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  1. AU="Huang, Sequin"
  2. AU="Robin Kageyama"
  3. AU="Thapa Shrestha, Upendra"
  4. AU="Litvinovskaya, Raisa P"
  5. AU="MacDougall‐Shackleton, Elizabeth A."
  6. AU="Rajendram, Rathie"
  7. AU=Laxminarayan Ramanan
  8. AU="Perriman, Diana M"
  9. AU=Radich Jerald P
  10. AU="Velthuis, Birgitta"
  11. AU="Gibbs, Tom"
  12. AU=Mezzabotta Federica
  13. AU="Jalas, Sören"
  14. AU="Suma, Rache"
  15. AU="Calderón, Alejandro"
  16. AU="Demertzi, Vasiliki"
  17. AU="Leonidov, A"
  18. AU="Luo, Suxin"
  19. AU="Thompson, Charlotte A S"
  20. AU="Dubbel, Polly"
  21. AU="Ten Bosch, Nora"
  22. AU="Giménez-Arnau, Ana Maria"
  23. AU=Maul Robert W.
  24. AU="Ivn Prez-MaldonadoauthorLaboratorio de Toxicologa Molecular, Centro de Investigacin Aplicada en Ambiente y Salud (CIAAS), Coordinacin para la Innovacin y Aplicacin de la Ciencia y la Tecnologa (CIACYT), Universidad Autnoma de San Luis Potos, MexicoFacultad de Medicina, Universidad Autnoma de San Luis Potos, San Luis Potos, MexicoFacultad de Enfermera, Universidad Autnoma de Zacatecas, Mexico"
  25. AU="Hansen, Kristian Schultz"
  26. AU="Davenport, Bennett"

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  1. Artikel: Isotope-coded affinity tag (ICAT) approach to redox proteomics: identification and quantitation of oxidant-sensitive cysteine thiols in complex protein mixtures.

    Sethuraman, Mahadevan / McComb, Mark E / Huang, Hua / Huang, Sequin / Heibeck, Tyler / Costello, Catherine E / Cohen, Richard A

    Journal of proteome research

    2004  Band 3, Heft 6, Seite(n) 1228–1233

    Abstract: An approach is described for the simultaneous identification and quantitation of oxidant-sensitive cysteine thiols in a complex protein mixture using a thiol-specific, acid-cleavable isotope-coded affinity tag (ICAT) reagent (Applied Biosystems, USA). ... ...

    Abstract An approach is described for the simultaneous identification and quantitation of oxidant-sensitive cysteine thiols in a complex protein mixture using a thiol-specific, acid-cleavable isotope-coded affinity tag (ICAT) reagent (Applied Biosystems, USA). The approach is based on the fact that only free cysteine thiols are susceptible to labeling by the iodoacetamide-based ICAT, and that mass spectrometry can be used to quantitate the relative labeling of free thiols. Applying this approach, we have identified cysteine thiols of proteins in a rabbit heart membrane fraction that are sensitive to a high concentration of hydrogen peroxide. Previously known and some novel proteins with oxidant-sensitive cysteines were identified. Of the many protein thiols labeled by the ICAT, only relatively few were oxidized more than 50% despite the high concentration of oxidant used, indicating that oxidant-sensitive thiols are relatively rare, and denoting their specificity and potential functional relevance.
    Mesh-Begriff(e) Affinity Labels ; Animals ; Carbon Isotopes ; Cysteine/analysis ; Cysteine/metabolism ; Hydrogen Peroxide/metabolism ; Membrane Proteins/analysis ; Myocardium/chemistry ; Oxidants/metabolism ; Oxidation-Reduction ; Proteins/analysis ; Proteins/metabolism ; Proteomics/methods ; Rabbits ; Sulfhydryl Compounds/analysis ; Sulfhydryl Compounds/metabolism
    Chemische Substanzen Affinity Labels ; Carbon Isotopes ; Membrane Proteins ; Oxidants ; Proteins ; Sulfhydryl Compounds ; Hydrogen Peroxide (BBX060AN9V) ; Cysteine (K848JZ4886)
    Sprache Englisch
    Erscheinungsdatum 2004-11
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2078618-9
    ISSN 1535-3893
    ISSN 1535-3893
    DOI 10.1021/pr049887e
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: A common open representation of mass spectrometry data and its application to proteomics research.

    Pedrioli, Patrick G A / Eng, Jimmy K / Hubley, Robert / Vogelzang, Mathijs / Deutsch, Eric W / Raught, Brian / Pratt, Brian / Nilsson, Erik / Angeletti, Ruth H / Apweiler, Rolf / Cheung, Kei / Costello, Catherine E / Hermjakob, Henning / Huang, Sequin / Julian, Randall K / Kapp, Eugene / McComb, Mark E / Oliver, Stephen G / Omenn, Gilbert /
    Paton, Norman W / Simpson, Richard / Smith, Richard / Taylor, Chris F / Zhu, Weimin / Aebersold, Ruedi

    Nature biotechnology

    2004  Band 22, Heft 11, Seite(n) 1459–1466

    Abstract: A broad range of mass spectrometers are used in mass spectrometry (MS)-based proteomics research. Each type of instrument possesses a unique design, data system and performance specifications, resulting in strengths and weaknesses for different types of ... ...

    Abstract A broad range of mass spectrometers are used in mass spectrometry (MS)-based proteomics research. Each type of instrument possesses a unique design, data system and performance specifications, resulting in strengths and weaknesses for different types of experiments. Unfortunately, the native binary data formats produced by each type of mass spectrometer also differ and are usually proprietary. The diverse, nontransparent nature of the data structure complicates the integration of new instruments into preexisting infrastructure, impedes the analysis, exchange, comparison and publication of results from different experiments and laboratories, and prevents the bioinformatics community from accessing data sets required for software development. Here, we introduce the 'mzXML' format, an open, generic XML (extensible markup language) representation of MS data. We have also developed an accompanying suite of supporting programs. We expect that this format will facilitate data management, interpretation and dissemination in proteomics research.
    Mesh-Begriff(e) Database Management Systems ; Databases, Factual ; Information Dissemination/methods ; Information Storage and Retrieval/methods ; Information Storage and Retrieval/standards ; Mass Spectrometry/methods ; Mass Spectrometry/standards ; Proteome/analysis ; Proteome/chemistry ; Proteome/classification ; Proteomics/methods ; Proteomics/standards ; Software ; User-Computer Interface
    Chemische Substanzen Proteome
    Sprache Englisch
    Erscheinungsdatum 2004-11-04
    Erscheinungsland United States
    Dokumenttyp Evaluation Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/nbt1031
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 137: Hefte anzeigen
    Zs.MG 43: Hefte anzeigen

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