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Article ; Online: Meta-analysis of cryoablation versus radiofrequency ablation in the treatment of malignant liver tumors.

Huang, Xiangzhong / Xu, Xinjian / Du, Hongtao / Sun, Qiulian / Wu, Minyu

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

2024 Volume 41, Issue 1, Page(s) 2300347

Abstract: Objective: A meta-analysis was conducted to assess the efficacy and safety of cryoablation (CRA) compared with radiofrequency ablation (RFA).: Methods: A systematic search of PubMed, EMBASE, Cochrane Library, Wanfang, CNKI, and VIP databases was ... ...

Abstract	Objective: A meta-analysis was conducted to assess the efficacy and safety of cryoablation (CRA) compared with radiofrequency ablation (RFA). Methods: A systematic search of PubMed, EMBASE, Cochrane Library, Wanfang, CNKI, and VIP databases was conducted to identify clinical controlled studies comparing CRA versus RFA for hepatic malignancies up to July 2022. The meta-analysis was performed using RevMan 5.3. Results: A comprehensive analysis was conducted on 8 clinical controlled studies involving a total of 943 patients. There were no significant differences in the incidence of complications, complete ablation of lesions, local recurrence, and 1-year survival between the CRA and RFA groups (OR = 0.98, 95%CI: 0.61-1.55, Conclusion: The efficacy and safety profile of CRA was comparable to that of RFA in the context of ablation therapy for hepatic malignancies. These findings suggested that CRA may be a valuable alternative to RFA in the treatment of hepatic malignancies.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular ; Cryosurgery ; Liver Neoplasms/surgery ; Radiofrequency Ablation
Language	English
Publishing date	2024-01-08
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Review ; Systematic Review
ZDB-ID	632526-9
ISSN	1464-5157 ; 0265-6736
ISSN (online)	1464-5157
ISSN	0265-6736
DOI	10.1080/02656736.2023.2300347
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Zs.A 2051: Show issues

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Article: The efficacy and safety of

Gao, Fulei / Huang, Xiangzhong / Wang, Yong

Quantitative imaging in medicine and surgery

2023 Volume 13, Issue 7, Page(s) 4589–4602

Abstract: Background: Currently, it is unknown whether iodine-125 (: Methods: A systematic search of the PubMed, Wiley Online Library, Cochrane library, Google Scholar, the Web of Science, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang ... ...

Abstract	Background: Currently, it is unknown whether iodine-125 ( Methods: A systematic search of the PubMed, Wiley Online Library, Cochrane library, Google Scholar, the Web of Science, China National Knowledge Infrastructure (CNKI), VIP, and Wanfang databases was conducted to screen all relevant studies up to October 30, 2022. Articles were not subjected to language or geographical limitations, but were required to meet the inclusion and exclusion criteria for this study. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of articles. The primary endpoint was survival, which was defined as the interval between initial treatment and death or the end of study. Meta analysis was performed using Stata/SE15.0. Results: A total of 12 eligible studies were enrolled including 679 patients. All the included studies were single-center studies carried out in China. The results showed that the death risk and stent occlusion risk in the Conclusions: For patients with MBO caused by hilar tumor or other tumors,
Language	English
Publishing date	2023-05-10
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-22-824
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Article ; Online: Transarterial embolization followed by staged hepatectomy versus emergency hepatectomy for ruptured HCC: a meta-analysis.

Pan, Tianfan / Gao, Feng / Huang, Xiangzhong / Xu, Xinjian

Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico

2023 Volume 26, Issue 1, Page(s) 155–170

Abstract: Background: To compare the efficacy and safety between emergency hepatectomy (EH) and emergency transarterial embolization (TAE) followed by staged hepatectomy (SH) in the treatment of spontaneous ruptured hepatocellular carcinoma (rHCC).: Methods: ... ...

Abstract	Background: To compare the efficacy and safety between emergency hepatectomy (EH) and emergency transarterial embolization (TAE) followed by staged hepatectomy (SH) in the treatment of spontaneous ruptured hepatocellular carcinoma (rHCC). Methods: Databases (PubMed, EMBASE, Web of science, Cochrane Library, ClinicalTrial.gov, CNKI, Wanfang and VIP) were searched for all relevant comparative studies from January 2000 to October 2020. Odds ratio (OR) and mean difference (MD) with 95% confidence interval (CI) were pooled for dichotomous and continuous variables, respectively. Subgroup analyses based on the kind of embolization were conducted. RevMan 5.3 software was adopted for meta-analysis. Results: Eighteen studies with 871 patients were finally included in this meta-analysis, 448 in EH group and 423 in TAE + SH group. No significant difference was observed in successful hemostasis (P = 0.42), postoperative hospital stay (P = 0.12), complication rate (P = 0.08) between EH and TAE + SH group. However, TAE + SH group was associated with shorter operating time (P < 0.00001), fewer perioperative blood loss (P = 0.007), fewer blood transfusion (P = 0.003), lower in-hospital mortality (P < 0.00001) and higher 1-year survival as well as 3-year survival (P < 0.0001; P = 0.003) compared with EH group. Conclusion: Compared with EH, TAE + SH could reduce perioperative operating time, blood loss, blood transfusion, mortality rate and increase the long-term survival rate of the rHCC patients, which may be a better treatment for resectable rHCC.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Embolization, Therapeutic ; Hepatectomy ; Liver Neoplasms/surgery ; Liver Neoplasms/pathology ; Rupture, Spontaneous/complications ; Rupture, Spontaneous/surgery ; Treatment Outcome
Language	English
Publishing date	2023-06-16
Publishing country	Italy
Document type	Journal Article ; Meta-Analysis
ZDB-ID	2397359-6
ISSN	1699-3055 ; 1699-048X
ISSN (online)	1699-3055
ISSN	1699-048X
DOI	10.1007/s12094-023-03232-3
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Zs.A 6644: Show issues

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Article: Exceptional response to immunotherapy monotherapy in a patient with an unfavorable subset of cancer of unknown primary.

Huang, Xiangzhong / Ren, Dongqing / Sun, Qiulian / Xu, Xinjian / Ding, Yiwen

Quantitative imaging in medicine and surgery

2023 Volume 13, Issue 12, Page(s) 8832–8838

Language	English
Publishing date	2023-10-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-23-284
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Article ; Online: Analysis for drug metabolism-related prognostic subtypes and gene signature in liver cancer.

Zhang, Yue / Chen, Jun / Hu, Chengru / Huang, Xiangzhong / Li, Yan

Genes & genetic systems

2023 Volume 97, Issue 6, Page(s) 271–284

Abstract: Liver cancer is highly heterogeneous and has a poor prognosis. We aimed to identify a drug metabolism-related prognostic subtype and a gene signature as references for prognosis and therapy options for patients with liver cancer. Patient information was ... ...

Abstract	Liver cancer is highly heterogeneous and has a poor prognosis. We aimed to identify a drug metabolism-related prognostic subtype and a gene signature as references for prognosis and therapy options for patients with liver cancer. Patient information was collected from online databases. Drug metabolism-related genes were obtained from previous studies and were used to screen differentially expressed prognostic genes. The patients were divided into different clusters and differences in clinical features, immunity, pathways and therapy responses between the clusters were analyzed. LASSO analysis was performed to identify the optimal prognostic genes and establish a risk score model. Finally, the risk score distribution in different subtypes was investigated. A total of 54 prognostic genes were identified to categorize the patients into cluster 1 and cluster 2. Cluster 1 showed worse survival than cluster 2, and cluster 1 also showed high levels of malignancy. Furthermore, cluster 1 exhibited a higher TIDE (tumor immune dysfunction and exclusion) score and lower IC50 response to paclitaxel, gemcitabine and camptothecin, indicating that cluster 1 individuals may derive more benefit from immunotherapy but less benefit from chemotherapy. The risk score, based on the six optimal prognostic genes, demonstrated an adequate prognostic capability. The high-risk group showed worse survival; meanwhile, cluster 1 contained the majority of high-risk samples. Our results should be useful for prognosis and specific therapy for patients with liver cancer. Patients with the features of cluster 1 and a high risk score will tend to exhibit worse survival. Furthermore, immunotherapy may be more suitable for cluster 1-type patients while chemotherapy may be more suitable for cluster 2 patients.
MeSH term(s)	Humans ; Prognosis ; Liver Neoplasms/genetics ; Gemcitabine ; Paclitaxel ; Risk Factors
Chemical Substances	Gemcitabine ; Paclitaxel (P88XT4IS4D)
Language	English
Publishing date	2023-03-02
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1323536-9
ISSN	1880-5779 ; 1341-7568
ISSN (online)	1880-5779
ISSN	1341-7568
DOI	10.1266/ggs.22-00093
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Zs.A 3466: Show issues

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Article: Spontaneous renal artery dissection complicated by renal infarction: description of two cases.

Gao, Fulei / Chen, Zejun / Gao, Feng / Ren, Dongqing / Huang, Xiangzhong

Quantitative imaging in medicine and surgery

2022 Volume 12, Issue 10, Page(s) 4972–4978

Language	English
Publishing date	2022-09-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-22-342
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Article ; Online: Metabolite of chiral cycloxaprid in solvent and in the raw of Puer tea.

Tian, Hen / Zhang, Jiao / Lin, Tao / Li, Qiwan / Huang, Xiangzhong / Liu, Hongcheng

Food chemistry: X

2023 Volume 18, Page(s) 100654

Abstract: Cycloxaprid (CYC) with a chiral oxabridged cis- structure contains a pair of enantiomers. Enantioselective degradation, transformation and metabolite of CYC was performed in different solvents under light and raw Puer tea processing. The results showed ... ...

Abstract	Cycloxaprid (CYC) with a chiral oxabridged cis- structure contains a pair of enantiomers. Enantioselective degradation, transformation and metabolite of CYC was performed in different solvents under light and raw Puer tea processing. The results showed that cycloxaprid enantiomers in acetonitrile and acetone was stable over 17 day, however the transformation of
Language	English
Publishing date	2023-03-29
Publishing country	Netherlands
Document type	Journal Article
ISSN	2590-1575
ISSN (online)	2590-1575
DOI	10.1016/j.fochx.2023.100654
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Article ; Online: Ethnobotanical study of medicinal plants used by the Yi people in Mile, Yunnan, China.

Li, Hongrui / Huang, Caiwen / Li, Yanhong / Wang, Pujing / Sun, Jingxian / Bi, Zizhen / Xia, Shisheng / Xiong, Yong / Bai, Xishan / Huang, Xiangzhong

Journal of ethnobiology and ethnomedicine

2024 Volume 20, Issue 1, Page(s) 22

Abstract: Background: The Yi people are a sociolinguistic group living in Mile City, which is their typical settlement in southeastern Yunnan, China. Over the long history of using medicinal plants, the Yi people have accumulated and developed a wealth of ... ...

Abstract	Background: The Yi people are a sociolinguistic group living in Mile City, which is their typical settlement in southeastern Yunnan, China. Over the long history of using medicinal plants, the Yi people have accumulated and developed a wealth of traditional medicinal knowledge, which has played a vital role in their health care. However, only a few studies have been performed to systematically document the medicinal plants commonly used by the Yi people. This study provides fundamental data for the development and application of ethnomedicine as well as supports the conservation of the traditional medical knowledge of the Yi people. Methods: This study was conducted from May 2020 to August 2022 and involved five townships in Mile. Information regarding medicinal plants was obtained through semistructured interviews, key informant interviews, and participatory observation. The collected voucher specimens were identified using the botanical taxonomy method and deposited in the herbarium. Ethnobotanical data were analyzed using informant consensus factor, relative frequency of citation, and fidelity level. Results: In total, 114 informants distributed in five townships of Mile were interviewed. The Yi people used 267 medicinal plant species belonging to 232 genera and 104 families to treat various diseases. Asteraceae, Lamiaceae, and Fabaceae were the most commonly used plant families by the Yi people. In addition, herbs were most commonly used by the Yi people. Whole plants and roots were the preferred medicinal parts. Decoctions were the most common method of herbal medicine preparation. There are 49 different recorded diseases treated by Yi medicinal plants, and among them, respiratory diseases, rheumatism, traumatic injury, fractures, and digestive system diseases have the largest number of species used. A quantitative analysis demonstrated that plants such as Zingiber officinale, Lycopodium japonicum, Aconitum carmichaelii, Panax notoginseng, Cyathula officinalis, and Leonurus japonicus played crucial roles in disease prevention and treatment. Conclusion: Traditional knowledge of medicinal plants is closely associated with the social culture of the local Yi people. The medicinal plants used for health care in the study area were diverse. Local healers were skilled at using medicinal plants to treat various diseases. Their treatment methods were convenient and unique, exhibiting distinctive regional characteristics. However, the inheritance of their traditional medicinal knowledge and protection of wild medicinal plant resources are facing serious challenges, including the decreasing number of local healers, aging of healers, lack of successors, and excessive harvesting of medicinal plant resources. This ethnobotanical survey provides a useful reference for the sustainable utilization and protection of medicinal plant resources in Mile and the inheritance of traditional medicinal knowledge of the Yi people.
MeSH term(s)	Humans ; Plants, Medicinal ; China ; Ethnobotany/methods ; Medicine, Traditional/methods ; Phytotherapy/methods ; Plant Preparations ; Southeast Asian People
Chemical Substances	Plant Preparations
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2202544-3
ISSN	1746-4269 ; 1746-4269
ISSN (online)	1746-4269
ISSN	1746-4269
DOI	10.1186/s13002-024-00656-1
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Article ; Online: A Meta-analysis of TAE/TACE Versus Emergency Surgery in the Treatment of Ruptured HCC.

Xu, Xinjian / Chen, Changsheng / Liu, Qiang / Huang, Xiangzhong

Cardiovascular and interventional radiology

2020 Volume 43, Issue 9, Page(s) 1263–1276

Abstract: Objectives: To evaluate the efficacy and safety of TAE/TACE versus emergency surgery (ES) for spontaneous rupture of HCC (rHCC).: Methods: Eight databases (Web of Science, Pubmed, Embase, Cochrane Library, ClinicalTrial.gov, Wanfang, CNKI and VIP) ... ...

Abstract	Objectives: To evaluate the efficacy and safety of TAE/TACE versus emergency surgery (ES) for spontaneous rupture of HCC (rHCC). Methods: Eight databases (Web of Science, Pubmed, Embase, Cochrane Library, ClinicalTrial.gov, Wanfang, CNKI and VIP) were searched to obtain all related literature from the inception dates to October 2019. Subgroup analyses based on the kind of study design and kind of embolization were conducted. Results: Twenty-one studies comparing TAE/TACE with ES were eligible. A total of 974 rHCC participants (485 participants treated with TACE/TAE and 489 participants treated with ES) were included in the present meta-analysis. TAE/TACE group was associated with lower risk of complications (OR = 0.36; 95% CI, 0.22-0.57; P < 0.0001) and in-hospital mortality (OR = 0.52; 95% CI, 0.29-0.94; P = 0.03) compared with ES group. In addition, no significant difference in successful hemostasis (OR = 1.67; 95% CI, 0.85-3.28; P = 0.13) and 1-year survival (OR = 1.08; 95% CI, 0.79-1.48; P = 0.64) between TAE/TACE and ES groups was demonstrated. Conclusions: TAE/TACE had comparable outcomes to ES in terms of successful hemostasis and 1-year survival. Meanwhile, TAE/TACE was significantly superior to ES in terms of complications and in-hospital mortality. Therefore, TAE/TACE may be recommended as a preferable treatment for rHCC.
MeSH term(s)	Carcinoma, Hepatocellular/blood supply ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic ; Hepatectomy/methods ; Humans ; Liver Neoplasms/blood supply ; Liver Neoplasms/therapy ; Rupture, Spontaneous ; Treatment Outcome
Language	English
Publishing date	2020-05-21
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	603082-8
ISSN	1432-086X ; 0342-7196 ; 0174-1551
ISSN (online)	1432-086X
ISSN	0342-7196 ; 0174-1551
DOI	10.1007/s00270-020-02514-5
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Zs.A 1378: Show issues

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Article ; Online: A stent with radioactive seed strand insertion for inoperable malignant biliary obstruction: A meta-analysis.

Huang, Yi-Yang / Xu, Xin-Jian / Huang, Xiang-Zhong / Cheng, Hong

Brachytherapy

2021 Volume 20, Issue 3, Page(s) 638–644

Abstract: Purpose: The purpose of the study was to assess the relative clinical effectiveness of stent insertion with or without radioactive seed strand (RSS) insertion in patients suffering from malignant biliary obstruction (MBO).: Methods and materials: ... ...

Abstract	Purpose: The purpose of the study was to assess the relative clinical effectiveness of stent insertion with or without radioactive seed strand (RSS) insertion in patients suffering from malignant biliary obstruction (MBO). Methods and materials: Relevant articles published as of November 2020 in the Embase, PubMed, and Cochrane Library databases were identified and analyzed. Primary study endpoints for this meta-analysis were stent dysfunction, stent patency, and overall survival (OS), whereas secondary endpoints were rates of clinical success and complications. RevMan v5.3 was used to perform all meta-analyses. Results: In total, there were nine studies incorporating 643 patients (280 and 363 who underwent stent insertion with and without RSS, respectively). No differences were observed between these groups with respect to pooled rates of clinical success (p = 0.25), stent dysfunction (p = 0.47), cholangitis (p = 0.97), cholecystitis (p = 0.95), or pancreatitis (p = 0.66). However, stent patency duration (p < 0.00001) and patients' OS (p < 0.00001) were significantly increased in patients in the stent + RSS group. No heterogeneity was detected for any of these endpoints, nor did funnel plots yield any publication bias. A subgroup analysis of patients with hilar MBO similarly exhibited stent + RSS insertion to be associated with longer stent patency and OS as compared with stent insertion alone. Conclusions: These findings showed that relative to stent insertion, stent + RSS insertion is associated with longer OS and stent patency in patients with inoperable MBO.
MeSH term(s)	Brachytherapy/methods ; Cholestasis ; Humans ; Neoplasms ; Stents ; Treatment Outcome
Language	English
Publishing date	2021-03-05
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	2098608-7
ISSN	1873-1449 ; 1538-4721
ISSN (online)	1873-1449
ISSN	1538-4721
DOI	10.1016/j.brachy.2021.01.010
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