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Article ; Online: Study on the Transport Properties of SO

Lin, Mingqi / Tian, Bobing / Huang, Ren / Xiao, Chao

The journal of physical chemistry. B

2024

Abstract: Gas-liquid interfaces have a unique structure different from the bulk phase due to the complex intermolecular interactions within them and are regarded as barriers that prevent gases from entering solution or as channels that affect gas reactions. In ... ...

Abstract	Gas-liquid interfaces have a unique structure different from the bulk phase due to the complex intermolecular interactions within them and are regarded as barriers that prevent gases from entering solution or as channels that affect gas reactions. In this study, the adsorption and mass-transfer mechanisms of sulfur dioxide and nitric oxide at the gas-liquid interface of a H
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.4c00013
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Article ; Online: Therapeutic effect and mechanism of Yougui Wan in rats with intervertebral disk degeneration.

Ma, She / Liu, Kan / Yang, Jing-Yan / Huang, Ren-Jun / Yu, Dong

Journal of orthopaedic surgery and research

2024 Volume 19, Issue 1, Page(s) 89

Abstract: Objective: To explore the potential mechanism of Yougui Wan on deformed lumbar intervertebral disk structure in rats.: Methods: Thirty male Sprague-Dawley rats were randomly divided into 3 groups, with 10 rats in each group. The animals in the blank ... ...

Abstract	Objective: To explore the potential mechanism of Yougui Wan on deformed lumbar intervertebral disk structure in rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into 3 groups, with 10 rats in each group. The animals in the blank control group were healthy rats without specific treatment, and those in the model group and traditional Chinese medicine (TCM) group were used to establish the intervertebral disk degeneration (IDD) model by puncturing the annulus. Four weeks after modeling, rats in the TCM group were administered Yougui Wan by gavage for 2 consecutive weeks. Serum interleukin-6 (IL-10), macrophage migration inhibitory factor (MIF) and tumor necrosis factor alpha (TNF-α) levels were measured by ELISA, and the protein expression levels of collagen II and Notch1 in intervertebral disk tissues were examined by Western blotting. Apoptosis was detected by the TUNEL method. Results: Compared with those in the blank group, IL-10, MIF and TNF-α levels in the model group and TCM group were increased (P < 0.05), the protein expression levels of collagen II were decreased, and the protein expression levels of Notch1 were increased. Compared with those in the model group, the levels of IL-10 in the TCM group were increased (P < 0.05), the levels of MIF and TNF-α were decreased (P < 0.05), the protein expression levels of collagen II were increased, and the protein expression levels of Notch1 were decreased. Conclusion: Yougui Wan can inhibit the inflammatory response in IDD rats, reduce the degradation of extracellular matrix, reduce apoptosis in nucleus pulposus cells, and alleviate intervertebral disk degeneration. The mechanism may be related to the regulation of the Notch signaling pathway.
MeSH term(s)	Male ; Rats ; Animals ; Intervertebral Disc Degeneration/drug therapy ; Interleukin-10 ; Rats, Sprague-Dawley ; Tumor Necrosis Factor-alpha ; Collagen ; Drugs, Chinese Herbal
Chemical Substances	yougui ; Interleukin-10 (130068-27-8) ; Tumor Necrosis Factor-alpha ; Collagen (9007-34-5) ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2252548-8
ISSN	1749-799X ; 1749-799X
ISSN (online)	1749-799X
ISSN	1749-799X
DOI	10.1186/s13018-024-04554-w
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Article ; Online: Dual-mode sensing strategy based on carbon dots for sensitive and selective detection of molybdate ions.

Zeng, Hui-Hui / Huang, Ren-Xiu / Jiang, Ming-Qiang / Liu, Fang / Shi, Wei-Guo / Chen, Lin

Mikrochimica acta

2024 Volume 191, Issue 4, Page(s) 187

Abstract: Two kinds of carbon dots with the maximum fluorescence peak of 492 nm (named as G-CDs) and 607 nm (named as R-CDs) were synthesized. In the presence of ... ...

Abstract	Two kinds of carbon dots with the maximum fluorescence peak of 492 nm (named as G-CDs) and 607 nm (named as R-CDs) were synthesized. In the presence of MoO
Language	English
Publishing date	2024-03-07
Publishing country	Austria
Document type	Journal Article
ZDB-ID	89-9
ISSN	1436-5073 ; 0026-3672
ISSN (online)	1436-5073
ISSN	0026-3672
DOI	10.1007/s00604-024-06275-7
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Article: Comprehensive Analysis of Clinicopathological and Molecular Features to Predict Anti-PD-1-Based Therapy Efficacy in Patients with Advanced Gastric Signet Ring Cell Carcinoma.

Hu, Yan / Chen, Nuo / Huang, Ren-Ze / Chen, Dong-Liang

Journal of personalized medicine

2023 Volume 13, Issue 1

Abstract: Background: Signet ring cell carcinoma (SRCC) is a specific type of gastric cancer. The clinicopathological and molecular characteristics that can be used to predict the response to anti-PD-1 therapy for these patients are still not clear.: Methods: ... ...

Abstract	Background: Signet ring cell carcinoma (SRCC) is a specific type of gastric cancer. The clinicopathological and molecular characteristics that can be used to predict the response to anti-PD-1 therapy for these patients are still not clear. Methods: Patients with advanced SRCC who received first-line anti-PD-1-based treatment were enrolled in this study. The clinicopathological characteristics of these patients were obtained from their medical records. The molecular features of these patients were analyzed by means of a next-generation-sequencing-based panel. The predictive significance of clinicopathological and molecular features for efficacy was analyzed. Results: A total of 71 patients with measurable lesions were included in this study, among which 46 patients had enough tissues for next-generation sequencing. The overall objective response rate (ORR) was 46.4%. ORR was significantly higher in mismatch repair (MMR)-deficient (dMMR) patients than in MMR-proficient (pMMR) patients, in patients with lymph node metastasis only than those with other metastasis sites, and in patients with an Eastern Cooperative Oncology Group performance status (ECOG PS) of 0 than with a PS of 1 or 2. The progression-free survival was significantly longer in patients with dMMR, lymph node metastasis only, PD-L1 combined positive score (CPS) ≥ 5, and CDH1 wild type. Conclusions: Several clinicopathological and molecular features are associated with anti-PD-1 treatment efficacy in SRCC, which might be used to identify patients who can benefit most from these therapies.
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662248-8
ISSN	2075-4426
ISSN	2075-4426
DOI	10.3390/jpm13010115
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Article: Antifatigue effects and antioxidant activity in polysaccharide fractions from Chinese

Zhou, Hai-Xu / Zhang, Xiao / Huang, Ren-Gui / Su, Tong-Chao

Food science & nutrition

2023 Volume 12, Issue 2, Page(s) 1218–1229

Abstract: Polysaccharides are the principal component in ... ...

Abstract	Polysaccharides are the principal component in Chinese
Language	English
Publishing date	2023-11-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703010-6
ISSN	2048-7177
ISSN	2048-7177
DOI	10.1002/fsn3.3836
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Article ; Online: Circular RNA circTNIK promotes tumor progression and metastasis in gastric cancer by regulating ZEB2.

Chen, Nuo / Hu, Yan / Huang, Ren-Ze / Chen, Dong-Liang

Journal of gastroenterology and hepatology

2023 Volume 38, Issue 7, Page(s) 1181–1191

Abstract: Background and aim: Tumor progression and distant metastasis are the main causes of deaths in gastric cancer. Growing evidence revealed that circular RNAs (circRNAs) play critical role in the pathology of malignant disease, the role of circRNAs in ... ...

Abstract	Background and aim: Tumor progression and distant metastasis are the main causes of deaths in gastric cancer. Growing evidence revealed that circular RNAs (circRNAs) play critical role in the pathology of malignant disease, the role of circRNAs in gastric cancer progression and metastasis is still unknown. Methods: Differentially expressed circRNAs was identified by circRNA microarray and validated by quantitative reverse transcription polymerase reaction. The biological function of circTNIK was evaluated by in vitro and in vivo experiments after ectopic expression or siRNA mediated knockdown of circTNIK. The interaction between circTNIK and miR-138-5p was determined by luciferase activity assay, RNA immunoprecipitation, and fluorescence in situ hybridization assays. Results: circTNIK rather than linear TINK mRNA was significantly upregulated in gastric cancer tissues, cell lines compared with normal controls. Higher circTNIK expression was correlated with aggressive tumor phenotypes and poor overall survival in gastric cancer patients. Ectopic circTNIK expression promoted cell proliferation, invasion, tumorigenesis, and metastasis in gastric cancer cells whereas knockdown of circTNIK inhibited cell proliferation, invasion, tumorigenesis, and metastasis in gastric cancer cells. Importantly, circTNIK functions as a molecular sponge for miR-138-5p to regulate the expression of ZEB2. Conclusions: Overall, our study demonstrates how circTNIK regulates gastric cancer progression and metastasis by sponging miR-138-5p to modulate the expression of ZEB2. CircTNIK might be used as a prognostic biomarker in gastric cancer patients.
MeSH term(s)	Humans ; RNA, Circular/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Stomach Neoplasms/pathology ; In Situ Hybridization, Fluorescence ; Cell Line, Tumor ; Carcinogenesis/genetics ; Cell Proliferation/genetics ; Gene Expression Regulation, Neoplastic/genetics ; Cell Movement ; Zinc Finger E-box Binding Homeobox 2/genetics ; Zinc Finger E-box Binding Homeobox 2/metabolism
Chemical Substances	RNA, Circular ; MicroRNAs ; ZEB2 protein, human ; Zinc Finger E-box Binding Homeobox 2 ; MIRN138 microRNA, human
Language	English
Publishing date	2023-04-20
Publishing country	Australia
Document type	Journal Article
ZDB-ID	632882-9
ISSN	1440-1746 ; 0815-9319
ISSN (online)	1440-1746
ISSN	0815-9319
DOI	10.1111/jgh.16189
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Article ; Online: Bio-inspired contour extraction via EM-driven deformable and rotatable directivity-probing mask.

Wang, Jung-Hua / Huang, Ren-Jie / Wang, Ting-Yuan

Scientific reports

2022 Volume 12, Issue 1, Page(s) 12309

Abstract: This paper presents a novel bio-inspired edge-oriented approach to perceptual contour extraction. Our method does not rely on segmentation and can unsupervised learn to identify edge points that are readily grouped, without invoking any connecting ... ...

Abstract	This paper presents a novel bio-inspired edge-oriented approach to perceptual contour extraction. Our method does not rely on segmentation and can unsupervised learn to identify edge points that are readily grouped, without invoking any connecting mechanism, into object boundaries as perceived by human. This goal is achieved by using a dynamic mask to statistically assess the inter-edge relations and probe the principal direction that acts as an edge-grouping cue. The novelty of this work is that the mask, centered at a target pixel and driven by EM algorithm, can iteratively deform and rotate until it covers pixels that best fit the Bayesian likelihood of the binary class w.r.t a target pixel. By creating an effect of enlarging receptive field, contiguous edges of the same object can be identified while suppressing noise and textures, the resulting contour is in good agreement with gestalt laws of continuity, similarity and proximity. All theoretical derivations and parameters updates are conducted under the framework of EM-based Bayesian inference. Issues of stability and parameter uncertainty are addressed. Both qualitative and quantitative comparison with existing approaches proves the superiority of the proposed method in terms of tracking curved contours, noises/texture resilience, and detection of low-contrast contours.
MeSH term(s)	Algorithms ; Bayes Theorem ; Form Perception ; Humans
Language	English
Publishing date	2022-07-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-16040-6
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Article: Key areas and pathways for carbon emissions reduction in Beijing for the “Dual Carbon” targets

Huang, Ren / Zhang, Sufang / Wang, Peng

Energy policy. 2022 May, v. 164

2022

Abstract: China pledges to have its carbon emissions peak before 2030 and achieve carbon neutrality before 2060 (“Dual Carbon” targets). Beijing, the capital of China, needs to take the lead in promoting carbon emissions reduction so as to provide an example for ... ...

Abstract	China pledges to have its carbon emissions peak before 2030 and achieve carbon neutrality before 2060 (“Dual Carbon” targets). Beijing, the capital of China, needs to take the lead in promoting carbon emissions reduction so as to provide an example for other cities. Based on the extended STIRPAT model and LEAP-Beijing model, this paper assesses the key areas and pathways for carbon emissions reduction in Beijing for the period of 2015–2060 under six different policy scenarios. The results show that energy structure upgrading and energy efficiency improvement are the key drivers for the city's emissions reduction. The realization of “Dual-Carbon” targets requires a low-carbon transition of all sectors, and the priority should first be put on the power, transportation and commercial sectors, followed by the thermal and industrial sectors, finally the residential and agricultural sectors. Considering that there exists a large number of carbon leakage, Beijing should start with the PES scenario, strive to achieve carbon peak by 2025, then accelerate the transition to the CES scenario between 2030 and 2035 depending on the ratio of renewable sources in its imported power, and finally achieve carbon neutrality via emissions absorption approaches such as CCUS and carbon sinks by 2060.
Keywords	absorption ; carbon ; energy efficiency ; energy policy ; models ; transportation ; China
Language	English
Dates of publication	2022-05
Publishing place	Elsevier Ltd
Document type	Article
ISSN	0301-4215
DOI	10.1016/j.enpol.2022.112873
Database	NAL-Catalogue (AGRICOLA)

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Article: Case report: PD-1 inhibitor-based treatment strategies in gastric cancer complicated by bone marrow metastasis and disseminated intravascular coagulation: A report of two cases.

Huang, Ren-Ze / Chen, Nuo / Hu, Yan / Hu, Wan-Ming / Wang, Feng-Hua / Chen, Dong-Liang

Frontiers in oncology

2023 Volume 13, Page(s) 1019702

Abstract: Introduction: Gastric cancer (GC) complicated by bone marrow metastasis (BMM) and disseminated intravascular coagulation (DIC) represents poor prognosis and most of these patients would die in a few months. Active treatment strategies such as ... ...

Abstract	Introduction: Gastric cancer (GC) complicated by bone marrow metastasis (BMM) and disseminated intravascular coagulation (DIC) represents poor prognosis and most of these patients would die in a few months. Active treatment strategies such as chemotherapy are effective in restoring coagulation function and prolonging patients' survival time. Immunotherapy including programmed death protein 1 (PD-1) or programmed death protein ligand 1 (PD-L1) inhibitors has emerged as a first-line treatment of gastric cancer. However, the efficacy of PD-1 inhibitor-based treatment strategies in these patients remains unknown. Case description: Herein, we presented two cases of advanced gastric cancer (AGC) complicated by BMM and DIC, in which two patients received chemotherapy and PD-1 inhibitor as the first-line treatment. Both of them achieved a partial response after treatment, and the coagulation function was restored. The patient who discontinued the PD-1 inhibitor after 6 months experienced DIC relapse, whereas the other patient who maintained the PD-1 inhibitor treatment cycle remained responsive after 10 months. Conclusions: We speculate that PD-1 inhibitor-based treatment strategies are effective and safe in prolonging survival against gastric cancer with BMM and DIC, and the coagulation function is well controlled by the treatment with a combination of immunotherapy and chemotherapy.
Language	English
Publishing date	2023-02-22
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2023.1019702
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Article ; Online: Supercharge end-to-side nerve transfer from anterior interosseous nerve to augment intrinsic recovery in high ulnar nerve injuries of varying magnitudes.

Li, Chun-Wei / Huang, Ren-Wen / Lin, Cheng-Hung / Hsu, Chung-Chen / Lin, Yu-Te / Chen, Hung-Chi / Tang, Yueh-Bih / Chen, Shih-Heng

Asian journal of surgery

2024

Abstract: Background: High ulnar nerve injuries result in intrinsic muscle weakness and are inconvenient for patients. Moreover, conventional surgical techniques often fail to achieve satisfactory motor recovery. A potential reconstructive solution in the form of ...

Abstract	Background: High ulnar nerve injuries result in intrinsic muscle weakness and are inconvenient for patients. Moreover, conventional surgical techniques often fail to achieve satisfactory motor recovery. A potential reconstructive solution in the form of the supercharge end-to-side (SETS) anterior interosseous nerve (AIN) transfer method has emerged. Therefore, this study aims to compare surgical outcomes of patients with transected and in-continuity high ulnar nerve lesions following SETS AIN transfer. Methods: Between June 2015 and May 2023, patients with high ulnar palsy in the form of transection injuries or lesion-in-continuity were recruited. The assessment encompassed several objective results, including grip strength, key pinch strength, compound muscle action potential, sensory nerve action potential, and two-point discrimination tests. The muscle power of finger abduction and adduction was also recorded. Additionally, subjective questionnaires were utilized to collect data on patient-reported outcomes. Overall, the patients were followed up for up to 2 years. Results: Patients with transected high ulnar nerve lesions exhibited worse baseline performance than those with lesion-in-continuity, including motor and sensory functions. However, they experienced greater motor improvement but less sensory recovery, resulting in comparable final motor outcomes in both groups. In contrast, the transection group showed worse sensory outcomes. Conclusions: Our findings suggest that SETS AIN transfer benefits patients with high ulnar nerve palsy, regardless of the lesion type. Nonetheless, improvements may be more pronounced in patients with transected lesions.
Language	English
Publishing date	2024-04-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2024.03.142
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