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  1. Article ; Online: Leveraging the Potential of Induction Therapy in Human Papillomavirus-Mediated Oropharyngeal Carcinoma.

    Hahn, Ezra / Huang, Shao Hui

    International journal of radiation oncology, biology, physics

    2023  Volume 118, Issue 1, Page(s) 179–181

    MeSH term(s) Humans ; Human Papillomavirus Viruses ; Induction Chemotherapy ; Oropharyngeal Neoplasms/radiotherapy ; Oropharyngeal Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Papillomavirus Infections/complications ; Papillomaviridae
    Language English
    Publishing date 2023-11-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2023.09.035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: What We Know So Far (As of March 26, 2020) About COVID-19-An MRT Point of View.

    Huang, Shao Hui

    Journal of medical imaging and radiation sciences

    2020  Volume 51, Issue 2, Page(s) 200–203

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/therapy ; Coronavirus Infections/virology ; Disease Management ; Humans ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/therapy ; Pneumonia, Viral/virology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-01
    Publishing country United States
    Document type Letter
    ZDB-ID 2426513-5
    ISSN 1876-7982 ; 1939-8654
    ISSN (online) 1876-7982
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2020.03.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In Reply to Duprez et al.

    Huang, Shao Hui

    International journal of radiation oncology, biology, physics

    2020  Volume 106, Issue 2, Page(s) 450–451

    MeSH term(s) Extranodal Extension ; Humans ; Oropharyngeal Neoplasms ; Papillomaviridae ; Papillomavirus Infections ; Radiology
    Language English
    Publishing date 2020-01-10
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2019.10.034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Broadening Our Horizons in the Milieu of Personalized Medicine.

    Huang, Shao Hui

    Journal of medical imaging and radiation sciences

    2018  Volume 49, Issue 4, Page(s) 338–339

    MeSH term(s) Evidence-Based Medicine/methods ; Humans ; Neoplasms/therapy ; Precision Medicine/methods
    Language English
    Publishing date 2018-10-19
    Publishing country United States
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2426513-5
    ISSN 1876-7982 ; 1939-8654
    ISSN (online) 1876-7982
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2018.09.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Élargir nos horizons dans le milieu de la médecine personnalisée.

    Huang, Shao Hui

    Journal of medical imaging and radiation sciences

    2018  Volume 49, Issue 4, Page(s) 339–341

    Language English
    Publishing date 2018-10-19
    Publishing country United States
    Document type Editorial
    ZDB-ID 2426513-5
    ISSN 1876-7982 ; 1939-8654
    ISSN (online) 1876-7982
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2018.09.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: What We Know So Far (As of March 26, 2020) About COVID-19—An MRT Point of View

    Huang, Shao Hui

    Journal of Medical Imaging and Radiation Sciences

    2020  Volume 51, Issue 2, Page(s) 200–203

    Keywords Radiological and Ultrasound Technology ; Radiology Nuclear Medicine and imaging ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2426513-5
    ISSN 1939-8654
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2020.03.004
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Unfinished Business in Classifying HPV-Positive Oropharyngeal Carcinoma: Identifying the Bad Apples in a Good Staging Barrel.

    Huang, Shao Hui / Koyfman, Shlomo / O'Sullivan, Brian

    The oncologist

    2022  Volume 27, Issue 1, Page(s) 4–6

    Abstract: This commentary highlights three important findings in the study by Vijayvargiya et al, published in this journal, involving 9554 oropharyngeal cancer patients from the SEER database. Firstly, there is improved performance in outcome prediction with TNM- ... ...

    Abstract This commentary highlights three important findings in the study by Vijayvargiya et al, published in this journal, involving 9554 oropharyngeal cancer patients from the SEER database. Firstly, there is improved performance in outcome prediction with TNM-8 in HPV+ OPC. However, heterogeneity exists, especially in TNM-8 stage I disease, and there is need for ongoing improvement in risk stratification. Several anatomical and non-anatomical prognostic factors have been proposed. Among them, radiologic extranodal extension has emerged as one of the promising parameters to be considered for future staging. These baseline prognostic factors should address sensitivity, specificity, and diagnostic accuracy to serve different clinical needs. Secondly, cure is possible for some patients presenting with M1 disease. Optimal management of such patients remains to be explored, and clinical trials targeting de novo M1 disease should be encouraged to optimize outcomes for this subset. Finally, methodologies to address missing tumor HPV status in historical cohorts have been discussed, including using baseline demographics and clinical characteristics, as well as statistical procedures such as multiple imputation.
    MeSH term(s) Carcinoma/pathology ; Humans ; Neoplasm Staging ; Oropharyngeal Neoplasms/pathology ; Papillomaviridae ; Papillomavirus Infections/complications ; Papillomavirus Infections/pathology ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2022-03-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1409038-7
    ISSN 1549-490X ; 1083-7159
    ISSN (online) 1549-490X
    ISSN 1083-7159
    DOI 10.1093/oncolo/oyab010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4845: Show issues Location:
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    Zs.MO 494: Show issues

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  9. Article: Oligometastatic Head and Neck Cancer: Challenges and Perspectives.

    Bahig, Houda / Huang, Shao Hui / O'Sullivan, Brian

    Cancers

    2022  Volume 14, Issue 16

    Abstract: A minority of patients with metastatic head and neck squamous cell carcinoma (HNSCC) present with oligometastatic disease. Oligometastasis not only reflects a disease state, but might also present an opportunity for cure in the metastatic setting. ... ...

    Abstract A minority of patients with metastatic head and neck squamous cell carcinoma (HNSCC) present with oligometastatic disease. Oligometastasis not only reflects a disease state, but might also present an opportunity for cure in the metastatic setting. Radical ablation of all oligometastatic sites may confer prolonged survival and possibly achieve cure in some patients. However, substantial debate remains about whether patients with oligometastatic disease could benefit from curative intent therapy or whether aggressive treatments expose some patients to futile toxicity. Optimal selection of patients, carefully balancing the currently known prognostic factors against the risks of toxicity is critical. Emerging evidence suggests that patients with a limited burden of disease, viral-related pharyngeal cancer, metachronous metastasis and lung-only metastasis may benefit most from this approach. Efforts are underway to identify biomarkers that can detect oligometastasis and better select patients who would derive the maximum benefit from an aggressive radical approach. The combination of radiotherapy and immunotherapy promises to enhance the anti-tumoral immune response and help overcome resistance. However, optimization of management algorithms, including patient selection, radiation dose and sequencing, will be critical in upcoming clinical trials. This review summarizes recent knowledge about the characteristics and investigational efforts regarding oligometastasis in HNSCC.
    Language English
    Publishing date 2022-08-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers14163894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Are we ready for deintensification in human papillomavirus-positive oropharyngeal carcinomas?

    Huang, Shao Hui / Hahn, Ezra / Salunkhe, Rohan / Barcelona, Marc Vincent N / O'Sullivan, Brian

    Current opinion in otolaryngology & head and neck surgery

    2023  Volume 31, Issue 2, Page(s) 118–128

    Abstract: Purpose of review: Excellent outcomes following contemporary treatment of human papillomavirus (HPV)-positive oropharyngeal carcinoma (HPV+ OPC) have prompted the exploration of deintensification approaches to minimize treatment-related toxicities. This ...

    Abstract Purpose of review: Excellent outcomes following contemporary treatment of human papillomavirus (HPV)-positive oropharyngeal carcinoma (HPV+ OPC) have prompted the exploration of deintensification approaches to minimize treatment-related toxicities. This review describes the landscape of deintensification to date (up to November 2022).
    Recent findings: Although several deintensification trials have been published, none are practice changing. Three phase III randomized-controlled trials studying cetuximab and radiation therapy vs. standard chemoradiotherapy all showed inferior outcomes. Although some phase II trials reported favourable outcomes, they are often single-arm trials without an adequate control arm, thereby limiting the ability to modify practice.
    Summary: Substantial effort has been expended to explore deintensification options for selected HPV+ OPC patients aiming to avoid unnecessary toxicity. Strategies have included replacing cisplatin with cetuximab, reduced chemotherapy or radiotherapy intensity, reduction of radiotherapy volumes and risk stratification after trans-oral surgery or following induction chemotherapy. Challenges remain in the current deintensification landscape, including identifying the most suitable candidates along with a choice of most appropriate deintensification strategies. Promising selection criteria included either static baseline features or kinetic characteristics of clinical-biological parameters. Practice-changing trials remain elusive, and the search continues to attempt optimization of the therapeutic ratio for these patients.
    MeSH term(s) Humans ; Human Papillomavirus Viruses ; Cetuximab ; Papillomavirus Infections ; Oropharyngeal Neoplasms/pathology ; Chemoradiotherapy ; Carcinoma
    Chemical Substances Cetuximab (PQX0D8J21J)
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1232518-1
    ISSN 1531-6998 ; 1068-9508
    ISSN (online) 1531-6998
    ISSN 1068-9508
    DOI 10.1097/MOO.0000000000000871
    Database MEDical Literature Analysis and Retrieval System OnLINE

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