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  1. Article ; Online: The development of new remote technologies in disaster medicine education: A scoping review.

    Kao, Chia-Lung / Chien, Li-Chien / Wang, Mei-Chin / Tang, Jing-Shia / Huang, Po-Chang / Chuang, Chia-Chang / Shih, Chung-Liang

    Frontiers in public health

    2023  Volume 11, Page(s) 1029558

    Abstract: Background: Remote teaching and online learning have significantly changed the responsiveness and accessibility after the COVID-19 pandemic. Disaster medicine (DM) has recently gained prominence as a critical issue due to the high frequency of worldwide ...

    Abstract Background: Remote teaching and online learning have significantly changed the responsiveness and accessibility after the COVID-19 pandemic. Disaster medicine (DM) has recently gained prominence as a critical issue due to the high frequency of worldwide disasters, especially in 2021. The new artificial intelligence (AI)-enhanced technologies and concepts have recently progressed in DM education.
    Objectives: The aim of this article is to familiarize the reader with the remote technologies that have been developed and used in DM education over the past 20 years.
    Literature scoping reviews: Mobile edge computing (MEC), unmanned aerial vehicles (UAVs)/drones, deep learning (DL), and visual reality stimulation, e.g., head-mounted display (HMD), are selected as promising and inspiring designs in DM education.
    Methods: We performed a comprehensive review of the literature on the remote technologies applied in DM pedagogy for medical, nursing, and social work, as well as other health discipline students, e.g., paramedics. Databases including PubMed (MEDLINE), ISI Web of Science (WOS), EBSCO (EBSCO Essentials), Embase (EMB), and Scopus were used. The sourced results were recorded in a Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) flowchart and followed in accordance with the PRISMA extension Scoping Review checklist. We included peer-reviewed articles, Epubs (electronic publications such as databases), and proceedings written in English. VOSviewer for related keywords extracted from review articles presented as a tabular summary to demonstrate their occurrence and connections among these DM education articles from 2000 to 2022.
    Results: A total of 1,080 research articles on remote technologies in DM were initially reviewed. After exclusion, 64 articles were included in our review.
    Discussions: Artificial intelligence-enhanced remote technologies promote learning incentives for medical undergraduate students or graduate professionals, but the efficacy of learning quality remains uncertain. More blended AI-modulating pedagogies in DM education could be increasingly important in the future. More sophisticated evaluation and assessment are needed to implement carefully considered designs for effective DM education.
    MeSH term(s) Humans ; Artificial Intelligence ; Disaster Medicine ; Pandemics ; COVID-19/epidemiology ; Students
    Language English
    Publishing date 2023-03-24
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1029558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The risk factors of the 72-h unscheduled return visit admission to emergency department in adults below 50 years old.

    Kao, Chia-Lung / Chuang, Chia-Chang / Hwang, Chi-Yuan / Lee, Chung-Hsun / Huang, Po-Chang / Hong, Ming-Yuan / Chi, Chih-Hsien

    European journal of medical research

    2023  Volume 28, Issue 1, Page(s) 379

    Abstract: Background: An unscheduled return visit (URV) to the emergency department (ED) within 72-h is an indicator of ED performance. An unscheduled return revisit (URV) within 72-h was used to monitor adverse events and medical errors in a hospital quality ... ...

    Abstract Background: An unscheduled return visit (URV) to the emergency department (ED) within 72-h is an indicator of ED performance. An unscheduled return revisit (URV) within 72-h was used to monitor adverse events and medical errors in a hospital quality improvement program. The study explores the potential factors that contribute to URV to the ED within 72-h and the unscheduled return revisit admission (URVA) in adults below 50 years old.
    Methods: The case-control study enrolled 9483 URV patients during 2015-2020 in National Cheng-Kung University Hospital. URVA and URV non-admission (URVNA) patients were analyzed. The Gini impurity index was calculated by decision tree (DT) to split the variables capable of partitioning the groups into URVA and URVNA. Logistic regression is applied to calculate the odds ratio (OR) of candidate variables. The α level was set at 0.05.
    Results: Among patients under the age of 50, the percentage of females in URVNA was 55.05%, while in URVA it was 53.25%. Furthermore, the average age of URVA patients was 38.20 ± 8.10, which is higher than the average age of 35.19 ± 8.65 observed in URVNA. The Charlson Comorbidity Index (CCI) of the URVA patients (1.59 ± 1.00) was significantly higher than that of the URVNA patients (1.22 ± 0.64). The diastolic blood pressure (DBP) of the URVA patients was 85.29 ± 16.22, which was lower than that of the URVNA (82.89 ± 17.29). Severe triage of URVA patients is 21.1%, which is higher than the 9.7% of URVNA patients. The decision tree suggests that the factors associated with URVA are "severe triage," "CCI higher than 2," "DBP less than 86.5 mmHg," and "age older than 34 years". These risk factors were verified by logistic regression and the OR of CCI was 2.42 (1.50-3.90), the OR of age was 1.84 (1.50-2.27), the OR of DBP less than 86.5 was 0.71 (0.58-0.86), and the OR of severe triage was 2.35 (1.83-3.03).
    Conclusions: The results provide physicians with a reference for discharging patients and could help ED physicians reduce the cognitive burden associated with the diagnostic errors and stress.
    MeSH term(s) Female ; Humans ; Adult ; Middle Aged ; Case-Control Studies ; Hospitalization ; Risk Factors ; Patient Discharge ; Emergency Service, Hospital
    Language English
    Publishing date 2023-09-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-023-01317-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Effect of the King Oyster Culinary-Medicinal Mushroom Pleurotus eryngii (Agaricomycetes) Basidiocarps Powder to Ameliorate Memory and Learning Deficit in Ability in Aβ-Induced Alzheimer's Disease C57BL/6J Mice Model.

    Liang, Chih-Hung / Huang, Po-Chang / Mau, Jeng-Leun / Chiang, Shen-Shih

    International journal of medicinal mushrooms

    2020  Volume 22, Issue 2, Page(s) 145–159

    Abstract: One of the major causes of Alzheimer's disease (AD) is oxidative stress, which accelerates β-amyloid peptide (AP) plaque and neurofibrillary tangle accumulation in the brain. Pleurotus eryngii is known to be rich in antioxidants, including ergothioneine, ...

    Abstract One of the major causes of Alzheimer's disease (AD) is oxidative stress, which accelerates β-amyloid peptide (AP) plaque and neurofibrillary tangle accumulation in the brain. Pleurotus eryngii is known to be rich in antioxidants, including ergothioneine, adenosine, and polyphenol, which can reduce oxidative stress-related aging. The aim of this study was to investigate the proximate and functional composition of P. eryngii, and evaluate the cognitive effects of low (LPE), medium (MPE), and high (HPE) P. eryngii dosages in an Aβ-induced Alzheimer's disease C57BL/6J mouse model. Mice fed P. eryngii for six weeks showed no adverse effects on body weight gain, food intake efficiency, serum biochemical parameters, and liver and kidney histopathological features. The relative brain weight was significantly lower in Aβ-injected mice (p < 0.05). Further, P. eryngii was shown to delay brain atrophy. Reference memory behavioral tasks showed that LPE, MPE, and HPE significantly decreased escape latency (49-85%) and distance (53-69%, p < 0.05). Probe and T-maze tasks showed that P. eryngii potently ameliorated memory deficit in mice. An AD pathology index analysis showed that P. eryngii significantly decreased levels of brain phosphorylated τ-protein, Aβ plaque deposition, malondialdehyde, and protein carbonyl (p < 0.05). P. eryngii may therefore promote memory and learning capacity in an Aβ-induced AD mouse model.
    MeSH term(s) Alzheimer Disease/chemically induced ; Alzheimer Disease/drug therapy ; Alzheimer Disease/pathology ; Amyloid beta-Peptides/metabolism ; Amyloid beta-Protein Precursor/adverse effects ; Amyloid beta-Protein Precursor/metabolism ; Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Brain/drug effects ; Brain/pathology ; Disease Models, Animal ; Fruiting Bodies, Fungal/chemistry ; Humans ; Learning Disabilities/drug therapy ; Learning Disabilities/pathology ; Memory Disorders/drug therapy ; Memory Disorders/pathology ; Mice ; Mice, Inbred C57BL ; Oxidative Stress ; Pleurotus/chemistry ; Powders/chemistry ; Powders/pharmacology
    Chemical Substances APP protein, mouse ; Amyloid beta-Peptides ; Amyloid beta-Protein Precursor ; Antioxidants ; Powders
    Language English
    Publishing date 2020-06-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2108803-2
    ISSN 1940-4344 ; 1521-9437
    ISSN (online) 1940-4344
    ISSN 1521-9437
    DOI 10.1615/IntJMedMushrooms.2020033766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Representative survey on idiopathic environmental intolerance attributed to electromagnetic fields in Taiwan and comparison with the international literature.

    Huang, Po-Chang / Cheng, Meng-Ting / Guo, How-Ran

    Environmental health : a global access science source

    2018  Volume 17, Issue 1, Page(s) 5

    Abstract: Background: Electromagnetic hypersensitivity refers to health effects attributed to electromagnetic fields (EMF) exposure and has been formally named "idiopathic environmental intolerance attributed to electromagnetic fields" (IEI-EMF) by the World ... ...

    Abstract Background: Electromagnetic hypersensitivity refers to health effects attributed to electromagnetic fields (EMF) exposure and has been formally named "idiopathic environmental intolerance attributed to electromagnetic fields" (IEI-EMF) by the World Health Organization. Because of the growing use of cell phones, IEI-EMF has become a global public health concern. A survey in 2007 in Taiwan showed that the prevalence rate of IEI-EMF was 13.3%, which is higher than rates in studies conducted previously. The survey also found that the rate was higher in women.
    Methods: To evaluate whether the prevalence rate of IEI-EMF is increasing and to verify the higher risk in women, we conducted a nationwide questionnaire survey using the same methods as the 2007 survey to assess the change in the prevalence rate of IEI-EMF in Taiwan. We also conducted a review of the literature and a meta-analysis to evaluate the changes in the prevalence rate around the world.
    Results: On the basis of the representative sample of 3303 participants, we found that the prevalence rate of IEI-EMF in Taiwan declined from 13.3% to 4.6% over a period of 5 years. The literature review also found the prevalence rates in other countries to be decreasing, instead of increasing as predicted previously. The meta-analysis of the data from the literature showed that women are more likely to have IEI-EMF than men, with an odds ratio of 1.19 (95% confidence interval: 1.01-1.40).
    Conclusions: We found the prevalence rate of IEI-EMF has been declining, instead of increasing as predicted previously. Women are more likely to report having IEI-EMF than men. Further studies to explore the causes leading to the declines may help the public, scientific community, and government deal with idiopathic intolerance to other environmental exposures.
    MeSH term(s) Adult ; Aged ; Cell Phone ; Electromagnetic Fields/adverse effects ; Environmental Exposure ; Female ; Humans ; Male ; Middle Aged ; Multiple Chemical Sensitivity/epidemiology ; Multiple Chemical Sensitivity/etiology ; Prevalence ; Surveys and Questionnaires ; Taiwan/epidemiology ; Young Adult
    Language English
    Publishing date 2018-01-15
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1476-069X
    ISSN (online) 1476-069X
    DOI 10.1186/s12940-018-0351-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Physiological changes and symptoms associated with short-term exposure to electromagnetic fields: a randomized crossover provocation study.

    Huang, Po-Chang / Chiang, Jui-Chin / Cheng, Ya-Yun / Cheng, Tain-Junn / Huang, Chien-Yuan / Chuang, Ya-Ting / Hsu, Ti / Guo, How-Ran

    Environmental health : a global access science source

    2022  Volume 21, Issue 1, Page(s) 31

    Abstract: Background: The biological association between electromagnetic fields (EMF) and idiopathic environmental intolerance attributed to EMF (IEI-EMF) has not been established. To assess the physiological changes and symptoms associated with exposure to EMF, ... ...

    Abstract Background: The biological association between electromagnetic fields (EMF) and idiopathic environmental intolerance attributed to EMF (IEI-EMF) has not been established. To assess the physiological changes and symptoms associated with exposure to EMF, we conducted a randomized crossover provocation study.
    Methods: We recruited 58 individuals with IEI-EMF (IEI-EMF group) and 92 individuals without IEI-EMF (control group). In a controlled environment, all participants received EMF signals mimicking those from mobile phone base stations in a randomized sequence under the blinded condition. During the course, participants reported their symptoms and whether they perceived EMF, and we monitored their physiological parameters, including blood pressure (BP), heart rate (HR), and HR variability.
    Results: The IEI-EMF and control groups reported similar frequencies of symptoms during both the provocation and sham sessions. No participant could accurately identify the provocation. In both groups, physiological parameters were similar between the two sessions. The control group, but not the IEI-EMF group, had elevated HR when they perceived EMF exposure.
    Conclusions: No symptoms or changes in physiological parameters were found to be associated with short-term exposure to EMF, and no participant could accurately detect the presence of EMF. Moreover, the participants in the control group, but not those in the IEI-EMF group, had elevated HR when they perceived EMF.
    MeSH term(s) Blood Pressure ; Cell Phone ; Electromagnetic Fields/adverse effects ; Environmental Exposure/adverse effects ; Heart Rate ; Humans ; Multiple Chemical Sensitivity
    Language English
    Publishing date 2022-03-08
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 2092232-2
    ISSN 1476-069X ; 1476-069X
    ISSN (online) 1476-069X
    ISSN 1476-069X
    DOI 10.1186/s12940-022-00843-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association between media coverage and prevalence of idiopathic environmental intolerance attributed to electromagnetic field in Taiwan.

    Huang, Po-Chang / Li, Kun-Hua / Guo, How-Ran

    Environmental research

    2017  Volume 161, Page(s) 329–335

    Abstract: Idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) describes symptoms sufferers attribute to exposure to electromagnetic fields (EMF). In Taiwan, the prevalence rate of IEI-EMF was 13.3% in 2007, but a survey using the ... ...

    Abstract Idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) describes symptoms sufferers attribute to exposure to electromagnetic fields (EMF). In Taiwan, the prevalence rate of IEI-EMF was 13.3% in 2007, but a survey using the same method found the rate declined to 4.6% in 2012. Because media reports may encourage readers to attribute their symptoms to EMF, the change might be related to media coverage. We searched articles indexed in the largest newspaper database in Taiwan to evaluate the association between media coverage and the prevalence of IEI-EMF. We also assessed the effects of other potential affecting factors. The number of newspaper articles related to EMF and IEI-EMF increased from 2005 to 2007 and then has been decreasing until 2012, which is compatible with the change in the prevalence of IEI-EMF. However, from 2007 to 2012, the other potential affecting factors such as density of mobile phone base stations, number of mobile phone users, total mobile phone calling time, and number of text messages sent through mobile phones all increased in Taiwan. This finding indicated a positive association between media coverage and the prevalence of IEI-EMF in Taiwan, which might also be true in other countries.
    MeSH term(s) Cell Phone ; Electromagnetic Fields ; Environmental Exposure ; Humans ; Mass Media ; Multiple Chemical Sensitivity/epidemiology ; Prevalence ; Taiwan/epidemiology
    Language English
    Publishing date 2017-11-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2017.11.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Association between media coverage and prevalence of idiopathic environmental intolerance attributed to electromagnetic field in Taiwan

    Huang, Po-Chang / How-Ran Guo / Kun-Hua Li

    Environmental research. 2018 Feb., v. 161

    2018  

    Abstract: Idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) describes symptoms sufferers attribute to exposure to electromagnetic fields (EMF). In Taiwan, the prevalence rate of IEI-EMF was 13.3% in 2007, but a survey using the ... ...

    Abstract Idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF) describes symptoms sufferers attribute to exposure to electromagnetic fields (EMF). In Taiwan, the prevalence rate of IEI-EMF was 13.3% in 2007, but a survey using the same method found the rate declined to 4.6% in 2012. Because media reports may encourage readers to attribute their symptoms to EMF, the change might be related to media coverage. We searched articles indexed in the largest newspaper database in Taiwan to evaluate the association between media coverage and the prevalence of IEI-EMF. We also assessed the effects of other potential affecting factors. The number of newspaper articles related to EMF and IEI-EMF increased from 2005 to 2007 and then has been decreasing until 2012, which is compatible with the change in the prevalence of IEI-EMF. However, from 2007 to 2012, the other potential affecting factors such as density of mobile phone base stations, number of mobile phone users, total mobile phone calling time, and number of text messages sent through mobile phones all increased in Taiwan. This finding indicated a positive association between media coverage and the prevalence of IEI-EMF in Taiwan, which might also be true in other countries.
    Keywords databases ; electromagnetic field ; mobile telephones ; surveys ; Taiwan
    Language English
    Dates of publication 2018-02
    Size p. 329-335.
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2017.11.034
    Database NAL-Catalogue (AGRICOLA)

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  8. Article ; Online: Impact of climate change on disaster events in metropolitan cities -trend of disasters reported by Taiwan national medical response and preparedness system.

    Lee, Chung-Hsun / Lin, Shih-Hao / Kao, Chia-Lung / Hong, Ming-Yuan / Huang, Po-Chang / Shih, Chung-Liang / Chuang, Chia-Chang

    Environmental research

    2020  Volume 183, Page(s) 109186

    Abstract: Background: Taiwan is geographically located in a zone that is vulnerable to earthquakes, typhoons, floods, and landslide hazards and has experienced various disasters. Six Regional Emergency Medical Operation Centers (REMOCs) are integrated and ... ...

    Abstract Background: Taiwan is geographically located in a zone that is vulnerable to earthquakes, typhoons, floods, and landslide hazards and has experienced various disasters. Six Regional Emergency Medical Operation Centers (REMOCs) are integrated and administered by the Ministry of Health and Welfare (MOHW) to be responsible for emergency situations during disastrous events, such as the emission of chemical toxicants, traffic accidents, industrial materials containment, and typhoons.
    Objective: To analyze events reported by the six REMOCs during the 2014 to 2018 for the government policy reference.
    Methods: Data were collected from injured and death toll reports provided by local designated hospitals in the emergency medical reporting system. Disaster events were categorized into three categories: natural disaster (NDs), disasters associated with technology (DTs), and disasters associated with security/violence/others (DSVOs). The three categories were further subdivided into sub-categories. Variables considered for trend analyses included the number of wounded and deaths, event characteristics, date/time, and triage. The frequency of disaster events among the six REMOCs was compared using the chi-square test. We used the global information system (GIS) to describe the distribution of events in Taiwan metropolitan cities. The α-level was set at 0.05.
    Results: Of 580 events during the study period, the distribution of disaster characteristics in the jurisdictions of the six REMOCs were different. The majority of disaster events were DTs (64.5%), followed by NDs (24.5%) and DSVOs (11.0%). Events for the three disaster categories in the six REMOCs were different (χ
    Conclusion: Our data revealed that extreme weather precautions reported in the Taipei branch were increasing. Disaster characteristics were different in each metropolitan city. Upgrading the ability to respond to natural disasters is ineluctable.
    MeSH term(s) Cities ; Civil Defense ; Climate Change ; Disaster Planning ; Disasters ; Environmental Health ; Taiwan
    Language English
    Publishing date 2020-01-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2020.109186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Impact of climate change on disaster events in metropolitan cities -trend of disasters reported by Taiwan national medical response and preparedness system

    Lee, Chung-Hsun / Chuang, Chia-Chang / Hong, Ming-Yuan / Huang, Po-Chang / Kao, Chia-Lung / Lin, Shih-Hao / Shih, Chung-Liang

    Environmental research. 2020 Apr., v. 183

    2020  

    Abstract: Taiwan is geographically located in a zone that is vulnerable to earthquakes, typhoons, floods, and landslide hazards and has experienced various disasters. Six Regional Emergency Medical Operation Centers (REMOCs) are integrated and administered by the ... ...

    Abstract Taiwan is geographically located in a zone that is vulnerable to earthquakes, typhoons, floods, and landslide hazards and has experienced various disasters. Six Regional Emergency Medical Operation Centers (REMOCs) are integrated and administered by the Ministry of Health and Welfare (MOHW) to be responsible for emergency situations during disastrous events, such as the emission of chemical toxicants, traffic accidents, industrial materials containment, and typhoons.To analyze events reported by the six REMOCs during the 2014 to 2018 for the government policy reference.Data were collected from injured and death toll reports provided by local designated hospitals in the emergency medical reporting system. Disaster events were categorized into three categories: natural disaster (NDs), disasters associated with technology (DTs), and disasters associated with security/violence/others (DSVOs). The three categories were further subdivided into sub-categories. Variables considered for trend analyses included the number of wounded and deaths, event characteristics, date/time, and triage. The frequency of disaster events among the six REMOCs was compared using the chi-square test. We used the global information system (GIS) to describe the distribution of events in Taiwan metropolitan cities. The α-level was set at 0.05.Of 580 events during the study period, the distribution of disaster characteristics in the jurisdictions of the six REMOCs were different. The majority of disaster events were DTs (64.5%), followed by NDs (24.5%) and DSVOs (11.0%). Events for the three disaster categories in the six REMOCs were different (χ2-test, p < 0.001). Furthermore, for the Taipei branch (Northern Taiwan), other NDs, especially heatwaves and cold spells, were most reported in New Taipei City (92.2%) and showed an increasing annual trend; for the Kaohsiung branch (Southern Taiwan), DT events were the most reported, especially in Kaohsiung City; and for the Taichung branch (Central Taiwan), DSVOs were the most reported, especially in Taichung City.Our data revealed that extreme weather precautions reported in the Taipei branch were increasing. Disaster characteristics were different in each metropolitan city. Upgrading the ability to respond to natural disasters is ineluctable.
    Keywords accidents ; chi-square distribution ; cities ; climate change ; cold ; death ; disasters ; earthquakes ; floods ; hospitals ; information systems ; issues and policy ; landslides ; toxic substances ; traffic ; typhoons ; violence ; Taiwan
    Language English
    Dates of publication 2020-04
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2020.109186
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Myricetin against myocardial injury in rat heat stroke model.

    Lin, Xiaojing / Lin, Cheng-Hsien / Liu, Ruoxu / Li, Chenyi / Jiao, Shuxin / Yi, Xueqing / Walker, M J / Xu, Xiao-Ming / Zhao, Tingbao / Huang, Po-Chang / Sun, Gang

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2020  Volume 127, Page(s) 110194

    Abstract: Background: Heat stroke-induced mortality is rising across the globe. So, the design of prophylactic and/or therapeutic modalities for heat stroke is pressing need. The common plant derived flavonoid exhibits strong anti-oxidant and anti-inflammatory ... ...

    Abstract Background: Heat stroke-induced mortality is rising across the globe. So, the design of prophylactic and/or therapeutic modalities for heat stroke is pressing need. The common plant derived flavonoid exhibits strong anti-oxidant and anti-inflammatory activities; however, its effects in heat stroke remain unknown. The study aimed to investigate the cardioprotective effects of myricetin on heat stroke induced acute myocardial injury as well as lethality in rats and to explore the underlying mechanisms.
    Methods: Myocardial injury was induced by subjecting the anesthetized rats to a high ambient temperature of 43 °C for 70 min. An intragastrical dose of myricetin (5-25 mg/kg body weight) was given to rats once per day for one week prior to the start of heat stress. Heat shock protein 72 antibodies was given intraperitoneally to rats 24 h before the start of heat stress. Myocardial injury severity was estimated by determing myocardial damage scores, myocardial injury indicators, myocardial oxidative and inflammatory factors. Western blot analysis was used for cardiac expression of heat shock protein (HSP)72.
    Results: Significant (P < 0.05) up-regulation of HSP-72 after chronic administration of myricetin coincided with significant (P < 0.05) reduction in hyperthermia, hypotension, cardiac inflammatory and oxidative damage and lethality. Inhibition of HSP-72 showed a significant (P < 0.05) reversal in the cardiaprotection as well as survival.
    Conclusions: Our results indicate that myricetin diminishes myocardial injury as well as lethality in heat stroke by up-regulating HSP-72 and show promise as a novel prevention therapeutic for heat stroke.
    MeSH term(s) Animals ; Cardiotonic Agents/administration & dosage ; Cardiotonic Agents/pharmacology ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Flavonoids/administration & dosage ; Flavonoids/pharmacology ; HSP72 Heat-Shock Proteins/genetics ; Heart Injuries/etiology ; Heart Injuries/prevention & control ; Heat Stroke/complications ; Heat Stroke/drug therapy ; Male ; Myocardium/pathology ; Rats ; Rats, Sprague-Dawley ; Up-Regulation
    Chemical Substances Cardiotonic Agents ; Flavonoids ; HSP72 Heat-Shock Proteins ; myricetin (76XC01FTOJ)
    Language English
    Publishing date 2020-05-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2020.110194
    Database MEDical Literature Analysis and Retrieval System OnLINE

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