Article ; Online: Virus infection induced pulmonary fibrosis.
Journal of translational medicine
2021 Volume 19, Issue 1, Page(s) 496
Abstract: Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmonary fibrosis is getting more and more ... ...
Abstract | Pulmonary fibrosis is the end stage of a broad range of heterogeneous interstitial lung diseases and more than 200 factors contribute to it. In recent years, the relationship between virus infection and pulmonary fibrosis is getting more and more attention, especially after the outbreak of SARS-CoV-2 in 2019, however, the mechanisms underlying the virus-induced pulmonary fibrosis are not fully understood. Here, we review the relationship between pulmonary fibrosis and several viruses such as Human T-cell leukemia virus (HTLV), Human immunodeficiency virus (HIV), Cytomegalovirus (CMV), Epstein-Barr virus (EBV), Murine γ-herpesvirus 68 (MHV-68), Influenza virus, Avian influenza virus, Middle East Respiratory Syndrome (MERS)-CoV, Severe acute respiratory syndrome (SARS)-CoV and SARS-CoV-2 as well as the mechanisms underlying the virus infection induced pulmonary fibrosis. This may shed new light on the potential targets for anti-fibrotic therapy to treat pulmonary fibrosis induced by viruses including SARS-CoV-2. |
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MeSH term(s) | Animals ; COVID-19 ; Epstein-Barr Virus Infections ; Herpesvirus 4, Human ; Humans ; Mice ; Pulmonary Fibrosis/etiology ; SARS Virus ; SARS-CoV-2 ; Virus Diseases |
Language | English |
Publishing date | 2021-12-07 |
Publishing country | England |
Document type | Journal Article ; Research Support, Non-U.S. Gov't ; Review |
ISSN | 1479-5876 |
ISSN (online) | 1479-5876 |
DOI | 10.1186/s12967-021-03159-9 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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