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Article ; Online: The relationship between serum iron levels and AChR-Ab and IL-6 in patients with myasthenia gravis.

Huang, P

European review for medical and pharmacological sciences

2023 Volume 27, Issue 1, Page(s) 98–102

Abstract: Objective: To investigate the correlation between serum iron (SI) levels and acetylcholine receptor antibodies (AChR-Ab) and interleukin 6 (IL-6) in patients with myasthenia gravis (MG).: Patients and methods: A total of 76 patients with myasthenia ... ...

Abstract	Objective: To investigate the correlation between serum iron (SI) levels and acetylcholine receptor antibodies (AChR-Ab) and interleukin 6 (IL-6) in patients with myasthenia gravis (MG). Patients and methods: A total of 76 patients with myasthenia gravis (MG group) between July 2015 to March 2018, and another 50 healthy subjects during the same period were selected for this study. SI levels in the peripheral blood serum of all participants were measured using the colorimetric method (a SI level of < 8.95 umol/L was considered the standard for SI deficiency). Enzyme-linked immunosorbent assays (ELISA) and radioimmunoassays (RIA) were used to detect the expression and levels of IL-6 and AChR-Ab in the peripheral blood of all participants. The presence and levels of IL-6 and AChR-Ab in the serum of MG patients and normal healthy subjects were compared. The levels of IL-6 and AChR-Ab in MG patients with normal SI levels and those with SI deficiency were analyzed. Results: The SI deficiency rate, AChR-Ab positivity rate, AChR-Ab levels, and IL-6 levels in the MG group were significantly higher than those in the control group (73.68% vs. 26.00%, 81.58% vs. 0.00%, 1.05 ± 0.40 nmol/L vs. 0.21 ± 0.09 nmol/L, and 183.54 ± 35.26 ng/mL vs. 121.43 ± 28.45 ng/mL, respectively; all p-values were < 0.01). In MG patients, the levels of AChR-AB and IL-6 in the SI deficiency group were significantly higher than those in the normal SI group (1.15 ± 0.34 nmol/L vs. 0.81 ± 0.45 nmol/L and 193.12 ± 31.70 ng/mL vs. 156.74 ± 31.19 ng/mL, respectively; all p-values were < 0.01). The correlation analysis showed that SI levels were negatively correlated with AChR-AB and IL-6 levels in MG patients (r = -0.776, r = -0.663, both p-values were < 0.01). Conclusions: Iron deficiency in MG patients and SI levels are negatively correlated with AChR-Ab and IL-6 levels in MG patients.
MeSH term(s)	Humans ; Interleukin-6 ; Myasthenia Gravis/diagnosis ; Receptors, Cholinergic ; Autoantibodies ; Iron
Chemical Substances	Interleukin-6 ; Receptors, Cholinergic ; Autoantibodies ; Iron (E1UOL152H7)
Language	English
Publishing date	2023-01-14
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202301_30857
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Article: Research progress on the protective mechanism of a novel soluble epoxide hydrolase inhibitor TPPU on ischemic stroke.

Huang, Pan

Frontiers in neurology

2023 Volume 14, Page(s) 1083972

Abstract: Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of ... ...

Abstract	Arachidonic Acid (AA) is the precursor of cerebrovascular active substances in the human body, and its metabolites are closely associated with the pathogenesis of cerebrovascular diseases. In recent years, the cytochrome P450 (CYP) metabolic pathway of AA has become a research hotspot. Furthermore, the CYP metabolic pathway of AA is regulated by soluble epoxide hydrolase (sEH). 1-trifluoromethoxyphenyl-3(1-propionylpiperidin-4-yl) urea (TPPU) is a novel sEH inhibitor that exerts cerebrovascular protective activity. This article reviews the mechanism of TPPU's protective effect on ischemic stroke disease.
Language	English
Publishing date	2023-02-08
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1083972
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Article: Rare cause of cerebral venous sinus thrombosis: Spontaneous intracranial hypotension syndrome: A case report.

Huang, Pan

World journal of clinical cases

2023 Volume 11, Issue 19, Page(s) 4677–4683

Abstract: Background: Spontaneous intracranial hypotension syndrome is a relatively uncommon neurological disorder of unknown etiology with a good prognosis. Cerebral venous sinus thrombosis is a specific type of cerebrovascular disease caused by multiple ... ...

Abstract	Background: Spontaneous intracranial hypotension syndrome is a relatively uncommon neurological disorder of unknown etiology with a good prognosis. Cerebral venous sinus thrombosis is a specific type of cerebrovascular disease caused by multiple etiologies of cerebral venous sinus or vein thrombosis that obstructs cerebral venous return and is associated with impaired cerebrospinal fluid absorption; this entity is rarely seen clinically. Spontaneous intracranial hypotension syndrome is one of the causes of cerebral venous sinus thrombosis, and the probability of their combined occurrence is only 1%-2%. As such, it is easily overlooked clinically, thus increasing the difficulty of diagnosis and treatment. Case summary: A 29-year-old young woman presented with postural headache. Lumbar puncture suggested a pressure of 50 mmH Conclusion: Spontaneous intracranial hypotension syndrome is one of the rare causes of cerebral venous sinus thrombosis, which is frequently misdiagnosed or missed and deserves consideration by clinicians during differential diagnosis. Dehydration should be avoided in such patients, and early rehydration and anticoagulation therapy are effective treatment options.
Language	English
Publishing date	2023-01-27
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i19.4677
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Article ; Online: Proanthocyanidins may be potential therapeutic agents for the treatment of carotid atherosclerosis: A review.

Huang, Pan

The Journal of international medical research

2023 Volume 51, Issue 4, Page(s) 3000605231167314

Abstract: Atherosclerotic cerebrovascular disease is one of the major causes of death in China, with associated serious risk of disability and burden on society and families. Therefore, the development of active and effective therapeutic drugs for this disease is ... ...

Abstract	Atherosclerotic cerebrovascular disease is one of the major causes of death in China, with associated serious risk of disability and burden on society and families. Therefore, the development of active and effective therapeutic drugs for this disease is of great significance. Proanthocyanidins are a class of naturally occurring active substances, rich in hydroxyl groups and from a wide range of sources. Studies have suggested that they have a strong potential for anti-atherosclerosis activity. In this paper, we review published evidence regarding anti-atherosclerotic effects of proanthocyanidins in different atherosclerotic research models.
MeSH term(s)	Humans ; Proanthocyanidins/pharmacology ; Atherosclerosis/drug therapy ; Carotid Artery Diseases/drug therapy ; Plant Extracts/pharmacology ; China ; Antioxidants/therapeutic use
Chemical Substances	Proanthocyanidins ; Plant Extracts ; Antioxidants
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	184023-x
ISSN	1473-2300 ; 0300-0605 ; 0142-2596
ISSN (online)	1473-2300
ISSN	0300-0605 ; 0142-2596
DOI	10.1177/03000605231167314
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Zs.A 925: Show issues

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Article ; Online: Potential new therapeutic targets: Association of microRNA with atherosclerotic plaque stability.

Huang, Pan

International journal of immunopathology and pharmacology

2023 Volume 37, Page(s) 3946320231185657

Abstract: Cardiovascular disease represents a major threat to human health with vascular atherosclerosis contributing significantly to its cause, particularly due to the ease of rupture of atherosclerotic plaques. The stability of atherosclerotic plaques is ... ...

Abstract	Cardiovascular disease represents a major threat to human health with vascular atherosclerosis contributing significantly to its cause, particularly due to the ease of rupture of atherosclerotic plaques. The stability of atherosclerotic plaques is influenced by a variety of factors, including intraplaque neovascularization, the inflammatory response, smooth muscle cells and macrophages, and core lipid volumes. Thus, the investigation of factors affecting the stability of atherosclerotic plaques is of great significance for the development of new drugs for the treatment of atherosclerotic diseases. MicroRNAs are small single-stranded non-coding RNAs between 17 and 22 nucleotides in length. They are translated together with the untranslated region (UTR) of the target gene mRNA, where the completeness of base-pairing can influence the translation or degradation of the target genes. MicroRNAs can thus regulate gene expression at the post-transcriptional level and have been demonstrated to be extensively involved in the regulation of various factors affecting plaque stability. In this paper, we review microRNA development, factors affecting atherosclerotic plaque stability, and the relationship between microRNAs and plaque stability, with the aim of describing the mechanisms by which microRNAs affect gene and protein expression in relation to atherosclerosis progression (including plaque rupture) to suggest new therapeutic targets for atherosclerotic disease.
MeSH term(s)	Humans ; Plaque, Atherosclerotic/drug therapy ; Plaque, Atherosclerotic/genetics ; Plaque, Atherosclerotic/metabolism ; MicroRNAs/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Cardiovascular Diseases
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	645171-8
ISSN	2058-7384 ; 0394-6320
ISSN (online)	2058-7384
ISSN	0394-6320
DOI	10.1177/03946320231185657
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Article ; Online: Predictive role of admission serum glucose, baseline NIHSS score, and fibrinogen on hemorrhagic transformation after intravenous thrombolysis with alteplase in acute ischemic stroke.

Huang, P / Yi, X-Y

European review for medical and pharmacological sciences

2023 Volume 27, Issue 20, Page(s) 9710–9720

Abstract: Objective: This study aimed to investigate the predictive role of admission serum glucose, baseline NIHSS score, and fibrinogen on hemorrhagic transformation after intravenous thrombolysis with alteplase in acute ischemic stroke.: Patients and methods! ...

Abstract	Objective: This study aimed to investigate the predictive role of admission serum glucose, baseline NIHSS score, and fibrinogen on hemorrhagic transformation after intravenous thrombolysis with alteplase in acute ischemic stroke. Patients and methods: A total of 254 patients admitted with acute ischemic stroke who received intravenous thrombolysis with alteplase from January 2016 to December 2017 were selected to collect clinical data. Patients were divided into a hemorrhagic transformation group (n=70) and a no-hemorrhagic transformation group (n=184) based on repeat CT/magnetic resonance imaging (MRI) findings during the acute period. The demographic data, past medical history and laboratory examination indexes of the two groups were compared. Multivariate Logistic regression analysis was used to explore the influencing factors of hemorrhage transformation after intravenous thrombolysis in patients with acute ischemic stroke. ROC curve was used to plot the ability of blood glucose at admission, baseline NIHSS score and fibrinogen alone to predict bleeding transformation after intravenous thrombolysis of alteplase, and then the combined model of the three was constructed and the predictive ability of this model to bleeding transformation was evaluated. Results: Among 254 patients, 70% (27.55%) had hemorrhage transformation. Except for DNT, red blood cell count, platelet count, fibrinogen, smoking, atrial fibrillation, baseline NIHSS score and admission serum glucose, there were statistically significant differences between the hemorrhagic transformation group and the non-hemorrhagic transformation group (p<0.05), and there were no statistically significant differences in other indicators between the two groups (p>0.05). The combined model was better than the three models alone in predicting the risk of bleeding conversion (p<0.05). Compared with the group without hemorrhagic transformation, the 90d prognosis was worse in the hemorrhage transformation group (p<0.05). Conclusions: Admission blood glucose, NIHSS score, and fibrinogen are independent risk factors for hemorrhage transformation after intravenous thrombolysis of alteplase in patients with acute ischemic stroke, and the combined model established by them has high predictive efficacy for hemorrhage transformation risk after intravenous thrombolysis of alteplase.
MeSH term(s)	Humans ; Tissue Plasminogen Activator/adverse effects ; Fibrinolytic Agents/adverse effects ; Stroke/drug therapy ; Stroke/etiology ; Ischemic Stroke/drug therapy ; Fibrinogen ; Blood Glucose ; Brain Ischemia/drug therapy ; Thrombolytic Therapy/adverse effects ; Thrombolytic Therapy/methods ; Treatment Outcome ; Hemorrhage/chemically induced
Chemical Substances	Tissue Plasminogen Activator (EC 3.4.21.68) ; Fibrinolytic Agents ; Fibrinogen (9001-32-5) ; Blood Glucose
Language	English
Publishing date	2023-10-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	605550-3
ISSN	2284-0729 ; 1128-3602 ; 0392-291X
ISSN (online)	2284-0729
ISSN	1128-3602 ; 0392-291X
DOI	10.26355/eurrev_202310_34141
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Article: Epidemic Japanese B encephalitis combined with contactin-associated protein-like 2 antibody-positive autoimmune encephalitis: A case report.

Huang, Pan

World journal of clinical cases

2022 Volume 11, Issue 6, Page(s) 1379–1384

Abstract: Background: It is not uncommon to develop viral encephalitis. Epidemic Japanese B encephalitis infection combined with contactin-associated protein-like 2 (CASPR-2) antibody-positive autoimmune encephalitis has not been reported at present. In clinical ... ...

Abstract	Background: It is not uncommon to develop viral encephalitis. Epidemic Japanese B encephalitis infection combined with contactin-associated protein-like 2 (CASPR-2) antibody-positive autoimmune encephalitis has not been reported at present. In clinical work, we need to consider more options. Case summary: A 32-year-old male worker presented with headache, fever and call-unresponsive presentation. Complete cranial magnetic resonance image showed symmetrical abnormal signals in bilateral medial temporal lobe, bilateral thalamus and basal ganglia. Improved lumbar puncture showed that cerebrospinal fluid protein and cell count increased significantly. Viral encephalitis was considered, and the patient's consciousness still increased rapidly after antiviral treatment. Further detection of Cerebrospinal fluid Japanese B encephalitis virus Polymerase Chain Reaction positive, serum autoimmune encephalitis antibody showed CASPR-2 antibody positive (1:320), the patient's condition gradually improved after plasma exchange treatment. 3 mo later, the serum CASPR-2 antibody was negative and the patient's condition was stable. Conclusion: This article reports the world's first case of Epidemic Japanese B encephalitis infection combined with CASPR-2 antibody-positive autoimmune encephalitis, with a view to raising awareness.
Language	English
Publishing date	2022-04-19
Publishing country	United States
Document type	Case Reports
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i6.1379
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Article ; Online: Construction of College Chinese Blended Teaching Mode Based on Decision Tree Classification Model in New Media Context.

Huang, Pingge

publication RETRACTED

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 4608631

Abstract: Based on the context of new media and big data, this article uses the decision tree classification model to construct the college Chinese hybrid teaching mode. In order to verify the accuracy of ID3 algorithm prediction, the comparison of the ID3 ... ...

Abstract	Based on the context of new media and big data, this article uses the decision tree classification model to construct the college Chinese hybrid teaching mode. In order to verify the accuracy of ID3 algorithm prediction, the comparison of the ID3 algorithm, K-means algorithm, and support vector machine classification algorithm was made, and the experimental results show that the ID3 decision tree classification algorithm has better prediction and classification ability, for the construction of college Chinese hybrid teaching mode provides certain practical value and reference basis.
MeSH term(s)	Algorithms ; China ; Decision Trees ; Humans ; Support Vector Machine
Language	English
Publishing date	2022-09-26
Publishing country	United States
Document type	Journal Article ; Retracted Publication
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/4608631
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Article ; Online: The association in diabetic retinopathy and stroke finding from NHANES evidence.

Tang, Jing / Huang, Ping

International ophthalmology

2024 Volume 44, Issue 1, Page(s) 170

Abstract: Purpose: Diabetic retinopathy and stroke are both vascular pathologies, and this study intends to investigate the relationship between diabetic retinopathy and stroke.: Methods: The NHANES database was used to find the relationship between diabetic ... ...

Abstract	Purpose: Diabetic retinopathy and stroke are both vascular pathologies, and this study intends to investigate the relationship between diabetic retinopathy and stroke. Methods: The NHANES database was used to find the relationship between diabetic retinopathy and stroke with 1948 individuals aged 40 years or older. The sensitivity of the data was verified by multiple interpolation, further analysis was done by subgroup analyses, and possible links were investigated with mediation studies. Results: Diabetes retinopathy was found to be closely associated with stroke, with the PDR group having a higher stroke incidence than the NPDR group. After controlling for covariates, there were still substantial differences in the risk of stroke among patients with NPDR and PDR. Overall, subgroup analysis revealed DR group showed an important distinction, compared to the non-DR (OR = 1.76, 95% CI 1.15-2.64). The results of the mediation research indicated that the connection between DR and stroke was mediated by the frailty index and hypertension. Conclusion: This study demonstrated a statistically significant correlation between DR and stroke, which persisted even after DR staging and was more prevalent in PDR patients than in NPDR patients. Stroke prevention may benefit from DR health management.
MeSH term(s)	Humans ; Diabetic Retinopathy/complications ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/epidemiology ; Nutrition Surveys ; Stroke/epidemiology ; Stroke/etiology ; Hypertension ; Diabetes Mellitus
Language	English
Publishing date	2024-04-08
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	800087-6
ISSN	1573-2630 ; 0165-5701
ISSN (online)	1573-2630
ISSN	0165-5701
DOI	10.1007/s10792-024-03098-6
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Zs.A 1479: Show issues

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Article ; Online: Centralisation of care improves overall survival for sarcoma patients.

Napolitano, A / Thway, K / Huang, P / Jones, R L

Annals of oncology : official journal of the European Society for Medical Oncology

2024 Volume 35, Issue 4, Page(s) 338–339

MeSH term(s)	Humans ; Sarcoma/therapy ; Delivery of Health Care ; Soft Tissue Neoplasms
Language	English
Publishing date	2024-02-10
Publishing country	England
Document type	Editorial
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1016/j.annonc.2024.01.009
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