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  1. Article ; Online: Skin proteomic profiling of irradiation-induced fibrosis and its modulation by low molecular weight fucoidan via tight junction pathway.

    Hsu, Pang-Hung / Chen, Yi-Hsuan / Huang, Pin-I / Hwang, Pai-An

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2022  Volume 153, Page(s) 113417

    Abstract: Fucoidans, sulfated and fucosylated polysaccharides extracted from brown seaweed, were found to inhibit radiotherapy-induced cell damage and fibrosis through the TGF-β1 pathway. However, the comprehensive molecular response during irradiation-induced ... ...

    Abstract Fucoidans, sulfated and fucosylated polysaccharides extracted from brown seaweed, were found to inhibit radiotherapy-induced cell damage and fibrosis through the TGF-β1 pathway. However, the comprehensive molecular response during irradiation-induced fibrosis and fucoidan-assisted recovery still remain unclear. Rat hind limbs were irradiated and smeared with low molecular weight fucoidan (LMF). Protein profiles were examined by a mass spectrometry-based proteomics analysis. Out of a total of 4625 proteins, 233 were found to be significantly up-regulated after irradiation and down-regulated after LMF treatment. Pathway and protein-protein interaction network analyses further indicated that four proteins including Actb, Ezr, Msn and Cdc42 were clustered into the tight junction and regulation of actin cytoskeleton pathways. These four proteins may serve as biomarkers for the detection of skin fibrosis induced by irradiation or TGF-β1, and for the recovery following LMF treatment.
    MeSH term(s) Animals ; Antineoplastic Agents ; Fibrosis ; Molecular Weight ; Polysaccharides/pharmacology ; Proteomics ; Rats ; Tight Junctions ; Transforming Growth Factor beta1
    Chemical Substances Antineoplastic Agents ; Polysaccharides ; Transforming Growth Factor beta1 ; fucoidan (9072-19-9)
    Language English
    Publishing date 2022-07-20
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2022.113417
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  2. Article ; Online: Correction to: Vertebral artery stenosis predicts cerebrovascular diseases following radiotherapy for nasopharyngeal carcinoma.

    Yeh, Chien-Fu / Chin, Yu-Ching / Hung, Wei / Huang, Pin-I / Lan, Ming-Ying

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2023  Volume 31, Issue 8, Page(s) 456

    Language English
    Publishing date 2023-07-10
    Publishing country Germany
    Document type Published Erratum
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-023-07924-y
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  3. Article: Preparation of Multifunctional Dopamine-Coated Zerovalent Iron/Reduced Graphene Oxide for Targeted Phototheragnosis in Breast Cancer.

    Lin, Chia-Hua / Chen, Yi-Chun / Huang, Pin-I

    Nanomaterials (Basel, Switzerland)

    2020  Volume 10, Issue 10

    Abstract: The present study aimed to develop a multifunctional nanoparticle platform with properties that are beneficial in imaging, targeting, and synergistic cancer phototherapy. To this end, we synthesized novel nanoparticles composed of polydopamine, nano zero- ...

    Abstract The present study aimed to develop a multifunctional nanoparticle platform with properties that are beneficial in imaging, targeting, and synergistic cancer phototherapy. To this end, we synthesized novel nanoparticles composed of polydopamine, nano zero-valent iron (nZVI), and reduced graphene oxide (rGO). We immobilized nZVI on the surface of GO (nZVI/GO), then further modified nZVI/GO with dopamine to form polydopamine-conjugated nZVI/rGO (nZVI/rGO@pDA). Because nZVI/rGO@pDA absorbs near infrared radiation (NIR) and binds biomolecules of cancer cells, this platform is highly efficacious in photothermal and photodynamic cancer therapy and enables specific targeting of breast cancer cells. Use of nZVI/rGO@pDA at a low concentration (10 μg/mL) resulted in irreversible damage to MCF-7 cells under NIR irradiation (808 nm) without inducing cytotoxic effects in normal cells. Furthermore, nZVI/rGO@pDA showed high sensitivity in magnetic resonance imaging (MRI), comparable to nZVI@pDA, even at low concentration. Monitoring the treatment response through evaluation of MRI signal intensity of nZVI/rGO@pDA in phototherapeutic therapy revealed that the novel material combines the advantages of nZVI, rGO, and pDA to provide specific targeting capabilities, excellent biocompatibility, and cancer phototherapeutic and tumor imaging abilities. Thus, this platform offers great potential in terms of imaging and therapeutic effects in phototherapy treatment for breast cancer.
    Language English
    Publishing date 2020-10-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano10101957
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  4. Article ; Online: Vertebral artery stenosis predicts cerebrovascular diseases following radiotherapy for nasopharyngeal carcinoma.

    Yeh, Chien-Fu / Chin, Yu-Ching / Hung, Wei / Huang, Pin-I / Lan, Ming-Ying

    Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer

    2022  Volume 30, Issue 7, Page(s) 5821–5830

    Abstract: Purpose: Radiotherapy for nasopharyngeal carcinoma (NPC) may induce cerebrovascular diseases including ischemic stroke and transient ischemic attack (TIA), which can cause severe disability. However, information on the incidence and predictors of ... ...

    Abstract Purpose: Radiotherapy for nasopharyngeal carcinoma (NPC) may induce cerebrovascular diseases including ischemic stroke and transient ischemic attack (TIA), which can cause severe disability. However, information on the incidence and predictors of cerebrovascular diseases is scarce. This study aimed to estimate the incidence of cerebrovascular diseases following NPC, and attempts to ascertain the predictors of cerebrovascular diseases to facilitate early prevention.
    Methods: We performed a retrospective cohort study on 655 NPC patients who received radiotherapy between 2006 and 2018 in a medical center. This study analyzed the incidence, clinical and imaging presentation of patients with cerebrovascular diseases. Cox proportional hazard model was used to identify risk factors associated with cerebrovascular diseases following radiotherapy.
    Results: There were 14 patients who developed an ischemic stroke, and 3 patients developed a TIA after a mean follow-up of 5.8 years. Most ischemic events were from large-artery atherosclerosis (76.5%), and the most common symptom of ischemic stroke was unilateral limb weakness (57.1%). The cumulative incidence of ischemic stroke or TIA 15 years after radiotherapy was 9.1% (95% confidence interval [CI] = 4.7-17.2%). Multivariate Cox regression identified vertebral artery stenosis (HR: 18.341; 95% CI = 3.907-86.100; P < 0.001), atrial fibrillation (HR: 13.314; 95% CI = 1.306-135.764; P = 0.029), and hypertension (HR: 7.511; 95% CI = 1.472-38.320; P = 0.015) as independent predictors of ischemic stroke or TIA.
    Conclusion: Our study found that NPC patients with vertebral artery stenosis, atrial fibrillation, or hypertension carry a higher risk for ischemic stroke or TIA. Regular assessment of vertebral artery after radiotherapy was suggested.
    MeSH term(s) Atrial Fibrillation/complications ; Humans ; Hypertension ; Ischemic Attack, Transient/diagnosis ; Ischemic Attack, Transient/epidemiology ; Ischemic Attack, Transient/etiology ; Ischemic Stroke ; Nasopharyngeal Carcinoma ; Nasopharyngeal Neoplasms/radiotherapy ; Retrospective Studies ; Risk Factors ; Stroke/diagnosis ; Stroke/epidemiology ; Stroke/etiology ; Vertebrobasilar Insufficiency/complications ; Vertebrobasilar Insufficiency/etiology
    Language English
    Publishing date 2022-03-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1134446-5
    ISSN 1433-7339 ; 0941-4355
    ISSN (online) 1433-7339
    ISSN 0941-4355
    DOI 10.1007/s00520-022-07011-8
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  5. Article ; Online: The effect of radiotherapy on patients with pathological stage IIB breast cancer after breast-conserving surgery or mastectomy: A cohort study.

    Pan, Yi-Ying / Lai, Tzu-Yu / Shiau, Cheng-Ying / Tseng, Ling-Ming / Lai, I-Chun / Liu, Yu-Ming / Huang, Pin-I

    Journal of the Chinese Medical Association : JCMA

    2023  Volume 87, Issue 2, Page(s) 202–211

    Abstract: Background: Breast cancer is one of the most common cancers in women, and treatment options include surgery, systemic therapies, and radiotherapy (RT). While postoperative RT plays an important role in reducing local recurrence rates and improving ... ...

    Abstract Background: Breast cancer is one of the most common cancers in women, and treatment options include surgery, systemic therapies, and radiotherapy (RT). While postoperative RT plays an important role in reducing local recurrence rates and improving survival outcomes, its exact impact on patients with pathological stage IIB breast cancers remains unidentified.
    Methods: In this retrospective cohort study, patients with newly diagnosed pathological stage IIB breast cancer who underwent surgery and postoperative RT were included. The data were collected from medical records, and survival outcomes were assessed using the Kaplan-Meier method, log-rank tests, and Cox regression models.
    Results: In total, 350 patients participated in this study. Overall survival, locoregional recurrence-free survival, event-free survival, and distant metastasis-free survival rates did not significantly differ between those who received RT and those who did not. Multivariate analyses revealed that patients who received anthracycline or taxane chemotherapy had better survival outcomes.
    Conclusion: Our findings demonstrated that postoperative RT had no significant effect on overall survival, locoregional recurrence, event-free survival, or distant metastasis rates in patients with pathological stage IIB breast cancer. However, anthracycline- and taxane-based chemotherapies were associated with improved outcomes. These findings demonstrated the complexities of treating such patient populations with multimodal therapies. Further research is needed to ensure optimal postoperative RT in patients with pathological stage IIB breast cancer. Clinicians must consider individual patient characteristics and incorporate comprehensive treatment approaches to ensure successful outcomes in this population.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/radiotherapy ; Breast Neoplasms/surgery ; Mastectomy/methods ; Mastectomy, Segmental/adverse effects ; Cohort Studies ; Retrospective Studies ; Neoplasm Recurrence, Local/epidemiology ; Taxoids ; Anthracyclines ; Neoplasm Staging
    Chemical Substances Taxoids ; Anthracyclines
    Language English
    Publishing date 2023-12-12
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000001037
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  6. Article ; Online: Combined modality therapy for patients with esophageal squamous cell carcinoma: Radiation dose and survival analyses.

    Shueng, Pei-Wei / Huang, Chun-Chieh / Liu, Yu-Ming / Wu, Yuan-Hong / Huang, Pin-I / Yen, Sang-Hue / Lin, Kuan-Heng / Hsu, Chen-Xiong

    Thoracic cancer

    2022  Volume 14, Issue 2, Page(s) 143–148

    Abstract: Background: We aimed to analyze the radiation dose and compare survival among combined modality therapy using modern radiation techniques for patients with esophageal squamous cell carcinoma (ESCC).: Methods: This retrospective study included ... ...

    Abstract Background: We aimed to analyze the radiation dose and compare survival among combined modality therapy using modern radiation techniques for patients with esophageal squamous cell carcinoma (ESCC).
    Methods: This retrospective study included patients with clinically staged T1-4N0-3M0 ESCC from 2014 to 2018. Patients who received combined modality therapies with curative intent were enrolled. The overall survival (OS) rates among combined modality therapy were compared. The clinical variables and impacts of radiation dose on survival were analyzed by the Kaplan-Meier method and Cox regression model.
    Results: Of the 259 patients, 141 (54.4%) received definitive concurrent chemoradiotherapy (DCCRT); 67 (25.9%) underwent neoadjuvant chemoradiotherapy followed by surgery (NCRT+S); 51 (19.7%) obtained surgery followed by adjuvant chemoradiotherapy (S+ACRT). Two-year OS rates of the DCCRT, NCRT+S and S+ACRT group were 48.9, 61.5 and 51.2%. In the subgroup analysis of DCCRT group, the 2-year OS of patients receiving radiation dose 55-60 Gy was 57.1%. Multivariate analyses showed that clinical stage (p = 0.004), DCCRT with 55-60 Gy (p = 0.043) and NCRT+S with pathological complete response (pCR) (p = 0.014) were significant prognostic factors for better OS. The radiation dose-survival curve demonstrated a highly positive correlation between higher radiation dose and better survival.
    Conclusion: Our results suggest that NCRT+S can provide a favorable survival for patients with ESCC, especially in patients who achieved pCR. The optimal radiation dose might be 55-60 Gy for patients receiving DCCRT via modern radiation techniques. Further randomized clinical studies are required to confirm the survival benefits between NCRT+S and DCCRT with escalated dose.
    MeSH term(s) Humans ; Esophageal Squamous Cell Carcinoma/radiotherapy ; Esophageal Squamous Cell Carcinoma/drug therapy ; Esophageal Neoplasms/radiotherapy ; Esophageal Neoplasms/drug therapy ; Retrospective Studies ; Combined Modality Therapy ; Chemoradiotherapy/methods ; Chemoradiotherapy, Adjuvant ; Survival Analysis ; Radiation Dosage
    Language English
    Publishing date 2022-11-09
    Publishing country Singapore
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.14724
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  7. Article ; Online: Feasibility estimation of injected hydrodissection before definitive radiotherapy of pancreatic adenocarcinoma.

    Wu, Yuan-Hung / Shen, Shu-Huei / Wang, Yen-Po / Chang, Nai-Wen / Lee, Pei-Chang / Li, Chung-Pin / Lan, Keng-Li / Shiau, Cheng-Yin / Hu, Yu-Wen / Huang, Pin-I / Hsu, Chen-Xiong / Yen, Sang-Hue / Hsu, Shih-Ming

    Journal of the Chinese Medical Association : JCMA

    2024  Volume 87, Issue 5, Page(s) 511–515

    Abstract: Background: Pancreatic adenocarcinoma is often not diagnosed until an advanced stage, and so most patients are not eligible for resection. For patients who are inoperable, definitive radiotherapy is crucial for local disease control. However, the ... ...

    Abstract Background: Pancreatic adenocarcinoma is often not diagnosed until an advanced stage, and so most patients are not eligible for resection. For patients who are inoperable, definitive radiotherapy is crucial for local disease control. However, the pancreas is located close to other vulnerable gastrointestinal organs, making it challenging to deliver an adequate radiation dose. The surgical insertion of spacers or injection of fluids such as hydrogel before radiotherapy has been proposed, however, no study has discussed which patients are suitable for the procedure.
    Methods: In this study, we reviewed 50 consecutive patients who received definitive radiotherapy at our institute to determine how many could have benefitted from hydrodissection to separate the pancreatic tumor from the adjacent gastrointestinal tract. By hypothetically injecting a substance using either computed tomography (CT)-guided or endoscopic methods, we aimed to increase the distance between the pancreatic tumor and surrounding hollow organs, as this would reduce the radiation dose delivered to the organs at risk.
    Results: An interventional radiologist considered that hydrodissection was feasible in 23 (46%) patients with a CT-guided injection, while a gastroenterologist considered that hydrodissection was feasible in 31 (62%) patients with an endoscopic injection. Overall, we found 14 (28%) discrepancies among the 50 patients reviewed. Except for 1 patient who had no available trajectory with a CT-guided approach but in whom hydrodissection was considered feasible with an endoscopic injection, the other 13 patients had different interpretations of whether direct invasion was present in the CT images.
    Conclusion: Our results suggested that about half of the patients could have benefited from hydrodissection before radiotherapy. This finding could allow for a higher radiation dose and potentially better disease control.
    MeSH term(s) Humans ; Pancreatic Neoplasms/radiotherapy ; Pancreatic Neoplasms/diagnostic imaging ; Adenocarcinoma/radiotherapy ; Adenocarcinoma/diagnostic imaging ; Male ; Aged ; Feasibility Studies ; Middle Aged ; Female ; Tomography, X-Ray Computed ; Aged, 80 and over ; Adult ; Injections
    Language English
    Publishing date 2024-03-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000001084
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    Zs.A 2699: Show issues Location:
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  8. Article ; Online: Association of radiation dose to cardiac substructures with major ischaemic events following breast cancer radiotherapy.

    Lai, Tzu-Yu / Hu, Yu-Wen / Wang, Ti-Hao / Chen, Jui-Pin / Shiau, Cheng-Ying / Huang, Pin-I / Lai, I Chun / Tseng, Ling-Ming / Huang, Nicole / Liu, Chia-Jen

    European heart journal

    2023  Volume 44, Issue 45, Page(s) 4796–4807

    Abstract: Background and aims: Patients with left-sided breast cancer receive a higher mean heart dose (MHD) after radiotherapy, with subsequent risk of ischaemic heart disease. However, the optimum dosimetric predictor among cardiac substructures has not yet ... ...

    Abstract Background and aims: Patients with left-sided breast cancer receive a higher mean heart dose (MHD) after radiotherapy, with subsequent risk of ischaemic heart disease. However, the optimum dosimetric predictor among cardiac substructures has not yet been determined.
    Methods and results: This study retrospectively reviewed 2158 women with breast cancer receiving adjuvant radiotherapy. The primary endpoint was a major ischaemic event. The dose-volume parameters of each delineated cardiac substructure were calculated. The risk factors for major ischaemic events and the association between MHD and major ischaemic events were analysed by Cox regression. The optimum dose-volume predictors among cardiac substructures were explored in multivariable models by comparing performance metrics of each model. At a median follow-up of 7.9 years (interquartile range 5.6-10.8 years), 89 patients developed major ischaemic events. The cumulative incidence rate of major ischaemic events was significantly higher in left-sided disease (P = 0.044). Overall, MHD increased the risk of major ischaemic events by 6.2% per Gy (hazard ratio 1.062, 95% confidence interval 1.01-1.12; P = 0.012). The model containing the volume of the left ventricle receiving 25 Gy (LV V25) with the cut-point of 4% presented with the best goodness of fit and discrimination performance in left-sided breast cancer. Age, chronic kidney disease, and hyperlipidaemia were also significant risk factors.
    Conclusion: Risk of major ischaemic events exist in the era of modern radiotherapy. LV V25 ≥ 4% appeared to be the optimum parameter and was superior to MHD in predicting major ischaemic events. This dose constraint could aid in achieving better heart protection in breast cancer radiotherapy, though a further validation study is warranted.
    MeSH term(s) Female ; Humans ; Unilateral Breast Neoplasms/radiotherapy ; Retrospective Studies ; Breast Neoplasms/radiotherapy ; Radiotherapy Dosage ; Heart ; Radiation Dosage
    Language English
    Publishing date 2023-08-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad462
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  9. Article ; Online: Autophagy reprogramming stem cell pluripotency and multiple-lineage differentiation.

    Yang, Yi-Ping / Lai, Wei-Yi / Lin, Tzu-Wei / Lin, Yi-Ying / Chien, Yueh / Tsai, Yi-Ching / Tai, Hsiao-Yun / Wang, Chia-Lin / Liu, Yung-Yang / Huang, Pin-I / Chen, Yi-Wei / Lo, Wen-Liang / Wang, Chien-Ying

    Journal of the Chinese Medical Association : JCMA

    2022  Volume 85, Issue 6, Page(s) 667–671

    Abstract: The cellular process responsible for the degradation of cytosolic proteins and subcellular organelles in lysosomes was termed "autophagy." This process occurs at a basal level in most tissues as part of tissue homeostasis that redounds to the regular ... ...

    Abstract The cellular process responsible for the degradation of cytosolic proteins and subcellular organelles in lysosomes was termed "autophagy." This process occurs at a basal level in most tissues as part of tissue homeostasis that redounds to the regular turnover of components inside cytoplasm. The breakthrough in the autophagy field is the identification of key players in the autophagy pathway, compounded under the name "autophagy-related genes" (ATG) encoding for autophagy effector proteins. Generally, the function of autophagy can be classified into two divisions: intracellular clearance of defective macromolecules and organelles and generation of degradation products. Therapeutic strategies using stem cell-based approach come as a promising therapy and develop rapidly recently as stem cells have high self-renewability and differentiation capability as known as mesenchymal stem cells (MSCs). They are defined as adherent fibroblast-like population with the abilities to self-renew and multi-lineage differentiate into osteogenic, adipogenic, and chondrogenic lineage cells. To date, they are the most extensively applied adult stem cells in clinical trials. The properties of MSCs, such as immunomodulation, neuroprotection, and tissue repair pertaining to cell differentiation, processes to replace lost, or damaged cells, for aiding cell repair and revival. Autophagy has been viewed as a remarkable mechanism for maintaining homeostasis, ensuring the adequate function and survival of long-lived stem cells. In addition, authophagy also plays a remarkable role in protecting stem cells against cellular stress when the stem cell regenerative capacity is harmed in aging and cellular degeneration. Understanding the under-explored mechanisms of MSC actions and expanding the spectrum of their clinical applications may improve the utility of the MSC-based therapeutic approach in the future.
    MeSH term(s) Autophagy ; Cell Differentiation ; Mesenchymal Stem Cells ; Osteogenesis ; Stem Cells
    Language English
    Publishing date 2022-06-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000000728
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  10. Article ; Online: The update of chimeric antigen receptor-T cells therapy in glioblastoma.

    Chou, Chi-Jen / Lin, Chun-Fu / Chen, Yi-Wei / Huang, Pin-I / Yang, Yi-Ping / Wang, Mong-Lien / Hung, Kai-Feng / Lee, Yi-Yen

    Journal of the Chinese Medical Association : JCMA

    2020  Volume 83, Issue 5, Page(s) 442–445

    Abstract: Glioblastoma (GBM) is the most malignant central nervous system neoplasm and the outcome is difficult to break through for decades. Ninety percent of patients who suffered from treatment failed. Since 2010, the chimeric antigen receptor (CAR)-T cell ... ...

    Abstract Glioblastoma (GBM) is the most malignant central nervous system neoplasm and the outcome is difficult to break through for decades. Ninety percent of patients who suffered from treatment failed. Since 2010, the chimeric antigen receptor (CAR)-T cell therapy has achieved a durable effect in the treatment of B-cell hematologic malignancies. Although several preclinical and clinical trials have emerged as a potential option in solid tumor including high-grade gliomas, the results are limited at present. The challenges of CAR-T cells in GBM are including identification of tumor-specific antigens, preservation activity of T cell, trafficking of enough CAR-T cells to the tumor site, and reversed unique immune suppressive environment of the central nervous system. The success of targeting brain tumors with CAR-T cells has more consideration. In this review article, we will summarize the current key clinical trials of CAR-T therapies in this field. And will outline the obstacles of application of CAR-T cells for the treatment of GBM as well. This review is intended to help guide the future direction of CAR-T therapy in GBM that will move the outcome forward in the future.
    MeSH term(s) Brain Neoplasms/therapy ; ErbB Receptors/immunology ; Glioblastoma/therapy ; Humans ; Immunotherapy, Adoptive/methods ; Interleukin-13 Receptor alpha2 Subunit/immunology ; Receptors, Chimeric Antigen/immunology ; T-Lymphocytes/immunology
    Chemical Substances Interleukin-13 Receptor alpha2 Subunit ; Receptors, Chimeric Antigen ; ErbB Receptors (EC 2.7.10.1)
    Language English
    Publishing date 2020-07-08
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2107283-8
    ISSN 1728-7731 ; 1726-4901
    ISSN (online) 1728-7731
    ISSN 1726-4901
    DOI 10.1097/JCMA.0000000000000302
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