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Article ; Online: Polyphosphate as an antithrombotic target and hemostatic agent.

Chen, Ruoyu / Huang, Mingdong / Xu, Peng

2023 Volume 11, Issue 33, Page(s) 7855–7872

Abstract: Polyphosphate (PolyP) is a polymer comprised of linear phosphate units connected by phosphate anhydride bonds. PolyP exists in a diverse range of eukaryotes and prokaryotes with varied chain lengths ranging from six to thousands of phosphate units. Upon ... ...

Abstract	Polyphosphate (PolyP) is a polymer comprised of linear phosphate units connected by phosphate anhydride bonds. PolyP exists in a diverse range of eukaryotes and prokaryotes with varied chain lengths ranging from six to thousands of phosphate units. Upon activation, human platelets and neutrophils release short-chain PolyP, along with other components, to initiate the coagulation pathway. Long-chain PolyP derived from cellular or bacterial organelles exhibits higher proinflammatory and procoagulant effects compared to short-chain PolyP. Notably, PolyP has been identified as a low-hemorrhagic antithrombotic target since neutralizing plasma PolyP suppresses the thrombotic process without impairing the hemostatic functions. As an inorganic polymer without uniform steric configuration, PolyP is typically targeted by cationic polymers or recombinant polyphosphatases rather than conventional antibodies, small-molecule compounds, or peptides. Additionally, because of its procoagulant property, PolyP has been incorporated in wound-dressing materials to facilitate blood hemostasis. This review summarizes current studies on PolyP as a low-hemorrhagic antithrombotic target and the development of hemostatic materials based on PolyP.
MeSH term(s)	Humans ; Polyphosphates/pharmacology ; Polyphosphates/metabolism ; Fibrinolytic Agents/pharmacology ; Fibrinolytic Agents/therapeutic use ; Hemostatics/pharmacology ; Hemostatics/therapeutic use ; Blood Coagulation ; Polymers/pharmacology
Chemical Substances	Polyphosphates ; Fibrinolytic Agents ; Hemostatics ; Polymers
Language	English
Publishing date	2023-08-24
Publishing country	England
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2702241-9
ISSN	2050-7518 ; 2050-750X
ISSN (online)	2050-7518
ISSN	2050-750X
DOI	10.1039/d3tb01152f
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Potential Roles and Future Perspectives of Chitinase 3-like 1 in Macrophage Polarization and the Development of Diseases.

Zhao, Hailong / Huang, Mingdong / Jiang, Longguang

International journal of molecular sciences

2023 Volume 24, Issue 22

Abstract: Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis, and carcinogenesis. Abnormal CHI3L1 expression has been associated with ... ...

Abstract	Chitinase-3-like protein 1 (CHI3L1), a chitinase-like protein family member, is a secreted glycoprotein that mediates macrophage polarization, inflammation, apoptosis, angiogenesis, and carcinogenesis. Abnormal CHI3L1 expression has been associated with multiple metabolic and neurological disorders, including diabetes, atherosclerosis, and Alzheimer's disease. Aberrant CHI3L1 expression is also reportedly associated with tumor migration and metastasis, as well as contributions to immune escape, playing important roles in tumor progression. However, the physiological and pathophysiological roles of CHI3L1 in the development of metabolic and neurodegenerative diseases and cancer remain unclear. Understanding the polarization relationship between CHI3L1 and macrophages is crucial for disease progression. Recent research has uncovered the complex mechanisms of CHI3L1 in different diseases, highlighting its close association with macrophage functional polarization. In this article, we review recent findings regarding the various disease types and summarize the relationship between macrophages and CHI3L1. Furthermore, this article also provides a brief overview of the various mechanisms and inhibitors employed to inhibit CHI3L1 and disrupt its interaction with receptors. These endeavors highlight the pivotal roles of CHI3L1 and suggest therapeutic approaches targeting CHI3L1 in the development of metabolic diseases, neurodegenerative diseases, and cancers.
MeSH term(s)	Humans ; Chitinases ; Neoplasms ; Inflammation/metabolism ; Macrophages/metabolism ; Neurodegenerative Diseases ; Chitinase-3-Like Protein 1
Chemical Substances	Chitinases (EC 3.2.1.14) ; Chitinase-3-Like Protein 1
Language	English
Publishing date	2023-11-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms242216149
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Article ; Online: Structural and Functional Insights into the Stealth Protein CpsY of

Liu, Dafeng / Yuan, Cai / Guo, Chenyun / Huang, Mingdong / Lin, Donghai

Biomolecules

2023 Volume 13, Issue 11

Abstract: Mycobacterium ... ...

Abstract	Mycobacterium tuberculosis
MeSH term(s)	Humans ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; Bacterial Proteins/metabolism ; Tuberculosis/microbiology ; Molecular Dynamics Simulation ; Polysaccharides
Chemical Substances	Bacterial Proteins ; Polysaccharides
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13111611
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Article ; Online: Recombinant expression and functional characterization of FadD2 protein in Mycobacterium tuberculosis.

Liu, Dafeng / Yuan, Cai / Guo, Chenyun / Huang, Mingdong / Lin, Donghai

Protein expression and purification

2023 Volume 214, Page(s) 106377

Abstract: Mycobacterium tuberculosis (Mtb) is a crucial and highly destructive intracellular pathogen responsible for causing tuberculosis (TB). The emergence and dissemination of multi-drug resistant Mtb has further aggravated the TB crisis, leading to high ... ...

Abstract	Mycobacterium tuberculosis (Mtb) is a crucial and highly destructive intracellular pathogen responsible for causing tuberculosis (TB). The emergence and dissemination of multi-drug resistant Mtb has further aggravated the TB crisis, leading to high mortality. Mtb FadD2 is a fatty acyl-coenzyme A (CoA) synthetase that modifies the cell envelope and plays an important role in reducing Mtb susceptibility to pyrazinoic acid (POA). However, the functional mechanism of Mtb FadD2 remains poorly understood. Here, we successfully expressed, purified and obtained monomeric FadD2 by using buffer (500 mM NaCl, 20 mM Tris-HCl, pH7.4 and 5 % glycerol). Palmitate was found to be the optimal substrate for FadD2. Fatty acyl-CoA synthetase activity reached maximum at 450 μM palmitate, and the K
MeSH term(s)	Humans ; Mycobacterium tuberculosis/metabolism ; Tuberculosis/microbiology ; Bacterial Proteins/chemistry ; Palmitates/metabolism ; Ligases/metabolism
Chemical Substances	Bacterial Proteins ; Palmitates ; Ligases (EC 6.-)
Language	English
Publishing date	2023-10-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1055455-5
ISSN	1096-0279 ; 1046-5928
ISSN (online)	1096-0279
ISSN	1046-5928
DOI	10.1016/j.pep.2023.106377
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Zs.A 3084: Show issues

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Article ; Online: Role of Angiopoietin-Tie axis in vascular and lymphatic systems and therapeutic interventions.

Wang, Rui / Yang, Moua / Jiang, Longguang / Huang, Mingdong

Pharmacological research

2022 Volume 182, Page(s) 106331

Abstract: The Angiopoietin (Ang)-Tyrosine kinase with immunoglobulin-like and EGF-like domains (Tie) axis is an endothelial cell-specific ligand-receptor signaling pathway necessary for vascular and lymphatic development. The Ang-Tie axis is involved in regulating ...

Abstract	The Angiopoietin (Ang)-Tyrosine kinase with immunoglobulin-like and EGF-like domains (Tie) axis is an endothelial cell-specific ligand-receptor signaling pathway necessary for vascular and lymphatic development. The Ang-Tie axis is involved in regulating angiogenesis, vascular remodeling, vascular permeability, and inflammation to maintain vascular quiescence. Disruptions in the Ang-Tie axis are involved in many vascular and lymphatic diseases and play an important role in physiological and pathological vascular processes. Given recent advances in the Ang-Tie axis in the vascular and lymphatic systems, this review focuses on the multiple functions of the Ang-Tie axis in inflammation-induced vascular permeability, vascular remodeling, atherosclerosis, ocular angiogenesis, tumor angiogenesis, and metastasis. A summary of relevant therapeutic approaches to the Ang-Tie axis, including therapeutic antibodies, recombinant proteins and small molecule drugs are also discussed. The purpose of this review is to provide new hypotheses and identify potential therapeutic strategies based on the Ang-Tie signaling axis for the treatment of vascular and lymphatic-related diseases.
MeSH term(s)	Angiopoietin-1 ; Angiopoietins/metabolism ; Humans ; Inflammation ; Lymphatic System/metabolism ; Neovascularization, Pathologic ; Receptor, TIE-2/metabolism
Chemical Substances	Angiopoietin-1 ; Angiopoietins ; Receptor, TIE-2 (EC 2.7.10.1)
Language	English
Publishing date	2022-06-27
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2022.106331
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Zs.A 721: Show issues

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Article ; Online: Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid.

Chen, Shanli / Yuan, Cai / Jiang, Longguang / Luo, Zhipu / Huang, Mingdong

International journal of biological macromolecules

2022 Volume 216, Page(s) 172–178

Abstract: Metallodrugs are important for anticancer treatments. They bind mainly to human serum albumin (HSA) in blood circulation, greatly modulating their pharmacokinetics and anticancer efficacy. Fatty acid (FA) is one of the most important endogenous ligands ... ...

Abstract	Metallodrugs are important for anticancer treatments. They bind mainly to human serum albumin (HSA) in blood circulation, greatly modulating their pharmacokinetics and anticancer efficacy. Fatty acid (FA) is one of the most important endogenous ligands of HSA with tight binding to HSA and affecting its conformation. However, the effect of fatty acids on metallodrugs interaction with HSA is unknown. Here we identify the binding sites of a widely used metallodrug, cisplatin, in HSA in the presence or absence of a representative fatty acid, myristate, by X-ray crystallography. Our crystal structures indicate that the sidechain of residue Met548 becomes more exposed to solvent in the presence of fatty acid, and is the main Pt binding site together with Met329 in HSA:Myr:cisplatin ternary structure. An undoubted new Pt binding site is detected at His338 in the presence of fatty acid, and additional two sites are also identified at His146 and His440 + K436. In addition, we revealed the mechanism of cisplatin-induced HSA aggregation, which is due to the crosslinking between Met298 and His510 of two HSA molecules.
MeSH term(s)	Binding Sites ; Cisplatin/pharmacology ; Fatty Acids/chemistry ; Humans ; Models, Molecular ; Protein Binding ; Serum Albumin/chemistry ; Serum Albumin, Human/metabolism
Chemical Substances	Fatty Acids ; Serum Albumin ; Cisplatin (Q20Q21Q62J) ; Serum Albumin, Human (ZIF514RVZR)
Language	English
Publishing date	2022-07-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.06.181
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Zs.B 2374: Show issues

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Article ; Online: Engineered protein cages with enhanced extracellular drug release for elevated antitumor efficacy.

Yan, Wen / Li, Hanlin / Ning, Jiamin / Huang, Shuhao / Jiang, Longguang / Xu, Peng / Huang, Mingdong / Yuan, Cai

International journal of biological macromolecules

2024 Volume 267, Issue Pt 1, Page(s) 131492

Abstract: Human heavy chain ferritin (HFn) protein cage has been explored as a nanocarrier for targeted anticancer drug delivery. Here, we introduced a matrix metalloproteinases (MMPs)-cleavable sequence into the DE loop of HFn, creating an MMP-responsive variant, ...

Abstract	Human heavy chain ferritin (HFn) protein cage has been explored as a nanocarrier for targeted anticancer drug delivery. Here, we introduced a matrix metalloproteinases (MMPs)-cleavable sequence into the DE loop of HFn, creating an MMP-responsive variant, MR-HFn, for localized and extracellular drug release. The crystal structure of MR-HFn revealed that the addition of the MMPs recognition sequence did not affect the self-assembly of HFn but presented a surface-exposed loop susceptible to MMPs cleavage. Biochemical analysis indicated that this engineered protein cage is responsive to MMPs, enabling the targeted release of encapsulated drugs. To evaluate the therapeutic potential of this engineered protein cage, monosubstituted β-carboxy phthalocyanine zinc (CPZ), a type of photosensitizer, was loaded inside this protein cage. The prepared CPZ@MR-HFn showed higher uptake and stronger phototoxicity in MMPs overexpressed tumor cells, as well as enhanced penetration into multicellular tumor spheroids compared with its counterpart CPZ@HFn in vitro. In vivo, CPZ@MR-HFn displayed a higher tumor inhibitory rate than CPZ@HFn under illumination. These results indicated that MR-HFn is a promising nanocarrier for anticancer drug delivery and the MMP-responsive strategy here can also be adapted for other stimuli.
MeSH term(s)	Humans ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/chemistry ; Protein Engineering ; Drug Liberation ; Matrix Metalloproteinases/metabolism ; Animals ; Cell Line, Tumor ; Mice ; Ferritins/chemistry ; Ferritins/metabolism ; Indoles/chemistry ; Indoles/pharmacology ; Drug Carriers/chemistry ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/chemistry
Chemical Substances	Antineoplastic Agents ; Matrix Metalloproteinases (EC 3.4.24.-) ; Ferritins (9007-73-2) ; Indoles ; Drug Carriers ; Photosensitizing Agents
Language	English
Publishing date	2024-04-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2024.131492
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Zs.B 2374: Show issues

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Article ; Online: Dental Bleaching with Phthalocyanine Photosensitizers: Effects on Dentin Color and Collagen Content.

Wu, Zhouyan / Wang, Guodong / Li, Zhiming / Li, Zhengquan / Huang, Dandan / Huang, Mingdong / Lin, Minkui

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 10

Abstract: With the increasing demand for tooth bleaching in esthetic dentistry, its safety has been the focus of a comprehensive body of literature. In this context, the aim of the present study was to evaluate the application effects of pentalysine β- ... ...

Abstract	With the increasing demand for tooth bleaching in esthetic dentistry, its safety has been the focus of a comprehensive body of literature. In this context, the aim of the present study was to evaluate the application effects of pentalysine β-carbonylphthalocyanine zinc (ZnPc(Lys)
MeSH term(s)	Hydrogen Peroxide/pharmacology ; Tooth Bleaching/methods ; Photosensitizing Agents/pharmacology ; Photosensitizing Agents/analysis ; Dentin/chemistry ; Hypochlorous Acid/analysis ; Collagen/pharmacology ; Color
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Photosensitizing Agents ; phthalocyanine (V5PUF4VLGY) ; Hypochlorous Acid (712K4CDC10) ; Collagen (9007-34-5)
Language	English
Publishing date	2023-05-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28104223
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Zs.MO 81: Show issues

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Article ; Online: Monomer and Oligomer Transition of Zinc Phthalocyanine Is Key for Photobleaching in Photodynamic Therapy.

Liu, Dafeng / Jiang, Longguang / Chen, Jincan / Chen, Zhuo / Yuan, Cai / Lin, Donghai / Huang, Mingdong

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 12

Abstract: Photodynamic therapy (PDT) is recognized as a powerful method to inactivate cells. However, the photosensitizer (PS), a key component of PDT, has suffered from undesired photobleaching. Photobleaching reduces reactive oxygen species (ROS) yields, leading ...

Abstract	Photodynamic therapy (PDT) is recognized as a powerful method to inactivate cells. However, the photosensitizer (PS), a key component of PDT, has suffered from undesired photobleaching. Photobleaching reduces reactive oxygen species (ROS) yields, leading to the compromise of and even the loss of the photodynamic effect of the PS. Therefore, much effort has been devoted to minimizing photobleaching in order to ensure that there is no loss of photodynamic efficacy. Here, we report that a type of PS aggregate showed neither photobleaching nor photodynamic action. Upon direct contact with bacteria, the PS aggregate was found to fall apart into PS monomers and thus possessed photodynamic inactivation against bacteria. Interestingly, the disassembly of the bound PS aggregate in the presence of bacteria was intensified by illumination, generating more PS monomers and leading to an enhanced antibacterial photodynamic effect. This demonstrated that on a bacterial surface, the PS aggregate photo-inactivated bacteria via PS monomer during irradiation, where the photodynamic efficiency was retained without photobleaching. Further mechanistic studies showed that PS monomers disrupted bacterial membranes and affected the expression of genes related to cell wall synthesis, bacterial membrane integrity, and oxidative stress. The results obtained here are applicable to other types of PSs in PDT.
MeSH term(s)	Organometallic Compounds ; Zinc Compounds/chemistry ; Photosensitizing Agents/chemistry ; Isoindoles/chemistry ; Photobleaching ; Photochemotherapy ; Escherichia coli/drug effects ; Escherichia coli/radiation effects ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/radiation effects
Chemical Substances	Zn(II)-phthalocyanine (14320-04-8) ; Organometallic Compounds ; Zinc Compounds ; Photosensitizing Agents ; Isoindoles
Language	English
Publishing date	2023-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28124639
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Zs.MO 81: Show issues

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Article ; Online: Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development.

Liang, Chenghui / Flaumenhaft, Robert / Yuan, Cai / Huang, Mingdong

Drug discovery today

2021 Volume 27, Issue 2, Page(s) 626–635

Abstract: Vascular thiol isomerases (VTIs), including PDI, ERp5, ERp57, ERp72, and thioredoxin-related transmembrane protein 1 (TMX1), have important roles in platelet aggregation and thrombosis. Research on VTIs, their substrates in thrombosis, their regulatory ... ...

Abstract	Vascular thiol isomerases (VTIs), including PDI, ERp5, ERp57, ERp72, and thioredoxin-related transmembrane protein 1 (TMX1), have important roles in platelet aggregation and thrombosis. Research on VTIs, their substrates in thrombosis, their regulatory mechanisms, and inhibitor development is an emerging and rapidly evolving area in vascular biology. Here, we describe the structures and functions of VTIs, summarize the relationship between the vascular TIs and thrombosis, and focus on the development of VTI inhibitors for antithrombotic applications.
MeSH term(s)	Blood Platelets/metabolism ; Humans ; Platelet Aggregation ; Protein Disulfide-Isomerases/metabolism ; Sulfhydryl Compounds/metabolism ; Thrombosis/metabolism
Chemical Substances	Sulfhydryl Compounds ; Protein Disulfide-Isomerases (EC 5.3.4.1)
Language	English
Publishing date	2021-10-29
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1324988-5
ISSN	1878-5832 ; 1359-6446
ISSN (online)	1878-5832
ISSN	1359-6446
DOI	10.1016/j.drudis.2021.10.018
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Zs.A 4725: Show issues

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