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Article: The extracellular matrix glycoprotein fibrillin-1 in health and disease.

Li, Li / Huang, Junxin / Liu, Youhua

Frontiers in cell and developmental biology

2024 Volume 11, Page(s) 1302285

Abstract: Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded ... ...

Abstract	Fibrillin-1 (FBN1) is a large, cysteine-rich, calcium binding extracellular matrix glycoprotein encoded by
Language	English
Publishing date	2024-01-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2023.1302285
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: How Does Climate Policy Uncertainty Affect Green Innovation? Evidence from China.

Mao, Ke / Huang, Junxin

International journal of environmental research and public health

2022 Volume 19, Issue 23

Abstract: In response to climate change, governments have adopted various climate policies. However, climate policy uncertainty (CPU) may have important implications for the business sector. Is enterprise green innovation (GI) affected by CPU? This study ... ...

Abstract	In response to climate change, governments have adopted various climate policies. However, climate policy uncertainty (CPU) may have important implications for the business sector. Is enterprise green innovation (GI) affected by CPU? This study investigates the impact of CPU on enterprise GI. The China CPU index is created first in this study. It uses panel data from Chinese A-share listed companies in China from 2010 to 2021 to explore the impact of CPU on GI through the fixed effects model, the mediating effects model, and the moderating effects model. The results show that: (1) CPU significantly suppresses GI, according to the findings. (2) CPU inhibits enterprise GI by exacerbating enterprise financing constraints. (3) Government subsidies can mitigate the inhibiting effect of CPU on GI. (4) There is heterogeneity in the negative impact of CPU on enterprise GI, mainly on non-state-owned enterprises. This study suggests several recommendations for coping with CPU in China.
MeSH term(s)	Humans ; Policy ; Uncertainty ; Government ; Adaptation, Psychological ; Asian People ; China
Language	English
Publishing date	2022-11-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192315745
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Article ; Online: Research of wet string grid dust removal vehicle and creation of dust control area on tunnel working face.

Deng, Huan / Chen, Shiqiang / Huang, Junxin / Wu, Zhirong / Rao, Ying / Qiu, Xinyi / Cheng, Jiujun

Scientific reports

2024 Volume 14, Issue 1, Page(s) 8292

Abstract: The spread of blast dust throughout the tunnel becomes a common problem in drill and blast tunneling,the key to breaking through the problem is the creation of a dust control area on the working face.In view of this key problem, a wet string grid dust ... ...

Abstract	The spread of blast dust throughout the tunnel becomes a common problem in drill and blast tunneling,the key to breaking through the problem is the creation of a dust control area on the working face.In view of this key problem, a wet string grid dust removal crawler vehicle was developed, the power of the vehicle came from the diesel generator, and further, the air cooler of the diesel generator was used to generate airflow, and the suction process formed by the on-board axial flow fan was coupled to create a dust control area of the working face after blasting.The results show that when the frequency of the axial flow fan is adjusted to 30 Hz, the airflow speed of the wet chord grid section reaches 3.34 m/s, and the dust removal efficiency is the highest, with a value of 94.3%.Compared with the non-use of the dust removal vehicle, when the air outlet of the air cooler is front, horizontal front, horizontal rear, the dust concentration is reduced by 74.37, 92.39 and 50.53%.Finally, the optimized wet grid dust removal crawler was installed in the Dading tunnel, and the actual dust reduction efficiency was about 78.49%. The results obtained provide an important technical way to improve the working environment of the drilling and blasting construction tunnel.
Language	English
Publishing date	2024-04-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-57748-x
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Article ; Online: Proteomic landscape of the extracellular matrix in the fibrotic kidney.

Li, Li / He, Meizhi / Tang, Xiaoman / Huang, Junxin / Li, Jing / Hong, Xue / Fu, Haiyan / Liu, Youhua

Kidney international

2023 Volume 103, Issue 6, Page(s) 1063–1076

Abstract: The extracellular matrix (ECM) is a complex three-dimensional network of proteins surrounding cells, forming a niche that controls cell adhesion, proliferation, migration and differentiation. The ECM network provides an architectural scaffold for ... ...

Abstract	The extracellular matrix (ECM) is a complex three-dimensional network of proteins surrounding cells, forming a niche that controls cell adhesion, proliferation, migration and differentiation. The ECM network provides an architectural scaffold for surrounding cells and undergoes dynamic changes in composition and contents during the evolution of chronic kidney disease (CKD). Here, we unveiled the proteomic landscape of the ECM by delineating proteome-wide and ECM-specific alterations in normal and fibrotic kidneys. Decellularized kidney tissue scaffolds were made and subjected to proteomic profiling by liquid chromatography with tandem mass spectrometry. A total of 172 differentially expressed proteins were identified in these scaffolds from mice with CKD. Through bioinformatics analysis and experimental validation, we identified a core set of nine signature proteins, which could play a role in establishing an oxidatively stressed, profibrotic, proinflammatory and antiangiogenetic microenvironment. Among these nine proteins, glutathione peroxidase 3 (GPX3) was the only protein with downregulated expression during CKD. Knockdown of GPX3 in vivo augmented ECM expression and aggravated kidney fibrotic lesions after obstructive injury. Transcriptomic profiling revealed that GPX3 depletion resulted in an altered expression of the genes enriched in hypoxia pathway. Knockdown of GPX3 induced NADPH oxidase 2 expression, promoted kidney generation of reactive oxygen species and activated p38 mitogen-activated protein kinase. Conversely, overexpression of exogenous GPX3 alleviated kidney fibrosis, inhibited NADPH oxidase 2 and p38 mitogen-activated protein kinase. These findings suggest that oxidative stress is a pivotal element of the fibrogenic microenvironment. Thus, our studies represent a comprehensive proteomic characterization of the ECM in the fibrotic kidney and provide novel insights into molecular composition of the fibrogenic microenvironment.
MeSH term(s)	Mice ; Animals ; NADPH Oxidase 2/metabolism ; Proteomics ; Extracellular Matrix/metabolism ; Fibrosis ; Kidney/pathology ; Renal Insufficiency, Chronic/pathology ; Extracellular Matrix Proteins/genetics ; Extracellular Matrix Proteins/metabolism
Chemical Substances	NADPH Oxidase 2 (EC 1.6.3.-) ; Extracellular Matrix Proteins
Language	English
Publishing date	2023-02-17
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	120573-0
ISSN	1523-1755 ; 0085-2538
ISSN (online)	1523-1755
ISSN	0085-2538
DOI	10.1016/j.kint.2023.01.021
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Article: Analysis of droplet size distribution and selection of spray parameters based on the fractal theory

Fan, Siyu / Chen, Shiqiang / Wu, Zhirong / Wu, Shixian / Chen, Yongping / Liu, Dong / Yao, Yuhong / Huang, Junxin

Journal of cleaner production. 2022 Oct. 15, v. 371

2022

Abstract: Using multiple parameters to represent the droplet size distribution (DSD) always leads to various outcomes that make it hard to decide. The research combined theoretical derivation with experiments to study the random fractal of the DSD. The function of ...

Abstract	Using multiple parameters to represent the droplet size distribution (DSD) always leads to various outcomes that make it hard to decide. The research combined theoretical derivation with experiments to study the random fractal of the DSD. The function of the DSD was deduced, and the fractal dimension (FD) was used as an independent parameter to characterize the DSD. The DSD was measured by the Malvern measuring apparatus under different spray pressure. The results showed that the FD of the five nozzles measured experimentally is between 1.5 and 3. The independent parameter FD has more advantages than multi-parameters (the Sauter mean diameter and the size distribution span). In the air cleaning technology by spray, the FD was used as an evaluation parameter. The optimal distance from the nozzle to the wetting fine wire plate was determined to be 75–85 cm, and the total dust efficiency of the wetting fine wire plate air cleaning device can reach 98.98%.
Keywords	air ; droplet size ; dust ; fractal dimensions
Language	English
Dates of publication	2022-1015
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0959-6526
DOI	10.1016/j.jclepro.2022.133315
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Examining the Prevalence of Peripartum Depressive Symptoms in a Border Community.

de la Rosa, Iván A / Huang, Junxin / Gard, Charlotte C / McDonald, Jill A

Women's health reports (New Rochelle, N.Y.)

2021 Volume 2, Issue 1, Page(s) 210–218

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2021-06-29
Publishing country	United States
Document type	Journal Article
ISSN	2688-4844
ISSN (online)	2688-4844
DOI	10.1089/whr.2020.0105
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Article: Experimental investigation and application of mine airflow purification and reuse technology

Wu, Zhirong / Wang, Haiqiao / Guo, Hua / Gu, Min / Jiang, Jiachuan / Chen, Shiqiang / Huang, Junxin / Fan, Siyu

Environmental technology & innovation. 2021 Nov., v. 24

2021

Abstract: To solve the problem of dust concentration higher than the standard on the -415 m roadway in the Fankou lead-zinc mine, a self-made dedusting equipment consisted of chord grid is proposed in this paper. This equipment aims to purify the polluted airflow ... ...

Abstract	To solve the problem of dust concentration higher than the standard on the -415 m roadway in the Fankou lead-zinc mine, a self-made dedusting equipment consisted of chord grid is proposed in this paper. This equipment aims to purify the polluted airflow for deep ventilation in mine. First of all, an image observation is shown that three types of water films on the chord grid surface. Specifically, the chord grid is wetted by the fog drops to form water films and can remove dust from airflow. Then, it is measured that a total dust removal efficiency and resistance are resulted by a single layer of wet chord grids under the conditions of different nozzle out diameters, water spray pressure, and velocities. The results show that: The dust removal efficiency is higher at the experimental conditions meet this conditions(the velocity is 3.5 m/s, the nozzle outlet diameter is 2 mm, and the water supply pressure is 0.75 MPa); (2) The spray pressure seldom influences the resistance of dust removed equipment, whereas this resistance correlates positively with velocities and nozzle out diameters. Finally, one purification system is optimally designed according to the experimental, and applied it in the -415 m middle section of the FKLZM. The field test data showed that the mass concentration of dust meets the quality standard of fresh airflow in metal mine.
Keywords	air flow ; dust ; environmental technology ; equipment ; roads ; water supply
Language	English
Dates of publication	2021-11
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2352-1864
DOI	10.1016/j.eti.2021.102035
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Using Co-polymers to Improve Soil Strength and Mitigate Fugitive Dust Emissions

Ho Chun-Hsing / Wu Ziyan / Zhang Zhonghan / Zhao Pengxiang / Huang Junxin

E3S Web of Conferences, Vol 92, p

Laboratory Evaluation

2019 Volume 11013

Abstract: A report by the Federal Highway Administration (FHWA) in the USA stated that there are over 1.4 million miles (2.3 million kilometres) of unpaved roads in the United States, over 1/3 of the U.S highway systems. Unpaved roads play an important role in ... ...

Abstract	A report by the Federal Highway Administration (FHWA) in the USA stated that there are over 1.4 million miles (2.3 million kilometres) of unpaved roads in the United States, over 1/3 of the U.S highway systems. Unpaved roads play an important role in transporting goods and passengers in between urban and suburban areas. However, most unpaved roads are gravel and unimproved that have exposed a severe issue for local transportation networks. Particularly when unpaved roads are in wet conditions (rain or snow), the muddy and soft surface roads have created a hazardous environment for traffic operations. The paper presents an improvement plan using co-polymer dust suppressants to be mixed with soils collected in Northern Arizona. Soil samples were mixed with the co-polymer dust suppressants using four concentration rates (0% water, 1%, 3%, and 5% by weight). A series of tests were performed including surface strength (resistant penetration) test, dynamic rolling test, and unconfined compressive shear test. The results show that the addition of co-polymer dust suppressants in the soil has improved the soil shear strength and decreased dust emissions, provided the results from the surface strength test, dynamic rolling test, and unconfined compressive strength test are promising.
Keywords	Environmental sciences ; GE1-350
Subject code	333
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	EDP Sciences
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Oxidatively stressed extracellular microenvironment drives fibroblast activation and kidney fibrosis.

Li, Li / Lu, Meizhi / Peng, Yiling / Huang, Junxin / Tang, Xiaoman / Chen, Jian / Li, Jing / Hong, Xue / He, Meizhi / Fu, Haiyan / Liu, Ruiyuan / Hou, Fan Fan / Zhou, Lili / Liu, Youhua

Redox biology

2023 Volume 67, Page(s) 102868

Abstract: Kidney fibrosis is associated with tubular injury, oxidative stress and activation of interstitial fibroblasts. However, whether these events are somehow connected is poorly understood. In this study, we show that glutathione peroxidase-3 (GPX3) ... ...

Abstract	Kidney fibrosis is associated with tubular injury, oxidative stress and activation of interstitial fibroblasts. However, whether these events are somehow connected is poorly understood. In this study, we show that glutathione peroxidase-3 (GPX3) depletion in renal tubular epithelium after kidney injury plays a central role in orchestrating an oxidatively stressed extracellular microenvironment, which drives interstitial fibroblast activation and proliferation. Through transcriptional profiling by RNA-sequencing, we found that the expression of GPX3 was down-regulated in various models of chronic kidney disease (CKD), which was correlated with induction of nicotinamide adenine dinucleotide phosphate (NAPDH) oxidase-4 (NOX4). By using decellularized extracellular matrix (ECM) scaffold, we demonstrated that GPX3-depleted extracellular microenvironment spontaneously induced NOX4 expression and reactive oxygen species (ROS) production in renal fibroblasts and triggered their activation and proliferation. Activation of NOX4 by advanced oxidation protein products (AOPPs) mimicked the loss of GPX3, increased the production of ROS, stimulated fibroblast activation and proliferation, and activated protein kinase C-α (PKCα)/mitogen-activated protein kinase (MAPK)/signal transducer and activator of transcription 3 (STAT3) signaling. Silencing NOX4 or inhibition of MAPK with small molecule inhibitors hampered fibroblast activation and proliferation. In mouse model of CKD, knockdown of NOX4 repressed renal fibroblast activation and proliferation and alleviated kidney fibrosis. These results indicate that loss of GPX3 orchestrates an oxidatively stressed extracellular microenvironment, which promotes fibroblast activation and proliferation through a cascade of signal transduction. Our studies underscore the crucial role of extracellular microenvironment in driving fibroblast activation and kidney fibrosis.
MeSH term(s)	Mice ; Animals ; Reactive Oxygen Species/metabolism ; Kidney/metabolism ; Renal Insufficiency, Chronic/metabolism ; Fibroblasts/metabolism ; NADPH Oxidase 4/genetics ; NADPH Oxidase 4/metabolism ; Fibrosis
Chemical Substances	Reactive Oxygen Species ; NADPH Oxidase 4 (EC 1.6.3.-)
Language	English
Publishing date	2023-09-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2023.102868
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Chlamydia-related knowledge, opinion to opportunistic testing, and practices of providers among different sexually transmitted infections related departments in hospitals in Shenzhen city, China.

Weng, Rongxing / Zhang, Chunlai / Wen, Lizhang / Luo, Yiting / Ye, Jianbin / Wang, Honglin / Li, Jing / Ning, Ning / Huang, Junxin / Chen, Xiangsheng / Cai, Yumao

BMC health services research

2022 Volume 22, Issue 1, Page(s) 601

Abstract: Background: Chlamydia trachomatis (CT) infection could lead to seriously adverse outcomes if left untreated. This study aimed to determine CT-related knowledge, opinion to testing, and practices of providers among different sexually transmitted ... ...

Abstract	Background: Chlamydia trachomatis (CT) infection could lead to seriously adverse outcomes if left untreated. This study aimed to determine CT-related knowledge, opinion to testing, and practices of providers among different sexually transmitted infections (STI) related departments in hospitals in Shenzhen city, China, and also to explore the differences in these responses. Materials and methods: From 1st April 2018 to 15th April 2018, a cross-sectional study was conducted in Shenzhen and 64 of 66 hospitals agreed to participate in this study. In the hospital sites, all the providers from the department of obstetrics and gynecology, department of dermatology and venereology, department of urology, and anorectal surgical department were recruited. A structured paper-based questionnaire was used to obtain data on CT-related information. Results: A total of 355 providers from 64 hospitals participated in the current study. Compared to providers from the department of dermatology and venereology, those from the department of obstetrics and gynecology (OR = 0.31, 95% CI 0.16-0.62), department of urology (OR = 0.32, 95% CI 0.16-0.65), and anorectal surgical department (OR = 0.25, 95% CI 0.09-0.71) were less likely to identify that "Be in a long-term mutually monogamous relationship with a partner who has been tested and has negative STI test results." is an appropriate way for a sexually active person to reduce risk of getting CT. Also, those from the department of obstetrics and gynecology (OR = 0.45, 95% CI 0.23-0.87) were less likely to identify that "Use latex condoms the right way every time you have sex" is another appropriate way. A high proportion of providers agreed that all sexually active patients attending to their department should be screened regularly (77.1%), and they are willing to offer opportunistic CT screening (96.0%). Only 11.4% of respondents correctly identified that the appropriate time frame of the CT retesting is three months. Conclusions: Providers among STI-related departments in hospitals showed a very high willingness to offer opportunistic CT screening. However, this study showed important gaps in providers' knowledge and practices in China, targeted training in CT-related knowledge and practice is urgently needed.
MeSH term(s)	Chlamydia Infections/diagnosis ; Chlamydia trachomatis ; Cross-Sectional Studies ; Female ; Hospitals ; Humans ; Pregnancy ; Prevalence ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/prevention & control
Language	English
Publishing date	2022-05-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-022-08012-3
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