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Article ; Online: Evolution of the Microstructure, Hybridization, and Internal Stress of Al-Doped Diamond-Like Carbon Coatings: A Molecular Dynamics Simulation.

Huang, Jinhai / Peng, Jihua / Qiu, Xianting / Li, Xiaoling

Langmuir : the ACS journal of surfaces and colloids

2023 Volume 39, Issue 11, Page(s) 3895–3904

Abstract: This work modified some parameters related to the bond order in REBO-II of the C-C interaction and simulated the ta-C:Al film deposition using the large-scale atomic/molecular massively parallel simulator especially focused on the effect of the Al-doping ...

Abstract	This work modified some parameters related to the bond order in REBO-II of the C-C interaction and simulated the ta-C:Al film deposition using the large-scale atomic/molecular massively parallel simulator especially focused on the effect of the Al-doping content on the microstructural and mechanical properties of tetrahedral amorphous carbon films. According to the Al existence state, the Al content in the films can be divided into three ranges: range I─under 5 at % Al, a single Al atom or a small cluster with 2-3 Al atoms disperses separately in the matrix; range II─at 5-20 at. % Al, the number and incorporating Al atoms of the clusters increase with the Al content; range III─above 20 at. % Al, only a solid network of aluminum atoms forms, which becomes thickened and densified with Al content increment. The existence states of Al atoms play an essential role in determining mechanical and structural properties. With Al content increasing in the films, the isolated small cluster of atoms evolved into a whole network of aluminum inter-crossing with the C-network. With the evolution of Al existence states, the sp
Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2005937-1
ISSN	1520-5827 ; 0743-7463
ISSN (online)	1520-5827
ISSN	0743-7463
DOI	10.1021/acs.langmuir.2c03200
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: An in vitro investigation into the impact of corneal rinsing on riboflavin/UVA corneal cross-linking.

Morgan, Siân R / O'Brart, David P S / Huang, Jinhai / Meek, Keith M / Hayes, Sally

Eye and vision (London, England)

2024 Volume 11, Issue 1, Page(s) 8

Abstract: Background: Corneal cross-linking (CXL) using riboflavin and ultraviolet-A light (UVA) is a treatment used to prevent progression of keratoconus. This ex vivo study assesses the impact on CXL effectiveness, as measured by tissue enzymatic resistance and ...

Abstract	Background: Corneal cross-linking (CXL) using riboflavin and ultraviolet-A light (UVA) is a treatment used to prevent progression of keratoconus. This ex vivo study assesses the impact on CXL effectiveness, as measured by tissue enzymatic resistance and confocal microscopy, of including a pre-UVA corneal surface rinse with balanced salt solution (BSS) as part of the epithelium-off treatment protocol. Methods: Sixty-eight porcine eyes, after epithelial debridement, were assigned to six groups in three experimental runs. Group 1 remained untreated. Groups 2-6 received a 16-min application of 0.1% riboflavin/Hydroxypropyl methylcellulose (HPMC) drops, after which Group 3 was exposed to 9 mW/cm Results: Application of riboflavin/HPMC solution led to an increase in CCT of 73 ± 14 µm (P < 0.01) after 16 min. All CXL-treated corneas displayed a 2-4 fold greater resistance to collagenase digestion than non-irradiated corneas. There was no difference in resistance between corneas that received no BSS rinse and those that received a 0.25 mL or 1 mL pre-UVA rinse, but each showed a greater level of resistance than those that received a 10 mL pre-UVA rinse (P < 0.05). Confocal microscopy demonstrated reduced stromal riboflavin fluorescence after rinsing. Conclusions: All protocols, with and without rinsing, were effective at enhancing the resistance to collagenase digestion, although resistance was significantly decreased, and stromal riboflavin fluorescence reduced with a 10 mL rinse. This suggests that a 10 mL surface rinse can reduce the efficacy of CXL through the dilution of the stromal riboflavin concentration.
Language	English
Publishing date	2024-02-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2806610-8
ISSN	2326-0254
ISSN	2326-0254
DOI	10.1186/s40662-024-00375-4
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Article ; Online: Rapid Rescue of Goose Astrovirus Genome via Red/ET Assembly.

Cui, Daqing / Li, Shujun / Yin, Boxuan / Li, Changyan / Zhang, Lilin / Li, Zexing / Huang, Jinhai

Food and environmental virology

2024

Abstract: The host-specific infection of Avian Astrovirus (AAstVs) has posed significant challenges to the poultry industry, resulting in substantial economic losses. However, few reports exist on the functional consequences of genome diversity, cross-species ... ...

Abstract	The host-specific infection of Avian Astrovirus (AAstVs) has posed significant challenges to the poultry industry, resulting in substantial economic losses. However, few reports exist on the functional consequences of genome diversity, cross-species infectivity and mechanisms governing virus replication of AAstVs, making it difficult to develop measures to control astrovirus transmission. Reverse genetics technique can be used to study the function of viruses at the molecular level, as well as investigating pathogenic mechanisms and guide vaccine development and disease treatment. Herein, the reverse genetics technique of goose astrovirus GAstV/JS2019 strain was developed based on use of a reconstructed vector including CMV promotor, hammerhead ribozyme (HamRz), hepatitis delta virus ribozyme (HdvRz), and SV40 tail, then the cloned viral genome fragments were connected using Red/ET recombineering. The recombinant rGAstV-JS2019 was readily rescued by transfected the infectious clone plasmid into LMH cells. Importantly, the rescued rGAstV/JS2019 exhibited similar growth kinetics comparable to those of the parental GAstV/JS2019 isolate in cultured cells. Our research results provide an alternative and more effective reverse genetic tool for a detailed understanding of viral replication, pathogenic mechanisms, and molecular mechanisms of evolution.
Language	English
Publishing date	2024-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2487173-4
ISSN	1867-0342 ; 1867-0334
ISSN (online)	1867-0342
ISSN	1867-0334
DOI	10.1007/s12560-024-09593-4
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Article ; Online: Combining small airway parameters with conventional parameters obtained during spirometry to diagnose airflow obstruction: A cross-sectional study.

Wang, Zhufeng / Lin, Junfeng / Liang, Lina / Li, Yun / Huang, Jinhai / Gao, Yi / Zheng, Jinping

Respirology (Carlton, Vic.)

2024

Abstract: Background and objective: The use of small airway parameters generated by spirometry, namely forced expiratory flow between 25% and 75% of forced vital capacity (FVC) (FEF: Methods: We conducted a cross-sectional observational study in which ... ...

Abstract	Background and objective: The use of small airway parameters generated by spirometry, namely forced expiratory flow between 25% and 75% of forced vital capacity (FVC) (FEF Methods: We conducted a cross-sectional observational study in which spirometry and bronchodilator responsiveness (BDR) data were collected in a healthcare centre from May 2021 to August 2022 and in a tertiary hospital from January 2017 to March 2022. Discordance was assessed between the classification of test results by the large airway parameters of forced expiratory volume in 1 second (FEV Results: Our study included 26,658 people. Among people with a normal FVC (n = 14,688), 3.7%, 4.5% and 3.6% of cases exhibited normal FEV Conclusion: It is important to consider both large and small airway parameters in spirometry to avoid missing a diagnosis of airflow obstruction.
Language	English
Publishing date	2024-04-24
Publishing country	Australia
Document type	Journal Article
ZDB-ID	1435849-9
ISSN	1440-1843 ; 1323-7799
ISSN (online)	1440-1843
ISSN	1323-7799
DOI	10.1111/resp.14725
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Zs.A 4957: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: Cell-Penetrating Peptide-Based Delivery of Macromolecular Drugs: Development, Strategies, and Progress.

Sun, Zhe / Huang, Jinhai / Fishelson, Zvi / Wang, Chenhui / Zhang, Sihe

Biomedicines

2023 Volume 11, Issue 7

Abstract: Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being extensively studied due to their excellent delivery performance. Compared with other delivery vehicles, CPPs hold promise for delivering different types of drugs. Here, ... ...

Abstract	Cell-penetrating peptides (CPPs), developed for more than 30 years, are still being extensively studied due to their excellent delivery performance. Compared with other delivery vehicles, CPPs hold promise for delivering different types of drugs. Here, we review the development process of CPPs and summarize the composition and classification of the CPP-based delivery systems, cellular uptake mechanisms, influencing factors, and biological barriers. We also summarize the optimization routes of CPP-based macromolecular drug delivery from stability and targeting perspectives. Strategies for enhanced endosomal escape, which prolong its half-life in blood, improved targeting efficiency and stimuli-responsive design are comprehensively summarized for CPP-based macromolecule delivery. Finally, after concluding the clinical trials of CPP-based drug delivery systems, we extracted the necessary conditions for a successful CPP-based delivery system. This review provides the latest framework for the CPP-based delivery of macromolecular drugs and summarizes the optimized strategies to improve delivery efficiency.
Language	English
Publishing date	2023-07-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines11071971
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Article ; Online: [Reform of biology experiment teaching in the context of "Strengthening Basic Disciplines Program"-taking the course of comprehensive biology design as an example].

Liu, Jing / Sun, Tao / Huang, Jinhai / Peng, Yuxin / Wang, Hanjie

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

2022 Volume 38, Issue 7, Page(s) 2655–2664

Abstract: Talent training is the core of future national competition. "Strengthening Basic Disciplines Program" is an important initiative exploring the training mode for top-notch creative talents in basic disciplines, and an important measure to meet the needs ... ...

Abstract	Talent training is the core of future national competition. "Strengthening Basic Disciplines Program" is an important initiative exploring the training mode for top-notch creative talents in basic disciplines, and an important measure to meet the needs for fostering future talents. The students enrolled in the "Strengthening Basic Disciplines Program" often have excellent grades and strong motivation, which puts forward new requirements and new goals for the talents training mode. Among them, the teaching reform under the background of "Strengthening Basic Disciplines Program" is imperative. The science, technology, engineering, arts, mathematics (STEAM) education concept is an interdisciplinary comprehensive educational philosophy that happens to coincide with the philosophy of the "Strengthening Basic Disciplines Program". In view of this, the School of Life Sciences of Tianjin University has explored and practiced the reform of biology experimental teaching based on the objective of fostering biology talents in the context of "Strengthening Basic Disciplines Plan" and the STEAM education concept, by taking the course of comprehensive biology design as an example.
MeSH term(s)	Biological Science Disciplines/education ; Biology/education ; Curriculum ; Humans ; Students ; Universities
Language	Chinese
Publishing date	2022-07-25
Publishing country	China
Document type	Journal Article
ZDB-ID	1042206-7
ISSN	1872-2075 ; 1042-749X
ISSN (online)	1872-2075
ISSN	1042-749X
DOI	10.13345/j.cjb.210953
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Zs.A 3505: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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ab Jg. 2022: Lesesaal (EG)

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Article: Increased Expression of Homeobox 5 Predicts Poor Prognosis: A Potential Prognostic Biomarker for Glioma.

Xu, Chengran / Huang, Jinhai / Yang, Yi / Li, Lun / Li, Guangyu

International journal of general medicine

2022 Volume 15, Page(s) 4399–4407

Abstract: Background: The homeobox gene 5 (: Methods: This study identified the relationship between HOXB5 and glioma by investigating : Results: The expression of HOXB5 was upregulated in glioma and generally increased with malignancy. HOXB5 was an ... ...

Abstract	Background: The homeobox gene 5 ( Methods: This study identified the relationship between HOXB5 and glioma by investigating Results: The expression of HOXB5 was upregulated in glioma and generally increased with malignancy. HOXB5 was an independent prognostic factor for glioma patients. A nomogram was further built that integrated HOXB5, and it showed stratifying prediction accuracy and efficiency. HOXB5 was associated with the regulation of cell growth, endothelial cell growth, and the IL-6/JAK-STAT3 pathway, and was determined to possibly promote stomatal specimen enrichment and angiogenesis. Conclusion: HOXB5 protein is overexpressed in glioma and might serve as a good predictive factor of this disease.
Language	English
Publishing date	2022-04-26
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2452220-X
ISSN	1178-7074
ISSN	1178-7074
DOI	10.2147/IJGM.S350454
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Article ; Online: Exploring Efficient Dual-Phase Emissive Fluorophores with High Mobility by Integrating a Rigid Donor and Flexible Acceptor.

Guo, Shiyan / Jin, Xin / Zhang, Daheng / Zhou, Haitao / Yu, Chao / Huang, Jinhai / Zhang, Zhiyun / Su, Jianhua

ACS applied materials & interfaces

2024 Volume 16, Issue 8, Page(s) 10407–10416

Abstract: Developing luminogens with a high emission efficiency in both single-molecule and aggregate states, as well as high mobility, shows promise for advancing the iteration and update of organic optoelectronic materials. However, achieving a delicate balance ... ...

Abstract	Developing luminogens with a high emission efficiency in both single-molecule and aggregate states, as well as high mobility, shows promise for advancing the iteration and update of organic optoelectronic materials. However, achieving a delicate balance between the plane configuration of luminophores and the strong exciton interactions of aggregates is a formidable task from the molecular design perspective. This dilemma was overcome by integrating a rigid donor and flexible acceptor to establish donor-acceptor (D-A) type emitters. The π-conjugate-extended donor ensures the substantial planarity of these molecules, allowing strong emission in solution with photoluminescence quantum yield values of 86% and 75%. Furthermore, the restricted molecular motion of the aggregation-induced emission moiety and the formation of
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c18176
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Article ; Online: On the self-consistency of DFT-1/2.

Cui, Hanli / Yang, Shengxin / Xue, Kan-Hao / Huang, Jinhai / Miao, Xiangshui

The Journal of chemical physics

2023 Volume 158, Issue 9, Page(s) 94103

Abstract: Density functional theory (DFT)-1/2 is an efficient bandgap rectification method for DFT under local density approximation (LDA) or generalized gradient approximation. It was suggested that non-self-consistent DFT-1/2 should be used for highly ionic ... ...

Abstract	Density functional theory (DFT)-1/2 is an efficient bandgap rectification method for DFT under local density approximation (LDA) or generalized gradient approximation. It was suggested that non-self-consistent DFT-1/2 should be used for highly ionic insulators like LiF, whereas self-consistent DFT-1/2 should still be used for other compounds. Nevertheless, there is no quantitative criterion prescribed for which implementation should work for an arbitrary insulator, which leads to severe ambiguity in this method. In this work, we analyze the impact of self-consistency in DFT-1/2 and shell DFT-1/2 calculations in insulators or semiconductors with ionic bonds, covalent bonds, and intermediate cases and show that self-consistency is required even for highly ionic insulators for globally better electronic structure details. The self-energy correction renders electrons more localized around the anions in self-consistent LDA-1/2. The well-known delocalization error of LDA is rectified, but with strong overcorrection, due to the presence of additional self-energy potential. However, in non-self-consistent LDA-1/2 calculations, the electron wave functions indicate that such localization is much more severe and beyond a reasonable range because the strong Coulomb repulsion is not counted in the Hamiltonian. Another common drawback of non-self-consistent LDA-1/2 is that the ionicity of the bonding gets substantially enhanced, and the bandgap can be enormously high in mixed ionic-covalent compounds like TiO
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3113-6
ISSN	1089-7690 ; 0021-9606
ISSN (online)	1089-7690
ISSN	0021-9606
DOI	10.1063/5.0137534
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Z 4' 49/16: Show issues

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Article ; Online: Evaluation of the Agreement Between a New Pyramid Wavefront Sensor Aberrometer and Scheiner-Smirnov Aberrometers.

Yang, Yizhou / Ning, Rui / Xu, Shuoyu / Xiahou, Jinxuan / Li, Jiawei / Savini, Giacomo / Schiano-Lomoriello, Domenico / Zhou, Xingtao / Huang, Jinhai

Journal of refractive surgery (Thorofare, N.J. : 1995)

2024 Volume 40, Issue 4, Page(s) e218–e228

Abstract: Purpose: To assess agreement between a new aberrometer (Osiris-T; CSO) employing pyramid wavefront sensor technique and Scheiner-Smirnov aberrometer (OPD-Scan III; Nidek) on measuring ocular, corneal, and internal aberrations in healthy participants.: ...

Abstract	Purpose: To assess agreement between a new aberrometer (Osiris-T; CSO) employing pyramid wavefront sensor technique and Scheiner-Smirnov aberrometer (OPD-Scan III; Nidek) on measuring ocular, corneal, and internal aberrations in healthy participants. Methods: The measurements were conducted three times consecutively by an experienced examiner. The total root mean square (RMS) aberrations, higher order aberration RMS, coma Z Results: This prospective study included 70 right eyes of 70 healthy participants with an average age of 25.94 ± 6.59 years (range: 18 to 47 years). The mean difference in the two devices ranged from 0.01 µm for astigmatism II Z Conclusions: The newly developed pyramid wavefront sensor technique aberrometer demonstrated a high agreement with a Scheiner-Smirnov aberrometer when measuring ocular, corneal, and internal aberrations in healthy participants. Thus, the two aberrometers may be considered interchangeable for clinical applications.
MeSH term(s)	Humans ; Young Adult ; Adult ; Astigmatism ; Prospective Studies ; Cornea ; Pupil ; Biometry ; Corneal Topography ; Refraction, Ocular
Language	English
Publishing date	2024-04-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1264796-2
ISSN	1938-2391 ; 0883-0444 ; 1081-597X ; 1081-0803
ISSN (online)	1938-2391
ISSN	0883-0444 ; 1081-597X ; 1081-0803
DOI	10.3928/1081597X-20240311-02
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Zs.A 3248: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 289: Show issues

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