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  1. Article ; Online: Metabolic engineering of probiotic Escherichia coli for cytolytic therapy of tumors.

    Chiang, Chung-Jen / Huang, Po-Han

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 5853

    Abstract: Bacterial cancer therapy was developed using probiotic Escherichia coli Nissle 1917 (EcN) for medical intervention of colorectal cancer. EcN was armed with HlyE, a small cytotoxic protein, under the control of the araBAD promoter ( ... ...

    Abstract Bacterial cancer therapy was developed using probiotic Escherichia coli Nissle 1917 (EcN) for medical intervention of colorectal cancer. EcN was armed with HlyE, a small cytotoxic protein, under the control of the araBAD promoter (P
    MeSH term(s) Animals ; Cell Death ; Cell Line, Tumor ; Escherichia coli/metabolism ; Escherichia coli Proteins/metabolism ; Genetic Vectors/metabolism ; Hemolysin Proteins/metabolism ; Immunity ; Male ; Metabolic Engineering ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasms/immunology ; Neoplasms/pathology ; Neoplasms/therapy ; Probiotics/metabolism ; Mice
    Chemical Substances Escherichia coli Proteins ; Hemolysin Proteins ; hlyE protein, E coli
    Language English
    Publishing date 2021-03-12
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-85372-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: 3D Printing of Glass Micro-Optics with Subwavelength Features on Optical Fiber Tips.

    Lai, Lee-Lun / Huang, Po-Han / Stemme, Göran / Niklaus, Frank / Gylfason, Kristinn B

    ACS nano

    2024  Volume 18, Issue 16, Page(s) 10788–10797

    Abstract: Integration of functional materials and structures on the tips of optical fibers has enabled various applications in micro-optics, such as sensing, imaging, and optical trapping. Direct laser writing is a 3D printing technology that holds promise for ... ...

    Abstract Integration of functional materials and structures on the tips of optical fibers has enabled various applications in micro-optics, such as sensing, imaging, and optical trapping. Direct laser writing is a 3D printing technology that holds promise for fabricating advanced micro-optical structures on fiber tips. To date, material selection has been limited to organic polymer-based photoresists because existing methods for 3D direct laser writing of inorganic materials involve high-temperature processing that is not compatible with optical fibers. However, organic polymers do not feature stability and transparency comparable to those of inorganic glasses. Herein, we demonstrate 3D direct laser writing of inorganic glass with a subwavelength resolution on optical fiber tips. We show two distinct printing modes that enable the printing of solid silica glass structures ("Uniform Mode") and self-organized subwavelength gratings ("Nanograting Mode"), respectively. We illustrate the utility of our approach by printing two functional devices: (1) a refractive index sensor that can measure the indices of binary mixtures of acetone and methanol at near-infrared wavelengths and (2) a compact polarization beam splitter for polarization control and beam steering in an all-in-fiber system. By combining the superior material properties of glass with the plug-and-play nature of optical fibers, this approach enables promising applications in fields such as fiber sensing, optical microelectromechanical systems (MEMS), and quantum photonics.
    Language English
    Publishing date 2024-03-29
    Publishing country United States
    Document type Journal Article
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.3c11030
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  3. Book ; Online: Improving Limited Supervised Foot Ulcer Segmentation Using Cross-Domain Augmentation

    Kuo, Shang-Jui / Huang, Po-Han / Lin, Chia-Ching / Li, Jeng-Lin / Chang, Ming-Ching

    2024  

    Abstract: Diabetic foot ulcers pose health risks, including higher morbidity, mortality, and amputation rates. Monitoring wound areas is crucial for proper care, but manual segmentation is subjective due to complex wound features and background variation. Expert ... ...

    Abstract Diabetic foot ulcers pose health risks, including higher morbidity, mortality, and amputation rates. Monitoring wound areas is crucial for proper care, but manual segmentation is subjective due to complex wound features and background variation. Expert annotations are costly and time-intensive, thus hampering large dataset creation. Existing segmentation models relying on extensive annotations are impractical in real-world scenarios with limited annotated data. In this paper, we propose a cross-domain augmentation method named TransMix that combines Augmented Global Pre-training AGP and Localized CutMix Fine-tuning LCF to enrich wound segmentation data for model learning. TransMix can effectively improve the foot ulcer segmentation model training by leveraging other dermatology datasets not on ulcer skins or wounds. AGP effectively increases the overall image variability, while LCF increases the diversity of wound regions. Experimental results show that TransMix increases the variability of wound regions and substantially improves the Dice score for models trained with only 40 annotated images under various proportions.

    Comment: 5 pages, 2 figures, accepted by ICASSP 2024
    Keywords Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2024-01-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Book ; Online: Optimal User-Cell Association for 360 Video Streaming over Dense Wireless Networks

    Huang, Po-Han / Psounis, Konstantinos

    2020  

    Abstract: Delivering 360 degree video streaming for virtual and augmented reality presents many technical challenges especially in bandwidth starved wireless environments. Recently, a so-called two-tier approach has been proposed which delivers a basic-tier chunk ... ...

    Abstract Delivering 360 degree video streaming for virtual and augmented reality presents many technical challenges especially in bandwidth starved wireless environments. Recently, a so-called two-tier approach has been proposed which delivers a basic-tier chunk and select enhancement-tier chunks to improve user experience while reducing network resources consumption. The video chunks are to be transmitted via unicast or multicast over an ultra-dense small cell infrastructure with enough bandwidth where small cells store video chunks in local caches. In this setup, user-cell association algorithms play a central role to efficiently deliver video since users may only download video chunks from the cell they are associated with. Motivated by this, we jointly formulate the problem of user-cell association and video chunk multicasting/unicasting as a mixed integer linear programming, prove its NP-hardness, and study the optimal solution via the Branch-and-Bound method. We then propose two polynomial-time, approximation algorithms and show via extensive simulations that they are near-optimal in practice and improve user experience by 30% compared to baseline user-cell association schemes.

    Comment: 12 pages
    Keywords Computer Science - Networking and Internet Architecture
    Subject code 004
    Publishing date 2020-04-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Child-Pugh Score and

    Huang, Po-Han / Yu, Jen / Chu, Yin-Yi / Lin, Yang-Hsiang / Yeh, Chau-Ting

    Journal of clinical medicine

    2022  Volume 11, Issue 9

    Abstract: Patients with advanced hepatocellular carcinoma (HCC) are treated by immunotherapy and/or targeted agents, such as sorafenib. Several single nucleotide polymorphisms (SNPs) and clinical scores have been proposed as prognostic markers in HCC patients ... ...

    Abstract Patients with advanced hepatocellular carcinoma (HCC) are treated by immunotherapy and/or targeted agents, such as sorafenib. Several single nucleotide polymorphisms (SNPs) and clinical scores have been proposed as prognostic markers in HCC patients treated with sorafenib. This study aimed to validate the prognostic values of these markers in a tertiary referral medical center. Two independent cohorts (cohort-1 [n = 97] and cohort-2 [n = 60]) of advanced HCC patients treated with sorafenib monotherapy were enrolled. Univariate followed by multivariate Cox proportional hazard analysis identified Child−Pugh (CP) score (p < 0.001) and renal insufficiency during treatment (p < 0.001) as independent predictors in cohort-1 patients. The same analytic method revealed ascites (p = 0.000), CP score (p = 0.001), infection during treatment (p < 0.001), and ATP-binding cassette subfamily G member 2 (ABCG2)-rs2231142 genotype (p = 0.003) as independent predictors in cohort-2 patients. ABCG2-rs2231142 genotype “CC” was associated with unfavorable overall survival in sorafenib-treated HCC patients. In conclusion, the CP score and ABCG2-rs2231142 genotype served as independent survival predictors for advanced HCC patients receiving sorafenib treatment.
    Language English
    Publishing date 2022-05-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm11092550
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  6. Article ; Online: Risk Factors for the Development of Colistin Resistance during Colistin Treatment of Carbapenem-Resistant Klebsiella pneumoniae Infections.

    Huang, Po-Han / Chen, Wen-Yin / Chou, Sheng-Hua / Wang, Fu-Der / Lin, Yi-Tsung

    Microbiology spectrum

    2022  Volume 10, Issue 3, Page(s) e0038122

    Abstract: Colistin is one of the last-resort options for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections if novel antibiotics are unavailable, where the development of colistin resistance during treatment represents a major challenge for clinicians. ... ...

    Abstract Colistin is one of the last-resort options for carbapenem-resistant Klebsiella pneumoniae (CRKP) infections if novel antibiotics are unavailable, where the development of colistin resistance during treatment represents a major challenge for clinicians. We aimed to investigate the risk factors associated with the development of colistin resistance in patients with CRKP infections following colistin treatment. We conducted a retrospective case-control study of patients with CRKP strains available before and after colistin treatment at a medical center in Taiwan, between October 2016 and November 2020. Cases (
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Carbapenems/pharmacology ; Carbapenems/therapeutic use ; Case-Control Studies ; Colistin/pharmacology ; Colistin/therapeutic use ; Drug Resistance, Bacterial ; Humans ; Klebsiella Infections/drug therapy ; Klebsiella pneumoniae ; Microbial Sensitivity Tests ; Retrospective Studies ; Risk Factors ; Tigecycline/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; Carbapenems ; Tigecycline (70JE2N95KR) ; Colistin (Z67X93HJG1)
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00381-22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: DEFAEK: Domain Effective Fast Adaptive Network for Face Anti-Spoofing.

    Lin, Jiun-Da / Han, Yue-Hua / Huang, Po-Han / Tan, Julianne / Chen, Jun-Cheng / Tanveer, M / Hua, Kai-Lung

    Neural networks : the official journal of the International Neural Network Society

    2023  Volume 161, Page(s) 83–91

    Abstract: Existing deep learning based face anti-spoofing (FAS) or deepfake detection approaches usually rely on large-scale datasets and powerful networks with significant amount of parameters to achieve satisfactory performance. However, these make them resource- ...

    Abstract Existing deep learning based face anti-spoofing (FAS) or deepfake detection approaches usually rely on large-scale datasets and powerful networks with significant amount of parameters to achieve satisfactory performance. However, these make them resource-heavy and unsuitable for handheld devices. Moreover, they are limited by the types of spoof in the dataset they train on and require considerable training time. To produce a robust FAS model, they need large datasets covering the widest variety of predefined presentation attacks possible. Testing on new or unseen attacks or environments generally results in poor performance. Ideally, the FAS model should learn discriminative features that can generalize well even on unseen spoof types. In this paper, we propose a fast learning approach called Domain Effective Fast Adaptive nEt-worK (DEFAEK), a face anti-spoofing approach based on the optimization-based meta-learning paradigm that effectively and quickly adapts to new tasks. DEFAEK treats differences in an environment as domains and simulates multiple domain shifts during training. To further improve the effectiveness and efficiency of meta-learning, we adopt the metric learning in the inner loop update with careful sample selection. With extensive experiments on the challenging CelebA-Spoof and FaceForensics++ datasets, the evaluation results show that DEFAEK can learn cues independent of the environment with good generalization capability. In addition, the resulting model is lightweight following the design principle of modern lightweight network architecture and still generalizes well on unseen classes. In addition, we also demonstrate our model's capabilities by comparing the numbers of parameters, FLOPS, and model performance with other state-of-the-art methods.
    MeSH term(s) Cues ; Generalization, Psychological
    Language English
    Publishing date 2023-01-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 740542-x
    ISSN 1879-2782 ; 0893-6080
    ISSN (online) 1879-2782
    ISSN 0893-6080
    DOI 10.1016/j.neunet.2023.01.018
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  8. Article ; Online: Relationship between the Interannual Variations of Summer Convective Afternoon Rainfall Activity in Taiwan and SSTA(Niño3.4) during 1961-2012: Characteristics and Mechanisms.

    Huang, Wan-Ru / Chang, Ya-Hui / Huang, Po-Han

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 9378

    Abstract: This study examines the interannual variation of the Convective Afternoon Rainfall (CAR) activity (including frequency and intensity) in Taiwan during the summers (JJA) of 1961-2012 with a focus on identifying its relationship with the changes in sea ... ...

    Abstract This study examines the interannual variation of the Convective Afternoon Rainfall (CAR) activity (including frequency and intensity) in Taiwan during the summers (JJA) of 1961-2012 with a focus on identifying its relationship with the changes in sea surface temperature anomalies over the Niño3.4 region [SSTA(Niño3.4)] and the underlying physical mechanisms. Our analyses show that during the colder (warmer) phase of SSTA(Niño3.4), the subtropical high system over the region east of Taiwan is enhanced (weakened), the local surface wind convergence is enhanced (weakened), and the local thermal instability is enhanced (weakened), which facilitates (suppresses) the formation of CAR in Taiwan. This consistent negative relationship between the interannual variation of CAR frequency in Taiwan and SSTA(Niño3.4) occurs throughout 1961-2012. In contrast, the relationship between the interannual variation of CAR intensity in Taiwan and SSTA(Niño3.4) changed from positively correlated to negatively correlated in the late 1980s. This change is attributed to the change in the moisture supply for maintaining the CAR intensity in Taiwan from an increase (decrease) in the warmer (colder) phase of SSTA(Niño3.4) before the mid-1980s to the opposite after the late 1980s. These findings highlight how the rainfall characteristics in East Asia may change in response to changes in SSTA(Niño3.4).
    Language English
    Publishing date 2019-06-28
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-45901-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Ultrafast Metal-Free Microsupercapacitor Arrays Directly Store Instantaneous High-Voltage Electricity from Mechanical Energy Harvesters.

    Chen, Shiqian / Li, Zheng / Huang, Po-Han / Ruiz, Virginia / Su, Yingchun / Fu, Yujie / Alesanco, Yolanda / Malm, B Gunnar / Niklaus, Frank / Li, Jiantong

    Advanced science (Weinheim, Baden-Wurttemberg, Germany)

    2024  , Page(s) e2400697

    Abstract: Harvesting renewable mechanical energy is envisioned as a promising and sustainable way for power generation. Many recent mechanical energy harvesters are able to produce instantaneous (pulsed) electricity with a high peak voltage of over 100 V. However, ...

    Abstract Harvesting renewable mechanical energy is envisioned as a promising and sustainable way for power generation. Many recent mechanical energy harvesters are able to produce instantaneous (pulsed) electricity with a high peak voltage of over 100 V. However, directly storing such irregular high-voltage pulse electricity remains a great challenge. The use of extra power management components can boost storage efficiency but increase system complexity. Here utilizing the conducting polymer PEDOT:PSS, high-rate metal-free micro-supercapacitor (MSC) arrays are successfully fabricated for direct high-efficiency storage of high-voltage pulse electricity. Within an area of 2.4 × 3.4 cm
    Language English
    Publishing date 2024-03-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2808093-2
    ISSN 2198-3844 ; 2198-3844
    ISSN (online) 2198-3844
    ISSN 2198-3844
    DOI 10.1002/advs.202400697
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  10. Article ; Online: A Gaseous Kidney and Ureter.

    Huang, Po-Han / Hsieh, Jyh-Tong / Yang, Chih-Yu

    The American journal of the medical sciences

    2019  Volume 358, Issue 6, Page(s) e25

    MeSH term(s) Aged ; Female ; Humans ; Kidney Diseases/diagnosis ; Tomography, X-Ray Computed ; Ureteral Diseases/diagnosis
    Language English
    Publishing date 2019-07-18
    Publishing country United States
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2019.07.004
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    Ua VI Zs.2/10: Show issues Location:
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