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  1. Book ; Online: mTOR Signaling in Metabolism and Cancer

    Huang, Shile

    2020  

    Keywords Medicine ; mTOR ; histone deacetylase ; prostate cancer ; integrins ; adhesion ; invasion ; cell metabolism ; T cells ; Foxp3 ; Acute Lymphoblastic leukemia ; targeted therapy ; metabolism ; cell signalling ; mTOR signalling ; head and neck cancer ; mutant genes ; biomarkers ; targeted therapies ; clinical trials ; cancers ; inhibitors ; photodynamic therapy ; PI3K ; Akt ; skin cancers ; phytochemicals ; melanoma ; basal cell carcinoma ; squamous cell carcinoma ; Merkel cell carcinoma ; TNBC ; eribulin ; PI3K/AKT/mTOR ; everolimus ; combination ; synergy ; mTOR signaling ; tissue regeneration ; neuron ; muscle ; liver ; intestine ; hematologic malignancies ; regulatory T cells ; tumor
    Size 1 electronic resource (204 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046454
    ISBN 9783039435548 ; 303943554X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: Shaping the Latitudinal Diversity Gradient: New Perspectives from a Synthesis of Paleobiology and Biogeography

    Huang, Shan

    The American naturalist, 189(1):1-12

    2016  

    Abstract: An impediment to understanding the origin and dynamics of the latitudinal diversity gradient (LDG)—the most pervasive large-scale biotic pattern on Earth—has been the tendency to focus narrowly on a single causal factor when a more synthetic, integrative ...

    Institution Senckenberg Biodiversität und Klima Forschungszentrum
    Abstract An impediment to understanding the origin and dynamics of the latitudinal diversity gradient (LDG)—the most pervasive large-scale biotic pattern on Earth—has been the tendency to focus narrowly on a single causal factor when a more synthetic, integrative approach is needed. Using marine bivalves as a model system and drawing on other systems where possible, we review paleobiologic and biogeographic support for two supposedly opposing views, that the LDG is shaped primarily by (a) local environmental factors that determine the number of species and higher taxa at a given latitude (in situ hypotheses) or (b) the entry of lineages arising elsewhere into a focal region (spatial dynamics hypotheses). Support for in situ hypotheses includes the fit of present-day diversity trends in many clades to such environmental factors as temperature and the correlation of extinction intensities in Pliocene bivalve faunas with net regional temperature changes. Support for spatial dynamics hypotheses includes the age-frequency distribution of bivalve genera across latitudes, which is consistent with an out-of-the-tropics dynamic, as are the higher species diversities in temperate southeastern Australia and southeastern Japan than in the tropical Caribbean. Thus, both in situ and spatial dynamics processes must shape the bivalve LDG and are likely to operate in other groups as well. The relative strengths of the two processes may differ among groups showing similar LDGs, but dissecting their effects will require improved methods of integrating fossil data with molecular phylogenies. We highlight several potential research directions and argue that many of the most dramatic biotic patterns, past and present, are likely to have been generated by diverse, mutually reinforcing drivers.
    Keywords geographic range dynamics ; extinction ; historical biogeography ; speciation ; paleobiology ; phylogeny
    Language English
    Document type Article
    Database Repository for Life Sciences

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  3. Article ; Online: Approaches to Item-Level Data with Cross-Classified Structure: An Illustration with Student Evaluation of Teaching.

    Huang, Sijia

    Multivariate behavioral research

    2024  , Page(s) 1–20

    Abstract: Student evaluation of teaching (SET) questionnaires are ubiquitously applied in higher education institutions in North America for both formative and summative purposes. Data collected from SET questionnaires are usually item-level data with cross- ... ...

    Abstract Student evaluation of teaching (SET) questionnaires are ubiquitously applied in higher education institutions in North America for both formative and summative purposes. Data collected from SET questionnaires are usually item-level data with cross-classified structure, which are characterized by multivariate categorical outcomes (i.e., multiple Likert-type items in the questionnaires) and cross-classified structure (i.e., non-nested students and instructors). Recently, a new approach, namely the cross-classified IRT model, was proposed for appropriately handling SET data. To inform researchers in higher education, in this article, the cross-classified IRT model, along with three existing approaches applied in SET studies, including the cross-classified random effects model (CCREM), the multilevel item response theory (MLIRT) model, and a two-step integrated strategy, was reviewed. The strengths and weaknesses of each of the four approaches were also discussed. Additionally, the new and existing approaches were compared through an empirical data analysis and a preliminary simulation study. This article concluded by providing general suggestions to researchers for analyzing SET data and discussing limitations and future research directions.
    Language English
    Publishing date 2024-02-13
    Publishing country United States
    Document type Journal Article
    ISSN 1532-7906
    ISSN (online) 1532-7906
    DOI 10.1080/00273171.2023.2288589
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An assessment of the perceptual elements of urban streets based on the context of urban tourism - The case of Sheffield.

    Huang, Siqi

    Frontiers in public health

    2024  Volume 12, Page(s) 1380723

    Abstract: Background: After COVID-19, more and more travelers are more inclined to walk in cities, and the sensory elements of streets can have a significant impact on urban tourism. Local residents and travelers have different perceptions of the street and ... ...

    Abstract Background: After COVID-19, more and more travelers are more inclined to walk in cities, and the sensory elements of streets can have a significant impact on urban tourism. Local residents and travelers have different perceptions of the street and preferences for its use. The purpose of this study is to evaluate and analyse the streets from the perspective of locals and travelers.
    Method: In this study, a questionnaire was designed to obtain local residents' and travelers' evaluations of the sensory elements of the street and a quadrant analysis of the street's sensory elements was carried out using the IPA-Kano model.
    Results: The results of the study show that travelers are particularly concerned about maps and signage guidance, while local residents are more concerned about the green environment of the surroundings and how well it is maintained.
    Conclusion: There is a difference in the indicators chosen by the two groups in the results of the comparison between locals and travelers, and this study is hoped to provide some data support for future urban managers and designers to learn from and refer to for street improvements and renewal.
    MeSH term(s) Humans ; Tourism ; COVID-19 ; Surveys and Questionnaires ; Cities ; Male ; Female ; Adult ; Middle Aged ; Urban Population ; Environment Design ; SARS-CoV-2 ; Walking ; Travel
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1380723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Tuning the rheostat of immune gene translation.

    Huang, Shuai

    Stress biology

    2023  Volume 3, Issue 1, Page(s) 7

    Abstract: Biomolecular condensates assembled through phase transitions regulate diverse aspects of plant growth, development, and stress responses. How biomolecular condensates control plant immunity is poorly understood. In Nature Plants, a new study (Zhou et al., ...

    Abstract Biomolecular condensates assembled through phase transitions regulate diverse aspects of plant growth, development, and stress responses. How biomolecular condensates control plant immunity is poorly understood. In Nature Plants, a new study (Zhou et al., Nat Plants 9:289-301, 2023) reveals how plants assemble translational condensates to balance tissue health and disease resistance.
    Language English
    Publishing date 2023-04-06
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2731-0450
    ISSN (online) 2731-0450
    DOI 10.1007/s44154-023-00087-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Efficient analysis of toxicity and mechanisms of environmental pollutants with network toxicology and molecular docking strategy: Acetyl tributyl citrate as an example.

    Huang, Shujun

    The Science of the total environment

    2023  Volume 905, Page(s) 167904

    Abstract: The study aims to promote network toxicology strategy to efficiently investigate the putative toxicity and underlying molecular mechanisms of environmental pollutants through an example of exploring brain injury induced by ATBC exposure. By utilizing ... ...

    Abstract The study aims to promote network toxicology strategy to efficiently investigate the putative toxicity and underlying molecular mechanisms of environmental pollutants through an example of exploring brain injury induced by ATBC exposure. By utilizing ChEMBL, STITCH, GeneCards, and OMIM databases, we identified 213 potential targets associated with ATBC exposure and brain injury. Further refinements via STRING and Cytoscape software highlight 23 core targets, including AKT1, CASP3, and HSP90AA1. GO and KEGG pathway analysis conducted through DAVID and FUMA databases reveal that core targets of ATBC-induced brain toxicity are predominantly enriched in cancer signaling and neuroactive ligand receptor interaction pathways. Molecular docking was performed with Autodock, which confirmed robust binding between ATBC and core targets. Together, these findings suggest that ATBC may impact the occurrence and development of brain cancer and brain related inflammation, whereas pose risks for cognitive impairment and neurodegeneration, by modulating the apoptosis and proliferation of brain cancer cells, activating inflammatory signaling pathways, and regulating neuroplasticity. This research provides a theoretical basis for understanding the molecular mechanism of ATBC-induced brain toxicity, as well as establishing a foundation for the prevention and treatment of prostatic diseases associated with exposure to plastic products containing ATBC and certain ATBC-overwhelmed environments. Moreover, our network toxicology approach also expedites the elucidation of toxicity pathways for uncharacterized environmental chemicals.
    MeSH term(s) Male ; Humans ; Environmental Pollutants/toxicity ; Molecular Docking Simulation ; Brain Neoplasms ; Brain Injuries
    Chemical Substances 2-acetyltributylcitrate (0ZBX0N59RZ) ; Environmental Pollutants
    Language English
    Publishing date 2023-10-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.167904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A novel strategy for the study on molecular mechanism of prostate injury induced by 4,4'-sulfonyldiphenol based on network toxicology analysis.

    Huang, Shujun

    Journal of applied toxicology : JAT

    2023  Volume 44, Issue 1, Page(s) 28–40

    Abstract: The study aimed to investigate the underlying molecular mechanisms of prostate injury induced by 4,4'-sulfonyldiphenol (BPS) exposure and propose a novel research strategy to systematically explore the molecular mechanisms of toxicant-induced adverse ... ...

    Abstract The study aimed to investigate the underlying molecular mechanisms of prostate injury induced by 4,4'-sulfonyldiphenol (BPS) exposure and propose a novel research strategy to systematically explore the molecular mechanisms of toxicant-induced adverse health effects. By utilizing the ChEMBL, STITCH, and GeneCards databases, a total of 208 potential targets associated with BPS exposure and prostate injury were identified. Through screening the potential target network in the STRING database and Cytoscape software, we determined 21 core targets including AKT1, EGFR, and MAPK3. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses conducted through the DAVID database illustrated that the potential targets of BPS in prostatic toxicity were primarily enriched in cancer signaling pathways and calcium signaling pathways. These findings suggest that BPS may actively participate in the occurrence and development of prostate inflammation, prostatic hyperplasia, prostate cancer, and other aspects of prostate injury by regulating prostate cancer cell apoptosis and proliferation, activating inflammatory signaling pathways, and modulating prostate adipocytes and fibroblasts. This research provides a theoretical basis for understanding the molecular mechanism of underlying BPS-induced prostatic toxicity and establishes a foundation for the prevention and treatment of prostatic diseases associated with exposure to plastic products containing BPS and certain BPS-overwhelmed environments.
    MeSH term(s) Male ; Humans ; Prostate ; Prostatic Diseases ; Prostatic Neoplasms/chemically induced ; Prostatic Neoplasms/genetics ; Adipocytes ; Apoptosis ; Drug-Related Side Effects and Adverse Reactions ; Molecular Docking Simulation ; Drugs, Chinese Herbal
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2023-06-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 604625-3
    ISSN 1099-1263 ; 0260-437X
    ISSN (online) 1099-1263
    ISSN 0260-437X
    DOI 10.1002/jat.4506
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1661: Show issues Location:
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  8. Article ; Online: Comment on "The relationship between family functioning and non-suicidal self-injury in adolescents: A structural equation modeling analysis".

    Huang, Shujun

    Journal of affective disorders

    2023  Volume 330, Page(s) 249

    MeSH term(s) Humans ; Adolescent ; Latent Class Analysis ; Suicidal Ideation ; Self-Injurious Behavior/epidemiology
    Language English
    Publishing date 2023-03-14
    Publishing country Netherlands
    Document type Letter ; Comment
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2023.03.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1485: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: A Review of the Relationship Between EFL Teachers' Academic Buoyancy, Ambiguity Tolerance, and Hopelessness.

    Huang, Shuyun

    Frontiers in psychology

    2022  Volume 13, Page(s) 831258

    Abstract: Second/foreign language education has been approved emotionally tense due to its inherent challenges, adversities, complications, and ambiguities. These factors can affect various language teaching and learning domains. Hence, it is critical for EFL ... ...

    Abstract Second/foreign language education has been approved emotionally tense due to its inherent challenges, adversities, complications, and ambiguities. These factors can affect various language teaching and learning domains. Hence, it is critical for EFL teachers to be buoyant and tolerant of ambiguity so that they can teach efficiently and prevent a sense of hopelessness that can damage everything. Although there are investigations on these variables in L2 contexts, their main focus has been on EFL students and teachers' perspectives have been largely ignored. Against this shortcoming, this study aimed to review the definitions, conceptualizations, and research findings related to teachers' academic buoyancy, ambiguity tolerance, and hopelessness. Moreover, practical implications for EFL teachers and teacher trainers are presented to increase their awareness of language teaching challenges and ways to overcome them. Finally, the study provides directions for future research.
    Language English
    Publishing date 2022-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.831258
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Reading the Moody chart with a linear interpolation method.

    Huang, Shuxin

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 6587

    Abstract: The error caused by pseudo-midpoint effect in the use of the Moody chart was analyzed. The pseudo-midpoint effect appears in the linear interpolation method usually used to read the Moody chart. The maximum of the error is about 4%, which is ... ...

    Abstract The error caused by pseudo-midpoint effect in the use of the Moody chart was analyzed. The pseudo-midpoint effect appears in the linear interpolation method usually used to read the Moody chart. The maximum of the error is about 4%, which is significantly lower than the 15% accuracy of the chart in the literature.
    MeSH term(s) Data Visualization
    Language English
    Publishing date 2022-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10552-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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