systematic Review ; Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: Effects of Corrosion Products Deposited on 304 Stainless Steel on Reduction of Se (IV/VI) in Simulated Groundwater.

    Huang, Guokai / Li, Teng / Zhang, Xian / Wang, Lingyu / Cui, Daqing / Yang, Miao

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 8

    Abstract: Selenium (Se) is a key mobile fission product in the geological disposal of nuclear waste. It is necessary to analyze the reductive deposition behavior of iron-based materials to Se(IV) and Se(VI) in groundwater. In the present work, the corrosion ... ...

    Abstract Selenium (Se) is a key mobile fission product in the geological disposal of nuclear waste. It is necessary to analyze the reductive deposition behavior of iron-based materials to Se(IV) and Se(VI) in groundwater. In the present work, the corrosion behavior of 304 stainless steel in simulated groundwater (SG) and the effects of corrosion products on the dissolution of Se were investigated by electrochemical and immersion tests. Experimental results revealed that passivation films formed on 304 stainless-steel samples were destroyed by polarization measurements, forming corrosion products consisting of Fe(II) compounds, such as Fe
    Language English
    Publishing date 2022-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15082705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Discrimination of Baphicacanthis Cusiae Rhizoma et radix and its adulterant species and establishment of an assay method for quality control.

    Li, Yue / Yu, Qiong-Xi / Yau, Lee-Fong / Huang, Guo-Kai / Lu, Jing-Guang / Liu, Xiao-Xiao / Jiang, Zhi-Hong / Wang, Jing-Rong

    Chinese medicine

    2023  Volume 18, Issue 1, Page(s) 65

    Abstract: Background: Baphicacanthis Cusiae Rhizoma et Radix, commonly known as Nan-Ban-Lan-Gen (NBLG), is an essential traditional Chinese medicine that possesses diverse bioactivities, particularly noteworthy for its antiviral properties. Although NBLG has been ...

    Abstract Background: Baphicacanthis Cusiae Rhizoma et Radix, commonly known as Nan-Ban-Lan-Gen (NBLG), is an essential traditional Chinese medicine that possesses diverse bioactivities, particularly noteworthy for its antiviral properties. Although NBLG has been listed in the Chinese Pharmacopoeia as an independent Chinese medicine, the establishment of a comprehensive quality standard for NBLG remains elusive. The absence of assay for marker compound in its quality standards has led to the lack of corresponding quality control measures for NBLG-containing preparations, and its discrimination from adulterant species in the market which thereby can significantly impact the efficacy and safety of NBLG-containing products.
    Methods: Ultra-high performance liquid chromatography (UHPLC) coupled with quadrupole-time-of-flight mass spectrometry (Q-TOF-MS) was employed for comprehensive profiling of the chemical constituents of NBLG, the stem of Baphicacanthus cusia (Nees) Bremek (NBLJ), and the roots of Isatis indigotica Fort. (Bei-Ban-Lan-Gen, BBLG). Additionally, multivariate analysis was conducted to compare the chemical components of NBLG with those of NBLJ and BBLG. Furthermore, we established an optimized and validated HPLC method to obtain the fingerprint of NBLG and quantify the content of 2-benzoxazolinone and acteoside in the samples.
    Results: A total of 73 compounds belonging to six classes were assigned in NBLG, with alkaloids being the most abundant and diverse species. High compositional similarities with significant differences in content were observed between NBLG and NBLJ. Moreover, the chemical profile of BBLG markedly differed from that of NBLG. An informative high performance liquid chromatography (HPLC) fingerprint of NBLG comprising seven characteristic peaks that can be used for quality assessment was established. Notably, we propose a quality control standard for NBLG, stipulating that the limit of content in dry weight for both 2-benzoxazolinone and acteoside should not be less than 0.010%.
    Conclusion: This study provides the most comprehensive chemical information to date on NBLG, offering valuable insights into its authentication and quality control. Our findings highlight the importance of comprehensive chemical profiling to differentiate potential substitutions and adulterations of herbal medicines, particularly when the original source is scarce or unavailable. These results can aid in the development of quality control measures for NBLG-containing preparations, ensuring their safety and efficacy.
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-023-00777-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Autophagy plays a pro-apoptotic role in arsenic trioxide-induced cell death of liver cancer.

    Deng, Zheng-Ting / Liang, Shu-Fang / Huang, Guo-Kai / Wang, Yu-Qian / Tu, Xiao-Yu / Zhang, Ya-Ni / Li, Shu / Liu, Tao / Cheng, Bin-Bin

    Journal of integrative medicine

    2024  

    Abstract: Objective: The effects of arsenic trioxide (As: Methods: The viability of hepatoma cells was determined using the MTT assay with or without fetal bovine serum. The rate of apoptosis in liver cancer cells treated with As: Results: Upon treatment ... ...

    Abstract Objective: The effects of arsenic trioxide (As
    Methods: The viability of hepatoma cells was determined using the MTT assay with or without fetal bovine serum. The rate of apoptosis in liver cancer cells treated with As
    Results: Upon treatment with As
    Conclusion: As
    Language English
    Publishing date 2024-03-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2705612-0
    ISSN 2095-4964
    ISSN 2095-4964
    DOI 10.1016/j.joim.2024.03.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6322: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Effects of Different Ions and Temperature on Corrosion Behavior of Pure Iron in Anoxic Simulated Groundwater.

    Li, Teng / Huang, Guokai / Feng, Yanpeng / Yang, Miao / Wang, Lingyu / Cui, Daqing / Zhang, Xian

    Materials (Basel, Switzerland)

    2020  Volume 13, Issue 12

    Abstract: As a typical material of the insert in high-level radioactive waste (HLW) geological disposal canisters, iron-based materials will directly contact with groundwater after the failure of a metallic canister, acting as a chemical barrier to prevent HLW ... ...

    Abstract As a typical material of the insert in high-level radioactive waste (HLW) geological disposal canisters, iron-based materials will directly contact with groundwater after the failure of a metallic canister, acting as a chemical barrier to prevent HLW leaking into groundwater. In this paper, anoxic groundwater was simulated by mixing 10 mM NaCl and 2 mM NaHCO
    Language English
    Publishing date 2020-06-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma13122713
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: UDCA Inhibits Hypoxic Hepatocellular Carcinoma Cell-Induced Angiogenesis Through Suppressing HIF-1α/VEGF/IL-8 Intercellular Signaling.

    Lin, Wanfu / Li, Shu / Meng, Yongbin / Huang, Guokai / Liang, Shufang / Du, Juan / Liu, Qun / Cheng, Binbin

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 755394

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.755394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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