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Article ; Online: Quantitative Proteomic Analysis on the Slightly Acidic Electrolyzed Water Triggered Viable but Non-Culturable

Chang, Hsin-Yi / Gui, Chin-Ying / Huang, Tsui-Chin / Hung, Yen-Con / Chen, Tai-Yuan

International journal of molecular sciences

2023 Volume 24, Issue 13

Abstract: This study undertakes a comprehensive exploration of the impact of slightly acidic electrolyzed water (SAEW) ... ...

Abstract	This study undertakes a comprehensive exploration of the impact of slightly acidic electrolyzed water (SAEW) on
MeSH term(s)	Water/chemistry ; Listeria monocytogenes ; Chromatography, Liquid ; Proteomics ; Tandem Mass Spectrometry ; Acids/pharmacology ; Electrolysis ; Hydrogen-Ion Concentration
Chemical Substances	Water (059QF0KO0R) ; Acids
Language	English
Publishing date	2023-06-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241310616
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Oxidative stress mediates the inhibitory effects of Manzamine A on uterine leiomyoma cell proliferation and extracellular matrix deposition via SOAT inhibition.

Lin, Li-Chun / Chang, Hsin-Yi / Kuo, Tzu-Ting / Chen, Hsin-Yuan / Liu, Wen-Shan / Lo, Yii-Jwu / Hsia, Shih-Min / Huang, Tsui-Chin

Redox biology

2023 Volume 66, Page(s) 102861

Abstract: Uterine fibroids, the most common benign tumors of the myometrium in women, are characterized by abnormal extracellular matrix deposition and uterine smooth muscle cell neoplasia, with high recurrence rates. Here, we investigated the potential of the ... ...

Abstract	Uterine fibroids, the most common benign tumors of the myometrium in women, are characterized by abnormal extracellular matrix deposition and uterine smooth muscle cell neoplasia, with high recurrence rates. Here, we investigated the potential of the marine natural product manzamine A (Manz A), which has potent anti-cancer effects, as a treatment for uterine fibroids. Manz A inhibited leiomyoma cell proliferation in vitro and in vivo by arresting cell cycle progression and inducing caspase-mediated apoptosis. We performed target prediction analysis and identified sterol o-acyltransferases (SOATs) as potential targets of Manz A. Cholesterol esterification and lipid droplet formation were reduced by Manz A, in line with reduced SOAT expression. As a downstream target of SOAT, Manz A also prevented extracellular matrix deposition by inhibiting the β-catenin/fibronectin/metalloproteinases axis and enhanced autophagy turnover. Excessive free fatty acid accumulation by SOAT inhibition led to reactive oxygen species to impair mitochondrial oxidative phosphorylation and trigger endoplasmic reticulum stress via PERK/eIF2α/CHOP signaling. The inhibitory effect of ManzA on cell proliferation was partially restored by PERK knockdown and eliminated by tauroursodeoxycholic acid, suggesting oxidative stress plays a critical role in the mechanism of action of Manz A. These findings suggest that targeting SOATs by Manz A may be a promising therapeutic approach for uterine fibroids.
MeSH term(s)	Female ; Humans ; Oxidative Stress ; Carbazoles ; Leiomyoma/drug therapy ; Leiomyoma/genetics ; Cell Proliferation
Chemical Substances	manzamine A (104196-68-1) ; Carbazoles
Language	English
Publishing date	2023-08-25
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701011-9
ISSN	2213-2317 ; 2213-2317
ISSN (online)	2213-2317
ISSN	2213-2317
DOI	10.1016/j.redox.2023.102861
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Article ; Online: Hinokitiol Inhibits Breast Cancer Cells In Vitro Stemness-Progression and Self-Renewal with Apoptosis and Autophagy Modulation via the CD44/Nanog/SOX2/Oct4 Pathway.

Chiang, Yi-Fen / Huang, Ko-Chieh / Chen, Hsin-Yuan / Hamdy, Nadia M / Huang, Tsui-Chin / Chang, Hsin-Yi / Shieh, Tzong-Ming / Huang, Yun-Ju / Hsia, Shih-Min

International journal of molecular sciences

2024 Volume 25, Issue 7

Abstract: Breast cancer (BC) represents one of the most prevalent malignant threats to women globally. Tumor relapse or metastasis is facilitated by BC stemness progression, contributing to tumorigenicity. Therefore, comprehending the characteristics of stemness ... ...

Abstract	Breast cancer (BC) represents one of the most prevalent malignant threats to women globally. Tumor relapse or metastasis is facilitated by BC stemness progression, contributing to tumorigenicity. Therefore, comprehending the characteristics of stemness progression and the underlying molecular mechanisms is pivotal for BC advancement. Hinokitiol (β-thujaplicin), a tropolone-related compound abundant in the heartwood of cupressaceous plants, exhibits antimicrobial activity. In our study, we employed three BC cell lines (MDA-MB-231, MCF-7, and T47D) to assess the expression of stemness-, apoptosis-, and autophagy-related proteins. Hinokitiol significantly reduced the viability of cancer cells in a dose-dependent manner. Furthermore, we observed that hinokitiol enhances apoptosis by increasing the levels of cleaved poly-ADP-ribose polymerase (PARP) and phospho-p53. It also induces dysfunction in autophagy through the upregulation of LC3B and p62 protein expression. Additionally, hinokitiol significantly suppressed the number and diameter of cancer cell line spheres by reducing the expression of cluster of differentiation44 (CD44) and key transcription factors. These findings underscore hinokitiol's potential as a therapeutic agent for breast cancer, particularly as a stemness-progression inhibitor. Further research and clinical studies are warranted to explore the full therapeutic potential of hinokitiol in the treatment of breast cancer.
MeSH term(s)	Humans ; Female ; Tropolone/pharmacology ; Tropolone/analogs & derivatives ; Breast Neoplasms/drug therapy ; Neoplasm Recurrence, Local ; Apoptosis ; Autophagy ; MCF-7 Cells ; Hyaluronan Receptors ; SOXB1 Transcription Factors ; Monoterpenes
Chemical Substances	beta-thujaplicin (U5335D6EBI) ; Tropolone (7L6DL16P1T) ; CD44 protein, human ; Hyaluronan Receptors ; SOX2 protein, human ; SOXB1 Transcription Factors ; Monoterpenes
Language	English
Publishing date	2024-03-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25073904
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Article ; Online: Combined impact of high-pressure processing and slightly acidic electrolysed water on Listeria monocytogenes proteomes.

Chen, Guan-Wen / Chen, Yi-An / Chang, Hsin-Yi / Huang, Tsui-Chin / Chen, Tai-Yuan

Food research international (Ottawa, Ont.)

2021 Volume 147, Page(s) 110494

Abstract: Slightly acidic electrolysed water (SAEW) and high-pressure processing (HPP) are well-established non-thermal preservation technologies. This study investigated the deactivation mechanisms of Listeria monocytogenes by label-free quantitative proteomics ... ...

Abstract	Slightly acidic electrolysed water (SAEW) and high-pressure processing (HPP) are well-established non-thermal preservation technologies. This study investigated the deactivation mechanisms of Listeria monocytogenes by label-free quantitative proteomics analysis. Samples were treated through HPP (300 MPa for 3 min), SAEW (20 ppm available chlorine concentration), and their combinations. The KEGG pathway analysis found SAEW + HPP induced differentially expressed proteins (DEPs) associated to biofunctions of ribosomes, secondary metabolite biosynthesis, microbial metabolism in diverse environments, carbon metabolism, and biosynthesis of amino acid and aminoacyl-transfer RNA. The results showed these non-thermal treatments were able to induce the shifting of ribosome biogenesis to initiate translation in L. monocytogenes. During protein translation, the initiation stage was upregulated. However, subsequent elongation, termination, and recycling of used ribosomes were retarded. Comparing various treatments, the combination of hurdles showed greater deactivation of L. monocytogenes than any single one. The approaches developed in this study provided crucial information for minimally processing in the food industries on the application of foodborne listeriosis prevention.
MeSH term(s)	Acids ; Electrolysis ; Listeria monocytogenes ; Proteome ; Water
Chemical Substances	Acids ; Proteome ; Water (059QF0KO0R)
Language	English
Publishing date	2021-06-08
Publishing country	Canada
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2021.110494
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Article ; Online: Capsaicin alleviates cisplatin-induced muscle loss and atrophy in vitro and in vivo.

Huang, Ko-Chieh / Chiang, Yi-Fen / Huang, Tsui-Chin / Chen, Hsin-Yuan / Lin, Po-Han / Ali, Mohamed / Hsia, Shih-Min

Journal of cachexia, sarcopenia and muscle

2022 Volume 14, Issue 1, Page(s) 182–197

Abstract: Background: Cisplatin (CP) is a widely used chemotherapeutic drug with subsequent adverse effects on different organs and tissues including skeletal muscle loss and atrophy as the most common clinical symptoms. The molecular mechanism of cisplatin- ... ...

Abstract	Background: Cisplatin (CP) is a widely used chemotherapeutic drug with subsequent adverse effects on different organs and tissues including skeletal muscle loss and atrophy as the most common clinical symptoms. The molecular mechanism of cisplatin-induced muscle atrophy is not clearly understood. However, recent significant advances indicate that it is related to an imbalance in both the protein status and apoptosis. Capsaicin (CAP) is one of the major ingredients in chilli peppers. It is a valuable pharmacological agent with several therapeutic applications in controlling pain and inflammation with particular therapeutic potential in muscle atrophy. However, the mechanisms underlying its protective effects against cisplatin-induced muscle loss and atrophy remain largely unknown. This study aims to investigate capsaicin's beneficial effects on cisplatin-induced muscle loss and atrophy in vitro and in vivo. Methods: The anti-muscle-atrophic effect of capsaicin on cisplatin-induced muscle loss was investigated using in vivo and in vitro studies. By using the pretreatment model, pretreated capsaicin for 24 h and treated with cisplatin for 48 h, we utilized a C Results: Our study results indicated that cisplatin caused lower cell viability and showed a subset of hallmark signs typically recognized during atrophy, including severe reduction in the myotube diameter, repression of Akt, and mTOR protein expression. However, pretreatment with capsaicin could ameliorate cisplatin-induced muscle atrophy by up-regulating the protein synthesis in skeletal muscle as well as down-regulating the markers of protein degradation. Additionally, capsaicin was able to downregulate the protein expression of apoptosis-related markers, activated TRPV1 and autophagy progress modulation and the recovery of lysosome function. In vivo, capsaicin could relieve oxidative stress and cytokine secretion while modulating autophagy-related lysosome fusion, improving grip strength, and alleviating cisplatin-induced body weight loss and gastrocnemius atrophy. Conclusions: These findings suggest that capsaicin can restore cisplatin-induced imbalance between protein synthesis and protein degradation pathways and it may have protective effects against cisplatin-induced muscle atrophy.
MeSH term(s)	Animals ; Mice ; Capsaicin/pharmacology ; Capsaicin/therapeutic use ; Cisplatin/adverse effects ; Mice, Inbred C57BL ; Muscle, Skeletal/drug effects ; Muscle, Skeletal/metabolism ; Muscle, Skeletal/pathology ; Muscular Atrophy/chemically induced ; Muscular Atrophy/drug therapy ; Muscular Atrophy/metabolism
Chemical Substances	Capsaicin (S07O44R1ZM) ; Cisplatin (Q20Q21Q62J)
Language	English
Publishing date	2022-11-18
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2586864-0
ISSN	2190-6009 ; 2190-5991
ISSN (online)	2190-6009
ISSN	2190-5991
DOI	10.1002/jcsm.13120
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Article ; Online: Quantitative Proteome Analysis Reveals

Kuo, Tzu-Ting / Lin, Li-Chun / Chang, Hsin-Yi / Chiang, Pei-Jung / Wu, Hsin-Yi / Chen, Tai-Yuan / Hsia, Shih-Min / Huang, Tsui-Chin

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 14

Abstract: ... Melissa ... ...

Abstract	Melissa officinalis
MeSH term(s)	Colonic Neoplasms/drug therapy ; Humans ; Melissa/chemistry ; Mitochondria/physiology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Proteome ; Reactive Oxygen Species/metabolism ; Water
Chemical Substances	Plant Extracts ; Proteome ; Reactive Oxygen Species ; Water (059QF0KO0R)
Language	English
Publishing date	2022-07-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27144533
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Article: Differential Proteomic Analysis of

Chen, Yi-An / Chen, Guan-Wen / Ku, Hao-Hsiang / Huang, Tsui-Chin / Chang, Hsin-Yi / Wei, Cheng-I / Tsai, Yung-Hsiang / Chen, Tai-Yuan

Biology

2022 Volume 11, Issue 8

Abstract: High-pressure processing (HPP) is a prevailing non-thermal food preservation technology. The inactivation mechanisms ... ...

Abstract	High-pressure processing (HPP) is a prevailing non-thermal food preservation technology. The inactivation mechanisms of
Language	English
Publishing date	2022-07-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology11081152
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Article ; Online: Structure-based virtual screening discovers novel kidney-type glutaminase inhibitors.

Lin, Li-Chun / Chang, Hsin-Yi / Lin, Tony Eight / Lin, Jyh-Ruey / Hsia, Shih-Min / Hsu, Kai-Cheng / Huang, Tsui-Chin

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2022 Volume 154, Page(s) 113585

Abstract: Glutaminase (GLS) serves a critical bioenergetic role for malignant tumor growth and has become a valuable therapeutic target for cancer treatment. Herein, we performed a structure-based virtual screening to discover novel GLS inhibitors and provide ... ...

Abstract	Glutaminase (GLS) serves a critical bioenergetic role for malignant tumor growth and has become a valuable therapeutic target for cancer treatment. Herein, we performed a structure-based virtual screening to discover novel GLS inhibitors and provide information for developing new GLS inhibitors. We identified critical pharmacological interactions in the GLS1 binding site by analyzing the known GLS1 inhibitors and selected potential inhibitors based on their docking score and pharmacological interactions. The inhibitory effects of compounds were further confirmed by enzymatic and cell viability assays. We treated colorectal cancer and triple-negative breast cancer cells with the selected candidates and measured the inhibitory efficacy of hit compounds on cell viability. In total, we identified three GLS1 inhibitors. The compounds identified from our structure-based virtual screening methodology exhibited great anticancer potential as a lead targeting glutamine metabolism.
MeSH term(s)	Cell Line, Tumor ; Cell Survival ; Glutaminase/metabolism ; Glutamine/metabolism ; Humans ; Kidney/metabolism ; Triple Negative Breast Neoplasms/drug therapy
Chemical Substances	Glutamine (0RH81L854J) ; Glutaminase (EC 3.5.1.2)
Language	English
Publishing date	2022-08-24
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2022.113585
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Article: An Integrated Bioinformatics Analysis Repurposes an Antihelminthic Drug Niclosamide for Treating HMGA2-Overexpressing Human Colorectal Cancer.

Leung, Stephen Wan / Chou, Chia-Jung / Huang, Tsui-Chin / Yang, Pei-Ming

Cancers

2019 Volume 11, Issue 10

Abstract: Aberrant overexpression of high mobility group AT-hook 2 (HMGA2) is frequently found in cancers and HMGA2 has been considered an anticancer therapeutic target. In this study, a pan-cancer genomics survey based on Cancer Cell Line Encyclopedia (CCLE) and ... ...

Abstract	Aberrant overexpression of high mobility group AT-hook 2 (HMGA2) is frequently found in cancers and HMGA2 has been considered an anticancer therapeutic target. In this study, a pan-cancer genomics survey based on Cancer Cell Line Encyclopedia (CCLE) and The Cancer Genome Atlas (TCGA) data indicated that HMGA2 was mainly overexpressed in gastrointestinal cancers including colorectal cancer. Intriguingly, HMGA2 overexpression had no prognostic impacts on cancer patients' overall and disease-free survivals. In addition, HMGA2-overexpressing colorectal cancer cell lines did not display higher susceptibility to a previously identified HMGA2 inhibitor (netroposin). By microarray profiling of HMGA2-driven gene signature and subsequent Connectivity Map (CMap) database mining, we identified that S100 calcium-binding protein A4 (S100A4) may be a druggable vulnerability for HMGA2-overexpressing colorectal cancer. A repurposing S100A4 inhibitor, niclosamide, was found to reverse the HMGA2-driven gene signature both in colorectal cancer cell lines and patients' tissues. In vitro and in vivo experiments validated that HMGA2-overexpressing colorectal cancer cells were more sensitive to niclosamide. However, inhibition of S100A4 by siRNAs and other inhibitors was not sufficient to exert effects like niclosamide. Further RNA sequencing analysis identified that niclosamide inhibited more cell-cycle-related gene expression in HMGA2-overexpressing colorectal cancer cells, which may explain its selective anticancer effect. Together, our study repurposes an anthelminthic drug niclosamide for treating HMGA2-overexpression colorectal cancer.
Language	English
Publishing date	2019-10-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers11101482
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Article: Combined impact of high-pressure processing and slightly acidic electrolysed water on Listeria monocytogenes proteomes

Chen, Guan-Wen / Chen, Yi-An / Chang, Hsin-Yi / Huang, Tsui-Chin / Chen, Tai-Yuan

Food research international. 2021 Sept., v. 147

2021

Abstract	Slightly acidic electrolysed water (SAEW) and high-pressure processing (HPP) are well-established non-thermal preservation technologies. This study investigated the deactivation mechanisms of Listeria monocytogenes by label-free quantitative proteomics analysis. Samples were treated through HPP (300 MPa for 3 min), SAEW (20 ppm available chlorine concentration), and their combinations. The KEGG pathway analysis found SAEW + HPP induced differentially expressed proteins (DEPs) associated to biofunctions of ribosomes, secondary metabolite biosynthesis, microbial metabolism in diverse environments, carbon metabolism, and biosynthesis of amino acid and aminoacyl-transfer RNA. The results showed these non-thermal treatments were able to induce the shifting of ribosome biogenesis to initiate translation in L. monocytogenes. During protein translation, the initiation stage was upregulated. However, subsequent elongation, termination, and recycling of used ribosomes were retarded. Comparing various treatments, the combination of hurdles showed greater deactivation of L. monocytogenes than any single one. The approaches developed in this study provided crucial information for minimally processing in the food industries on the application of foodborne listeriosis prevention.
Keywords	Listeria monocytogenes ; biogenesis ; biosynthesis ; carbon metabolism ; chlorine ; electrolyzed water ; food research ; gene expression regulation ; listeriosis ; proteome ; proteomics ; ribosomes ; secondary metabolites
Language	English
Dates of publication	2021-09
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1111695-x
ISSN	1873-7145 ; 0963-9969
ISSN (online)	1873-7145
ISSN	0963-9969
DOI	10.1016/j.foodres.2021.110494
Database	NAL-Catalogue (AGRICOLA)

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