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  1. Article ; Online: Dynamic MDETR: A Dynamic Multimodal Transformer Decoder for Visual Grounding.

    Shi, Fengyuan / Gao, Ruopeng / Huang, Weilin / Wang, Limin

    IEEE transactions on pattern analysis and machine intelligence

    2024  Volume 46, Issue 2, Page(s) 1181–1198

    Abstract: Multimodal transformer exhibits high capacity and flexibility to align image and text for visual grounding. However, the existing encoder-only grounding framework (e.g., TransVG) suffers from heavy computation due to the self-attention operation with ... ...

    Abstract Multimodal transformer exhibits high capacity and flexibility to align image and text for visual grounding. However, the existing encoder-only grounding framework (e.g., TransVG) suffers from heavy computation due to the self-attention operation with quadratic time complexity. To address this issue, we present a new multimodal transformer architecture, coined as Dynamic Mutilmodal detection transformer (DETR) (Dynamic MDETR), by decoupling the whole grounding process into encoding and decoding phases. The key observation is that there exists high spatial redundancy in images. Thus, we devise a new dynamic multimodal transformer decoder by exploiting this sparsity prior to speed up the visual grounding process. Specifically, our dynamic decoder is composed of a 2D adaptive sampling module and a text guided decoding module. The sampling module aims to select these informative patches by predicting the offsets with respect to a reference point, while the decoding module works for extracting the grounded object information by performing cross attention between image features and text features. These two modules are stacked alternatively to gradually bridge the modality gap and iteratively refine the reference point of grounded object, eventually realizing the objective of visual grounding. Extensive experiments on five benchmarks demonstrate that our proposed Dynamic MDETR achieves competitive trade-offs between computation and accuracy. Notably, using only 9% feature points in the decoder, we can reduce  ∼ 44% GFLOPs of the multimodal transformer, but still get higher accuracy than the encoder-only counterpart. With the same number of encoder layers as TransVG, our Dynamic MDETR (ResNet-50) outperforms TransVG (ResNet-101) but only brings marginal extra computational cost relative to TransVG. In addition, to verify its generalization ability and scale up our Dynamic MDETR, we build the first one-stage CLIP empowered visual grounding framework, and achieve the state-of-the-art performance on these benchmarks.
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article
    ISSN 1939-3539
    ISSN (online) 1939-3539
    DOI 10.1109/TPAMI.2023.3328185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: S(-II) reactivates Cd2+-stressed Shewanella oneidensis via promoting low-molecular-weight thiols synthesis and activating antioxidant defense

    Zhang, Siyu / Ke, Changdong / Jiang, Mengge / Li, Yuancheng / Huang, Weilin / Dang, Zhi / Guo, Chuling

    Environmental Pollution. 2023 June, v. 327 p.121516-

    2023  

    Abstract: Efficient remedies for living organisms including bacteria to counteract cadmium (Cd²⁺) toxicity are still highly needed. Plant toxicity studies have showed that exogenous S(-II) (including hydrogen sulfide and its ionic forms, i.e., H₂S, HS⁻, and S²⁻) ... ...

    Abstract Efficient remedies for living organisms including bacteria to counteract cadmium (Cd²⁺) toxicity are still highly needed. Plant toxicity studies have showed that exogenous S(-II) (including hydrogen sulfide and its ionic forms, i.e., H₂S, HS⁻, and S²⁻) application can effectively alleviate adverse effects of Cd stress, but whether S(-II) could mitigate bacterial Cd toxicity remains unclear. In this study, S(-II) was applied exogenously to Cd-stressed Shewanella oneidensis MR-1 and the results showed that S(-II) can significantly reactivate impaired physiological processes including growth arrest and enzymatic ferric (Fe(III) reduction inhibition. The efficacy of S(-II) treatment is negatively correlated with the concentration and time length of Cd exposure. Energy-dispersive X-ray (EDX) analysis suggested the presence of cadmium sulfide inside cells treated with S(-II). Both compared proteomic analysis and RT-qPCR showed that enzymes associated with sulfate transport, sulfur assimilation, methionine, and glutathione biosynthesis were up-regulated in both mRNA and protein levels after the treatment, indicating S(-II) may induce the biosynthesis of functional low-molecular-weight (LMW) thiols to counteract Cd toxicity. Meanwhile, the antioxidant enzymes were positively modulated by S(-II) and thus the activity of intracellular reactive oxygen species was attenuated. The study demonstrated that exogenous S(-II) can effectively alleviate Cd stress for S. oneidensis likely through inducing intracellular trapping mechanisms and modulating cellular redox status. It suggested that S(-II) may be a highly effective remedy for bacteria such as S. oneidensis under Cd-polluted environments.
    Keywords Shewanella oneidensis ; X-radiation ; antioxidant activity ; biosynthesis ; cadmium ; cadmium sulfide ; glutathione ; hydrogen sulfide ; methionine ; pollution ; proteomics ; reactive oxygen species ; sulfates ; sulfur ; thiols ; toxicity ; Iron-reducing bacteria ; Cadmium detoxification ; Assimilatory sulfate reduction ; Antioxidant system
    Language English
    Dates of publication 2023-06
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121516
    Database NAL-Catalogue (AGRICOLA)

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  3. Article ; Online: S(-II) reactivates Cd

    Zhang, Siyu / Ke, Changdong / Jiang, Mengge / Li, Yuancheng / Huang, Weilin / Dang, Zhi / Guo, Chuling

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 327, Page(s) 121516

    Abstract: Efficient remedies for living organisms including bacteria to counteract cadmium ( ... ...

    Abstract Efficient remedies for living organisms including bacteria to counteract cadmium (Cd
    MeSH term(s) Antioxidants/metabolism ; Ferric Compounds/metabolism ; Cadmium/toxicity ; Proteomics ; Oxidation-Reduction
    Chemical Substances Antioxidants ; Ferric Compounds ; Cadmium (00BH33GNGH)
    Language English
    Publishing date 2023-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.121516
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Robust Seismic Image Interpolation with Mathematical Morphological Constraint.

    Huang, Weilin / Liu, Jianxin

    IEEE transactions on image processing : a publication of the IEEE Signal Processing Society

    2019  

    Abstract: Seismic image interpolation is a currently popular research subject in modern reflection seismology. The interpolation problem is generally treated as a process of inversion. Under the compressed sensing framework, various sparse transformations and low- ... ...

    Abstract Seismic image interpolation is a currently popular research subject in modern reflection seismology. The interpolation problem is generally treated as a process of inversion. Under the compressed sensing framework, various sparse transformations and low-rank constraints based methods have great performances in recovering irregularly missing traces. However, in the case of regularly missing traces, their applications are limited because of the strong spatial aliasing energies. In addition, the erratic noise always poses a serious impact on the interpolation results obtained by the sparse transformations and low-rank constraints-based methods. This is because the erratic noise is far from satisfying the statistical assumption behind these methods. In this study, we propose a mathematical morphology-based interpolation technique, which constrains the morphological scale of the model in the inversion process. The inversion problem is solved by the shaping regularization approach. The mathematical morphological constraint (MMC)-based interpolation technique has a satisfactory robustness to the spatial aliasing and erratic energies. We provide a detailed algorithmic framework and discuss the extension from 2D to higher dimensional version and the back operator in the shaping inversion. A group of numerical examples demonstrates the successful performance of the proposed technique.
    Language English
    Publishing date 2019-08-30
    Publishing country United States
    Document type Journal Article
    ISSN 1941-0042
    ISSN (online) 1941-0042
    DOI 10.1109/TIP.2019.2936744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Interferon-regulatory factor-1 boosts bevacizumab cardiotoxicity by the vascular endothelial growth factor A/14-3-3γ axis.

    Chen, Xuan-Ying / Xie, Meng-Qi / Huang, Wei-Lin / Li, Wen-Juan / Lv, Yan-Ni / Peng, Xiao-Ping

    ESC heart failure

    2024  Volume 11, Issue 2, Page(s) 986–1000

    Abstract: Aim: Myocardial injury is a significant cause of death. This study investigated the role and underlying mechanism of interferon-regulatory factor-1 (IRF1) in bevacizumab (BVZ)-induced cardiomyocyte injury.: Methods and results: HL-1 cells and C57BL/6 ...

    Abstract Aim: Myocardial injury is a significant cause of death. This study investigated the role and underlying mechanism of interferon-regulatory factor-1 (IRF1) in bevacizumab (BVZ)-induced cardiomyocyte injury.
    Methods and results: HL-1 cells and C57BL/6 mice receiving BVZ treatment were used to establish in vitro and in vivo models of myocardial injury. The relationship between VEGFA and 14-3-3γ was verified through co-immunoprecipitation and Glutathione S Transferase (GST) pull-down assay. Cell viability and apoptosis were analysed by MTT, propidium iodide (PI) staining and flow cytometry. The release of lactate dehydrogenase (LDH), cardiac troponins T (cTnT), and creatine kinase MB (CK-MB) was measured using the enzyme linked immunosorbent assay. The effects of knocking down IRF1 on BVZ-induced mice were analysed in vivo. IRF1 levels were increased in BVZ-treated HL-1 cells. BVZ treatment induced apoptosis, inhibited cell viability, and promoted the release of LDH, cTnT, and CK-MB. IRF1 silencing suppressed BVZ-induced myocardial injury, whereas IRF1 overexpression had the opposite effect. IRF1 regulated VEGFA expression by binding to its promoter, with the depletion of VEGFA or 14-3-3γ reversing the effects of IRF1 knockdown on the cell viability and apoptosis of BVZ-treated HL-1 cells. 14-3-3γ overexpression promoted cell proliferation, inhibited apoptosis, and reduced the release of LDH, cTnT, and CK-MB, thereby alleviating BVZ-induced HL-1 cell damage. In vivo, IRF1 silencing alleviated BVZ-induced cardiomyocyte injury by regulating the VEGFA/14-3-3γ axis.
    Conclusion: The IRF1-mediated VEGFA/14-3-3γ signalling pathway promotes BVZ-induced myocardial injury. Our study provides evidence for potentially new target genes for the treatment of myocardial injury.
    MeSH term(s) Mice ; Animals ; Bevacizumab/pharmacology ; Vascular Endothelial Growth Factor A ; Cardiotoxicity ; Mice, Inbred C57BL ; Interferons
    Chemical Substances Bevacizumab (2S9ZZM9Q9V) ; Vascular Endothelial Growth Factor A ; Interferons (9008-11-1)
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 2814355-3
    ISSN 2055-5822 ; 2055-5822
    ISSN (online) 2055-5822
    ISSN 2055-5822
    DOI 10.1002/ehf2.14640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Boron Reduced Copper Excess-Induced Oxidative Damage in

    Chen, Xu-Feng / Chen, Huan-Huan / Huang, Wei-Lin / Huang, Wei-Tao / Huang, Zeng-Rong / Yang, Lin-Tong / Ye, Xin / Chen, Li-Song

    Antioxidants (Basel, Switzerland)

    2024  Volume 13, Issue 3

    Abstract: Citrus is mainly cultivated in acid soil with low boron (B) and high copper (Cu). In this study, ...

    Abstract Citrus is mainly cultivated in acid soil with low boron (B) and high copper (Cu). In this study,
    Language English
    Publishing date 2024-02-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox13030268
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Heteroaggregation kinetics of nanoplastics and soot nanoparticles in aquatic environments.

    Zeng, Dehua / Yang, Chen / Huang, Ziqing / Liu, Yanjun / Liu, Sijia / Zhang, Zhiyu / Huang, Weilin / Dang, Zhi / Chen, Chengyu

    Journal of hazardous materials

    2024  Volume 472, Page(s) 134564

    Abstract: Heteroaggregation between polystyrene nanoplastics (PSNPs) and soot nanoparticles (STNPs) in aquatic environments may affect their fate and transport. This study investigated the effects of particle concentration ratio, electrolytes, pH, and humic acid ... ...

    Abstract Heteroaggregation between polystyrene nanoplastics (PSNPs) and soot nanoparticles (STNPs) in aquatic environments may affect their fate and transport. This study investigated the effects of particle concentration ratio, electrolytes, pH, and humic acid on their heteroaggregation kinetics. The critical coagulation concentration (CCC) ranked CCC
    Language English
    Publishing date 2024-05-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.134564
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book ; Online: Cross-domain Augmentation Networks for Click-Through Rate Prediction

    Chen, Xu / Cheng, Zida / Xiao, Shuai / Zeng, Xiaoyi / Huang, Weilin

    2023  

    Abstract: Data sparsity is an important issue for click-through rate (CTR) prediction, particularly when user-item interactions is too sparse to learn a reliable model. Recently, many works on cross-domain CTR (CDCTR) prediction have been developed in an effort to ...

    Abstract Data sparsity is an important issue for click-through rate (CTR) prediction, particularly when user-item interactions is too sparse to learn a reliable model. Recently, many works on cross-domain CTR (CDCTR) prediction have been developed in an effort to leverage meaningful data from a related domain. However, most existing CDCTR works have an impractical limitation that requires homogeneous inputs (\textit{i.e.} shared feature fields) across domains, and CDCTR with heterogeneous inputs (\textit{i.e.} varying feature fields) across domains has not been widely explored but is an urgent and important research problem. In this work, we propose a cross-domain augmentation network (CDAnet) being able to perform knowledge transfer between two domains with \textit{heterogeneous inputs}. Specifically, CDAnet contains a designed translation network and an augmentation network which are trained sequentially. The translation network is able to compute features from two domains with heterogeneous inputs separately by designing two independent branches, and then learn meaningful cross-domain knowledge using a designed cross-supervised feature translator. Later the augmentation network encodes the learned cross-domain knowledge via feature translation performed in the latent space and fine-tune the model for final CTR prediction. Through extensive experiments on two public benchmarks and one industrial production dataset, we show CDAnet can learn meaningful translated features and largely improve the performance of CTR prediction. CDAnet has been conducted online A/B test in image2product retrieval at Taobao app over 20days, bringing an absolute \textbf{0.11 point} CTR improvement and a relative \textbf{1.26\%} GMV increase.
    Keywords Computer Science - Information Retrieval
    Subject code 006
    Publishing date 2023-05-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: P4HA2-induced prolyl hydroxylation of YAP1 restricts vascular smooth muscle cell proliferation and neointima formation

    Wang, Liang / Liu, Ting / Zheng, Yaofu / Zhou, Jiamin / Hua, Hexiang / Kong, Liming / Huang, Weilin / Peng, Xiaoping / Wen, Tong

    Life Sciences. 2023 Aug. 06, p.122002-

    2023  , Page(s) 122002–

    Abstract: Vascular smooth muscle cell (VSMC) proliferation and neointima formation play significant roles in atherosclerosis development and restenosis following percutaneous coronary intervention. Our team previously discovered that TEA domain transcription ... ...

    Abstract Vascular smooth muscle cell (VSMC) proliferation and neointima formation play significant roles in atherosclerosis development and restenosis following percutaneous coronary intervention. Our team previously discovered that TEA domain transcription factor 1 (TEAD1) promotes vascular smooth muscle differentiation, which is necessary for vascular development. Conversely, aberrant YAP1 activation upregulates the platelet-derived growth factor receptor beta to encourage VSMC proliferation and neointima formation. In this study, we aimed to investigate the molecular mechanisms of YAP1/TEAD signaling during neointima formation. Our research focused on the prolyl 4-hydroxylase alpha 2 (P4HA2) and its downstream target, Yes-associated protein 1 (YAP1), in regulating VSMC differentiation and neointima formation. Our results indicated that P4HA2 reduction leads to VSMC dedifferentiation and promotes neointima formation after injury. Furthermore, we found that P4HA2-induced prolyl hydroxylation of YAP1 restricts its transcriptional activity, which is essential to maintaining VSMC differentiation. These findings suggest that targeting P4HA2-mediated prolyl hydroxylation of YAP1 may be a promising therapeutic approach to prevent injury-induced neointima formation in cardiovascular disease.
    Keywords atherosclerosis ; cell proliferation ; hydroxylation ; platelet-derived growth factor receptor beta ; procollagen-proline dioxygenase ; smooth muscle ; therapeutics ; transcription (genetics) ; transcription factors ; Neointima formation ; Proliferation ; P4HA2 ; Prolyl hydroxylation ; YAP1
    Language English
    Dates of publication 2023-0806
    Publishing place Elsevier Inc.
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2023.122002
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Extracellular polymeric substances sustain photoreduction of Cr(VI) by Shewanella oneidensis-CdS biohybrid system

    Zhang, Siyu / Li, Changhao / Ke, Changdong / Liu, Sijia / Yao, Qian / Huang, Weilin / Dang, Zhi / Guo, Chuling

    Water Research. 2023 July 13, p.120339-

    2023  , Page(s) 120339–

    Abstract: Photosensitized biohybrid system (PBS) enables bacteria to exploit light energy harvested by semiconductors for rapid pollutants transformation, possessing a promising future for water reclamation. Maintaining a biocompatible environment under ... ...

    Abstract Photosensitized biohybrid system (PBS) enables bacteria to exploit light energy harvested by semiconductors for rapid pollutants transformation, possessing a promising future for water reclamation. Maintaining a biocompatible environment under photocatalytic conditions is the key to developing PBS-based treatment technologies. Natural microbial cell is surrounded by extracellular polymeric substances (EPS) that either be tightly bound to the cell wall (i.e., tightly bound EPS, tbEPS) or loosely associated with cell surface (i.e., loosely bound EPS, lbEPS), which provides protection from unfavorable environment. We hypothesized that providing EPS fractions can enhance bacterial viability under adverse environment created by photocatalytic reactions. We constructed a model PBS consisting of Shewanella oneidensis and CdS using Cr(VI) as the target pollutant. Results showed complete removal of 25 mg/L Cr(VI) within 90 minutes without an electron donor, which may mainly rely on the synergistic effect of CdS and bacteria on photoelectron transfer. Further sustainability evaluation of pristine PBS and PBS with extra EPS fractions (including lbEPS and tbEPS) for Cr(VI) treatment showed that PBS with extra lbEPS achieved efficient Cr(VI) removal within five consecutive batch treatment cycles, compared to the three cycles both in pristine PBS and PBS with tbEPS. After addition of lbEPS, the accumulation of reactive oxygen species (ROS) was greatly reduced via the EPS-capping effect and quenching effect, and the toxic metal internalization potential was lowered by complexation with Cd and Cr, resulting in enhanced bacterial viability during photocatalysis. This facile and efficient cytoprotective method helps the rational design of PBS for environmental remediation.
    Keywords Shewanella oneidensis ; cell walls ; energy ; photocatalysis ; photoreduction ; pollutants ; polymers ; reactive oxygen species ; remediation ; research ; synergism ; toxicity ; viability ; water ; water reuse ; Shewanella sp. ; Cadmium sulfide ; Photosensitized bacteria ; Hexavalent chromium reduction ; Free radicals
    Language English
    Dates of publication 2023-0713
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Pre-press version
    ZDB-ID 202613-2
    ISSN 1879-2448 ; 0043-1354
    ISSN (online) 1879-2448
    ISSN 0043-1354
    DOI 10.1016/j.watres.2023.120339
    Database NAL-Catalogue (AGRICOLA)

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