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Article: [Impact of hypoxic-ischemic injury on brain development in neonatal rats of different sexes].

Huang, H Z / Wen, X H / Liu, H / Tang, H B / Chen, N / Yuan, Z X

Zhonghua er ke za zhi = Chinese journal of pediatrics

2019 Volume 58, Issue 1, Page(s) 30–34

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Animals ; Animals, Newborn ; Brain ; Disease Models, Animal ; Female ; Humans ; Hypoxia-Ischemia, Brain/mortality ; Male ; Random Allocation ; Rats ; Rats, Sprague-Dawley
Language	Chinese
Publishing date	2019-12-31
Publishing country	China
Document type	Journal Article
ZDB-ID	784523-6
ISSN	0578-1310
ISSN	0578-1310
DOI	10.3760/cma.j.issn.0578-1310.2020.01.008
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Article: [Economic burden of hepatitis C patients and related influencing factors in Guangdong province].

Wu, Q M / Li, Y / Fu, X B / Yang, F / Li, J / Huang, H Z / Yan, J / Lin, P

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi

2018 Volume 39, Issue 7, Page(s) 931–936

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adult ; China/epidemiology ; Cities ; Cost of Illness ; Female ; Health Care Costs/statistics & numerical data ; Hepatitis B/epidemiology ; Hepatitis C/drug therapy ; Hepatitis C/economics ; Hospitalization ; Humans ; Liver Cirrhosis/economics ; Liver Cirrhosis/epidemiology ; Male ; Surveys and Questionnaires
Language	Chinese
Publishing date	2018-07-30
Publishing country	China
Document type	Journal Article
ZDB-ID	645026-x
ISSN	0254-6450
ISSN	0254-6450
DOI	10.3760/cma.j.issn.0254-6450.2018.07.013
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Article ; Online: Clinical practice guideline for image-guided multimode tumour ablation therapy in hepatic malignant tumours.

Wang, G Z / He, X H / Wang, Y / Xu, L C / Huang, H Z / Wang, Y H / Shen, Z / Qu, X D / Ding, X Y / Yang, J J / Li, W T

Current oncology (Toronto, Ont.)

2019 Volume 26, Issue 5, Page(s) e658–e664

Abstract: Multimode tumour ablation therapy is a treatment method that combines cryoablation with radiofrequency ablation, guided by medical imaging technology and based on precise planning, targeting, monitoring, and control of the thermal energy delivered, with ... ...

Abstract	Multimode tumour ablation therapy is a treatment method that combines cryoablation with radiofrequency ablation, guided by medical imaging technology and based on precise planning, targeting, monitoring, and control of the thermal energy delivered, with the aim of achieving a whole-body antitumour immune response to malignant tumours. To develop standardized criteria for the application of multimode tumour ablation therapy to malignant hepatic tumours, to facilitate actualization of the criteria in various hospitals, and to ensure therapeutic efficacy and safety, the Society of Interventional Therapy of the Chinese Anti-Cancer Association and the Solid Tumor Theranostics Committee of the Shanghai Anti-Cancer Association assembled experts who specialize in oncology to discuss this treatment method and to arrive at a clinical practice consensus guideline for the indications, contraindications, and techniques of multimode tumour ablation therapy for malignant hepatic tumours.
MeSH term(s)	Catheter Ablation ; Consensus ; Humans ; Liver/surgery ; Liver Neoplasms/surgery ; Surgery, Computer-Assisted
Language	English
Publishing date	2019-10-01
Publishing country	Canada
Document type	Journal Article ; Practice Guideline ; Research Support, Non-U.S. Gov't
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3747/co.26.5423
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Article ; Online: Assessment of the cryoablation margin using MRI-CT fusion imaging in hepatic malignancies.

Chen, C / Xu, L C / Wang, Y / Wang, Y H / Li, G D / Huang, H Z / Wang, B / Li, W T / He, X H

Clinical radiology

2019 Volume 74, Issue 8, Page(s) 652.e21–652.e28

Abstract: Aim: To demonstrate the feasibility of magnetic resonance imaging (MRI)-computed tomography (CT) fusion imaging for the assessment of the ablative margin after cryoablation in hepatic malignancies.: Materials and methods: This retrospective study ... ...

Abstract	Aim: To demonstrate the feasibility of magnetic resonance imaging (MRI)-computed tomography (CT) fusion imaging for the assessment of the ablative margin after cryoablation in hepatic malignancies. Materials and methods: This retrospective study analysed 35 patients with 47 liver tumours treated with CT-guided cryoablation. Fusion images of pre-ablation MRI and intraoperative CT data were created on a workstation. Minimal ablative margin (MAM) assessment was categorised into three groups: (I) MAM <0 mm (tumour protruded through the ablation zone), (II) MAM 0-5 mm, and (III) MAM ≥5 mm. Local tumour progression (LTP) was assessed during follow-up. Results: MRI-CT fusion imaging was successfully achieved in 46 (97.9%) of 47 lesions. LTP was detected in 67.4% (31/46) of cases. Twenty-four (77.4%) of 31 LTPs occurred in the subcapsular region of the liver. Using fusion images, the MAM was classified as groups I, II, and III in 18, 25, and three tumours, respectively. In group I, LTP was found in 15 (83.3%) of 18 lesions, whereas in group II, LTP was detected in 16 (64%) of 25 lesions. The cumulative LTP rate in group II was significantly lower than that in group I (p=0.012). Conclusion: Pre-ablation MRI and intraoperative CT fusion imaging is feasible and useful for evaluating the MAM of cryoablation in hepatic malignancies.
MeSH term(s)	Adult ; Aged ; Cryosurgery/methods ; Feasibility Studies ; Humans ; Liver/diagnostic imaging ; Liver/surgery ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/surgery ; Magnetic Resonance Imaging/methods ; Male ; Margins of Excision ; Middle Aged ; Multimodal Imaging/methods ; Retrospective Studies ; Tomography, X-Ray Computed/methods
Language	English
Publishing date	2019-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	391227-9
ISSN	1365-229X ; 0009-9260
ISSN (online)	1365-229X
ISSN	0009-9260
DOI	10.1016/j.crad.2019.03.021
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Article ; Online: Transarterial chemoembolization with raltitrexed-based or floxuridine-based chemotherapy for unresectable colorectal cancer liver metastasis.

Wei, N / Zhang, B / Wang, Y / He, X H / Xu, L C / Li, G D / Wang, Y H / Wang, G Z / Huang, H Z / Li, W T

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2018 Volume 21, Issue 4, Page(s) 443–450

Abstract: Purpose: To evaluate and compare the efficiency and safety of raltitrexed- or floxuridine (FUDR)-based transarterial chemoembolization (TACE) in patients with unresectable colorectal cancer liver metastasis (CRCLM).: Methods: We conducted a ... ...

Abstract	Purpose: To evaluate and compare the efficiency and safety of raltitrexed- or floxuridine (FUDR)-based transarterial chemoembolization (TACE) in patients with unresectable colorectal cancer liver metastasis (CRCLM). Methods: We conducted a retrospective analysis of 81 patients with unresectable CRCLM who failed systemic chemotherapy and were treated with TACE in our department from Oct 2014 to Oct 2017. Of these, 61 patients received TACE using raltitrexed, oxaliplatin, and pirarubicin (raltitrexed group), and 20 received TACE using FUDR, oxaliplatin, and pirarubicin (FUDR group). The objective response rate (ORR), disease control rate (DCR), overall survival (OS, from the first TACE), progression-free survival (PFS, from the first TACE), and adverse reactions were evaluated and compared between the two groups, and prognostic factors for OS were analyzed. Results: The ORRs of the raltitrexed group and FUDR group were 67.2 and 45.0%, respectively (P = 0.076), and the DCRs were 86.9 and 80.0%, respectively (P = 0.452). The median OS (from first TACE) was 14.0 months in the raltitrexed group and 13.0 months in the FUDR group (P = 0.556). The median PFS (from first TACE) was 2.1 months in the raltitrexed group and 2.4 months in the FUDR group (P = 0.878). Univariate and multivariate analyses showed that the primary tumor site, Child-Pugh class, and combination with local ablation (RFA or CRA) were independent significant factors affecting survival. There were no significant differences in adverse reactions between the two groups (P > 0.05), and no treatment-related death occurred in either group. Conclusion: TACE treatment based on raltitrexed or FUDR is an efficient and safe alternative choice for treating unresectable CRCLM.
MeSH term(s)	Aged ; Antineoplastic Combined Chemotherapy Protocols/administration & dosage ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Chemoembolization, Therapeutic ; Colorectal Neoplasms/pathology ; Female ; Floxuridine/administration & dosage ; Floxuridine/adverse effects ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Male ; Middle Aged ; Prognosis ; Quinazolines/administration & dosage ; Quinazolines/adverse effects ; Retrospective Studies ; Survival Analysis ; Thiophenes/administration & dosage ; Thiophenes/adverse effects ; Treatment Outcome
Chemical Substances	Quinazolines ; Thiophenes ; Floxuridine (039LU44I5M) ; raltitrexed (FCB9EGG971)
Language	English
Publishing date	2018-10-10
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-018-1942-0
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Article ; Online: Genetic mechanism associated with congenital cytomegalovirus infection and analysis of effects of the infection on pregnancy outcome.

Li, J M / Zhang, H F / Zhang, X Q / Huang, G L / Huang, H Z / Yu, W W

Genetics and molecular research : GMR

2015 Volume 14, Issue 4, Page(s) 13247–13257

Abstract: We aimed to compare the diagnostic value of various detection methods for cytomegalovirus (CMV) infection, to investigate the genetic mechanism associated with CMV infection in pregnant women, and to analyze the risk of sequelae development in fetuses ... ...

Abstract	We aimed to compare the diagnostic value of various detection methods for cytomegalovirus (CMV) infection, to investigate the genetic mechanism associated with CMV infection in pregnant women, and to analyze the risk of sequelae development in fetuses with CMV infection. A total of 300 participants who had the same immunosuppressive regimen and received preemptive therapy for CMV infection were prospectively enrolled in this study; they included 289 vaccine trial participants. The gB-absorbed CMV IgG assay was performed for each vaccine trial participant. The healthy women were divided into 2 groups, and amniotic fluids were collected from them at 15-18 weeks of gestation to test for CMV seropositivity before conception by using IgM specific antibodies, CMV-DNA, and IgG analysis. In 104 cases, cord blood sera and urine specimens were also collected from the infants and examined. The sensitivity and specificity of immediate-early messenger RNA and pp67 (late) messenger RNA detection by the nucleic acid sequence-based amplification technique was comparable to those of virus isolation and PCR. Furthermore, an association between single nucleotide polymorphisms in the TLR-2 gene and congenital CMV infection was observed and confirmed. Moreover, CMV infection during early pregnancy has been shown to have a much more severe effect on the pregnancy outcome compared to infection during later stages of pregnancy.
MeSH term(s)	Adult ; Alleles ; Antibodies, Viral/immunology ; Birth Weight ; Case-Control Studies ; Cytomegalovirus/classification ; Cytomegalovirus/genetics ; Cytomegalovirus/immunology ; Cytomegalovirus Infections/congenital ; Cytomegalovirus Infections/diagnosis ; Cytomegalovirus Infections/epidemiology ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/prevention & control ; Cytomegalovirus Vaccines/immunology ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Gestational Age ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin M/immunology ; Infant, Newborn ; Male ; Polymorphism, Single Nucleotide ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/genetics ; Pregnancy Complications, Infectious/prevention & control ; Pregnancy Outcome ; Prenatal Diagnosis/methods ; Sensitivity and Specificity
Chemical Substances	Antibodies, Viral ; Cytomegalovirus Vaccines ; Immunoglobulin G ; Immunoglobulin M
Language	English
Publishing date	2015-10-27
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2114039-X
ISSN	1676-5680 ; 1676-5680
ISSN (online)	1676-5680
ISSN	1676-5680
DOI	10.4238/2015.October.26.21
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Article: [Histiocytosis X involving the oral and maxillofacial area].

Huang, H Z

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology

1987 Volume 22, Issue 3, Page(s) 178–9, 190–1

MeSH term(s)	Adolescent ; Adult ; Child ; Child, Preschool ; Eosinophilic Granuloma/diagnosis ; Female ; Histiocytosis, Langerhans-Cell/diagnosis ; Humans ; Jaw Diseases/diagnosis ; Male ; Middle Aged ; Mouth Diseases/diagnosis
Language	Chinese
Publishing date	1987-05
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	1027950-7
ISSN	1002-0098
ISSN	1002-0098
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Article: [Therapeutic effect of traditional Chinese medicine-western medicine on severe jaundice of hepatitis].

Huang, H Z

Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine

1984 Volume 4, Issue 2, Page(s) 84–85

MeSH term(s)	Adrenal Cortex Hormones/therapeutic use ; Hepatitis/drug therapy ; Humans ; Jaundice/drug therapy ; Medicine, Chinese Traditional ; Medicine, East Asian Traditional
Chemical Substances	Adrenal Cortex Hormones
Language	Chinese
Publishing date	1984-02
Publishing country	China
Document type	English Abstract ; Journal Article
ISSN	0254-9034
ISSN	0254-9034
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Article ; Online: Synthetic radiation-inducible promoters mediated HSV-TK/GCV gene therapy in the treatment of oral squamous cell carcinoma.

Yu, D-S / Zhao, W / Huang, H-Z / Hu, X-W / Liu, X-Q / Tang, H-K

Oral diseases

2010 Volume 16, Issue 5, Page(s) 445–452

Abstract: Objective: To investigate the therapeutic effect of herpes simplex virus thymidine kinase (HSV-TK) gene mediated by synthetic radiation-inducible promoters in the treatment of oral squamous cell carcinoma (OSCC) in vitro and in vivo.: Methods: The ... ...

Abstract	Objective: To investigate the therapeutic effect of herpes simplex virus thymidine kinase (HSV-TK) gene mediated by synthetic radiation-inducible promoters in the treatment of oral squamous cell carcinoma (OSCC) in vitro and in vivo. Methods: The plasmids pcDNA3.1(+)E6-HSV-TK were constructed, in which the HSV-TK genes were mediated by synthetic radiation-inducible promoters. The recombined plasmids were transfected into the Tca8113 cells and golden hamster buccal carcinoma, respectively. Low-dose radiotherapy was used to upregulate the HSV-TK genes expression. HSV-TK mRNA was assayed by RT-PCR. Apoptosis and proliferating cell nuclear antigen were detected respectively by in situ end-labeling and immunohistochemical method. Results: Compared with control group, the comparative survival rate of Tca8113 cells in HSV-TK/GCV/IR group was markedly decreased and the golden hamster buccal carcinoma in HSV-TK/GCV/IR group was obviously suppressed. Up-regulation of HSV-TK gene expression was found in the Tca8113 cells and in the golden hamster buccal carcinoma resulting from exposure to low-dose irradiation. The apoptosis indexes in Tca8113 cells or golden hamster buccal carcinoma with irradiation were markedly higher than those without irradiation. At the same time, the proliferation indexes in Tca8113 cells or golden hamster buccal carcinoma with irradiation were markedly lower than those without irradiation. Conclusion: The results indicate that the synthetic radiation-inducible promoters can serve as a molecular switch to adjust the expression of HSV-TK gene in the treatment of OSCC, and low-dose induction radiation can significantly improve therapeutic efficiency.
MeSH term(s)	Animals ; Apoptosis/physiology ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Cell Line, Tumor ; Cell Proliferation ; Cell Survival/physiology ; Cricetinae ; Disease Models, Animal ; Gene Expression Regulation, Enzymologic/genetics ; Gene Expression Regulation, Enzymologic/radiation effects ; Genetic Therapy ; Genetic Vectors/genetics ; Humans ; Mouth Neoplasms/pathology ; Mouth Neoplasms/therapy ; Plasmids/genetics ; Proliferating Cell Nuclear Antigen/analysis ; Promoter Regions, Genetic/genetics ; Promoter Regions, Genetic/radiation effects ; Radiation Dosage ; Simplexvirus/enzymology ; Simplexvirus/genetics ; Thymidine Kinase/genetics ; Thymidine Kinase/therapeutic use ; Transfection/methods ; Up-Regulation/radiation effects
Chemical Substances	Proliferating Cell Nuclear Antigen ; Thymidine Kinase (EC 2.7.1.21)
Language	English
Publishing date	2010-07
Publishing country	Denmark
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1290529-x
ISSN	1601-0825 ; 1354-523X
ISSN (online)	1601-0825
ISSN	1354-523X
DOI	10.1111/j.1601-0825.2010.01655.x
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Article ; Online: Measurement of the 2νββ Decay Rate and Spectral Shape of ^{100}Mo from the CUPID-Mo Experiment.

Augier, C / Barabash, A S / Bellini, F / Benato, G / Beretta, M / Bergé, L / Billard, J / Borovlev, Yu A / Cardani, L / Casali, N / Cazes, A / Celi, E / Chapellier, M / Chiesa, D / Dafinei, I / Danevich, F A / De Jesus, M / Dixon, T / Dumoulin, L /

Eitel, K / Ferri, F / Fujikawa, B K / Gascon, J / Gironi, L / Giuliani, A / Grigorieva, V D / Gros, M / Helis, D L / Huang, H Z / Huang, R / Imbert, L / Johnston, J / Juillard, A / Khalife, H / Kleifges, M / Kobychev, V V / Kolomensky, Yu G / Konovalov, S I / Kotila, J / Loaiza, P / Ma, L / Makarov, E P / de Marcillac, P / Mariam, R / Marini, L / Marnieros, S / Navick, X-F / Nones, C / Norman, E B / Olivieri, E / Ouellet, J L / Pagnanini, L / Pattavina, L / Paul, B / Pavan, M / Peng, H / Pessina, G / Pirro, S / Poda, D V / Polischuk, O G / Pozzi, S / Previtali, E / Redon, Th / Rojas, A / Rozov, S / Sanglard, V / Scarpaci, J A / Schmidt, B / Shen, Y / Shlegel, V N / Šimkovic, F / Singh, V / Tomei, C / Tretyak, V I / Umatov, V I / Vagneron, L / Velázquez, M / Ware, B / Welliver, B / Winslow, L / Xue, M / Yakushev, E / Zarytskyy, M / Zolotarova, A S

Physical review letters

2023 Volume 131, Issue 16, Page(s) 162501

Abstract: Neutrinoless double beta decay (0νββ) is a yet unobserved nuclear process that would demonstrate Lepton number violation, a clear evidence of beyond standard model physics. The process two neutrino double beta decay (2νββ) is allowed by the standard ... ...

Abstract	Neutrinoless double beta decay (0νββ) is a yet unobserved nuclear process that would demonstrate Lepton number violation, a clear evidence of beyond standard model physics. The process two neutrino double beta decay (2νββ) is allowed by the standard model and has been measured in numerous experiments. In this Letter, we report a measurement of 2νββ decay half-life of ^{100}Mo to the ground state of ^{100}Ru of [7.07±0.02(stat)±0.11(syst)]×10^{18} yr by the CUPID-Mo experiment. With a relative precision of ±1.6% this is the most precise measurement to date of a 2νββ decay rate in ^{100}Mo. In addition, we constrain higher-order corrections to the spectral shape, which provides complementary nuclear structure information. We report a novel measurement of the shape factor ξ_{3,1}=0.45±0.03(stat)±0.05(syst) based on a constraint on the ratio of higher-order terms from theory, which can be reliably calculated. This is compared to theoretical predictions for different nuclear models. We also extract the first value for the effective axial vector coupling constant obtained from a spectral shape study of 2νββ decay.
Language	English
Publishing date	2023-11-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.131.162501
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