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Article ; Online: Obstetric service demand is the main health need of the Vietnamese population in Guangxi, China: A cross-sectional study.

Lan, Zhini / Wu, Xiaoqiu / Huang, Jiefang / Pan, Cuizhu / Lai, Jingzhen / Liang, Xia

2024 Volume 103, Issue 6, Page(s) e37234

Abstract: China has become an emerging destination for international migration, especially in some Association of South East Asian Nations countries, but the situation of migrants seeking medical care in China remains unclear. A retrospective cross-sectional study ...

Abstract	China has become an emerging destination for international migration, especially in some Association of South East Asian Nations countries, but the situation of migrants seeking medical care in China remains unclear. A retrospective cross-sectional study was conducted in a hospital in Chongzuo, which provides medical services for foreigners, to investigate the situation of Vietnamese people seeking health care in Guangxi, China. Vietnamese patients who visited the hospital between 2018 and 2020 were included in the study. Demographic characteristics, clinical characteristics, characteristics of payment for medical costs, and characteristics of hospitalization were compared between outpatients and inpatients. In total, 778 Vietnamese outpatients and 173 inpatients were included in this study. The percentages of female outpatients and inpatients were 93.44% and 88.44% (χ2 = 5.133, P = .023), respectively. Approximately 30% of outpatients and 47% of inpatients visited the hospital due to obstetric needs. The proportions of outpatients with basic medical insurance for urban residents, basic medical insurance for urban employees, and new cooperative medical schemes were 28.02%, 3.21%, and 2.31%, respectively. In comparison, the proportion of inpatients with the above 3 types of medical insurance was 16.76%, 1.73%, and 2.31%, respectively. The proportion of different payments for medical costs between outpatients and inpatients were significantly different (χ2 = 24.404, P < .01). Middle-aged Vietnamese females in Guangxi, China, may have much greater healthcare needs. Their main medical demand is for obstetric services. Measurements should be taken to improve the health services targeting Vietnamese female, but the legitimacy of Vietnamese in Guangxi is a major prerequisite for them to access more and better healthcare services.
MeSH term(s)	Female ; Humans ; Middle Aged ; China/epidemiology ; Cross-Sectional Studies ; Insurance, Health/statistics & numerical data ; Retrospective Studies ; Southeast Asian People/ethnology ; Southeast Asian People/statistics & numerical data ; Vietnam/ethnology ; Health Services Needs and Demand/economics ; Health Services Needs and Demand/statistics & numerical data ; Transients and Migrants/statistics & numerical data ; Emigration and Immigration/statistics & numerical data ; Obstetrics/economics ; Obstetrics/statistics & numerical data ; Patient Acceptance of Health Care ; Health Services Accessibility/statistics & numerical data
Language	English
Publishing date	2024-02-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037234
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Article: Comparison of color Doppler ultrasonography and computed tomography angiography (CTA) and computed tomography venography (CTV) in the diagnosis of arteriovenous thrombosis after simultaneous pancreas-kidney transplantation: a retrospective diagnostic accuracy study.

Lin, Lan / Chen, Zheng / Liu, Luhao / Mai, Xinghuan / Huang, Jiefang / Liu, Sijie

Annals of translational medicine

2022 Volume 10, Issue 14, Page(s) 770

Abstract: Background: Simultaneous pancreas-kidney transplantation is an important treatment approach for diabetic renal insufficiency, but pancreatic arteriovenous thrombosis is among the early serious surgical complications that can lead to graft loss and even ... ...

Abstract	Background: Simultaneous pancreas-kidney transplantation is an important treatment approach for diabetic renal insufficiency, but pancreatic arteriovenous thrombosis is among the early serious surgical complications that can lead to graft loss and even be fatal. Ultrasound is considered to be a safe and non-invasive approach, but it is often affected by intestinal gas interference and operator proficiency, partial thromboses may be easily missed. Computed tomography angiography (CTA) and computed tomography venography (CTV) are highly accurate but radiative, requiring the use of contrast agents. Methods: A total of 194 patients with end-stage diabetic nephropathy who underwent simultaneous pancreas-kidney transplantation from September 2016 to May 2021 were selected, among which 32 patients with highly suspected arteriovenous thrombosis were enrolled as the research subjects. All patients were examined by color Doppler ultrasonography, CTA and CTV. CTA and CTV are the gold standard for diagnostic imaging. The diagnostic value of color Doppler ultrasound, CTA and CTV in the diagnosis of pancreatic arteriovenous thrombosis was compared. and Kappa coefficient was used for consistency test. Results: Among the 32 patients with high clinical suspicion of transplanted pancreatic arteriovenous thrombosis after simultaneous pancreas-kidney transplantation, 9 patients were diagnosed by CTA/CTV and 10 patients were diagnosed by color Doppler ultrasonography, of which 2 cases were false positive and 1 case false negative. After transplantation, the normal diameter of the donor splenic vein was 3.96±0.16 mm. The difference in the diameter of the donor splenic vein between those with and without donor splenic vein thrombosis was statistically significant (P<0.05). The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of color Doppler ultrasound in the diagnosis of arteriovenous thrombosis were 88.9%, 91.3%, 90.6%, 80%, and 95.5%, respectively. There was no significant difference between color Doppler ultrasound diagnosis of arteriovenous thrombosis and CTA and CTV results (McNemar test P=1). The diagnosis of arteriovenous thrombosis by color Doppler ultrasonography was consistent with that of CTA and CTV (Kappa coefficient =0.776). Conclusions: Color Doppler ultrasonography has the advantages of safety and radiation-free, and can be used as the first choice for diagnosis of pancreatic arteriovenous thrombosis after simultaneous pancreas-kidney transplantation.
Language	English
Publishing date	2022-07-19
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-3134
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Article ; Online: Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees

Yu, Chunna / Zhang, Chengchao / Xu, Xinyun / Huang, Jiefang / Chen, Yueyue / Luo, Xiujun / Wang, Huizhong / Shen, Chenjia

BMC Plant Biol. 2021 Dec., v. 21, no. 1 p.104-104

2021

Abstract: BACKGROUND: Taxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown. RESULTS: High accumulation of 10-DAB, taxol, and 7- ...

Abstract	BACKGROUND: Taxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown. RESULTS: High accumulation of 10-DAB, taxol, and 7-E-PTX suggested that P. chienii is a good taxol-yielding species for large-scale cultivation. By the omics approaches, a total of 3,387 metabolites and 61,146 unigenes were detected and annotated. Compared with a representative Taxus tree (Taxus yunnanensis), most of the differentially accumulated metabolites and differential expressed genes were assigned into 10 primary and secondary metabolism pathways. Comparative analyses revealed the variations in the precursors and intermediate products of taxol biosynthesis between P. chienii and T. yunnanensis. Taxusin-like metabolites highly accumulated in P. chienii, suggesting a wider value of P. chienii in pharmaceutical industry. CONCLUSIONS: In our study, the occurrence of taxoids in P. chienii was determined. The differential expression of key genes involved in the taxol biosynthesis pathway is the major cause of the differential accumulation of taxoids. Moreover, identification of a number of differentially expressed transcription factors provided more candidate regulators of taxol biosynthesis. Our study may help to reveal the differences between Pseudotaxus and Taxus trees, and promote resource utilization of the endangered and rarely studied P. chienii.
Keywords	Taxus ; antineoplastic agents ; biosynthesis ; gene expression regulation ; metabolites ; paclitaxel ; pharmaceutical industry ; trees ; unigenes
Language	English
Dates of publication	2021-12
Size	p. 104.
Publishing place	BioMed Central
Document type	Article ; Online
ZDB-ID	2059868-3
ISSN	1471-2229
ISSN	1471-2229
DOI	10.1186/s12870-021-02883-0
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Article ; Online: Investigation of the role of TmMYB16/123 and their targets (TmMTP1/11) in the tolerance of Taxus media to cadmium.

Feng, Shangguo / Hou, Kailin / Zhang, Hongshan / Chen, Cheng / Huang, Jiefang / Wu, Qicong / Zhang, Zhenhao / Gao, Yadi / Wu, Xiaomei / Wang, Huizhong / Shen, Chenjia

Tree physiology

2023 Volume 43, Issue 6, Page(s) 1009–1022

Abstract: The toxicity and stress caused by heavy metal contamination has become an important constraint to the growth and flourishing of trees. In particular, species belonging to the genus Taxus, which are the only natural source for the anti-tumor medicine ... ...

Abstract	The toxicity and stress caused by heavy metal contamination has become an important constraint to the growth and flourishing of trees. In particular, species belonging to the genus Taxus, which are the only natural source for the anti-tumor medicine paclitaxel, are known to be highly sensitive to environmental changes. To investigate the response of Taxus spp. to heavy metal stress, we analyzed the transcriptomic profiles of Taxus media trees exposed to cadmium (Cd2+). In total, six putative genes from the metal tolerance protein (MTP) family were identified in T. media, including two Cd2+ stress inducible TMP genes (TmMTP1, TmMTP11 and Taxus media). Secondary structure analyses predicted that TmMTP1 and TmMTP11, which are members of the Zn-CDF and Mn-CDF subfamily proteins, respectively, contained six and four classic transmembrane domains, respectively. The introduction of TmMTP1/11 into the ∆ycf1 yeast cadmium-sensitive mutant strain showed that TmMTP1/11 might regulate the accumulation of Cd2+ to yeast cells. To screen the upstream regulators, partial promoter sequences of the TmMTP1/11 genes were isolated using the chromosome walking method. Several myeloblastosis (MYB) recognition elements were identified in the promoters of these genes. Furthermore, two Cd2+-induced R2R3-MYB TFs, TmMYB16 and TmMYB123, were identified. Both in vitro and in vivo assays confirmed that TmMTB16/123 play a role in Cd2+ tolerance by activating and repressing the expression of TmMTP1/11 genes. The present study elucidated new regulatory mechanisms underlying the response to Cd stress and can contribute to the breeding of Taxus species with high environmental adaptability.
MeSH term(s)	Cadmium/metabolism ; Taxus/genetics ; Taxus/metabolism ; Saccharomyces cerevisiae ; Metals, Heavy/metabolism ; Paclitaxel/metabolism
Chemical Substances	Cadmium (00BH33GNGH) ; Metals, Heavy ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2023-02-10
Publishing country	Canada
Document type	Journal Article
ZDB-ID	743341-4
ISSN	1758-4469 ; 0829-318X
ISSN (online)	1758-4469
ISSN	0829-318X
DOI	10.1093/treephys/tpad019
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Article ; Online: Omic analysis of the endangered Taxaceae species Pseudotaxus chienii revealed the differences in taxol biosynthesis pathway between Pseudotaxus and Taxus yunnanensis trees.

Yu, Chunna / Zhang, Chengchao / Xu, Xinyun / Huang, Jiefang / Chen, Yueyue / Luo, Xiujun / Wang, Huizhong / Shen, Chenjia

BMC plant biology

2021 Volume 21, Issue 1, Page(s) 104

Abstract: Background: Taxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown.: Results: High accumulation of 10-DAB, taxol, ... ...

Abstract	Background: Taxol is an efficient anticancer drug accumulated in Taxus species. Pseudotaxus chienii is an important member of Taxaceae, however, the level of six taxoids in P. chienii is largely unknown. Results: High accumulation of 10-DAB, taxol, and 7-E-PTX suggested that P. chienii is a good taxol-yielding species for large-scale cultivation. By the omics approaches, a total of 3,387 metabolites and 61,146 unigenes were detected and annotated. Compared with a representative Taxus tree (Taxus yunnanensis), most of the differentially accumulated metabolites and differential expressed genes were assigned into 10 primary and secondary metabolism pathways. Comparative analyses revealed the variations in the precursors and intermediate products of taxol biosynthesis between P. chienii and T. yunnanensis. Taxusin-like metabolites highly accumulated in P. chienii, suggesting a wider value of P. chienii in pharmaceutical industry. Conclusions: In our study, the occurrence of taxoids in P. chienii was determined. The differential expression of key genes involved in the taxol biosynthesis pathway is the major cause of the differential accumulation of taxoids. Moreover, identification of a number of differentially expressed transcription factors provided more candidate regulators of taxol biosynthesis. Our study may help to reveal the differences between Pseudotaxus and Taxus trees, and promote resource utilization of the endangered and rarely studied P. chienii.
MeSH term(s)	Biosynthetic Pathways ; Endangered Species ; Genetic Variation ; Metabolome ; Metabolomics ; Paclitaxel/biosynthesis ; Plants, Medicinal/metabolism ; Species Specificity ; Taxaceae/metabolism
Chemical Substances	Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2021-02-19
Publishing country	England
Document type	Comparative Study ; Journal Article
ISSN	1471-2229
ISSN (online)	1471-2229
DOI	10.1186/s12870-021-02883-0
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Article: Role of female-predominant MYB39-bHLH13 complex in sexually dimorphic accumulation of taxol in

Yu, Chunna / Huang, Jiefang / Wu, Qicong / Zhang, Chengchao / Li, Xiao-Lin / Xu, Xinyun / Feng, Shangguo / Zhan, Xiaori / Chen, Zhehao / Wang, Huizhong / Shen, Chenjia

Horticulture research

2022 Volume 9, Page(s) uhac062

Abstract: ... ...

Abstract	Taxus
Language	English
Publishing date	2022-03-14
Publishing country	England
Document type	Journal Article
ISSN	2662-6810
ISSN	2662-6810
DOI	10.1093/hr/uhac062
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Article: Tissue‐specific study across the stem of Taxus media identifies a phloem‐specific TmMYB3 involved in the transcriptional regulation of paclitaxel biosynthesis

Yu, Chunna / Luo, Xiujun / Zhang, Chengchao / Xu, Xinyun / Huang, Jiefang / Chen, Yueyue / Feng, Shangguo / Zhan, Xiaori / Zhang, Lei / Yuan, Huwei / Zheng, Bingsong / Wang, Huizhong / Shen, Chenjia

plant journal. 2020 July, v. 103, no. 1

2020

Abstract: Taxus stem barks can be used for extraction of paclitaxel. However, the composition of taxoids across the whole stem and the stem tissue‐specificity of paclitaxel biosynthesis‐related enzymes remain largely unknown. We used cultivated Taxus media trees ... ...

Abstract	Taxus stem barks can be used for extraction of paclitaxel. However, the composition of taxoids across the whole stem and the stem tissue‐specificity of paclitaxel biosynthesis‐related enzymes remain largely unknown. We used cultivated Taxus media trees for analyses of the chemical composition and protein of major stem tissues by an integrated metabolomic and proteomic approach, and the role of TmMYB3 in paclitaxel biosynthesis was investigated. The metabolomic landscape analysis showed differences in stem tissue‐specific accumulation of metabolites. Phytochemical analysis revealed that there is high accumulation of paclitaxel in the phloem. Ten key enzymes involved in paclitaxel biosynthesis were identified, most of which are predominantly produced in the phloem. The full‐length sequence of TmMYB3 and partial promoter sequences of five paclitaxel biosynthesis‐related genes were isolated. Several MYB recognition elements were found in the promoters of TBT, DBTNBT and TS. Further in vitro and in vivo investigations indicated that TmMYB3 is involved in paclitaxel biosynthesis by activating the expression of TBT and TS. Differences in the taxoid composition of different stem tissues suggest that the whole stem of T. media has potential for biotechnological applications. Phloem‐specific TmMYB3 plays a role in the transcriptional regulation of paclitaxel biosynthesis, and may explain the phloem‐specific accumulation of paclitaxel.
Keywords	biosynthesis ; chemical composition ; landscapes ; metabolites ; metabolomics ; paclitaxel ; phloem ; phytochemicals ; proteomics ; transcription (genetics)
Language	English
Dates of publication	2020-07
Size	p. 95-110.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-AP-2-clean ; JOURNAL ARTICLE
ZDB-ID	1088037-9
ISSN	1365-313X ; 0960-7412
ISSN (online)	1365-313X
ISSN	0960-7412
DOI	10.1111/tpj.14710
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Article ; Online: GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure.

Yu, Hongshuang / Yang, Wanlin / Huang, Jiefang / Miao, Xiang / Wang, Bei / Ren, Xiaohui / Gu, Yuting / Wang, Qiwei / Ding, Xinyuan / Guo, Xin / Qian, Fengtao / Zhang, Yanyun / Xu, Huanbai / Zheng, Leizhen / Jin, Min

Cell death & disease

2021 Volume 13, Issue 1, Page(s) 1

Abstract: Fulminant hepatic failure (FHF) is a potentially fatal liver disease that is associated with intrahepatic infiltration of inflammatory cells. As the receptor of polyunsaturated long chain fatty acids, GPR120 can regulate cell differentiation, ... ...

Abstract	Fulminant hepatic failure (FHF) is a potentially fatal liver disease that is associated with intrahepatic infiltration of inflammatory cells. As the receptor of polyunsaturated long chain fatty acids, GPR120 can regulate cell differentiation, proliferation, metabolism, and immune response. However, whether GPR120 is involved in FHF remains unknown. Using Propionibacterium acnes (P. acnes)-primed, LPS-induced FHF in mice, we found that interference with GPR120 activity using pharmacological agonist attenuated the severity of the liver injury and mortality of FHF in mice, while a lack of GPR120 exacerbated the disease. GPR120 activation potently alleviated FHF and led to decreased T helper (Th) 1 cell response and expansion of regulatory T cells (Tregs). Interestingly, GPR120 agonist didn't directly target T cells, but dramatically induced a distinct population of CD11c
MeSH term(s)	Animals ; Case-Control Studies ; Dendritic Cells/metabolism ; Disease Models, Animal ; Female ; Glycolysis ; Humans ; Liver Failure, Acute/genetics ; Mice ; Receptors, G-Protein-Coupled/metabolism
Chemical Substances	FFAR4 protein, mouse ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2021-12-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-021-04394-0
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Article ; Online: Protective role of GPR120 in the maintenance of pregnancy by promoting decidualization via regulation of glucose metabolism.

Huang, Jiefang / Xue, Mingxing / Zhang, Jie / Yu, Hongshuang / Gu, Yuting / Du, Meirong / Ye, Wenfeng / Wan, Bing / Jin, Min / Zhang, Yanyun

EBioMedicine

2018 Volume 39, Page(s) 540–551

Abstract: Background: Intake of ω-3 PUFAs have been demonstrated to have positive effects on pregnancy outcome, whose receptor, GPR120, regulates several cellular functions including differentiation, metabolism and immune reaction. However, whether GPR120 is ... ...

Abstract	Background: Intake of ω-3 PUFAs have been demonstrated to have positive effects on pregnancy outcome, whose receptor, GPR120, regulates several cellular functions including differentiation, metabolism and immune reaction. However, whether GPR120 is involved in decidualization and pregnancy remains unknown. Methods: Decidua tissue from women with normal pregnancy and spontaneous abortion were collected to determine the expression profile of GPR120. Abortion mouse models and artificially induced deciduoma in mice were established to evaluate the effect of GPR120 on pregnancy outcome and in vivo decidualization. HESCs and primary DSCs were used to explore the roles of GPR120 in decidualization and mechanisms involved. Findings: We found that GPR120 functioned to promote decidualization by upregulating glucose uptake and pentose-phosphate pathway (PPP) of human endometrial stromal cells. Firstly, the expression of GPR120 in decidua of spontaneous abortion was downregulated compared to normal decidua. Lack of GPR120 predisposed mice to LPS or RU486 induced abortion. Decidualization was augmented by GPR120 via improving GLUT1-mediated glucose uptake and G6PD- mediated PPP. FOXO1 was upregulated by GPR120 via activation of ERK1/2 and AMPK signaling and increased the expression of GLUT1. Furthermore, the expression of chemokines and cytokines in decidual stromal cells was enhanced by GPR120. Lastly, GPR120 agonist ameliorated LPS-induced abortion in the mice. Interpretation: GPR120 plays significant roles in decidualization and the maintenance of pregnancy, which might be a potential target for diagnosis and treatment of spontaneous abortion. FUND: Ministry of Science and Technology of China, National Natural Science Foundation of China, the Program of Science and Technology Commission of Shanghai Municipality.
MeSH term(s)	Abortion, Spontaneous/chemically induced ; Abortion, Spontaneous/genetics ; Abortion, Spontaneous/metabolism ; Adult ; Animals ; Cell Line ; Decidua/metabolism ; Disease Models, Animal ; Down-Regulation ; Fatty Acids, Omega-3 ; Female ; Glucose/metabolism ; Humans ; Lipopolysaccharides/adverse effects ; Mice ; Mifepristone/adverse effects ; Pentose Phosphate Pathway ; Pregnancy ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Stromal Cells/cytology ; Stromal Cells/metabolism
Chemical Substances	FFAR4 protein, human ; Fatty Acids, Omega-3 ; Lipopolysaccharides ; Receptors, G-Protein-Coupled ; Mifepristone (320T6RNW1F) ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2018-12-18
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2018.12.019
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Article ; Online: Leonurine suppresses neuroinflammation through promoting oligodendrocyte maturation.

Jin, Min / Li, Qian / Gu, Yuting / Wan, Bing / Huang, Jiefang / Xu, Xuanbai / Huang, Rui / Zhang, Yanyun

Journal of cellular and molecular medicine

2018 Volume 23, Issue 2, Page(s) 1470–1485

Abstract: Focal inflammation and remyelination failure are major hallmarks of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). In this study, we found that leonurine, a bioactive alkaloid, alleviated EAE disease severity ... ...

Abstract	Focal inflammation and remyelination failure are major hallmarks of multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). In this study, we found that leonurine, a bioactive alkaloid, alleviated EAE disease severity along with reduced central nervous system inflammation and myelin damage. During the pathogenesis of EAE, leonurine dramatically suppressed the recruitment of encephalitogenic T cells into the central nervous system, whereas did not impair periphery immune responses and microglia activation. Mechanistically, leonurine protected mice against demyelination along with enhanced remyelination through promoting the maturation of oligodendrocytes in both EAE and cuprizone-induced demyelination mouse models. Moreover, we identified that the expression of demethylase jumonji domain-containing protein D3 was significantly enhanced upon treatment of leonurine, which suppressed the trimethylation of histone H3 lysine-27 and enhanced oligodendrocyte maturation accordingly. Collectively, our study identified the therapeutic effect of leonurine on EAE model, which potentially represents a promising therapeutic strategy for multiple sclerosis, even other demyelination disorders.
MeSH term(s)	Animals ; Cell Differentiation/drug effects ; Central Nervous System/drug effects ; Central Nervous System/pathology ; Cuprizone/toxicity ; Disease Models, Animal ; Encephalomyelitis, Autoimmune, Experimental ; Gallic Acid/analogs & derivatives ; Gallic Acid/pharmacology ; Humans ; Inflammation/chemically induced ; Inflammation/drug therapy ; Inflammation/genetics ; Inflammation/pathology ; Jumonji Domain-Containing Histone Demethylases/genetics ; Mice ; Microglia/drug effects ; Microglia/pathology ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/genetics ; Multiple Sclerosis/pathology ; Myelin Sheath/genetics ; Neurogenesis/drug effects ; Oligodendroglia/metabolism ; Oligodendroglia/pathology ; Remyelination/drug effects
Chemical Substances	leonurine (09Q5W34QDA) ; Cuprizone (5N16U7E0AO) ; Gallic Acid (632XD903SP) ; Jumonji Domain-Containing Histone Demethylases (EC 1.14.11.-) ; Kdm6b protein, mouse (EC 1.5.-)
Language	English
Publishing date	2018-12-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2074559-X
ISSN	1582-4934 ; 1582-4934 ; 1582-1838
ISSN (online)	1582-4934
ISSN	1582-4934 ; 1582-1838
DOI	10.1111/jcmm.14053
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