LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 30

Search options

  1. Article: Ligand-controlled regiodivergent Ni-catalyzed

    Chen, Zunsheng / Nie, Biao / Li, Xiaoning / Liu, Teng / Li, Chunsheng / Huang, Jiuzhong

    Chemical science

    2024  Volume 15, Issue 6, Page(s) 2236–2242

    Abstract: Unprecedented ... ...

    Abstract Unprecedented regioselective
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/d3sc04184k
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Rh(III)-catalyzed selective mono- and dual-functionalization/cyclization of 1-aryl-5-aminopyrazoles with iodonium ylides.

    Chen, Longkun / Zhang, Mingshuai / Liu, Meichen / Liu, Zhuoyuan / Qiu, Yuetong / Zhang, Zhilai / Yu, Fuchao / Huang, Jiuzhong

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 4, Page(s) 432–435

    Abstract: An efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as a single coupling partner was demonstrated, in which fused benzodiazepine skeletons were obtained in excellent yields. This method ... ...

    Abstract An efficient Rh(III)-catalyzed selective mono- and dual-C-H bond functionalization/cyclization with iodonium ylide as a single coupling partner was demonstrated, in which fused benzodiazepine skeletons were obtained in excellent yields. This method greatly improved an effective approach to dual C-H unsymmetrical functionalization.
    Language English
    Publishing date 2024-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05266d
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Synthesis of Tetrahydro-indolones through Rh(III)-Catalyzed [3 + 2] Annulation of Enaminones with Iodonium Ylides.

    Zhang, Mingshuai / Chen, Longkun / Sun, Haifeng / Liu, Zhuoyuan / Huang, Jiuzhong / Yu, Fuchao

    Organic letters

    2023  Volume 25, Issue 40, Page(s) 7298–7303

    Abstract: An unprecedented protocol for a Rh(III)-catalyzed [3 + 2] annulation from simple and readily available enaminones and iodonium ylides has been developed. The novel strategy allows for access to a new class of structurally diverse tetrahydro-indolones ... ...

    Abstract An unprecedented protocol for a Rh(III)-catalyzed [3 + 2] annulation from simple and readily available enaminones and iodonium ylides has been developed. The novel strategy allows for access to a new class of structurally diverse tetrahydro-indolones with high efficiency and a broad substrate scope. In addition, this transformation represents the first example of the selective Rh(III)-catalyzed alkenyl C-H bond functionalization and annulation of enaminones. Finally, the potential applications of this protocol are demonstrated through gram-scale reaction and late-stage modification.
    Language English
    Publishing date 2023-10-03
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c02515
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Recent Advances in Organic Synthesis Based on N,N-Dimethyl Enaminones

    Huang, Jiuzhong / Yu, Fuchao

    Synthesis

    2020  Volume 53, Issue 04, Page(s) 587–610

    Abstract: Enaminones are gaining increasing interest because of their unique properties and their importance in organic synthesis as versatile building blocks. N N -Dimethyl enaminones offer a better leaving group (a dimethylamine group) than other enaminones, ... ...

    Abstract Enaminones are gaining increasing interest because of their unique properties and their importance in organic synthesis as versatile building blocks. N N -Dimethyl enaminones offer a better leaving group (a dimethylamine group) than other enaminones, and allow further elaboration via a range of facile chemical transformations. Over the past five years, there have been an increasing number of reports describing the synthetic applications of N N -dimethyl enaminones. This review provides a comprehensive overview on the synthetic applications of N N -dimethyl enaminones that have been reported since 2016. 1

    Introduction 2

    Direct C(sp 2 )–H α-Functionalization 2.1

    Synthesis of α-Sulfenylated N N -Dimethyl Enaminones 2.2

    Synthesis of α-Thiocyanated N N -Dimethyl Enaminones 2.3

    Synthesis of α-Acyloxylated N N -Dimethyl Enaminones 3

    Functionalization Reactions via C=C Double Bond Cleavage 3.1

    Synthesis of Functionalized Methyl Ketones 3.2

    Synthesis of α-Ketoamides, α-Ketoesters and 1,2-Diketones 3.3

    Synthesis of N -Sulfonyl Amidines 4

    Construction of All-Carbon Aromatic Scaffolds 4.1

    Synthesis of Benzaldehydes 4.2

    Synthesis of the Naphthalenes 5

    Construction of Heterocyclic Scaffolds 5.1

    Synthesis of Five-Membered Heterocycles 5.2

    Synthesis of Six-Membered Heterocycles 5.3

    Synthesis of Quinolines 5.4

    Synthesis of Functionalized Chromones 5.5

    Synthesis of Other Fused Polycyclic Heterocycles 6

    Conclusions and Perspectives
    Keywords , ; -dimethyl enaminones ; C(sp ; )–H α-functionalization ; cyclization reactions ; C=C double bond cleavage ; heterocycles
    Language English
    Publishing date 2020-11-03
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2033062-5
    ISSN 1437-210X ; 0039-7881
    ISSN (online) 1437-210X
    ISSN 0039-7881
    DOI 10.1055/s-0040-1707328
    Database Thieme publisher's database

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Facile access to the 2,2-difluoro-2,3-dihydrofuran skeleton without extra additives: DMF-promoted difluorocarbene formation of ClCF

    Chen, Zunsheng / Xie, Xin / Chen, Weiming / Luo, Nianhua / Li, Xiaoning / Yu, Fuchao / Huang, Jiuzhong

    Organic & biomolecular chemistry

    2022  Volume 20, Issue 41, Page(s) 8037–8041

    Abstract: A practical and facile difluorocarbene-triggered cycloaddition reaction of enaminones was developed, which delivered 2,2-difluoro-2,3-dihydrofurans with a broad substrate scope. Notably, the reaction proceeded smoothly without any extra additives. ... ...

    Abstract A practical and facile difluorocarbene-triggered cycloaddition reaction of enaminones was developed, which delivered 2,2-difluoro-2,3-dihydrofurans with a broad substrate scope. Notably, the reaction proceeded smoothly without any extra additives. Readily available sodium chlorodifluoroacetate (ClCF
    MeSH term(s) Humans ; Molecular Structure ; Sodium ; Skeleton
    Chemical Substances difluorocarbene ; 2,3-dihydrofuran (1191-99-7) ; 5(6)-carboxy-2',7'-dichlorofluorescein (111843-78-8) ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2022-10-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d2ob01542k
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Cyclometalated iridium complexes-catalyzed acceptorless dehydrogenative coupling reaction: construction of quinoline derivatives and evaluation of their antimicrobial activities.

    Shui, Hongling / Zhong, Yuhong / Luo, Renshi / Zhang, Zhanyi / Huang, Jiuzhong / Yang, Ping / Luo, Nianhua

    Beilstein journal of organic chemistry

    2022  Volume 18, Page(s) 1507–1517

    Abstract: The acceptorless dehydrogenative coupling (ADC) reaction is an efficient method for synthesizing quinoline and its derivatives. In this paper, various substituted quinolines were synthesized from 2-aminobenzyl alcohols and aryl/heteroaryl/alkyl secondary ...

    Abstract The acceptorless dehydrogenative coupling (ADC) reaction is an efficient method for synthesizing quinoline and its derivatives. In this paper, various substituted quinolines were synthesized from 2-aminobenzyl alcohols and aryl/heteroaryl/alkyl secondary alcohols in one pot via a cyclometalated iridium-catalyzed ADC reaction. This method has some advantages, such as easy availability of raw materials, mild reaction conditions, wide range of substrates, and environmental friendliness which conforms to the principles of green chemistry. Furthermore, a gram-scale experiment with low catalyst loading offers the potential to access the aryl/heteroaryl quinolones in suitable amounts. In addition, the antibacterial and antifungal activities of the synthesized quinolines were evaluated in vitro, and the experimental results showed that the antibacterial activities of compounds
    Language English
    Publishing date 2022-10-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2192461-2
    ISSN 1860-5397
    ISSN 1860-5397
    DOI 10.3762/bjoc.18.159
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Mn(OAc)

    Huang, Jiuzhong / Wu, Yi / Hu, Zhihao / Han, Shihong / Rong, Lanlan / Xie, Xin / Chen, Weiming / Peng, Xiaopeng

    Bioorganic chemistry

    2023  Volume 140, Page(s) 106748

    Abstract: The practical and facile Mn(OAc) ...

    Abstract The practical and facile Mn(OAc)
    MeSH term(s) Structure-Activity Relationship ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Pyrroles/pharmacology ; Pyrroles/chemistry ; Cyclization ; Esters/chemistry ; Cell Proliferation ; Drug Screening Assays, Antitumor ; Cell Line, Tumor ; Molecular Structure
    Chemical Substances Antineoplastic Agents ; Pyrroles ; Esters
    Language English
    Publishing date 2023-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2023.106748
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Small change for big improvement in the preparation of the key intermediate

    Hu, Wei / Liu, Yuanchang / Zhang, Xiang / Zheng, Panpan / Yang, Feifei / Guo, Guangyang / Xie, Xin / Huang, Jiuzhong / Chen, Weiming

    RSC advances

    2023  Volume 13, Issue 6, Page(s) 3688–3693

    Abstract: In this study, the key ... ...

    Abstract In this study, the key intermediate
    Language English
    Publishing date 2023-01-25
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra07844a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Access to thiionized-, selenolized-, and alkylated 5-alkylidene 3-pyrrolin-2-one derivatives

    Liu, Donghan / Song, Siyu / Chen, Longkun / Zhang, Mingshuai / Liu, Zhuoyuan / Lu, Xihang / Huang, Jiuzhong / Yu, Fuchao

    Organic & biomolecular chemistry

    2023  Volume 21, Issue 12, Page(s) 2596–2602

    Abstract: A metal-free regioselective oxidative annulation reaction of readily available 2,4-pentanediones with primary amines has been described. This protocol provides a divergent strategy for the incorporation of various radical donors into 5-alkylidene 3- ... ...

    Abstract A metal-free regioselective oxidative annulation reaction of readily available 2,4-pentanediones with primary amines has been described. This protocol provides a divergent strategy for the incorporation of various radical donors into 5-alkylidene 3-pyrrolin-2-one skeletons, producing a variety of thiionized-, selenolized-, and alkylated 5-alkylidene 3-pyrrolin-2-one derivatives. Moreover, the diverse synthetic transformations of the 5-alkylidene 3-pyrrolin-2-one products were also investigated.
    Language English
    Publishing date 2023-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob00014a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Recent advancements in the discovery of small-molecule non-nucleoside inhibitors targeting SARS-CoV-2 RdRp.

    Zhou, Bangdi / Chen, Dianming / Zhang, Tingyan / Song, Chenggui / Zhang, Xianwu / Lin, Leying / Huang, Jiuzhong / Peng, Xiaopeng / Liu, Yuanchang / Wu, Gaorong / Li, Jingyuan / Chen, Weiming

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 171, Page(s) 116180

    Abstract: The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds ...

    Abstract The RNA-dependent RNA polymerase (RdRp) of SARS-CoV-2 plays a pivotal role in the life cycle of the novel coronavirus and stands as a significant and promising target for anti-SARS-CoV-2 drugs. Non-nucleoside inhibitors (NNIs), as a category of compounds directed against SARS-CoV-2 RdRp, exhibit a unique and highly effective mechanism, effectively overcoming various factors contributing to drug resistance against nucleoside inhibitors (NIs). This review investigates various NNIs, including both natural and synthetic inhibitors, that closely interacting with the SARS-CoV-2 RdRp with valid evidences from in vitro and in silico studies.
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; RNA-Dependent RNA Polymerase ; Antiviral Agents/pharmacology ; Molecular Docking Simulation
    Chemical Substances RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Antiviral Agents
    Language English
    Publishing date 2024-01-23
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116180
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top