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Article ; Online: Endoskeleton Soft Multi-Fingered Hand with Variable Stiffness.

Pan, Dayu / Yan, Peng / Li, Yunong / Huang, Hailin / Li, Bing / Liu, Honghai

Soft robotics

2024

Abstract: The use of a soft multi-fingered hand in handling fragile objects has been widely acknowledged. Nevertheless, high flexibility often results in decreased load capacity, necessitating the need for variable stiffness. This article introduces a new soft ... ...

Abstract	The use of a soft multi-fingered hand in handling fragile objects has been widely acknowledged. Nevertheless, high flexibility often results in decreased load capacity, necessitating the need for variable stiffness. This article introduces a new soft multi-fingered hand featuring variable stiffness. The finger of the hand has three chambers and an endoskeleton mechanism. Two chambers facilitate bending and swinging motions, whereas the third adjusts stiffness. An endoskeleton mechanism is embedded in the third chamber, and the friction between its moving parts increases as negative air pressure rises, causing the finger's stiffness to increase. This mechanism can alter its stiffness in any configuration, which is particularly useful in manipulating irregular-shaped fragile objects post-grasping. The effectiveness of the proposed soft multi-fingered hand is validated through five experiments: stiffness adjustment, finger stiffening under a specific orientation, bulb screwing, heavy object lifting, and bean curd grasping. The results demonstrate that the proposed soft multi-fingered hand exhibits robust grasping capabilities for various fragile objects.
Language	English
Publishing date	2024-04-17
Publishing country	United States
Document type	Journal Article
ISSN	2169-5180
ISSN (online)	2169-5180
DOI	10.1089/soro.2023.0039
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Article ; Online: Inflatable Metamorphic Origami.

Wang, Sen / Yan, Peng / Huang, Hailin / Zhang, Ning / Li, Bing

Research (Washington, D.C.)

2023 Volume 6, Page(s) 133

Abstract: This study created a new type of inflatable metamorphic origami that has the advantage of being a highly simplified deployable system capable of realizing multiple sequential motion patterns with a monolithic actuation. The main body of the proposed ... ...

Abstract	This study created a new type of inflatable metamorphic origami that has the advantage of being a highly simplified deployable system capable of realizing multiple sequential motion patterns with a monolithic actuation. The main body of the proposed metamorphic origami unit was designed as a soft inflatable metamorphic origami chamber with multiple sets of contiguous/collinear creases. In response to pneumatic pressure, the metamorphic motions are characterized by an initial unfolding around the first set of contiguous/collinear creases followed by another unfolding around the second set of contiguous/collinear creases. Furthermore, the effectiveness of the proposed approach was verified by constructing a radial deployable metamorphic origami for supporting the deployable planar solar array, a circumferential deployable metamorphic origami for supporting the deployable curved-surface antenna, a multi-fingered deployable metamorphic origami grasper for grasping large-sized objects, and a leaf-shaped deployable metamorphic origami grasper for capturing heavy objects. The proposed novel metamorphic origami is expected to serve as a foundation for designing lightweight, high-deploy/fold-ratio, low-energy-consumption space deployable systems.
Language	English
Publishing date	2023-05-04
Publishing country	United States
Document type	Journal Article
ISSN	2639-5274
ISSN (online)	2639-5274
DOI	10.34133/research.0133
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Article: Research advances in imaging markers for predicting hematoma expansion in intracerebral hemorrhage: a narrative review.

Huang, Yong-Wei / Huang, Hai-Lin / Li, Zong-Ping / Yin, Xiao-Shuang

Frontiers in neurology

2023 Volume 14, Page(s) 1176390

Abstract: Introduction: Stroke is a major global health concern and is ranked as the second leading cause of death worldwide, with the third highest incidence of disability. Intracerebral hemorrhage (ICH) is a devastating form of stroke that is responsible for a ... ...

Abstract	Introduction: Stroke is a major global health concern and is ranked as the second leading cause of death worldwide, with the third highest incidence of disability. Intracerebral hemorrhage (ICH) is a devastating form of stroke that is responsible for a significant proportion of stroke-related morbidity and mortality worldwide. Hematoma expansion (HE), which occurs in up to one-third of ICH patients, is a strong predictor of poor prognosis and can be potentially preventable if high-risk patients are identified early. In this review, we provide a comprehensive summary of previous research in this area and highlight the potential use of imaging markers for future research studies. Recent advances: Imaging markers have been developed in recent years to aid in the early detection of HE and guide clinical decision-making. These markers have been found to be effective in predicting HE in ICH patients and include specific manifestations on Computed Tomography (CT) and CT Angiography (CTA), such as the spot sign, leakage sign, spot-tail sign, island sign, satellite sign, iodine sign, blend sign, swirl sign, black hole sign, and hypodensities. The use of imaging markers holds great promise for improving the management and outcomes of ICH patients. Conclusion: The management of ICH presents a significant challenge, and identifying high-risk patients for HE is crucial to improving outcomes. The use of imaging markers for HE prediction can aid in the rapid identification of such patients and may serve as potential targets for anti-HE therapies in the acute phase of ICH. Therefore, further research is needed to establish the reliability and validity of these markers in identifying high-risk patients and guiding appropriate treatment decisions.
Language	English
Publishing date	2023-04-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1176390
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Article ; Online: Comparative evaluation of double- and single-armed two-suture longitudinal intussusception techniques in microsurgical vasoepididymostomy: An updated systematic review and meta-analysis.

Xiao, Hong / Zhou, Shan / Chen, Qiang / Ding, Yilang / Yang, Peng / Huang, Hailin / Chen, Xi / Zhou, Huiliang / Tang, Songxi

PloS one

2024 Volume 19, Issue 2, Page(s) e0298019

Abstract: Background: This study aimed to compare the outcomes of double-armed two-suture longitudinal intussusception microsurgical vasoepididymostomy (LIVE) and single-armed two-suture LIVE techniques in patients with epididymal obstructive azoospermia (EOA). ... ...

Abstract	Background: This study aimed to compare the outcomes of double-armed two-suture longitudinal intussusception microsurgical vasoepididymostomy (LIVE) and single-armed two-suture LIVE techniques in patients with epididymal obstructive azoospermia (EOA). The main outcomes assessed were patency rates, patency time, semen quality and natural pregnancy rates. Methods: Data from patients with EOA who underwent two-suture LIVE were obtained from databases including PubMed, EMBASE, and Web of Science. Weighted data were analyzed using a random-effects model, and weighted mean differences were reported. Results: A total of 1574 patients with EOA from 24 studies were included. The overall patency rate was approximately 68% (95% confidence interval [CI]: 63-72%), with a patency time of approximately 4.63 months (95% CI: 4.15-5.12). The sperm concentration reached 26.90 million/ml and the sperm motility was 23.74%. The natural pregnancy rate was 38% (95% CI: 31-46%). The different definitions of patency do not seem to have any meaningful impact when comparing patency rates. There was no significant difference in patency rates, patency time, semen quality and natural pregnancy rates between the double-armed and single-armed LIVE techniques. Conclusion: The single-armed LIVE is a potential alternative surgical option when high quality double-needle sutures are not easily accessible.
MeSH term(s)	Pregnancy ; Female ; Humans ; Male ; Semen Analysis ; Intussusception ; Treatment Outcome ; Sperm Motility ; Microsurgery/methods ; Semen ; Epididymis/surgery ; Azoospermia/surgery ; Sutures ; Vas Deferens/surgery
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0298019
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Article ; Online: Association between anti-Müllerian hormone concentrations and sperm retrieval outcomes in patients with idiopathic nonobstructive azoospermia: a systematic review and meta-analysis.

Xiao, Hong / Ding, Yi-Lang / Yang, Peng / Chen, Qiang / Huang, Hai-Lin / Chen, Xi / Zhou, Hui-Liang / Tang, Song-Xi

Asian journal of andrology

2024

Abstract: Abstract: Microdissection testicular sperm extraction (mTESE) is commonly performed to retrieve sperm in the testes for assisted reproductive techniques in patients with idiopathic nonobstructive azoospermia (iNOA). However, the success rate of sperm ... ...

Abstract	Abstract: Microdissection testicular sperm extraction (mTESE) is commonly performed to retrieve sperm in the testes for assisted reproductive techniques in patients with idiopathic nonobstructive azoospermia (iNOA). However, the success rate of sperm retrieval varies among individuals. We aim to investigate the association between clinical parameters and sperm retrieval outcomes in patients with iNOA. We searched PubMed, EMBASE, and Web of Science from database inception to August 2, 2023. The main measure was whether sperm retrieval was successful in patients with iNOA who underwent mTESE. Pooled estimates of the sperm retrieval rate and weighted mean differences were calculated using random-effects models. The overall sperm retrieval rate was 36.8% (95% confidence interval [CI]: 27.5%-46.0%, I2 = 95.0%) in nine studies comprising 1892 patients with iNOA. No significant differences were found in age, testicular volume, serum total testosterone concentrations, or inhibin B concentrations between positive and negative sperm retrieval outcomes. Lower anti-Müllerian hormone concentrations in patients with iNOA were associated with a positive outcome of mTESE (weighted mean differences: -2.70; 95% CI: -3.94--1.46, I2 = 79.0%). In conclusion, this study shows a significant relationship between anti-Müllerian hormone and sperm retrieval outcomes in patients with iNOA, while age, testicular volume, total testosterone, and inhibin B show no significant association. These findings have important implications for assessing the potential success of sperm retrieval and selecting appropriate treatment strategies in patients with iNOA.
Language	English
Publishing date	2024-05-14
Publishing country	China
Document type	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja202419
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Article ; Online: High-dimensional single-index models with censored responses.

Huang, Hailin / Shangguan, Jizi / Li, Xinmin / Liang, Hua

Statistics in medicine

2020 Volume 39, Issue 21, Page(s) 2743–2754

Abstract: In this article, we study the estimation of high-dimensional single index models when the response variable is censored. We hybrid the estimation methods for high-dimensional single-index models (but without censorship) and univariate nonparametric ... ...

Abstract	In this article, we study the estimation of high-dimensional single index models when the response variable is censored. We hybrid the estimation methods for high-dimensional single-index models (but without censorship) and univariate nonparametric models with randomly censored responses to estimate the index parameters and the link function and apply the proposed methods to analyze a genomic dataset from a study of diffuse large B-cell lymphoma. We evaluate the finite sample performance of the proposed procedures via simulation studies and establish large sample theories for the proposed estimators of the index parameter and the nonparametric link function under certain regularity conditions.
MeSH term(s)	Computer Simulation ; Data Interpretation, Statistical ; Genomics
Language	English
Publishing date	2020-05-07
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	843037-8
ISSN	1097-0258 ; 0277-6715
ISSN (online)	1097-0258
ISSN	0277-6715
DOI	10.1002/sim.8571
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Article: Silencing

Tang, Songxi / Yang, Peng / Ding, Yilang / Chen, Qiang / Huang, Hailin / Chen, Xi / Zhou, Huiliang

publication RETRACTED

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 7121245

Abstract: Varicocele is regarded as the main factor that contributes to male infertility. This study aimed to explore the effect ... ...

Abstract	Varicocele is regarded as the main factor that contributes to male infertility. This study aimed to explore the effect of
Language	English
Publishing date	2022-07-19
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/7121245
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Article ; Online: Testicular volume is a noninvasive predictor of sperm retrieval failure in idiopathic nonobstructive azoospermia.

Xiao, Hong / Tang, Song-Xi / Yao, Rui-Jie / Ding, Yi-Lang / Yang, Peng / Chen, Qiang / Huang, Hai-Lin / Chen, Xi / Zhou, Hui-Liang

Asian journal of andrology

2024

Abstract: Abstract: We investigated the prognostic importance of noninvasive factors in predicting sperm retrieval failure in idiopathic nonobstructive azoospermia (iNOA). We studied 193 patients with nonobstructive azoospermia who underwent microsurgical ... ...

Abstract	Abstract: We investigated the prognostic importance of noninvasive factors in predicting sperm retrieval failure in idiopathic nonobstructive azoospermia (iNOA). We studied 193 patients with nonobstructive azoospermia who underwent microsurgical testicular sperm extraction. The Chi-square test and Mann-Whitney U tests for clinical parameters and seminiferous tubule distribution were used for between-group comparisons. A logistic regression analysis was conducted to identify predictors of retrieval failure. Area under the receiver operating characteristic curve for each variable was evaluated, and the net clinical benefit was calculated using a clinical decision curve. Patients with iNOA had a lower sperm retrieval rate than those with known causes. Moreover, testicular volume was an independent factor affecting sperm extraction outcomes (odds ratio = 0.79, P < 0.05). The testicular volume cut-off value was 6.5 ml (area under the curve: 0.694). The patients with iNOA were categorized into two groups on the basis of the distribution of seminiferous tubules observed. The sperm retrieval rate and testicular volume were significantly different between the groups with a uniform or heterogeneous tubule distribution. There was also a significant association between a uniform tubule distribution and testicular volume. In conclusion, a testicular volume of more than 6.5 ml effectively predicts microsurgical testicular sperm extraction failure due to a uniform tubule distribution in patients with iNOA.
Language	English
Publishing date	2024-02-13
Publishing country	China
Document type	Journal Article
ZDB-ID	2075824-8
ISSN	1745-7262 ; 1008-682X
ISSN (online)	1745-7262
ISSN	1008-682X
DOI	10.4103/aja202379
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Article ; Online: Bi-level feature selection in high dimensional AFT models with applications to a genomic study.

Huang, Hailin / Shangguan, Jizi / Ruan, Peifeng / Liang, Hua

Statistical applications in genetics and molecular biology

2019 Volume 18, Issue 5

Abstract: We propose a new bi-level feature selection method for high dimensional accelerated failure time models by formulating the models to a single index model. The method yields sparse solutions at both the group and individual feature levels along with an ... ...

Abstract	We propose a new bi-level feature selection method for high dimensional accelerated failure time models by formulating the models to a single index model. The method yields sparse solutions at both the group and individual feature levels along with an expedient algorithm, which is computationally efficient and easily implemented. We analyze a genomic dataset for an illustration, and present a simulation study to show the finite sample performance of the proposed method.
MeSH term(s)	Algorithms ; Computer Simulation ; Genomics/methods ; Humans ; Kaplan-Meier Estimate ; Melanoma/genetics ; Melanoma/metabolism ; Melanoma/secondary ; Models, Statistical ; Prognosis
Language	English
Publishing date	2019-09-17
Publishing country	Germany
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ISSN	1544-6115
ISSN (online)	1544-6115
DOI	10.1515/sagmb-2019-0016
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Article ; Online: Switch to bictegravir/emtricitabine/tenofovir alafenamide from dolutegravir-based therapy.

Orkin, Chloe / Antinori, Andrea / Rockstroh, Jürgen K / Moreno-Guillén, Santiago / Martorell, Claudia T / Molina, Jean-Michel / Lazzarin, Adriano / Maggiolo, Franco / Yazdanpanah, Yazdan / Andreatta, Kristen / Huang, Hailin / Hindman, Jason T / Martin, Hal / Pozniak, Anton

AIDS (London, England)

2024 Volume 38, Issue 7, Page(s) 983–991

Abstract: Objective: To evaluate the efficacy and safety of 96 weeks of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) treatment in participants switching from dolutegravir (DTG)-based therapy.: Design: Studies 1489 (NCT02607930) and 1490 ( ... ...

Abstract	Objective: To evaluate the efficacy and safety of 96 weeks of bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) treatment in participants switching from dolutegravir (DTG)-based therapy. Design: Studies 1489 (NCT02607930) and 1490 (NCT02607956) were phase 3 randomized, double-blind, active-controlled, first-line therapy trials in people with HIV-1. After 144 weeks of DTG-based or B/F/TAF treatment, participants could enter a 96-week open-label extension (OLE) of B/F/TAF. Methods: A pooled analysis evaluated viral suppression (HIV-1 RNA <50 copies/ml) and changes in CD4 + cell count at OLE Weeks 48 and 96, treatment-emergent resistance, safety, and tolerability after switch from a DTG-based regimen to B/F/TAF. Outcomes by prior treatment were summarized using descriptive statistics and compared by two-sided Wilcoxon rank sum test. Results: At OLE Week 96, participants who switched to B/F/TAF ( N = 519) maintained high levels of virologic suppression (99.5 and 99.1% in those switching from DTG/abacavir/lamivudine and DTG+F/TAF, respectively) and CD4 + cell count, with no treatment-emergent resistance to B/F/TAF. Twenty-one participants experienced drug-related adverse events after switching, with diarrhea, weight gain, and headache occurring most commonly. There were no cases of proximal renal tubulopathy, drug-related Grade 4 adverse events, or serious adverse events. Two participants discontinued B/F/TAF due to treatment-related adverse events. Participants who switched from DTG/abacavir/lamivudine experienced statistically significant greater weight gain than those who switched from DTG+F/TAF; however, median weight change from the blinded phase baseline to OLE Week 96 was numerically similar across treatment groups. Conclusion: This medium-term analysis demonstrates the safety and efficacy of switching to B/F/TAF from a DTG-containing regimen in people with HIV-1.
MeSH term(s)	Adult ; Aged ; Female ; Humans ; Male ; Middle Aged ; Young Adult ; Adenine/analogs & derivatives ; Adenine/therapeutic use ; Adenine/adverse effects ; Alanine/therapeutic use ; Amides/therapeutic use ; Anti-HIV Agents/therapeutic use ; Anti-HIV Agents/adverse effects ; CD4 Lymphocyte Count ; Double-Blind Method ; Drug Substitution ; Drug-Related Side Effects and Adverse Reactions ; Emtricitabine/therapeutic use ; Emtricitabine/administration & dosage ; Emtricitabine/adverse effects ; Heterocyclic Compounds, 3-Ring/adverse effects ; Heterocyclic Compounds, 3-Ring/therapeutic use ; Heterocyclic Compounds, 3-Ring/administration & dosage ; Heterocyclic Compounds, 4 or More Rings/therapeutic use ; Heterocyclic Compounds, 4 or More Rings/adverse effects ; Heterocyclic Compounds, 4 or More Rings/administration & dosage ; HIV Infections/drug therapy ; HIV-1/drug effects ; Oxazines ; Piperazines ; Pyridones ; Tenofovir/therapeutic use ; Tenofovir/adverse effects ; Tenofovir/administration & dosage ; Tenofovir/analogs & derivatives ; Treatment Outcome ; Viral Load
Chemical Substances	bictegravir ; dolutegravir ; tenofovir alafenamide
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article ; Clinical Trial, Phase III ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	639076-6
ISSN	1473-5571 ; 0269-9370 ; 1350-2840
ISSN (online)	1473-5571
ISSN	0269-9370 ; 1350-2840
DOI	10.1097/QAD.0000000000003865
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