LIVIVO - Search results -

Search results

Result 1 - 10 of total 32

Search options

Article ; Online: Preoperative overweight and obesity do not cause inferior outcomes following open-wedge high tibial osteotomy: A retrospective cohort study of 123 patients.

Wu, Cheng-Yi / Huang, Jen-Wei / Lin, Chang-Hao / Chih, Wei-Hsing

2023 Volume 18, Issue 1, Page(s) e0280687

Abstract: Open-wedge high tibial osteotomy (OWHTO) is effective in treating medial compartment osteoarthritis. The association between body mass index (BMI) and outcomes following OWHTO is being debated. This study compared radiographic and clinical outcomes ... ...

Abstract	Open-wedge high tibial osteotomy (OWHTO) is effective in treating medial compartment osteoarthritis. The association between body mass index (BMI) and outcomes following OWHTO is being debated. This study compared radiographic and clinical outcomes between patients with preoperative overweight, obesity, and normal BMI following OWHTO for medial compartment osteoarthritis. In total, 123 patients (123 knees) who underwent OWHTO for medial compartment osteoarthritis were enrolled and were divided into normal-BMI (18.5-24.9 kg/m2), overweight (25-29.9 kg/m2), and obese (>30 kg/m2) groups based on body mass index. The numeric rating scale for pain, mechanical tibiofemoral angle (mTFA), tibia tilting angle (TTA), and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for function were evaluated preoperatively and at postoperative follow-ups. The improvements of clinical and radiological outcomes in normal-BMI, overweight, and obese groups were not significantly different. The incidence of soft tissue irritation, wound infection, nonunion, and conversion to total knee arthroplasty were not significantly different between groups.The clinical and radiological outcomes in patients with preoperative overweight, obesity, and normal-BMI were not significantly different. Preoperative overweight and obesity thus has no effect on outcomes following OWHTO during the two years follow-up period. These findings cannot be generalized to patients with morbid obesity.
MeSH term(s)	Humans ; Knee Joint/diagnostic imaging ; Knee Joint/surgery ; Osteoarthritis, Knee/diagnostic imaging ; Osteoarthritis, Knee/surgery ; Retrospective Studies ; Overweight/complications ; Tibia/diagnostic imaging ; Tibia/surgery ; Osteotomy/adverse effects ; Obesity/complications ; Obesity/surgery
Language	English
Publishing date	2023-01-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0280687
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article: Reductive Degradation of 1,1,1-Trichloroethane with Alkaline Green Tea/Ferrous Ion in Aqueous Phase

Wu, Siang Chen / Huang, Jen-Wei / Liang, Chenju

Industrial & engineering chemistry process design and development. 2020 Oct. 20, v. 59, no. 43

2020

Abstract: 1,1,1-Trichloroethane (1,1,1-TCA) is a USEPA Priority Pollutant that has caused serious environmental contamination in the soil and groundwater. This study verified a chemical approach using an alkaline green tea (GT)/Fe²⁺ system at pH 10 to degrade ... ...

Abstract	1,1,1-Trichloroethane (1,1,1-TCA) is a USEPA Priority Pollutant that has caused serious environmental contamination in the soil and groundwater. This study verified a chemical approach using an alkaline green tea (GT)/Fe²⁺ system at pH 10 to degrade reductively 1,1,1-TCA in an aqueous phase. Evaluation of the effect of GT dosage, Fe²⁺ concentrations, and reaction temperatures on the 1,1,1-TCA degradation through batch-scale experiments revealed that initiation of the degradation process is dependent on the GT/Fe²⁺ dosing ratio, with a minimum polyphenol concentration of 367 mg L–¹ and a polyphenol-to-Fe mass ratio of 0.44. The reductive degradation of 1,1,1-TCA by the alkaline GT/Fe²⁺ system exhibited an initial rapid reaction stage, followed by a slower pseudo-first-order reaction kinetic stage. The highest initial degradation rate and fitted rate constant observed in this study were 0.106 mM h–¹ and 0.046 h–¹, respectively. The polyphenol–Fe complexes, especially epigallocatechin gallate (EGCG) Fe²⁺/Fe³⁺, were expected to trigger the reductive degradation of 1,1,1-TCA via interactions between GT and Fe. Ethane was generated as the major end product through the reductive dehalogenation route with 1,1-dichloroethane and chloroethane as intermediate products. This study demonstrated the potential of the alkaline GT/Fe²⁺ system as a chemical reductive treatment of recalcitrant chlorinated solvents.
Keywords	United States Environmental Protection Agency ; dehalogenation ; epigallocatechin gallate ; ethane ; green tea ; groundwater ; pH ; pollutants ; pollution ; polyphenols ; process design ; soil
Language	English
Dates of publication	2020-1020
Size	p. 19093-19101.
Publishing place	American Chemical Society
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	1484436-9
ISSN	1520-5045 ; 0888-5885
ISSN (online)	1520-5045
ISSN	0888-5885
DOI	10.1021/acs.iecr.0c03443
Database	NAL-Catalogue (AGRICOLA)

Order via subito

Article ; Online: TADILOF: Time Aware Density-Based Incremental Local Outlier Detection in Data Streams.

Huang, Jen-Wei / Zhong, Meng-Xun / Jaysawal, Bijay Prasad

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 20

Abstract: Outlier detection in data streams is crucial to successful data mining. However, this task is made increasingly difficult by the enormous growth in the quantity of data generated by the expansion of Internet of Things (IoT). Recent advances in outlier ... ...

Abstract	Outlier detection in data streams is crucial to successful data mining. However, this task is made increasingly difficult by the enormous growth in the quantity of data generated by the expansion of Internet of Things (IoT). Recent advances in outlier detection based on the density-based local outlier factor (LOF) algorithms do not consider variations in data that change over time. For example, there may appear a new cluster of data points over time in the data stream. Therefore, we present a novel algorithm for streaming data, referred to as time-aware density-based incremental local outlier detection (TADILOF) to overcome this issue. In addition, we have developed a means for estimating the LOF score, termed "approximate LOF," based on historical information following the removal of outdated data. The results of experiments demonstrate that TADILOF outperforms current state-of-the-art methods in terms of AUC while achieving similar performance in terms of execution time. Moreover, we present an application of the proposed scheme to the development of an air-quality monitoring system.
Language	English
Publishing date	2020-10-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20205829
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Finding Possible Promoter Binding Sites in DNA Sequences by Sequential Patterns Mining With Specific Numbers of Gaps.

Ke, Yu-Hao / Huang, Jen-Wei / Lin, Wei-Chen / Jaysawal, Bijay Prasad

IEEE/ACM transactions on computational biology and bioinformatics

2021 Volume 18, Issue 6, Page(s) 2459–2470

Abstract: Identifying motifs in promoter regions is crucial to our understanding of transcription regulation. Researchers commonly use known promoter features in a variety of species to predict promoter motifs. However the results are not particularly useful. ... ...

Abstract	Identifying motifs in promoter regions is crucial to our understanding of transcription regulation. Researchers commonly use known promoter features in a variety of species to predict promoter motifs. However the results are not particularly useful. Different species rarely have similar features in promoter binding sites. In this study, we adopt sequence analysis techniques to find the possible promoter binding sites among different species. We sought to improve the existing algorithm to suit the task of mining sequential patterns with specific number of gaps. Moreover, we discuss the implementation of proposed method in a distributed environment. The proposed method finds the transcription start sites (TSS) and extracts possible promoter regions from DNA sequences according to TSS. We derived the motifs in the possible promoter regions, while taking into account the number of gaps in the motifs to deal with unimportant nucleotides. The motifs generated from promoter regions using the proposed methodology were shown to tolerate unimportant nucleotides. A comparison with known promoter motifs verified the efficacy of the proposed method.
MeSH term(s)	Algorithms ; Base Sequence/genetics ; Binding Sites/genetics ; Computational Biology/methods ; Data Mining ; Promoter Regions, Genetic/genetics ; Sequence Analysis, DNA/methods
Language	English
Publishing date	2021-12-08
Publishing country	United States
Document type	Journal Article
ISSN	1557-9964
ISSN (online)	1557-9964
DOI	10.1109/TCBB.2020.2980234
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Mechanism of DNA unwinding by MCM8-9 in complex with HROB.

Acharya, Ananya / Bret, Hélène / Huang, Jen-Wei / Mütze, Martin / Göse, Martin / Kissling, Vera Maria / Seidel, Ralf / Ciccia, Alberto / Guérois, Raphaël / Cejka, Petr

Nature communications

2024 Volume 15, Issue 1, Page(s) 3584

Abstract: HROB promotes the MCM8-9 helicase in DNA damage response. To understand how HROB activates MCM8-9, we defined their interaction interface. We showed that HROB makes important yet transient contacts with both MCM8 and MCM9, and binds the MCM8-9 ... ...

Abstract	HROB promotes the MCM8-9 helicase in DNA damage response. To understand how HROB activates MCM8-9, we defined their interaction interface. We showed that HROB makes important yet transient contacts with both MCM8 and MCM9, and binds the MCM8-9 heterodimer with the highest affinity. MCM8-9-HROB prefer branched DNA structures, and display low DNA unwinding processivity. MCM8-9 unwinds DNA as a hexamer that assembles from dimers on DNA in the presence of ATP. The hexamer involves two repeating protein-protein interfaces between the alternating MCM8 and MCM9 subunits. One of these interfaces is quite stable and forms an obligate heterodimer across which HROB binds. The other interface is labile and mediates hexamer assembly, independently of HROB. The ATPase site formed at the labile interface contributes disproportionally more to DNA unwinding than that at the stable interface. Here, we show that HROB promotes DNA unwinding downstream of MCM8-9 loading and ring formation on ssDNA.
MeSH term(s)	Minichromosome Maintenance Proteins/metabolism ; Minichromosome Maintenance Proteins/genetics ; Humans ; DNA, Single-Stranded/metabolism ; Protein Binding ; DNA/metabolism ; DNA/chemistry ; DNA-Binding Proteins/metabolism ; Adenosine Triphosphate/metabolism ; Protein Multimerization
Chemical Substances	Minichromosome Maintenance Proteins (EC 3.6.4.12) ; DNA, Single-Stranded ; DNA (9007-49-2) ; DNA-Binding Proteins ; Adenosine Triphosphate (8L70Q75FXE) ; MCM8 protein, human (EC 3.6.4.12) ; MCM9 protein, human (EC 3.6.4.12)
Language	English
Publishing date	2024-04-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-024-47936-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Time for remodeling: SNF2-family DNA translocases in replication fork metabolism and human disease.

Joseph, Sarah A / Taglialatela, Angelo / Leuzzi, Giuseppe / Huang, Jen-Wei / Cuella-Martin, Raquel / Ciccia, Alberto

DNA repair

2020 Volume 95, Page(s) 102943

Abstract: Over the course of DNA replication, DNA lesions, transcriptional intermediates and protein-DNA complexes can impair the progression of replication forks, thus resulting in replication stress. Failure to maintain replication fork integrity in response to ... ...

Abstract	Over the course of DNA replication, DNA lesions, transcriptional intermediates and protein-DNA complexes can impair the progression of replication forks, thus resulting in replication stress. Failure to maintain replication fork integrity in response to replication stress leads to genomic instability and predisposes to the development of cancer and other genetic disorders. Multiple DNA damage and repair pathways have evolved to allow completion of DNA replication following replication stress, thus preserving genomic integrity. One of the processes commonly induced in response to replication stress is fork reversal, which consists in the remodeling of stalled replication forks into four-way DNA junctions. In normal conditions, fork reversal slows down replication fork progression to ensure accurate repair of DNA lesions and facilitates replication fork restart once the DNA lesions have been removed. However, in certain pathological situations, such as the deficiency of DNA repair factors that protect regressed forks from nuclease-mediated degradation, fork reversal can cause genomic instability. In this review, we describe the complex molecular mechanisms regulating fork reversal, with a focus on the role of the SNF2-family fork remodelers SMARCAL1, ZRANB3 and HLTF, and highlight the implications of fork reversal for tumorigenesis and cancer therapy.
MeSH term(s)	DNA/metabolism ; DNA Helicases/metabolism ; DNA Repair ; DNA Replication ; DNA-Binding Proteins/metabolism ; Genomic Instability ; Humans ; Transcription Factors/metabolism
Chemical Substances	DNA-Binding Proteins ; HLTF protein, human ; Transcription Factors ; DNA (9007-49-2) ; SMARCAL1 protein, human (EC 2.7.7.-) ; DNA Helicases (EC 3.6.4.-) ; ZRANB3 protein, human (EC 3.6.4.-)
Language	English
Publishing date	2020-08-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2071608-4
ISSN	1568-7856 ; 1568-7864
ISSN (online)	1568-7856
ISSN	1568-7864
DOI	10.1016/j.dnarep.2020.102943
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5555: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB.

Acharya, Ananya / Bret, Hélène / Huang, Jen-Wei / Mütze, Martin / Göse, Martin / Kissling, Vera / Seidel, Ralf / Ciccia, Alberto / Guérois, Raphaël / Cejka, Petr

Research square

2023

Abstract: The human MCM8-9 helicase functions in concert with HROB in the context of homologous recombination, but its precise function is unknown. To gain insights into how HROB regulates MCM8-9, we first used molecular modeling and biochemistry to define their ... ...

Abstract	The human MCM8-9 helicase functions in concert with HROB in the context of homologous recombination, but its precise function is unknown. To gain insights into how HROB regulates MCM8-9, we first used molecular modeling and biochemistry to define their interaction interface. We show that HROB makes important contacts with both MCM8 and MCM9 subunits, which directly promotes its DNA-dependent ATPase and helicase activities. MCM8-9-HROB preferentially binds and unwinds branched DNA structures, and single-molecule experiments reveal a low DNA unwinding processivity. MCM8-9 unwinds DNA as a hexameric complex that assembles from dimers on DNA in the presence of ATP, which is prerequisite for its helicase function. The hexamer formation thus involves two repeating protein-protein interfaces forming between the alternating MCM8 and MCM9 subunits. One of these interfaces is rather stable and forms an obligate heterodimer, while the other interface is labile and mediates the assembly of the hexamer on DNA, independently of HROB. The ATPase site composed of the subunits forming the labile interface disproportionally contributes to DNA unwinding. HROB does not affect the MCM8-9 ring formation, but promotes DNA unwinding downstream by possibly coordinating ATP hydrolysis with structural transitions accompanying translocation of MCM8-9 on DNA.
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Preprint
DOI	10.21203/rs.3.rs-3054483/v1
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Mechanism of DNA unwinding by hexameric MCM8-9 in complex with HROB.

Acharya, Ananya / Bret, Hélène / Huang, Jen-Wei / Mütze, Martin / Göse, Martin / Kissling, Vera / Seidel, Ralf / Ciccia, Alberto / Guérois, Raphaël / Cejka, Petr

bioRxiv : the preprint server for biology

2023

Abstract	The human MCM8-9 helicase functions in concert with HROB in the context of homologous recombination, but its precise function is unknown. To gain insights into how HROB regulates MCM8-9, we first used molecular modeling and biochemistry to define their interaction interface. We show that HROB makes important contacts with both MCM8 and MCM9 subunits, which directly promotes its DNA-dependent ATPase and helicase activities. MCM8-9-HROB preferentially binds and unwinds branched DNA structures, and single-molecule experiments reveal a low DNA unwinding processivity. MCM8-9 unwinds DNA as a hexameric complex that assembles from dimers on DNA in the presence of ATP, which is prerequisite for its helicase function. The hexamer formation thus involves two repeating protein-protein interfaces forming between the alternating MCM8 and MCM9 subunits. One of these interfaces is rather stable and forms an obligate heterodimer, while the other interface is labile and mediates the assembly of the hexamer on DNA, independently of HROB. The ATPase site composed of the subunits forming the labile interface disproportionally contributes to DNA unwinding. HROB does not affect the MCM8-9 ring formation, but promotes DNA unwinding downstream by possibly coordinating ATP hydrolysis with structural transitions accompanying translocation of MCM8-9 on DNA.
Language	English
Publishing date	2023-06-12
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.12.544631
Database	MEDical Literature Analysis and Retrieval System OnLINE

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: REV1-Polζ maintains the viability of homologous recombination-deficient cancer cells through mutagenic repair of PRIMPOL-dependent ssDNA gaps

Taglialatela, Angelo / Leuzzi, Giuseppe / Sannino, Vincenzo / Cuella-Martin, Raquel / Huang, Jen-Wei / Wu-Baer, Foon / Baer, Richard / Costanzo, Vincenzo / Ciccia, Alberto

Molecular cell. 2021 Oct. 07, v. 81, no. 19

2021

Abstract: BRCA1/2 mutant tumor cells display an elevated mutation burden, the etiology of which remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous mutations during unperturbed DNA replication due to repriming by the DNA primase- ...

Abstract	BRCA1/2 mutant tumor cells display an elevated mutation burden, the etiology of which remains unclear. Here, we report that these cells accumulate ssDNA gaps and spontaneous mutations during unperturbed DNA replication due to repriming by the DNA primase-polymerase PRIMPOL. Gap accumulation requires the DNA glycosylase SMUG1 and is exacerbated by depletion of the translesion synthesis (TLS) factor RAD18 or inhibition of the error-prone TLS polymerase complex REV1-Polζ by the small molecule JH-RE-06. JH-RE-06 treatment of BRCA1/2-deficient cells results in reduced mutation rates and PRIMPOL- and SMUG1-dependent loss of viability. Through cellular and animal studies, we demonstrate that JH-RE-06 is preferentially toxic toward HR-deficient cancer cells. Furthermore, JH-RE-06 remains effective toward PARP inhibitor (PARPi)-resistant BRCA1 mutant cells and displays additive toxicity with crosslinking agents or PARPi. Collectively, these studies identify a protective and mutagenic role for REV1-Polζ in BRCA1/2 mutant cells and provide the rationale for using REV1-Polζ inhibitors to treat BRCA1/2 mutant tumors.
Keywords	DNA glycosylases ; DNA replication ; animals ; crosslinking ; etiology ; mutagens ; mutants ; neoplasms ; toxicity ; tumor suppressor proteins ; viability
Language	English
Dates of publication	2021-1007
Size	p. 4008-4025.e7.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2021.08.016
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 2005/501: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Using land-use machine learning models to estimate daily NO2 concentration variations in Taiwan

Wong, Pei-Yi / Su, Huey-Jen / Lee, Hsiao-Yun / Chen, Yu-Cheng / Hsiao, Ya-Ping / Huang, Jen-Wei / Teo, Tee-Ann / Wu, Chih-Da / Spengler, John D.

Journal of cleaner production. 2021 Oct. 01, v. 317

2021

Abstract: It is likely that exposure surrogates from monitoring stations with various limitations are not sufficient for epidemiological studies covering large areas. Moreover, the spatiotemporal resolution of air pollution modelling approaches must be improved in ...

Abstract	It is likely that exposure surrogates from monitoring stations with various limitations are not sufficient for epidemiological studies covering large areas. Moreover, the spatiotemporal resolution of air pollution modelling approaches must be improved in order to achieve more accurate estimates. If not, the exposure assessments will not be applicable in future health risk assessments. To deal with this challenge, this study featured Land-Use Regression (LUR) models that use machine learning to assess the spatial-temporal variability of Nitrogen Dioxide (NO₂). Daily average NO₂ data was collected from 70 fixed air quality monitoring stations, belonging to the Taiwanese EPA, on the main island of Taiwan. Around 0.41 million observations from 2000 to 2016 were used for the analysis. Several datasets were employed to determine spatial predictor variables, including the EPA environmental resources dataset, the meteorological dataset, the land-use inventory, the landmark dataset, the digital road network map, the digital terrain model, MODIS Normalized Difference Vegetation Index database, and the power plant distribution dataset. Regarding analyses, conventional LUR and Hybrid Kriging-LUR were performed first to identify important predictor variables. A Deep Neural Network, Random Forest, and XGBoost algorithms were then used to fit the prediction model based on the variables selected by the LUR models. Lastly, data splitting, 10-fold cross validation, external data verification, and seasonal-based and county-based validation methods were applied to verify the robustness of the developed models. The results demonstrated that the proposed conventional LUR and Hybrid Kriging-LUR models captured 65% and 78%, respectively, of NO₂ variation. When the XGBoost algorithm was further incorporated in LUR and hybrid-LUR, the explanatory power increased to 84% and 91%, respectively. The Hybrid Kriging-LUR with XGBoost algorithm outperformed all other integrated methods. This study demonstrates the value of combining Hybrid Kriging-LUR model and an XGBoost algorithm to estimate the spatial-temporal variability of NO₂ exposure. For practical application, the associations of specific land-use/land cover types selected in the final model can be applied in land-use management and in planning emission reduction strategies.
Keywords	air pollution ; air quality ; algorithms ; data collection ; databases ; hybrids ; inventories ; landscapes ; models ; nitrogen dioxide ; population distribution ; power plants ; risk ; roads ; Taiwan
Language	English
Dates of publication	2021-1001
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2021.128411
Database	NAL-Catalogue (AGRICOLA)

Full text online

Accessible to users with ZB MED library card

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- Full text online
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Order via subito

Inter-library loan at ZB MED