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Article ; Online: Deciphering the Genetic Code of Autoimmune Kidney Diseases.

Huang, Stephanie U-Shane / Kulatunge, Oneli / O'Sullivan, Kim Maree

2023 Volume 14, Issue 5

Abstract: Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, resulting in inflammation and pathological damage to the kidneys. This review focuses on the known genetic associations of the major autoimmune kidney diseases that result in ...

Abstract	Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, resulting in inflammation and pathological damage to the kidneys. This review focuses on the known genetic associations of the major autoimmune kidney diseases that result in the development of glomerulonephritis: lupus nephritis (LN), anti-neutrophil cytoplasmic associated vasculitis (AAV), anti-glomerular basement disease (also known as Goodpasture's disease), IgA nephropathy (IgAN), and membranous nephritis (MN). Genetic associations with an increased risk of disease are not only associated with polymorphisms in the human leukocyte antigen (HLA) II region, which governs underlying processes in the development of autoimmunity, but are also associated with genes regulating inflammation, such as
MeSH term(s)	Humans ; Kidney Glomerulus/pathology ; Genome-Wide Association Study ; Autoimmune Diseases ; Kidney/pathology ; Anti-Glomerular Basement Membrane Disease/pathology ; Kidney Diseases/genetics ; Kidney Diseases/pathology ; Inflammation/pathology ; Genetic Code
Language	English
Publishing date	2023-04-30
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14051028
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Expanding Role of Extracellular Traps in Inflammation and Autoimmunity: The New Players in Casting Dark Webs.

Huang, Stephanie U-Shane / O'Sullivan, Kim Maree

International journal of molecular sciences

2022 Volume 23, Issue 7

Abstract: The first description of a new form of neutrophil cell death distinct from that of apoptosis or necrosis was discovered in 2004 and coined neutrophil extracellular traps "(NETs)" or "NETosis". Different stimuli for NET formation, and pathways that drive ... ...

Abstract	The first description of a new form of neutrophil cell death distinct from that of apoptosis or necrosis was discovered in 2004 and coined neutrophil extracellular traps "(NETs)" or "NETosis". Different stimuli for NET formation, and pathways that drive neutrophils to commit to NETosis have been elucidated in the years that followed. Critical enzymes required for NET formation have been discovered and targeted therapeutically. NET formation is no longer restricted to neutrophils but has been discovered in other innate cells: macrophages/monocytes, mast Cells, basophils, dendritic cells, and eosinophils. Furthermore, extracellular DNA can also be extruded from both B and T cells. It has become clear that although this mechanism is thought to enhance host defense by ensnaring bacteria within large webs of DNA to increase bactericidal killing capacity, it is also injurious to innocent bystander tissue. Proteases and enzymes released from extracellular traps (ETs), injure epithelial and endothelial cells perpetuating inflammation. In the context of autoimmunity, ETs release over 70 well-known autoantigens. ETs are associated with pathology in multiple diseases: lung diseases, vasculitis, autoimmune kidney diseases, atherosclerosis, rheumatoid arthritis, cancer, and psoriasis. Defining these pathways that drive ET release will provide insight into mechanisms of pathological insult and provide potential therapeutic targets.
MeSH term(s)	Autoimmune Diseases ; Autoimmunity ; DNA/metabolism ; Endothelial Cells ; Extracellular Traps/metabolism ; Humans ; Inflammation/pathology ; Neutrophils/metabolism
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2022-03-30
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23073793
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Article ; Online: Deciphering the Genetic Code of Autoimmune Kidney Diseases

Huang, Stephanie U-Shane / Kulatunge, Oneli / O’Sullivan, Kim Maree

Genes (Basel). 2023 Apr. 30, v. 14, no. 5

2023

Abstract	Autoimmune kidney diseases occur due to the loss of tolerance to self-antigens, resulting in inflammation and pathological damage to the kidneys. This review focuses on the known genetic associations of the major autoimmune kidney diseases that result in the development of glomerulonephritis: lupus nephritis (LN), anti-neutrophil cytoplasmic associated vasculitis (AAV), anti-glomerular basement disease (also known as Goodpasture’s disease), IgA nephropathy (IgAN), and membranous nephritis (MN). Genetic associations with an increased risk of disease are not only associated with polymorphisms in the human leukocyte antigen (HLA) II region, which governs underlying processes in the development of autoimmunity, but are also associated with genes regulating inflammation, such as NFkB, IRF4, and FC γ receptors (FCGR). Critical genome-wide association studies are discussed both to reveal similarities in gene polymorphisms between autoimmune kidney diseases and to explicate differential risks in different ethnicities. Lastly, we review the role of neutrophil extracellular traps, critical inducers of inflammation in LN, AAV, and anti-GBM disease, where inefficient clearance due to polymorphisms in DNase I and genes that regulate neutrophil extracellular trap production are associated with autoimmune kidney diseases.
Keywords	HLA antigens ; autoimmunity ; deoxyribonucleases ; genes ; genetic code ; glomerulonephritis ; inflammation ; kidneys ; neutrophils ; risk ; vasculitis
Language	English
Dates of publication	2023-0430
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes14051028
Database	NAL-Catalogue (AGRICOLA)

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Article: A facile fluid pressure system reveals differential cellular response to interstitial pressure gradients and flow.

Wang, Hao / Lu, Jingming / Rathod, Mitesh / Aw, Wen Yih / Huang, Stephanie A / Polacheck, William J

Biomicrofluidics

2023 Volume 17, Issue 5, Page(s) 54103

Abstract: Interstitial fluid pressure gradients and interstitial flow have been shown to drive morphogenic processes that shape tissues and influence progression of diseases including cancer. The advent of porous media microfluidic approaches has enabled ... ...

Abstract	Interstitial fluid pressure gradients and interstitial flow have been shown to drive morphogenic processes that shape tissues and influence progression of diseases including cancer. The advent of porous media microfluidic approaches has enabled investigation of the cellular response to interstitial flow, but questions remain as to the critical biophysical and biochemical signals imparted by interstitial fluid pressure gradients and resulting flow on resident cells and extracellular matrix (ECM). Here, we introduce a low-cost method to maintain physiological interstitial fluid pressures that is built from commonly accessible laboratory equipment, including a laser pointer, camera, Arduino board, and a commercially available linear actuator. We demonstrate that when the system is connected to a microfluidic device containing a 3D porous hydrogel, physiologic pressure is maintained with sub-Pascal resolution and when basic feedback control is directed using an Arduino, constant pressure and pressure gradient can be maintained even as cells remodel and degrade the ECM hydrogel over time. Using this model, we characterized breast cancer cell growth and ECM changes to ECM fibril structure and porosity in response to constant interstitial fluid pressure or constant interstitial flow. We observe increased collagen fibril bundling and the formation of porous structures in the vicinity of cancer cells in response to constant interstitial fluid pressure as compared to constant interstitial flow. Collectively, these results further define interstitial fluid pressure as a driver of key pathogenic responses in cells, and the systems and methods developed here will allow for future mechanistic work investigating mechanotransduction of interstitial fluid pressures and flows.
Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article
ISSN	1932-1058
ISSN	1932-1058
DOI	10.1063/5.0165119
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Equal inheritance: genome management for proliferating parasites.

Huang, Stephanie

PLoS biology

2012 Volume 10, Issue 12, Page(s) e1001445

MeSH term(s)	Animals ; Apicomplexa/genetics ; Apicomplexa/growth & development ; Cell Nucleus/metabolism ; Centrosome/metabolism ; DNA Replication/genetics ; Genome/genetics ; Inheritance Patterns/genetics ; Parasites/genetics ; Parasites/growth & development ; Protozoan Proteins/metabolism
Chemical Substances	Protozoan Proteins
Language	English
Publishing date	2012-12-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.1001445
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Article ; Online: Making magnetic yeast.

Huang, Stephanie

PLoS biology

2012 Volume 10, Issue 2, Page(s) e1001274

Abstract: This study demonstrates that normal yeast cells can be magnetized, and identifies local redox control via carbon metabolism and iron supply as key factors involved in magnetization. ...

Abstract	This study demonstrates that normal yeast cells can be magnetized, and identifies local redox control via carbon metabolism and iron supply as key factors involved in magnetization.
Language	English
Publishing date	2012-02-28
Publishing country	United States
Document type	Comment ; Journal Article
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.1001274
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Article ; Online: Voluntary Control of Residual Antagonistic Muscles in Transtibial Amputees: Reciprocal Activation, Coactivation, and Implications for Direct Neural Control of Powered Lower Limb Prostheses.

Huang, Stephanie / Huang, He

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2018 Volume 27, Issue 1, Page(s) 85–95

Abstract: Residual ankle muscles (i.e., previously antagonistic ankle muscles) of transtibial amputees are a potential source for continuous feedforward control of powered ankle prostheses using proportional myoelectric control. The ability for transtibial ... ...

Abstract	Residual ankle muscles (i.e., previously antagonistic ankle muscles) of transtibial amputees are a potential source for continuous feedforward control of powered ankle prostheses using proportional myoelectric control. The ability for transtibial amputees to use their residual ankle muscles for two control input degrees of freedom (i.e., two independent myoelectric control input sources) for direct neural control depends on the ability for amputees to generate varying magnitudes of reciprocal activation and coactivation using their residual ankle muscles, which is not well understood. In this paper, we aimed to fill this knowledge gap. We asked 12 transtibial amputees to control the 2-D movement of a computer cursor using continuous proportional myoelectric control via their residual plantar flexor and residual dorsiflexor muscles to define their reachable 2-D control input space. The x-y position of the computer cursor was directly proportional to the independent continuous myoelectric control signals from the residual lateral gastrocnemius (x-axis) and the residual tibialis anterior (y-axis) where the limits of each axis were 0%-100% maximum voluntary activation of the corresponding residual muscle. Our results show that the reachable control input space varied widely across amputee subjects ranging from 38% to 81% of the maximum possible control input space. The cumulative time for the amputee subjects to saturate their reachable control input space ranged from 1.95 to 6.85 min. The amputee subjects used different residual muscle activation patterns and coordination strategies to expand their reachable control input space depending on their ability to perform coactivation and reciprocal activation using their residual plantar flexor and dorsiflexor muscles. The future development of powered lower limb prostheses using direct continuous proportional myoelectric control via residual muscles (e.g., for direct voluntary control of prosthesis joint impedance) should consider how an amputee user's immediately accessible residual muscle activation patterns and reachable 2-D control input space may affect their learning and performance.
MeSH term(s)	Adolescent ; Adult ; Aged ; Amputees ; Ankle ; Artificial Limbs ; Biomechanical Phenomena ; Electromyography ; Female ; Humans ; Male ; Middle Aged ; Muscle, Skeletal ; Prosthesis Design ; Psychomotor Performance
Language	English
Publishing date	2018-12-07
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2018.2885641
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Article ; Online: Voluntary Control of Residual Antagonistic Muscles in Transtibial Amputees: Feedforward Ballistic Contractions and Implications for Direct Neural Control of Powered Lower Limb Prostheses.

Huang, Stephanie / Huang, He

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

2018 Volume 26, Issue 4, Page(s) 894–903

Abstract: Discrete, rapid (i.e., ballistic like) muscle activation patterns have been observed in ankle muscles (i.e., plantar flexors and dorsiflexors) of able-bodied individuals during voluntary posture control. This observation motivated us to investigate ... ...

Abstract	Discrete, rapid (i.e., ballistic like) muscle activation patterns have been observed in ankle muscles (i.e., plantar flexors and dorsiflexors) of able-bodied individuals during voluntary posture control. This observation motivated us to investigate whether transtibial amputees are capable of generating such a ballistic-like activation pattern accurately using their residual ankle muscles in order to assess whether the volitional postural control of a powered ankle prosthesis using proportional myoelectric control via residual muscles could be feasible. In this paper, we asked ten transtibial amputees to generate ballistic-like activation patterns using their residual lateral gastrocnemius and residual tibialis anterior to control a computer cursor via proportional myoelectric control to hit targets positioned at 20% and 40% of maximum voluntary contraction of the corresponding residual muscle. During practice conditions, we asked amputees to hit a single target repeatedly. During testing conditions, we asked amputees to hit a random sequence of targets. We compared movement time to target and end-point accuracy. We also examined motor recruitment synchronization via time-frequency representations of residual muscle activation. The result showed that median end-point error ranged from -0.6% to 1% maximum voluntary contraction across subjects during practice, which was significantly lower compared to testing ( ). Average movement time for all amputees was 242 ms during practice and 272 ms during testing. Motor recruitment synchronization varied across subjects, and amputees with the highest synchronization achieved the fastest movement times. End-point accuracy was independent of movement time. Results suggest that it is feasible for transtibial amputees to generate ballistic control signals using their residual muscles. Future work on volitional control of powered power ankle prostheses might consider anticipatory postural control based on ballistic-like residual muscle activation patterns and direct continuous proportional myoelectric control.
MeSH term(s)	Adolescent ; Adult ; Aged ; Amputees/psychology ; Ankle/physiology ; Artificial Limbs ; Biomechanical Phenomena ; Electromyography/statistics & numerical data ; Electrophysiological Phenomena ; Feedback, Physiological ; Female ; Humans ; Lower Extremity ; Male ; Middle Aged ; Muscle Contraction/physiology ; Muscle, Skeletal/physiology ; Prosthesis Design/methods ; Psychomotor Performance ; Recruitment, Neurophysiological ; Task Performance and Analysis
Language	English
Publishing date	2018-04-23
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1166307-8
ISSN	1558-0210 ; 1063-6528 ; 1534-4320
ISSN (online)	1558-0210
ISSN	1063-6528 ; 1534-4320
DOI	10.1109/TNSRE.2018.2811544
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Article ; Online: And now there are five: a new player in intracellular trafficking pathways.

Huang, Stephanie

PLoS biology

2011 Volume 9, Issue 10, Page(s) e1001173

MeSH term(s)	Adaptor Proteins, Vesicular Transport/genetics ; Apoptosis Regulatory Proteins/genetics ; Humans
Chemical Substances	AP5B1 protein, human ; AP5M1 protein, human ; Adaptor Proteins, Vesicular Transport ; Apoptosis Regulatory Proteins
Language	English
Publishing date	2011-10-11
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.1001173
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Article ; Online: Plexin activation relies on an array of receptors.

Huang, Stephanie

PLoS biology

2011 Volume 9, Issue 8, Page(s) e1001140

MeSH term(s)	Humans ; Nerve Tissue Proteins/metabolism ; Receptors, Cell Surface/metabolism ; Signal Transduction ; rac1 GTP-Binding Protein/metabolism
Chemical Substances	Nerve Tissue Proteins ; PLXNB1 protein, human ; Receptors, Cell Surface ; rac1 GTP-Binding Protein (EC 3.6.5.2)
Language	English
Publishing date	2011-08-30
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	2126776-5
ISSN	1545-7885 ; 1544-9173
ISSN (online)	1545-7885
ISSN	1544-9173
DOI	10.1371/journal.pbio.1001140
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