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  1. Article ; Online: Janus kinase inhibitors: a future all-rounder in axial spondyloarthritis?

    Huang, Jin-Xian / Wei, James Cheng-Chung

    Immunotherapy

    2023  Volume 15, Issue 15, Page(s) 1195–1198

    MeSH term(s) Humans ; Janus Kinase Inhibitors/therapeutic use ; Axial Spondyloarthritis
    Chemical Substances Janus Kinase Inhibitors
    Language English
    Publishing date 2023-09-18
    Publishing country England
    Document type Editorial
    ZDB-ID 2495964-9
    ISSN 1750-7448 ; 1750-743X
    ISSN (online) 1750-7448
    ISSN 1750-743X
    DOI 10.2217/imt-2023-0176
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  2. Article ; Online: Optimal composite measures for psoriatic arthritis.

    Huang, Jin-Xian / Lee, Yung-Heng / Wei, James Cheng-Chung

    International journal of rheumatic diseases

    2023  Volume 26, Issue 10, Page(s) 1897–1898

    MeSH term(s) Humans ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Psoriasis ; Severity of Illness Index
    Language English
    Publishing date 2023-10-19
    Publishing country England
    Document type Editorial
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14829
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    Zs.A 6098: Show issues Location:
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  3. Article ; Online: Patient-tailored dose reduction of tumor necrosis factor inhibitors in axial spondyloarthritis.

    Huang, Jin-Xian / Lee, Yung-Heng / Wei, James Cheng-Chung

    International immunopharmacology

    2023  Volume 116, Page(s) 109804

    Abstract: Tumor necrosis factor inhibitors have been widely used in the field of axial spondyloarthritis, with current guidelines now recommending dose reduction instead of withdrawal of biologics. Systemic review and meta-analyses in literature have summarized ... ...

    Abstract Tumor necrosis factor inhibitors have been widely used in the field of axial spondyloarthritis, with current guidelines now recommending dose reduction instead of withdrawal of biologics. Systemic review and meta-analyses in literature have summarized present tapering strategies and principles in published heterogeneous studies. In this study, we reviewed and provided an update on present evidence based on prospective and retrospective studies from 2008 to 2022 by performing a literature review of related publications on remission or relapse from PubMed. We further stated the core issues concerning dose reduction, including the timing, optimization, intensity, maintenance, monitoring, factors associated with tapering and solutions to de-escalation failure. Remission/relapse should be the principal consideration in dose reduction implementation for individuals without comorbidities. As a treat-to-target scope of this multifaceted systemic disease, extra-articular manifestations such as uveitis, psoriasis, inflammatory bowel disease, cardiovascular complication, hip involvement and progressed structural damage influence patient-tailored dose reduction plans. Safety concerns and costs should be integrated into the decision-making schedule to optimize the individualized dose reduction paradigm.
    MeSH term(s) Humans ; Axial Spondyloarthritis/drug therapy ; Drug Tapering ; Prospective Studies ; Recurrence ; Retrospective Studies ; Tumor Necrosis Factor Inhibitors/therapeutic use
    Chemical Substances Tumor Necrosis Factor Inhibitors
    Language English
    Publishing date 2023-02-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2023.109804
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    Zs.A 5408: Show issues Location:
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  4. Article ; Online: Correspondence on 'Efficacy and safety of brodalumab, an anti-IL17RA monoclonal antibody, in patients with axial spondyloarthritis: 16-week results from a randomized, placebo-controlled, phase 3 trial'.

    Zhao, Yan / Huang, Jin-Xian

    Annals of the rheumatic diseases

    2021  Volume 82, Issue 7, Page(s) e168

    MeSH term(s) Humans ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antirheumatic Agents/therapeutic use ; Axial Spondyloarthritis ; Double-Blind Method ; Spondylitis, Ankylosing/drug therapy ; Treatment Outcome
    Chemical Substances brodalumab (6ZA31Y954Z) ; Antibodies, Monoclonal, Humanized ; Antirheumatic Agents
    Language English
    Publishing date 2021-06-25
    Publishing country England
    Document type Randomized Controlled Trial ; Clinical Trial, Phase III ; Letter ; Comment
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2021-220759
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    Zs.MO 167: Show issues

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  5. Article ; Online: Surfactant Additives Containing Hydrophobic Fluorocarbon Chains and Hydrophilic Sulfonate Anion for Highly Reversible Zn Anode.

    Huang, Jinxian / Fu, Zhao / Sun, Chuan-Fu / Deng, Wenzhuo

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 10

    Abstract: Aqueous zinc-ion batteries (AZIBs) show enormous potential as a large-scale energy storage technique. However, the growth of Zn dendrites and serious side reactions occurring at the Zn anode hinder the practical application of AZIBs. For the first time, ... ...

    Abstract Aqueous zinc-ion batteries (AZIBs) show enormous potential as a large-scale energy storage technique. However, the growth of Zn dendrites and serious side reactions occurring at the Zn anode hinder the practical application of AZIBs. For the first time, we reported a fluorine-containing surfactant, i.e., potassium perfluoro-1-butanesulfonate (PPFBS), as an additive to the 2 M ZnSO
    Language English
    Publishing date 2023-05-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104177
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    Zs.MO 81: Show issues

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  6. Article ; Online: Postvaccination Acute Exacerbations of Idiopathic Pulmonary Fibrosis?

    Huang, Jin-Xian / Wei, James Cheng-Chung

    American journal of respiratory and critical care medicine

    2022  Volume 206, Issue 7, Page(s) 917

    MeSH term(s) Acute Disease ; Humans ; Idiopathic Pulmonary Fibrosis ; Risk Factors
    Language English
    Publishing date 2022-05-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202204-0756LE
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    Uh II Zs.80: Show issues Location:
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  7. Article ; Online: Successful treatment of tofacitinib in a case with rheumatoid arthritis who experienced hepatitis B virus reactivation induced by tocilizumab and recovered from entecavir rescue therapy.

    Huang, Jin-Xian / Zhang, Li-Jun

    Archives of rheumatology

    2020  Volume 36, Issue 3, Page(s) 458–460

    Language English
    Publishing date 2020-12-14
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3012972-2
    ISSN 2618-6500 ; 2148-5046
    ISSN (online) 2618-6500
    ISSN 2148-5046
    DOI 10.46497/ArchRheumatol.2021.8230
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  8. Article ; Online: Benefits of tumor necrosis factor inhibitors for cardiovascular disease in ankylosing spondylitis.

    Huang, Jin-Xian / Lee, Yung-Heng / Cheng-Chung Wei, James

    International immunopharmacology

    2022  Volume 112, Page(s) 109207

    Abstract: Ankylosing spondylitis (AS) has been associated with an increased cardiovascular disease (CVD) risk, with current guidelines recommending multiple CVD-related risk assessment strategies. CVD risk prediction using a scoring model with lipids might be ... ...

    Abstract Ankylosing spondylitis (AS) has been associated with an increased cardiovascular disease (CVD) risk, with current guidelines recommending multiple CVD-related risk assessment strategies. CVD risk prediction using a scoring model with lipids might be another promising alternative, for which ultrasound screening for subclinical atherosclerosis may be considered together with surrogate markers. Theoretically, tumor necrosis factor inhibitors (TNFi), which are known to inhibit endothelial activation and inflammation caused by the disease and underlying metabolic dysfunction, might prevent microvascular events. In this narrative review, we summarized the evidence of TNFi effects on CVD in AS. Although early case reports revealed that CVD occurred during TNFi treatment, more recent evidence shows that it could be successfully treated. Studies of TNFi on lipid changes and subclinical atherosclerosis have shown controversial results, possibly due to genetic predisposition, differences in affinity for membrane-bound TNF leading to insufficient inhibition of inflammation or primary failure response to TNFi, and not enough follow-up time to identify potential significance. Overall, patients vulnerable to CVD could benefit from long-term administration of TNFi when inflammation is under control. Besides healthy lifestyle modification, traditional CVD risk factors and metabolic syndrome-related diseases should be further assessed and treated if necessary.
    MeSH term(s) Humans ; Spondylitis, Ankylosing/drug therapy ; Tumor Necrosis Factor Inhibitors ; Antirheumatic Agents/therapeutic use ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/complications ; Tumor Necrosis Factor-alpha ; Biomarkers ; Inflammation/drug therapy ; Atherosclerosis/drug therapy ; Lipids/therapeutic use ; Treatment Outcome
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Antirheumatic Agents ; Tumor Necrosis Factor-alpha ; Biomarkers ; Lipids
    Language English
    Publishing date 2022-09-05
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2022.109207
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    Zs.A 5408: Show issues Location:
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  9. Article ; Online: Calprotectin in psoriatic arthritis: Inflammation and beyond.

    Huang, Jin-Xian / Lee, Yung-Heng / Ko, Meng-Yu / Wei, James Cheng-Chung

    International journal of rheumatic diseases

    2023  Volume 26, Issue 1, Page(s) 11–12

    MeSH term(s) Humans ; Arthritis, Psoriatic/diagnosis ; Arthritis, Psoriatic/drug therapy ; Leukocyte L1 Antigen Complex ; Inflammation/diagnosis ; Psoriasis
    Chemical Substances Leukocyte L1 Antigen Complex
    Language English
    Publishing date 2023-01-02
    Publishing country England
    Document type Editorial
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14470
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  10. Article ; Online: Personalized tapering of tumor necrosis factor inhibitor in axial spondyloarthritis.

    Huang, Jin-Xian / Lee, Yung-Heng / Leong, Pui-Ying / Wei, James Cheng-Chung

    International journal of rheumatic diseases

    2023  Volume 27, Issue 1, Page(s) e15008

    MeSH term(s) Humans ; Tumor Necrosis Factor Inhibitors/adverse effects ; Antirheumatic Agents/adverse effects ; Adalimumab/therapeutic use ; Axial Spondyloarthritis ; Spondylarthritis/diagnosis ; Spondylarthritis/drug therapy ; Tumor Necrosis Factor-alpha ; Spondylitis, Ankylosing/diagnosis ; Spondylitis, Ankylosing/drug therapy
    Chemical Substances Tumor Necrosis Factor Inhibitors ; Antirheumatic Agents ; Adalimumab (FYS6T7F842) ; Tumor Necrosis Factor-alpha
    Language English
    Publishing date 2023-12-23
    Publishing country England
    Document type Editorial
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.15008
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