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Article: Research progress on the pathogenesis of chest tightness variant asthma characterized by chest tightness.

Che, Luanqing / Lai, Jianxing / Huang, Huaqiong / Li, Wen / Shen, Huahao

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2024 Volume 53, Issue 2, Page(s) 213–220

Abstract: Chest tightness variant asthma (CTVA) is an atypical form of asthma with chest tightness as the sole or predominant symptom. The underlying receptors for chest tightness are bronchial C-fibers or rapidly adapting receptors. The nerve impulses are ... ...

Title translation	以胸闷为特点的胸闷变异性哮喘发病机制研究进展.
Abstract	Chest tightness variant asthma (CTVA) is an atypical form of asthma with chest tightness as the sole or predominant symptom. The underlying receptors for chest tightness are bronchial C-fibers or rapidly adapting receptors. The nerve impulses are transmitted via the vagus nerve and processed in different regions of the cerebral cortex. Chest tightness is associated with sensory perception, and CTVA patients may have heightened ability to detect subtle changes in lung function, but such sensory perception is unrelated to respiratory muscle activity, lung hyperinflation, or mechanical loading of the respiratory system. Airway inflammation, pulmonary ventilation dysfunction (especially involving small airways), and airway hyperresponsiveness may underlie the sensation of chest tightness. CTVA patients are prone to comorbid anxiety and depression, which share similar central nervous system processing pathways with dyspnea, suggesting a possible neurological basis for the development of CTVA. This article examines the recognition and mechanisms of chest tightness, and explores the pathogenesis of CTVA, focusing on its association with airway inflammation, ventilation dysfunction, airway hyperresponsiveness, and psychosocial factors.
MeSH term(s)	Humans ; Asthma/physiopathology
Language	Chinese
Publishing date	2024-02-04
Publishing country	China
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ISSN	1008-9292
ISSN	1008-9292
DOI	10.3724/zdxbyxb-2023-0442
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Article ; Online: Neoadjuvant chemotherapy combined with immunotherapy for pulmonary large-cell neuroendocrine carcinoma: a case report.

Chen, Fei / Hua, Haibo / Huang, Huaqiong

Annals of palliative medicine

2021 Volume 10, Issue 7, Page(s) 8479–8483

Abstract: Lung cancer can be divided into small cell lung cancer and non-small cell lung cancer (NSCLC). NSCLC can be further divided into squamous cell carcinoma, adenocarcinoma, and large-cell neuroendocrine carcinoma (LCNEC). At present, our understanding of ... ...

Abstract	Lung cancer can be divided into small cell lung cancer and non-small cell lung cancer (NSCLC). NSCLC can be further divided into squamous cell carcinoma, adenocarcinoma, and large-cell neuroendocrine carcinoma (LCNEC). At present, our understanding of LCNEC is limited. LCNEC is a rare condition but is highly malignant with a poor prognosis. The mean age of onset was about 65 years old, and was highly correlated with smoking. Although many treatment methods, including surgery, radiotherapy, and chemotherapy, are available, the therapeutic effect was limited and there is still a lack of clear guidelines and recommendations for its therapy. At present, immunotherapy is rapidly developing, and its application in lung cancer is increasing. However, there is limited literature about immunotherapy in LCNEC. Here, we present a case of LCNEC at stage IIIA, which involved a 64-year-old man with a 30-year history of smoking. Enhanced chest radiography indicated a malignant tumor in the upper lobe of the left lung. We treated this patient with neoadjuvant chemo-immunotherapy with albumin paclitaxel, carboplatin, and sintilimab. We also performed postoperative chemo-immunotherapy the same as before surgery. The patient has well tolerated this treatment and remains under postoperative observation for 6 months at the time of writing.
MeSH term(s)	Aged ; Carcinoma, Neuroendocrine/therapy ; Carcinoma, Non-Small-Cell Lung ; Humans ; Immunotherapy ; Lung Neoplasms/therapy ; Male ; Middle Aged ; Neoadjuvant Therapy
Language	English
Publishing date	2021-05-26
Publishing country	China
Document type	Case Reports
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-20-2536
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Article ; Online: A case of subclinical immune checkpoint inhibitor-associated myocarditis in non-small cell lung cancer.

Hu, Yue / Liu, Cuixia / Jin, Shaojun / Yi, Zihan / Wang, Chao / Pan, Xiaohong / Huang, Huaqiong

BMC pulmonary medicine

2023 Volume 23, Issue 1, Page(s) 119

Abstract: Background: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of cancer. Moreover, immune-related adverse events (irAEs) have become a new clinical challenge. ICI-associated myocarditis is a rare but fatal condition among ... ...

Abstract	Background: Immune checkpoint inhibitors (ICIs) have been widely used in the treatment of cancer. Moreover, immune-related adverse events (irAEs) have become a new clinical challenge. ICI-associated myocarditis is a rare but fatal condition among diverse organ injuries, and early recognition and effective interventions are critical for patients. Case presentation: In this report, we present the case of a healthy 60-year-old male who was diagnosed with lung squamous cell carcinomas following chemotherapy and received ICIs. The patient presented with asymptomatic cardiac biomarker elevation followed by immune-related myocarditis. Fortunately, the patient achieved a good clinical result after receiving high-dose steroids. The treatment with ICIs was discontinued because of recurrent increases in troponin T. Conclusion: ICI-mediated associated myocarditis is an uncommon but potentially life-threatening adverse event. The current data suggest that clinicians need to be cautious about reinitiation in low-grade patients; however, further study of the diagnosis and treatment is necessary.
MeSH term(s)	Male ; Humans ; Middle Aged ; Carcinoma, Non-Small-Cell Lung/pathology ; Immune Checkpoint Inhibitors/adverse effects ; Lung Neoplasms/pathology ; Myocarditis/chemically induced ; Myocarditis/diagnosis ; Myocarditis/drug therapy ; Immunotherapy/adverse effects
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-04-14
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-023-02417-4
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Article: Case Report: Premature Ventricular Beats-Induced Chronic Cough and Cough Syncope.

Hu, Yue / Hua, Wen / Li, Na / Huang, Huaqiong

Frontiers in medicine

2021 Volume 8, Page(s) 641948

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-03-10
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2775999-4
ISSN	2296-858X
ISSN	2296-858X
DOI	10.3389/fmed.2021.641948
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Article ; Online: Asthma in Pregnancy: Pathophysiology, Diagnosis, Whole-Course Management, and Medication Safety.

Wang, Huijie / Li, Na / Huang, Huaqiong

Canadian respiratory journal

2020 Volume 2020, Page(s) 9046842

Abstract: Asthma in pregnancy is a health issue of great concern. Physiological changes and drug compliance during pregnancy can affect asthma control in varying degrees, and the control level of asthma and the side effects of asthma medications are closely ... ...

Abstract	Asthma in pregnancy is a health issue of great concern. Physiological changes and drug compliance during pregnancy can affect asthma control in varying degrees, and the control level of asthma and the side effects of asthma medications are closely related to the adverse perinatal outcomes of mother and fetus. This article provides an update on the available literature regarding the alleviating or aggravating mechanism of asthma in pregnancy, diagnosis, disease assessment, and systematic management, to provide a new guidance for physician, obstetric joint doctor, and health care practitioner.
MeSH term(s)	Anti-Asthmatic Agents/pharmacology ; Asthma/physiopathology ; Asthma/therapy ; Female ; Humans ; Patient Care Management/standards ; Practice Guidelines as Topic ; Pregnancy ; Pregnancy Complications/physiopathology ; Pregnancy Complications/therapy ; Pregnancy Outcome
Chemical Substances	Anti-Asthmatic Agents
Keywords	covid19
Language	English
Publishing date	2020-02-22
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	1213103-9
ISSN	1916-7245 ; 1198-2241
ISSN (online)	1916-7245
ISSN	1198-2241
DOI	10.1155/2020/9046842
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Zs.A 4140: Show issues

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Article: The role of neutrophils in asthma.

Chen, Fei / Yu, Min / Zhong, Yonghong / Hua, Wen / Huang, Huaqiong

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2021 Volume 50, Issue 1, Page(s) 123–130

Abstract: Bronchial asthma is a chronic respiratory disease，characterized by airway inflammation，airway hyperresponsiveness，reversible airway obstruction and airway remodeling，in which a variety of cells including airway inflammatory cells and structural cells are ...

Abstract	Bronchial asthma is a chronic respiratory disease，characterized by airway inflammation，airway hyperresponsiveness，reversible airway obstruction and airway remodeling，in which a variety of cells including airway inflammatory cells and structural cells are involved. Previous studies have shown that asthma is mainly driven by Th2 cytokines IL-4，IL-5，and IL-13，leading to airway eosinophil inflammation. With further research，however，it has been found that neutrophils are also closely related to asthma. Numbers of neutrophils are elevated in airway through increased chemotaxis and decreased apoptosis，which is earlier than eosinophils，leading to airway neutrophilic inflammation. Neutrophils can produce elastase，myeloperoxidase，neutrophil extra- cellular traps，chemokines and cytokines，participating in the occurrence and development of asthma. The antagonists against these molecules，such as anti-IL-8 receptor antibody，anti-IL-17 antibody，and DNase，have shown positive effects on neutrophilic asthma，but further studies are needed to support their clinical application. This article mainly reviews the role of neutrophils in asthma and related mechanisms.
MeSH term(s)	Asthma/immunology ; Cytokines ; Eosinophils ; Humans ; Inflammation ; Neutrophils/immunology
Chemical Substances	Cytokines
Language	English
Publishing date	2021-07-05
Publishing country	China
Document type	Journal Article ; Review
ISSN	1008-9292
ISSN	1008-9292
DOI	10.3724/zdxbyxb-2021-0030
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Article ; Online: Eosinopenia Predicting Long-term Mortality in Hospitalized Acute Exacerbation of COPD Patients with Community-acquired Pneumonia-A Retrospective Analysis.

Mao, Yanxiong / Qian, Yuanyuan / Sun, Xiaoyan / Li, Na / Huang, Huaqiong

International journal of chronic obstructive pulmonary disease

2021 Volume 16, Page(s) 3551–3559

Abstract: Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) could be triggered by community-acquired pneumonia (CAP). Peripheral blood eosinopenia are strongly associated with increased mortality. In hospitalized AECOPD patients ... ...

Abstract	Background: Acute exacerbation of chronic obstructive pulmonary disease (AECOPD) could be triggered by community-acquired pneumonia (CAP). Peripheral blood eosinopenia are strongly associated with increased mortality. In hospitalized AECOPD patients with CAP, eosinopenia may be used to identify patients with high risk of death on admission. Methods: We conducted a retrospective cohort study in 82 hospitalized AECOPD patients with CAP. Patients who had received systemic corticosteroids preadmission were excluded. The patients were identified by individual case file review. According to blood eosinophil count, patients were grouped as eosinopenia (<50/μL) and non-eosinopenia (≥50/μL). Association of eosinopenia with infection and 18-month survival were analyzed using appropriate statistical methods. Results: Baseline demographic, comorbidity, CURB65 and Pneumonia Severity Index scores were similar between two groups. The eosinopenia group had significantly higher pro-brain natriuretic peptide, D-dimer, neutrophil percentage, and lower lymphocyte count and lymphocyte percentage. The eosinopenia group had significantly higher C-reactive protein (median 77.30 vs 16.55, Conclusion: Eosinopenia (<50/μL) was a strong predictor of 18-month mortality and associated with more severe infection in hospitalized AECOPD patients with CAP. Eosinophil count at admission can be used as a prognosis marker of mortality in those population.
MeSH term(s)	Community-Acquired Infections/diagnosis ; Disease Progression ; Hospitalization ; Humans ; Pneumonia ; Pulmonary Disease, Chronic Obstructive ; Retrospective Studies
Language	English
Publishing date	2021-12-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2212419-6
ISSN	1178-2005 ; 1176-9106
ISSN (online)	1178-2005
ISSN	1176-9106
DOI	10.2147/COPD.S347948
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Article ; Online: Characteristics and Role of Neutrophil Extracellular Traps in Asthma.

Chen, Fei / Yu, Min / Zhong, Yonghong / Wang, Lina / Huang, Huaqiong

Inflammation

2021 Volume 45, Issue 1, Page(s) 6–13

Abstract: Asthma is a common chronic respiratory disease that affects millions of people worldwide. The incidence of asthma has continued to increase every year. Bronchial asthma involves a variety of cells, including airway inflammatory cells, structural cells, ... ...

Abstract	Asthma is a common chronic respiratory disease that affects millions of people worldwide. The incidence of asthma has continued to increase every year. Bronchial asthma involves a variety of cells, including airway inflammatory cells, structural cells, and neutrophils, which have gained more attention because they secrete substances that play an important role in the occurrence and development of asthma. Neutrophil extracellular traps (NETs) are mesh-like structures composed of DNA, histones, and non-histone molecules that can be secreted from neutrophils. NETs can enrich anti-bacterial substances and limit pathogen migration, thus having a protective effect in case of inflammation. However, despite of their anti-inflammatory properties, NETs have been shown to trigger allergic asthma and worsen asthma progression. Here, we provide a systematic review of the roles of NETs in asthma.
MeSH term(s)	Asthma/immunology ; Disease Progression ; Extracellular Traps/immunology ; Humans ; Neutrophils/immunology ; Patient Acuity
Language	English
Publishing date	2021-09-04
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	434408-x
ISSN	1573-2576 ; 0360-3997
ISSN (online)	1573-2576
ISSN	0360-3997
DOI	10.1007/s10753-021-01526-8
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Zs.A 1401: Show issues

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Article ; Online: Epidemiological features and sociodemographic factors associated with mumps in mainland China from 2004 to 2018.

Fu, Xiaofang / Ge, Minjie / Xu, Wucheng / Yu, Min / Ju, Jiangang / Zhong, Yonghong / Huang, Huaqiong

Journal of medical virology

2022 Volume 94, Issue 10, Page(s) 4850–4859

Abstract: Mumps is an acute infectious disease that spreads widely around the world. The aim of this study was to investigate the epidemiological features and sociodemographic factors associated with mumps in mainland China from 2004 to 2018. Incidence data for ... ...

Abstract	Mumps is an acute infectious disease that spreads widely around the world. The aim of this study was to investigate the epidemiological features and sociodemographic factors associated with mumps in mainland China from 2004 to 2018. Incidence data for mumps during the period 2004-2018 were collected from the Public Health Sciences Data Center of China. Joinpoint regression analysis was performed to explore the trends of mumps. Space-time clustering analysis was conducted to spatial and temporal aggregation areas of mumps. A generalized linear model was used to explore sociodemographic factors associated with the incidence of mumps. The average annual incidence of mumps was 21.44/100 000 in mainland China. It was increased dramatically during 2004-2012 (annual percentage change [APC] = 7.51, 95% confidence interval [CI]: 2.28-13.00). After 2012, it remained stable, however, significantly increased in intermediately developed regions from 2015 to 2018 (APC = 25.84, 95% CI: 3.59-52.86). The first-level spatial and temporal aggregation areas were distributed in Xinjiang, Gansu, Qinghai, Ningxia and Shaanxi, Tibet, Sichuan, Yunnan, Chongqing, Guizhou, and Guangxi, with gathering times from January 1, 2006 to December 31, 2012 (relative risk [RR] = 1.87, p < 0.001). The percentage of the population aged 0-14 years, number of health workers per capital, and number of passengers were found to be positively associated with the incidence of mumps. Overall, after 2012, the incidence of mumps in mainland China remained stable. High-risk periods, clusters of regions, and sociodemographic factors for mumps were identified, which will help the government develop the disease- and location-specific interventive measures.
MeSH term(s)	China/epidemiology ; Humans ; Incidence ; Mumps/epidemiology ; Sociodemographic Factors ; Tibet
Language	English
Publishing date	2022-07-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.27955
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Zs.A 1320: Show issues

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Article ; Online: Chronic cough caused by choledochoduodenal fistula: a case report.

Cao, Jiaofei / Hu, Yue / Jin, Shaojun / Chen, Fei / Li, Li / Huang, Huaqiong

BMC pulmonary medicine

2021 Volume 21, Issue 1, Page(s) 290

Abstract: Background: Chronic cough is characterized by cough as the only or main symptom, with a duration of more than 8 weeks and no obvious abnormality in chest X-ray examination. Its etiology is complex, including respiratory disease, digestive system disease, ...

Abstract	Background: Chronic cough is characterized by cough as the only or main symptom, with a duration of more than 8 weeks and no obvious abnormality in chest X-ray examination. Its etiology is complex, including respiratory disease, digestive system disease, circulation system disease, and psychological disease. Although a set of etiological diagnosis procedures for chronic cough have been established, it is still difficult to diagnose chronic cough and there are still some patients with misdiagnosis. Case presentation: We present a case of a 54-year-old female patient who had chronic cough for 28 years. Physical examination had no positive signs and she denied any illness causing cough like tuberculosis, rhinitis. Recurrent clinic visits and symptomatic treatment didn't improve the condition. Finally, gastroscopy identified the possible etiology of choledochoduodenal fistula that was proved by surgery. And after surgery, the patient's cough symptoms were significantly improved. Conclusion: We report a rare case of chronic cough caused by choledochoduodenal fistula which demonstrates our as yet inadequate recognition of the etiology and pathogenesis. Written informed consent was obtained from the patient.
MeSH term(s)	Biliary Fistula/diagnosis ; Biliary Fistula/surgery ; Cholangiopancreatography, Magnetic Resonance ; Chronic Disease ; Common Bile Duct Diseases/diagnosis ; Common Bile Duct Diseases/surgery ; Cough/etiology ; Duodenal Diseases/diagnosis ; Duodenal Diseases/surgery ; Female ; Gastroscopy ; Humans ; Intestinal Fistula/diagnosis ; Intestinal Fistula/surgery ; Middle Aged ; Treatment Outcome
Language	English
Publishing date	2021-09-10
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-021-01658-5
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