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Article ; Online: A Survey of Decision Making for Mode of Pediatric Procedural Sedation: A Pilot Study.

Stewart, Charles G / Huang, Shirley

2023 Volume 39, Issue 6, Page(s) 463–464

MeSH term(s)	Child ; Humans ; Pilot Projects ; Hypnotics and Sedatives ; Surveys and Questionnaires ; Decision Making ; Conscious Sedation
Chemical Substances	Hypnotics and Sedatives
Language	English
Publishing date	2023-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	632588-9
ISSN	1535-1815 ; 0749-5161
ISSN (online)	1535-1815
ISSN	0749-5161
DOI	10.1097/PEC.0000000000002907
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Chinese American Immigrant Parents' Socialization of Emotions in Bilingual Bicultural Preschool Children.

Huang, Shirley / Kan, Pui Fong

Frontiers in psychology

2021 Volume 12, Page(s) 642417

Abstract: The purpose of this study was to examine Cantonese-speaking Chinese American immigrant parents' socialization of emotions in bilingual bicultural preschool children, using a combination of a parent questionnaire and parent language samples from emotion- ... ...

Abstract	The purpose of this study was to examine Cantonese-speaking Chinese American immigrant parents' socialization of emotions in bilingual bicultural preschool children, using a combination of a parent questionnaire and parent language samples from emotion-elicited storytelling tasks. Sixteen Cantonese-speaking parents and their children participated in this study. Children were sequential bilinguals who were exposed to Cantonese (L1) at home since birth, and then learned English (L2) at school. The Chinese parent questionnaire examined parents' emotion talk in the home, as well as the child's dual language background and language distribution. Parents' language samples in Cantonese were collected from three parent-child storytelling tasks that each elicited a different type of negative emotion (sad, angry, scared). Results from the parent questionnaire and the parent language samples were analyzed using quantitative and qualitative methods. In the parent questionnaire, correlation analysis revealed that parents' use of guilt emotions was not associated with any of the other emotion words, suggesting that parents may not talk about guilt as frequently as the other emotions. Results from the parents' language samples showed no significant differences between parents' number of emotion words and emotion explanations across the storytelling tasks, suggesting that parents used negative emotion words similarly across all three books. Further qualitative analysis between the parent questionnaire and the language samples revealed patterns in the way parents use Chinese emotion words with their children. Findings illustrate how the combined use of a parent questionnaire and parent language samples offer complementary information to provide a more comprehensive understanding about Chinese American immigrant parents' socialization of emotions.
Language	English
Publishing date	2021-07-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2021.642417
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Article ; Online: Cross-linguistic transfer between aspect in Cantonese and past tense in English in Cantonese-English bilingual preschool children.

Huang, Shirley / Kan, Pui Fong

International journal of speech-language pathology

2021 Volume 24, Issue 4, Page(s) 385–394

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Child ; Child, Preschool ; Humans ; Language ; Language Development Disorders/diagnosis ; Language Tests ; Linguistics ; Multilingualism
Language	English
Publishing date	2021-10-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2402483-1
ISSN	1754-9515 ; 1754-9507
ISSN (online)	1754-9515
ISSN	1754-9507
DOI	10.1080/17549507.2021.1981445
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Article ; Online: Hereditary factor X deficiency in America survey: impact on quality of life and burden of disease in patients and caregivers.

Branchford, Brian / Clark, Kim / Stanford, Richard H / Garner, Denise A / Huang, Shirley P / Wolford, Eric

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis

2024 Volume 35, Issue 3, Page(s) 73–81

Abstract: Hereditary factor X deficiency (HFXD) is a rare bleeding disorder causing delayed haemostasis and potentially life-threatening bleeds. Patient/caregiver burden and diagnosis path have not been well characterized.: The aim of this study was to: ... ...

Abstract	Hereditary factor X deficiency (HFXD) is a rare bleeding disorder causing delayed haemostasis and potentially life-threatening bleeds. Patient/caregiver burden and diagnosis path have not been well characterized. The aim of this study was to: describe the diagnosis path, disease burden, and HFXD impact on quality of life (QoL) in patients and caregivers.This was a prospective, cross-sectional, web-based survey of patients with HFXD and caregivers addressing the patient/caregiver experience, QoL, humanistic and unmet needs.Thirty patients and 38 caregivers completed the survey with mean ages 24.7 and 44.6 years, respectively. Mean age at diagnosis was 4.1 years. The diagnostic process was somewhat/very difficult for 23% of patients and 26% of caregivers. Approximately half (53%) received single factor replacement (SFR) as prophylaxis or on-demand. Most patients (71%) reported regular prophylaxis treatment. Over one-fourth (27%) reported treatment with fresh frozen plasma. Bleeding episodes were less common in patients using SFR versus non-SFR: three bleeds or fewer were reported by 92% SFR and 75% non-SFR patients. HFXD patients reported low well being in work/school/social activities with mean HFXD-adapted Hemophilia Well being Index. Patient symptoms negatively impacted caregiver burden with a mean HFXD-adapted Hemophilia Caregiver Index (±SD) of 15.9 (4.6), but also unexpectedly had a positive impact on self-worth and inner strength.To our knowledge, this is the first study to assess patient and caregiver burden of HFXD and impact on QoL. Improvements in symptom recognition, prompt diagnosis, and adherence to expert recommendations for treatment could improve QoL and decrease burden on HFXD patients and caregivers.
MeSH term(s)	Humans ; Young Adult ; Adult ; Child, Preschool ; Quality of Life ; Caregivers ; Hemophilia A ; Factor X Deficiency ; Cross-Sectional Studies ; Prospective Studies ; Cost of Illness ; Hemorrhage ; Surveys and Questionnaires
Language	English
Publishing date	2024-02-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1033551-1
ISSN	1473-5733 ; 0957-5235
ISSN (online)	1473-5733
ISSN	0957-5235
DOI	10.1097/MBC.0000000000001275
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Article ; Online: [No title information]

Fereshtehnejad, Seyed-Mohammad / Nicholls, Mitchell / Huang, Shirley / Akter, Ripa

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2023 Volume 195, Issue 12, Page(s) E457–E461

Title translation	Hydrocéphalie à pression normale traitée par dérivation ventriculo-péritonéale.
MeSH term(s)	Humans ; Hydrocephalus, Normal Pressure ; Ventriculoperitoneal Shunt
Language	French
Publishing date	2023-03-25
Publishing country	Canada
Document type	Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.221027-f
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Article ; Online: Normal pressure hydrocephalus treated with ventriculoperitoneal shunt.

Fereshtehnejad, Seyed-Mohammad / Nicholls, Mitchell / Huang, Shirley / Akter, Ripa

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

2023 Volume 195, Issue 3, Page(s) E115–E119

MeSH term(s)	Humans ; Hydrocephalus, Normal Pressure ; Ventriculoperitoneal Shunt ; Hydrocephalus/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2023-01-17
Publishing country	Canada
Document type	Journal Article
ZDB-ID	215506-0
ISSN	1488-2329 ; 0008-4409 ; 0820-3946
ISSN (online)	1488-2329
ISSN	0008-4409 ; 0820-3946
DOI	10.1503/cmaj.221027
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Article ; Online: Monkeypox Virus Infection in 22-Year-Old Woman after Sexual Intercourse, New York, USA.

Zayat, Nawras / Huang, Shirley / Wafai, Jude / Philadelphia, Melissa

Emerging infectious diseases

2022 Volume 29, Issue 1, Page(s) 222–223

Abstract: We report a case of a 22-year-old woman in New York, USA, who had painful vulvar and intravaginal lesions after sexual intercourse and tested positive for monkeypox virus. Literature documenting the clinical manifestations of monkeypox in female ... ...

Abstract	We report a case of a 22-year-old woman in New York, USA, who had painful vulvar and intravaginal lesions after sexual intercourse and tested positive for monkeypox virus. Literature documenting the clinical manifestations of monkeypox in female genitalia remains insufficient.
MeSH term(s)	Humans ; Female ; Young Adult ; Adult ; Monkeypox virus ; Coitus ; Mpox (monkeypox) ; New York
Language	English
Publishing date	2022-11-10
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	1380686-5
ISSN	1080-6059 ; 1080-6040
ISSN (online)	1080-6059
ISSN	1080-6040
DOI	10.3201/eid2901.221662
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Article ; Online: A cost-effective sample pooling strategy for line blot assay in detecting onconeural antibodies.

Chen, Renfen / Luo, Irene / Rae, Megan / Huang, Shirley

Journal of immunological methods

2022 Volume 503, Page(s) 113235

Abstract: Background: Onconeural antibodies are a group of autoantibodies present in patients with paraneoplastic syndromes (PNS), and are indicative for underlying malignancies. The use of indirect immunofluorescence assay (IFA) as the sole screening method for ... ...

Abstract	Background: Onconeural antibodies are a group of autoantibodies present in patients with paraneoplastic syndromes (PNS), and are indicative for underlying malignancies. The use of indirect immunofluorescence assay (IFA) as the sole screening method for onconeural antibodies without line blot assay (LBA) could potentially miss a significant population of patients with PNS. However, testing each serum individually on LBA will pose significant economical and labour burdens to clinical laboratories. Based on the screening result from IFA, we developed a cost-effective pooling strategy for the detection of onconeural antibodies on LBA. Methods: Results of onconeural antibodies tested by IFA and LBA from 1887 serum samples received in the Central Sydney Immunology Laboratory were retrospectively analysed. Sera were pre-screened by IFA before proceeding to LBA. Sera with positive staining on IFA were tested individually on LBA while sera with negative IFA were examined by pooling. Agreements of antibody reactivity against onconeural antigens were evaluated for sera run by pooling and by individually. The estimate of the cost saving was also conducted for the pooling strategy. Results: Antibody reactivity to each specific onconeural antigen from pooling run had over 95% qualitative result agreement with sera run individually on LBA. An excellent correlation (r = 0.88) of positive reactions quantitated by band signal intensity was also observed. Using our well-established sera pooling strategy for LBA, a cost saving of 50.1% was achieved for reagent alone. Conclusions: The sera pooling strategy for LBA is a reliable and cost-effective approach for testing low prevalence diseases such as PNS.
MeSH term(s)	Autoantibodies ; Cost-Benefit Analysis ; Humans ; Neoplasms/diagnosis ; Retrospective Studies
Chemical Substances	Autoantibodies
Language	English
Publishing date	2022-02-10
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2022.113235
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Article: A cost-effective sample pooling strategy for line blot assay in detecting onconeural antibodies

Chen, Renfen / Luo, Irene / Rae, Megan / Huang, Shirley

Journal of immunological methods. 2022 Apr., v. 503

2022

Abstract: Onconeural antibodies are a group of autoantibodies present in patients with paraneoplastic syndromes (PNS), and are indicative for underlying malignancies. The use of indirect immunofluorescence assay (IFA) as the sole screening method for onconeural ... ...

Abstract	Onconeural antibodies are a group of autoantibodies present in patients with paraneoplastic syndromes (PNS), and are indicative for underlying malignancies. The use of indirect immunofluorescence assay (IFA) as the sole screening method for onconeural antibodies without line blot assay (LBA) could potentially miss a significant population of patients with PNS. However, testing each serum individually on LBA will pose significant economical and labour burdens to clinical laboratories. Based on the screening result from IFA, we developed a cost-effective pooling strategy for the detection of onconeural antibodies on LBA. Results of onconeural antibodies tested by IFA and LBA from 1887 serum samples received in the Central Sydney Immunology Laboratory were retrospectively analysed. Sera were pre-screened by IFA before proceeding to LBA. Sera with positive staining on IFA were tested individually on LBA while sera with negative IFA were examined by pooling. Agreements of antibody reactivity against onconeural antigens were evaluated for sera run by pooling and by individually. The estimate of the cost saving was also conducted for the pooling strategy. Antibody reactivity to each specific onconeural antigen from pooling run had over 95% qualitative result agreement with sera run individually on LBA. An excellent correlation (r = 0.88) of positive reactions quantitated by band signal intensity was also observed. Using our well-established sera pooling strategy for LBA, a cost saving of 50.1% was achieved for reagent alone. The sera pooling strategy for LBA is a reliable and cost-effective approach for testing low prevalence diseases such as PNS.
Keywords	antigens ; autoantibodies ; blood serum ; cost effectiveness ; fluorescent antibody technique ; labor
Language	English
Dates of publication	2022-04
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	120142-6
ISSN	1872-7905 ; 0022-1759
ISSN (online)	1872-7905
ISSN	0022-1759
DOI	10.1016/j.jim.2022.113235
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The cost of flares among patients with systemic lupus erythematosus with and without lupus nephritis in the United States.

Bell, Christopher F / Huang, Shirley P / Cyhaniuk, Anissa / Averell, Carlyne M

Lupus

2022 Volume 32, Issue 2, Page(s) 301–309

Abstract: Objective: Assess healthcare costs associated with systemic lupus erythematosus (SLE) flares among patients with and without lupus nephritis (LN).: Methods: This retrospective cohort study used medical and pharmacy claims data from the United States- ... ...

Abstract	Objective: Assess healthcare costs associated with systemic lupus erythematosus (SLE) flares among patients with and without lupus nephritis (LN). Methods: This retrospective cohort study used medical and pharmacy claims data from the United States-based Optum Clinformatics database to identify adults with SLE between 1 January 2016, and 31 December 2018. Index was the date of a patient's earliest SLE diagnosis claim during the identification period. Patients were categorized based on ICD-9/-10 diagnosis codes into one of two cohorts: SLE with LN (LN) and SLE without LN (non-LN). Baseline characteristics were assessed in the 12 months preceding index (baseline period). The presence, severity, and healthcare costs (in 2019 US dollars) of flares were determined in the 12 months following index (follow-up period). Results: Overall, 11,663 patients with SLE were included (LN, Conclusions: Patients with SLE with LN have greater healthcare costs than those without LN. Flares among patients with LN were more frequent, severe, and costly than among patients without LN. This highlights the need for treatments that prevent or reduce flares among patients with SLE, both with and without LN.
MeSH term(s)	Adult ; Humans ; United States/epidemiology ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Nephritis ; Retrospective Studies ; Health Care Costs ; Early Diagnosis
Language	English
Publishing date	2022-12-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1154407-7
ISSN	1477-0962 ; 0961-2033
ISSN (online)	1477-0962
ISSN	0961-2033
DOI	10.1177/09612033221146093
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