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Article ; Online: Methylation of lncSHGL promotes adipocyte differentiation by regulating miR-149/Mospd3 axis.

Huang, Xianwei / Liu, Xiong / Lin, Jiyan

2024 Volume 22, Issue 21-22, Page(s) 2361–2380

Abstract: Obesity poses significant health risks and can negatively impact an individual's quality of life. The human obesity phenotype results from the differentiation of pre-adipocytes into adipocytes, which leads to hypertrophy and hyperplasia in adipose tissue. ...

Abstract	Obesity poses significant health risks and can negatively impact an individual's quality of life. The human obesity phenotype results from the differentiation of pre-adipocytes into adipocytes, which leads to hypertrophy and hyperplasia in adipose tissue. The molecular mechanisms by which long non-coding RNAs (lncRNAs) modulate adipocyte differentiation, a process implicated in obesity development, remain poorly characterized. A lncRNA which suppressed the hepatic gluconeogenesis and lipogenesis (lncSHGL) was newly identified. Our research aims to elucidate the functional role and mechanistic underpinnings of suppressor of lncSHGL in adipocyte differentiation. We observed that lncSHGL expression progressively diminished during 3T3-L1 differentiation and was downregulated in the liver and perirenal adipose tissue of ob/ob mice. lncSHGL acts as a molecular sponge for miR-149, with Mospd3 identified as a target of miR-149.Overexpression of lncSHGL and inhibition of miR-149 led to suppressed 3T3-L1 proliferation, decreased lipid droplet accumulation, and attenuated promoter activity of PPARγ2 and C/EBPα. These changes consequently resulted in reduced expression of Cyclin D1, LPL, PPARγ2, AP2, and C/EBPα, as well as inhibited the PI3K/AKT/mTOR signaling pathway. In contrast, lncSHGL suppression yielded opposing outcomes. Moreover, the effects of lncSHGL overexpression and miR-149 inhibition on reduced expression of Cyclin D1, LPL, PPARγ2, AP2, and C/EBPα were reversible upon miR-149 overexpression and Mospd3 suppression. These findings were further validated
MeSH term(s)	Animals ; Humans ; Mice ; 3T3-L1 Cells ; Adipocytes/metabolism ; Adipogenesis/genetics ; CCAAT-Enhancer-Binding Protein-alpha/genetics ; CCAAT-Enhancer-Binding Protein-alpha/metabolism ; CCAAT-Enhancer-Binding Protein-alpha/pharmacology ; Cell Differentiation ; Cyclin D1/metabolism ; Methylation ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Obesity/genetics ; Obesity/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; PPAR gamma/metabolism ; Quality of Life
Chemical Substances	CCAAT-Enhancer-Binding Protein-alpha ; Cyclin D1 (136601-57-5) ; MicroRNAs ; MIRN149 microRNA, human ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; PPAR gamma ; MIRN149 microRNA, mouse
Language	English
Publishing date	2024-01-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2146183-1
ISSN	1551-4005 ; 1538-4101 ; 1554-8627
ISSN (online)	1551-4005
ISSN	1538-4101 ; 1554-8627
DOI	10.1080/15384101.2023.2287367
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Article ; Online: Quantitative structure-activity relationship predicting toxicity of pesticides towards Daphnia magna.

Chen, Cong / Yang, Bowen / Li, Mingwang / Huang, Saijin / Huang, Xianwei

Ecotoxicology (London, England)

2024

Abstract: Global pesticide usage reaching 2.7 million metric tons annually, brings a grave threat to non-target organisms, especially aquatic organisms, resulting in serious concerns. Predicting aquatic toxicity of pesticides towards Daphnia magna is significant. ... ...

Abstract	Global pesticide usage reaching 2.7 million metric tons annually, brings a grave threat to non-target organisms, especially aquatic organisms, resulting in serious concerns. Predicting aquatic toxicity of pesticides towards Daphnia magna is significant. In this work, random forest (RF) algorithm, together with ten Dragon molecular descriptors, was successfully utilized to develop a quantitative structure-activity/toxicity relationship (QSAR/QSTR) model for the toxicity pEC
Language	English
Publishing date	2024-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	34042-x
ISSN	1573-3017 ; 0963-9292
ISSN (online)	1573-3017
ISSN	0963-9292
DOI	10.1007/s10646-024-02751-1
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Article ; Online: Fast focusing method in ghost imaging with a tracking trajectory.

Huang, Xianwei / Xu, Yangting / Bai, Yanfeng / Fu, Xiquan

Optics letters

2023 Volume 48, Issue 21, Page(s) 5543–5546

Abstract: The imaging environment is unstable for trembling disturbance, which is detrimental to object reconstruction. In this Letter, we experimentally investigated ghost imaging (GI) under a temporal trembling disturbance. The fast-focusing method based on ... ...

Abstract	The imaging environment is unstable for trembling disturbance, which is detrimental to object reconstruction. In this Letter, we experimentally investigated ghost imaging (GI) under a temporal trembling disturbance. The fast-focusing method based on imaging with small sampling measurements is proposed, and the theoretical model and algorithm are validated. It is demonstrated that the proposed method is effective to obtain a better-resolution image of the object under the strong trembling disturbance including a laboratory and a real trembling environment. The results provide a promising approach to deal with image degradation caused by an unstable environment and can find potential applications for ghost imaging in remote sensing.
Language	English
Publishing date	2023-10-31
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.503027
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Article ; Online: Controlling beam dynamics with spectral quadratic phase modulation in the fractional Schrödinger equation.

Jiao, Caoyi / Huang, Xianwei / Bai, Yanfeng / Fu, Xiquan

Journal of the Optical Society of America. A, Optics, image science, and vision

2023 Volume 40, Issue 11, Page(s) 2019–2025

Abstract: The propagation dynamics of Gaussian beams and finite energy Airy beams with spectral quadratic phase modulation (QPM) modeled by the fractional Schrödinger equation (FSE) are numerically investigated. Compared with beam propagation in the standard ... ...

Abstract	The propagation dynamics of Gaussian beams and finite energy Airy beams with spectral quadratic phase modulation (QPM) modeled by the fractional Schrödinger equation (FSE) are numerically investigated. Compared with beam propagation in the standard Schrödinger equation, the focusing property of beams under FSE is influenced by the QPM coefficient and the Lévy index. For symmetric Gaussian beams, the focusing position increases and the focusing intensity decreases for the larger QPM coefficient or smaller Lévy index. For asymmetric Airy beams, multiple focusing positions occur, and the tendency of focusing intensity is opposite to that of Gaussian beams. Our results show the promising application of the FSE system for optical manipulation and optical splitting by controlling the QPM.
Language	English
Publishing date	2023-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	283633-6
ISSN	1520-8532 ; 1084-7529 ; 0740-3232
ISSN (online)	1520-8532
ISSN	1084-7529 ; 0740-3232
DOI	10.1364/JOSAA.502726
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Article ; Online: Automated Delineation of Smallholder Farm Fields Using Fully Convolutional Networks and Generative Adversarial Networks

Qiuyu YAN,Wufan ZHAO,Xiao HUANG, Xianwei LYU

Journal of Geodesy and Geoinformation Science, Vol 5, Iss 4, Pp 10-

2022 Volume 22

Abstract: Accurate boundaries of smallholder farm fields are important and indispensable geo-information that benefits farmers, managers, and policymakers in terms of better managing and utilizing their agricultural resources. Due to their small size, irregular ... ...

Abstract	Accurate boundaries of smallholder farm fields are important and indispensable geo-information that benefits farmers, managers, and policymakers in terms of better managing and utilizing their agricultural resources. Due to their small size, irregular shape, and the use of mixed-cropping techniques, the farm fields of smallholder can be difficult to delineate automatically. In recent years, numerous studies on field contour extraction using a deep Convolutional Neural Network (CNN) have been proposed. However, there is a relative shortage of labeled data for filed boundaries, thus affecting the training effect of CNN. Traditional methods mostly use image flipping, and random rotation for data augmentation. In this paper, we propose to apply Generative Adversarial Network (GAN) for the data augmentation of farm fields label to increase the diversity of samples. Specifically, we propose an automated method featured by Fully Convolutional Neural networks (FCN) in combination with GAN to improve the delineation accuracy of smallholder farms from Very High Resolution (VHR) images. We first investigate four State-Of-The-Art (SOTA) FCN architectures, i.e., U-Net, PSPNet, SegNet and OCRNet, to find the optimal architecture in the contour detection task of smallholder farm fields. Second, we apply the identified optimal FCN architecture in combination with Contour GAN and pixel2pixel GAN to improve the accuracy of contour detection. We test our method on the study area in the Sudano-Sahelian savanna region of northern Nigeria. The best combination achieved F1 scores of 0.686 on Test Set 1 (TS1), 0.684 on Test Set 2 (TS2), and 0.691 on Test Set 3 (TS3). Results indicate that our architecture adapts to a variety of advanced networks and proves its effectiveness in this task. The conceptual, theoretical, and experimental knowledge from this study is expected to seed many GAN-based farm delineation methods in the future.
Keywords	\|field boundary\|contour detection\|fully convolutional neural networks\|generative adversarial networks ; Science ; Q ; Geodesy ; QB275-343
Subject code	006
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	Surveying and Mapping Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Propagation dynamics of Laguerre-Gaussian beams in the fractional Schrödinger equation with noise disturbance.

Zhou, Weijun / Liu, Aixin / Huang, Xianwei / Bai, Yanfeng / Fu, Xiquan

Journal of the Optical Society of America. A, Optics, image science, and vision

2022 Volume 39, Issue 4, Page(s) 736–743

Abstract: The evolution of Laguerre-Gaussian (LG) beams in the fractional Schrödinger equation (FSE) with Gaussian noise disturbance is numerically investigated. Without noise disturbance, the peak intensity of LG beams increases with the increment of radial or ... ...

Abstract	The evolution of Laguerre-Gaussian (LG) beams in the fractional Schrödinger equation (FSE) with Gaussian noise disturbance is numerically investigated. Without noise disturbance, the peak intensity of LG beams increases with the increment of radial or azimuthal indices, and the turning point of the peak intensity between different radial indices exists. As propagation distance gets longer, the intensity of the outermost sub-lobe exceeds that of the main lobe. When Gaussian noise is added, for a given noise level, the stability of peak intensity is enhanced as the Lévy index increases, while the center of gravity shows the opposite phenomenon. Moreover, the increment of the radial index can weaken the stability of the center of gravity. We also investigate the stability of the peak intensity of Airy beams in the FSE, and generally, the stability of LG beams is better than that of Airy beams. All these properties show that LG beams modeled by the FSE have potential applications in optical manipulation and communications.
Language	English
Publishing date	2022-04-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	283633-6
ISSN	1520-8532 ; 1084-7529 ; 0740-3232
ISSN (online)	1520-8532
ISSN	1084-7529 ; 0740-3232
DOI	10.1364/JOSAA.455164
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Article ; Online: Association between triglyceride glucose index, coronary artery calcification and multivessel coronary disease in Chinese patients with acute coronary syndrome.

Wang, Jiayu / Huang, Xianwei / Fu, Caihua / Sheng, Qiping / Liu, Ping

Cardiovascular diabetology

2022 Volume 21, Issue 1, Page(s) 187

Abstract: Background: Multivessel coronary disease (MVCD) is the common type of coronary artery disease in acute coronary syndrome (ACS). Coronary artery calcification (CAC) has been confirmed the strong predictor of major adverse cardiovascular events (MACEs). ... ...

Abstract	Background: Multivessel coronary disease (MVCD) is the common type of coronary artery disease in acute coronary syndrome (ACS). Coronary artery calcification (CAC) has been confirmed the strong predictor of major adverse cardiovascular events (MACEs). Several studies have validated that triglyceride glucose (TyG) index can reflect the degree of coronary calcification or predict MACEs. However, no evidence to date has elucidated and compared the predictive intensity of TyG index or/and coronary artery calcification score (CACS) on multi-vascular disease and MACEs in ACS patients. Methods: A total of 935 patients, diagnosed with ACS and experienced coronary computed tomography angiography (CCTA) from August 2015 to March 2022 in the Second Hospital of Shandong University, were selected for retrospective analysis. The subjects were divided into TyG index quartile 1-4 groups (Q1-Q4 groups), non-multivessel coronary disease (non-MVCD) and multivessel coronary disease (MVCD) groups, respectively. The general data, past medical or medication history, laboratory indicators, cardiac color Doppler ultrasound, CACS, and TyG indexes were respectively compared among these groups. The ROC curve preliminarily calculated and analyzed the diagnostic value of TyG index, CACS, and the combination of the two indicators for MVCD. Univariate and multivariate logistic regression analysis discriminated the independent hazard factors for forecasting MVCD. Results: Compared with the lower TyG index and non-MVCD groups, the higher TyG index and MVCD groups had higher values of age, smoking history, waist circumference, systolic blood pressure, low-density lipoprotein cholesterol(LDL-C), fasting blood glucose and glycosylated hemoglobin, and CACS, but lower values of high-density lipoprotein cholesterol(HDL-C) (all P < 0.01). Coronary artery calcification is more common in the left anterior descending artery. Compared with non-MVCD, each unit increase in TyG index was associated with a 1.213-fold increased risk of MVCD. Logistic regression analysis adjusted for potential confounders indicated that TyG index is an independent risk factor for MVCD. With the increase of TyG index, the incidence of MACEs, apart from all-cause death, cardiac death, unexpected re-hospitalization of heart failure, recurrent ACS or unplanned revascularization, and non-fatal stroke in coronary artery increased (P log-rank < 0.001). Conclusion: TyG index could completely substitute for CACS as a reliable, practical, and independent indicator for predicting the severity and prognosis of MVCD in patients with ACS.
MeSH term(s)	Acute Coronary Syndrome/diagnostic imaging ; Acute Coronary Syndrome/epidemiology ; Biomarkers ; Blood Glucose ; China/epidemiology ; Cholesterol, LDL ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/epidemiology ; Glucose ; Glycated Hemoglobin A ; Humans ; Lipoproteins, HDL ; Retrospective Studies ; Triglycerides
Chemical Substances	Biomarkers ; Blood Glucose ; Cholesterol, LDL ; Glycated Hemoglobin A ; Lipoproteins, HDL ; Triglycerides ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2022-09-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2093769-6
ISSN	1475-2840 ; 1475-2840
ISSN (online)	1475-2840
ISSN	1475-2840
DOI	10.1186/s12933-022-01615-4
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Article ; Online: Sodium-glucose co-transporter 1 promotes the bio-functions of perivascular preadipocytes mediated by Akt/mTOR/p70S6K signaling pathway.

Liu, Zhiquan / Wang, Jiayu / Tian, Peiqing / Liu, Yixuan / Xing, Liyun / Fu, Caihua / Huang, Xianwei / Liu, Ping

American journal of physiology. Cell physiology

2024

Abstract: The influence of SGLT-1 on perivascular preadipocytes (PVPACs) and vascular remodeling is not well understood. This study aimed to elucidate the role and mechanism of SGLT-1-mediated PVPACs bioactivity. PVPACs were ... ...

Abstract	The influence of SGLT-1 on perivascular preadipocytes (PVPACs) and vascular remodeling is not well understood. This study aimed to elucidate the role and mechanism of SGLT-1-mediated PVPACs bioactivity. PVPACs were cultured
Language	English
Publishing date	2024-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	392098-7
ISSN	1522-1563 ; 0363-6143
ISSN (online)	1522-1563
ISSN	0363-6143
DOI	10.1152/ajpcell.00606.2023
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Article ; Online: Bone marrow mesenchymal stem cell-derived exosomal microRNA regulates microglial polarization.

Huang, Xianwei / Liu, Xiong / Zeng, Jiaqi / Du, Penghui / Huang, Xiaodong / Lin, Jiyan

PeerJ

2023 Volume 11, Page(s) e16359

Abstract: Objective: This study aimed to explore the effects of bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-146a-5p on microglial polarization and the potential underlying mechanisms in oxygen-glucose deprivation (OGD)-exposed microglial cells.!# ...

Abstract	Objective: This study aimed to explore the effects of bone marrow mesenchymal stem cell (BMSC)-derived exosomal miR-146a-5p on microglial polarization and the potential underlying mechanisms in oxygen-glucose deprivation (OGD)-exposed microglial cells. Methods: Exosomes were isolated from BMSCs, and their characteristics were examined. The effects of BMSC-derived exosomes on microglial polarization were investigated in OGD-exposed BV-2 cells. Differentially expressed miRNAs were identified and their biological function was explored using enrichment analyses. The regulatory role of miR-146a-5p in microglial polarization was studied via flow cytometry. Finally, the downstream target gene Traf6 was validated, and the role of the miR-146a-5p/Traf6 axis in modulating microglial polarization was investigated in OGD-exposed BV-2 cells. Results: BMSC-derived exosomes were successfully isolated and characterized. A total of 10 upregulated and 33 downregulated miRNAs were identified. Exosomal treatment resulted in significant changes in microglial polarization markers. miR-146a-5p was found to be significantly downregulated in OGD-exposed microglial cells treated with exosomes. Manipulation of miR-146a-5p expression modulated microglial polarization. Moreover, the miR-146a-5p/Traf6 axis regulated microglial polarization. Conclusion: Our findings demonstrate that BMSC-derived exosomal via miR-146a-5p modulates microglial polarization by targeting Traf6, providing a potential thermal target for the treatment of neurological diseases involving microglial activation.
MeSH term(s)	MicroRNAs/genetics ; Microglia/metabolism ; TNF Receptor-Associated Factor 6/genetics ; Mesenchymal Stem Cells
Chemical Substances	MicroRNAs ; TNF Receptor-Associated Factor 6
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359 ; 2167-8359
ISSN (online)	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.16359
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ghost imaging lidar system for remote imaging.

Jiang, Teng / Bai, Yanfeng / Tan, Wei / Zhu, Xiaohui / Huang, Xianwei / Nan, Suqin / Fu, Xiquan

Optics express

2023 Volume 31, Issue 9, Page(s) 15107–15117

Abstract: Research towards practical applications of ghost imaging lidar system especially in longer sensing distance has been urgent in recent years. In this paper we develop a ghost imaging lidar system to boost an extension of remote imaging, where the ... ...

Abstract	Research towards practical applications of ghost imaging lidar system especially in longer sensing distance has been urgent in recent years. In this paper we develop a ghost imaging lidar system to boost an extension of remote imaging, where the transmission distance of the collimated pseudo-thermal beam can be improved hugely over long range and just shifting the adjustable lens assembly generates wide field of view suiting for short-range imaging. Based on the proposed lidar system, the changing tendency of illuminating field of view, energy density, and reconstructed images is analyzed and verified experimentally. Some considerations on the improvement of this lidar system are also discussed.
Language	English
Publishing date	2023-05-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.485831
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