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  1. Article ; Online: Application and subgroup analysis of competing risks model based on different lymph node staging systems in differentiated thyroid cancer.

    Cao, Zhe Xu / Huang, Jiang Sheng / Wang, Ming Ming

    Updates in surgery

    2024  

    Abstract: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy, with a rising incidence worldwide. Accurate prognostic models are essential for effective patient management. This study evaluates the prognostic value of various lymph node ... ...

    Abstract Differentiated thyroid cancer (DTC) is the most common endocrine malignancy, with a rising incidence worldwide. Accurate prognostic models are essential for effective patient management. This study evaluates the prognostic value of various lymph node staging systems in DTC using a competing risks model. We used SEER database records (1998-2016) of 16,527 DTC patients, analyzing N stage, positive lymph node numbers (PLNNs), metastatic lymph node ratio (MLNR), log odds of positive lymph nodes (LODDS), and log odds of the negative lymph node (NLN)/T stage ratio (LONT). Univariate and multivariate analyses in a competing risks model were performed, along with subgroup analyses based on demographic and clinical characteristics. In this study of 16,527 patients with DTC, different lymph node staging systems showed different prognostic correlations in univariate and multivariate analyses. In particular, PLNNs showed significant prognostic correlations in several subgroups. Additionally, PLNNs were more suitable as a lymph node staging system for DTC than LODDS and MLNR in N1 stage subgroups, with an optimal cut-off of 13. Receiver operating characteristic curves, calibration curves and nomograms improved the clinical utility of the prognostic model based on PLNNs. Using competing risks model and subgroup analyses, we found that PLNNs had the best prognostic discriminatory efficacy for patients with DTC, especially those with N1 stage disease, and had an optimal cut-off value of 13.
    Language English
    Publishing date 2024-05-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-024-01851-1
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  2. Article: Lymph Node Ratio Enhances Predictive Value for Treatment Outcomes in Patients with Non-Small Cell Lung Cancer Undergoing Surgery: A Retrospective Cohort Study.

    Wang, Shou-Feng / Mao, Nai-Quan / Huang, Jiang-Qiong / Pan, Xin-Bin

    Journal of Cancer

    2024  Volume 15, Issue 2, Page(s) 466–472

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.90525
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  3. Article ; Online: Microstructure and properties analysis of Ni60-based/WC composite coatings prepared by laser cladding

    Huang jiang / Zhu Zhikai / Shi Wenqing / Zhao Yang / Jiao Tianwen / Li Kaiyue

    Heliyon, Vol 10, Iss 2, Pp e24494- (2024)

    2024  

    Abstract: In this study, Ni60-WCx coatings (x = 0, 2, 4, 6 %) on 316L stainless steel (316Lss) were prepared via laser cladding technology. We examined all specimens s for microstructure, phase composition, microhardness and electrochemistry using several ... ...

    Abstract In this study, Ni60-WCx coatings (x = 0, 2, 4, 6 %) on 316L stainless steel (316Lss) were prepared via laser cladding technology. We examined all specimens s for microstructure, phase composition, microhardness and electrochemistry using several characterization techniques. It shows that the microstructure of the Ni-based coatings can be changed with WC powder. When the WC ratio is 2 %, crystalline crystals and cellular crystals can be found in the coating. As the WC ratio increases, more cellular crystals and fewer spiny crystals appear in the coating. When the WC ratio changes to 6 %, only cellular crystals can be found in the coating. The microhardness resultsshow that the Ni-based overcoat with added WC has a better microhardness compared to the pure Ni coating, and its average value of the coating area reaches a maximum value of 822.8 HV at a WC ratio of 2 %. That is due to the addition of WC which can cause regime transition. In addition, the Ni-based coating has better corrosion properties due to its different microstructure. When the WC ratio is 2 %, the specimen possesses the maximum Ecorr and smaller icorr with the best corrosion resistance.
    Keywords Ni-based ; laser cladding ; WC particles ; Corrosion resistance ; Microhardness ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 669
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Evaluation of health-related quality of life in children with postoperative delirium after surgical repair of ventricular septal defect: short- and mid-term follow-up.

    Huang, Jiang-Shan / Lin, Wen-Hao / Chen, Yu-Kun

    BMC pediatrics

    2023  Volume 23, Issue 1, Page(s) 73

    Abstract: Background: To investigate health-related quality of life (HRQOL) in children with postoperative delirium (POD) after surgical repair of ventricular septal defects (VSDs).: Methods: A total of 109 patients were enrolled and assigned to the POD group ( ...

    Abstract Background: To investigate health-related quality of life (HRQOL) in children with postoperative delirium (POD) after surgical repair of ventricular septal defects (VSDs).
    Methods: A total of 109 patients were enrolled and assigned to the POD group (n = 47) and the non-POD group (n = 62). HRQOL was assessed by the PedsQLTM 3.0 Cardiac Module at discharge, and at the three- and six-month postoperative follow.
    Results: Significant differences were detected in age, operation time, CPB time, mechanical ventilation duration, and length of ICU stay between the two groups, whereas sex and the VSD size did not significantly differ between groups. In terms of "cardiac heart problems and treatment" and "treatment-II", the HRQOL scores of the non-POD group were significantly better than those of the POD group. In terms of "perceived physical appearance" and "treatment anxiety", the POD group had significantly higher scores than the non-POD group at discharge and at the three-month postoperative follow-up. In terms of "cognitive problems" and "communication", the occurrence of POD still affected HRQOL at three months postoperatively, but the effect was significantly reduced at six months postoperatively. In terms of "total scores", both groups scored increasingly higher over time. The non-POD group had higher scores at discharge and three months postoperatively than the POD group, but no significant difference persisted at six months postoperatively.
    Conclusion: During the follow-up period, the HRQOL of the children with POD after surgical repair of VSD was inferior to that of the children without POD at discharge and three months postoperatively. However, the HRQOL did not differ between the two groups at six months postoperatively.
    MeSH term(s) Humans ; Child ; Emergence Delirium ; Quality of Life/psychology ; Follow-Up Studies ; Postoperative Complications/etiology ; Postoperative Complications/epidemiology ; Heart Septal Defects, Ventricular/surgery
    Language English
    Publishing date 2023-02-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041342-7
    ISSN 1471-2431 ; 1471-2431
    ISSN (online) 1471-2431
    ISSN 1471-2431
    DOI 10.1186/s12887-023-03843-3
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  5. Article ; Online: HIF-1α Induced by Hypoxia Promotes Peripheral Nerve Injury Recovery Through Regulating Ferroptosis in DRG Neuron.

    An, Shuai / Shi, Jingfei / Huang, Jiang / Li, Zheng / Feng, Mingli / Cao, Guanglei

    Molecular neurobiology

    2024  

    Abstract: Peripheral nerve injury (PNI) usually has a poor effect on functional recovery and severely declines the patient's quality of life. Our prior findings indicated that hypoxia remarkably promoted nerve regeneration of rats with sciatic nerve transection. ... ...

    Abstract Peripheral nerve injury (PNI) usually has a poor effect on functional recovery and severely declines the patient's quality of life. Our prior findings indicated that hypoxia remarkably promoted nerve regeneration of rats with sciatic nerve transection. However, the underlying molecular mechanisms of hypoxia in functional recovery of PNI still remain elusive. In this research, we tried to explain the functional roles and mechanisms of hypoxia and the hypoxia-inducible factor-1α (HIF-1α) in PNI. Our results indicated that hypoxia promoted proliferation and migration of dorsal root ganglia (DRG) and increased the expression of brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF). Mechanistically, hypoxia suppressed ferroptosis through activating HIF-1α in DRG neurons. Gain and loss of function studies were performed to evaluate the regulatory roles of HIF-1α in ferroptosis and neuron recovery. The results revealed that up-regulation of HIF-1α enhanced the expression of solute carrier family membrane 11 (SLC7A11) and glutathione peroxidase 4 (GPX4) and increased the contents of cysteine and glutathione, while inhibiting the accumulation of reactive oxygen species (ROS). Our findings provided novel light on the mechanism of ferroptosis involved in PNI and manifest hypoxia as a potential therapeutic strategy for PNI recovery.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645020-9
    ISSN 1559-1182 ; 0893-7648
    ISSN (online) 1559-1182
    ISSN 0893-7648
    DOI 10.1007/s12035-024-03964-5
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2411: Show issues Location:
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  6. Article ; Online: Continuous southwestward spread of Fukushima-derived

    Zhang, Fule / Zhong, Qiangqiang / Huang, Jiang / Huang, Dekun / Du, Jinzhou / Yu, Tao

    Journal of hazardous materials

    2024  Volume 467, Page(s) 133708

    Abstract: We provide transect profiles ... ...

    Abstract We provide transect profiles of
    Language English
    Publishing date 2024-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.133708
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  7. Article ; Online: Multiplex Aptamer-Based Fluorescence Assay Using Magnetism-Encoded Nanoparticles for Simultaneous Detection of Multiple Pathogenic Bacteria.

    Wu, Sixuan / Huang, Yingjie / Wen, Jin / Huang, Jiang / Ma, Guangran / Liu, Yongjun / Tan, Hongliang

    Analytical chemistry

    2024  Volume 96, Issue 6, Page(s) 2341–2350

    Abstract: Multiplex assay has emerged as a robust and versatile method for the simultaneous detection of multiple analytes in a single test. However, challenges in terms of poor accuracy and complexity remained. In this work, we developed a multiplex aptamer-based ...

    Abstract Multiplex assay has emerged as a robust and versatile method for the simultaneous detection of multiple analytes in a single test. However, challenges in terms of poor accuracy and complexity remained. In this work, we developed a multiplex aptamer-based fluorescence assay using magnetism-encoded nanoparticles for the simultaneous detection of multiple pathogenic bacteria. The encapsulation of different amounts of Fe
    MeSH term(s) Limit of Detection ; Nanoparticles ; Bacteria ; Aptamers, Nucleotide ; Metal-Organic Frameworks
    Chemical Substances ZIF-90 ; Aptamers, Nucleotide ; Metal-Organic Frameworks
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1508-8
    ISSN 1520-6882 ; 0003-2700
    ISSN (online) 1520-6882
    ISSN 0003-2700
    DOI 10.1021/acs.analchem.3c03628
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    Zs.A 4033: Show issues Location:
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  8. Article ; Online: Cepharanthine maintains integrity of the blood-brain barrier (BBB) in stroke via the VEGF/VEGFR2/ZO-1 signaling pathway.

    Yang, Yunfang / Li, Changjiang / Yang, Sijin / Zhang, Zhuo / Bai, Xue / Tang, Hongmei / Huang, Jiang

    Aging

    2024  Volume 16, Issue 7, Page(s) 5905–5915

    Abstract: Dysfunction of tight junctions such as zonula occludens protein-1 (ZO-1)-associated aggravation of blood-brain barrier (BBB) permeability plays an important role in the progression of stroke. Cepharanthine (CEP) is an extract from the ... ...

    Abstract Dysfunction of tight junctions such as zonula occludens protein-1 (ZO-1)-associated aggravation of blood-brain barrier (BBB) permeability plays an important role in the progression of stroke. Cepharanthine (CEP) is an extract from the plant
    MeSH term(s) Animals ; Zonula Occludens-1 Protein/metabolism ; Blood-Brain Barrier/drug effects ; Blood-Brain Barrier/metabolism ; Vascular Endothelial Growth Factor Receptor-2/metabolism ; Benzylisoquinolines/pharmacology ; Benzylisoquinolines/therapeutic use ; Vascular Endothelial Growth Factor A/metabolism ; Mice ; Signal Transduction/drug effects ; Stroke/metabolism ; Stroke/drug therapy ; Humans ; Male ; Infarction, Middle Cerebral Artery/metabolism ; Infarction, Middle Cerebral Artery/drug therapy ; Disease Models, Animal ; Mice, Inbred C57BL ; Endothelial Cells/drug effects ; Endothelial Cells/metabolism ; Cell Line ; Benzodioxoles
    Chemical Substances Zonula Occludens-1 Protein ; Vascular Endothelial Growth Factor Receptor-2 (EC 2.7.10.1) ; Benzylisoquinolines ; cepharanthine (7592YJ0J6T) ; Vascular Endothelial Growth Factor A ; Kdr protein, mouse (EC 2.7.10.1) ; Tjp1 protein, mouse ; Benzodioxoles
    Language English
    Publishing date 2024-03-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205678
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  9. Article: 

    Zhang, Jian-Wen / Kilian, Norbert / Huang, Jiang-Hua / Sun, Hang

    PhytoKeys

    2023  Volume 230, Page(s) 115–130

    Abstract: Our first record of the rare and scatteredly ... ...

    Abstract Our first record of the rare and scatteredly distributed
    Language English
    Publishing date 2023-08-07
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.230.107733
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  10. Article: Staged open reduction and internal fixation with double-locking plates to treat bilateral distal femur periprosthetic fractures after total knee arthroplasty: A case report.

    Wu, Jiangpeng / Li, Zheng / Huang, Jiang / Jiao, Xufeng / Cao, Guanglei

    Frontiers in surgery

    2023  Volume 9, Page(s) 987953

    Abstract: Background: The incidence of periprosthetic fractures after total knee arthroplasty (TKA) increases in parallel with the number of procedures. Comminuted fractures along the primary fracture line extending to the edge of the prosthesis are challenging, ... ...

    Abstract Background: The incidence of periprosthetic fractures after total knee arthroplasty (TKA) increases in parallel with the number of procedures. Comminuted fractures along the primary fracture line extending to the edge of the prosthesis are challenging, and bilateral fractures are rarely reported, especially with open injuries.
    Case presentation: A 65-year-old female had undergone bilateral TKA in our hospital 5 years before admission. She was admitted with a traumatic bilateral Rorabeck type II B distal femur periprosthetic fracture (closed right, open left, Gustilo II) and was treated with bilateral staged open reduction and internal fixation (ORIF) with double-locking plates. The patient experienced a prolonged delayed fracture union and finally healed around 21 months postoperatively. The function was satisfactory after 4 years of follow-up.
    Conclusion: ORIF with double-locking plates can be used to treat Rorabeck II B periprosthetic fracture where the primary fracture line extends beyond the edge of the prosthesis; however, there may be delayed healing or nonunion. Patients need to undergo long-term rehabilitation and endure long disability times and require good rehabilitation nursing care. Once they achieve bone healing, the treatment achieves bone preservation and substantial prosthesis survival.
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2773823-1
    ISSN 2296-875X
    ISSN 2296-875X
    DOI 10.3389/fsurg.2022.987953
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