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  1. AU="Huang, Xiao-Fan"
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  3. AU="Varchetta, Veronica"
  4. AU="Zhang, Lingye"
  5. AU="Venko, Katja"
  6. AU="Kasthuri, Thirupathi"
  7. AU="Pirtskhalava, Tamar"
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  9. AU="Vithana, Eranga N"
  10. AU="Suárez-Lledó, M"
  11. AU="Olivo-Marston, Susan"
  12. AU="Denise P Momesso"
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  1. Artikel ; Online: Aortic Dissection Research in China: Analysis of Studies Funded by the National Natural Science Foundation of China.

    Yue, Zhang / Wang, Da-Shuai / Le, Sheng / Xia, Jia-Hong / Ye, Ping / Huang, Xiao-Fan

    Current medical science

    2023  Band 43, Heft 1, Seite(n) 206–212

    Abstract: Objective: The National Natural Science Foundation of China (NSFC) has made great progress in promoting the development of aortic dissection research in recent years. This study aimed to examine the development and research status of aortic dissection ... ...

    Abstract Objective: The National Natural Science Foundation of China (NSFC) has made great progress in promoting the development of aortic dissection research in recent years. This study aimed to examine the development and research status of aortic dissection research in China so as to provide references for future research.
    Methods: The NSFC projects data from 2008 to 2019 were collected from the Internet-based Science Information System and other websites utilized as search engines. The publications and citations were retrieved by Google Scholar, and the impact factors were checked by the InCite Journal Citation Reports database. The investigator's degree and department were identified from the institutional faculty profiles.
    Results: A total of 250 grant funds totaling 124.3 million Yuan and resulting in 747 publications were analyzed. The funds in economically developed and densely populated areas were more than those in underdeveloped and sparsely populated areas. There was no significant difference in the amount of funding per grant between different departments' investigators. However, the funding output ratios of the grants for cardiologists were higher than those for basic science investigators. The amount of funding for clinical researchers and basic scientific researchers in aortic dissection was also similar. Clinical researchers were better in terms of the funding output ratio.
    Conclusion: These results suggest that the medical and scientific research level of aortic dissection in China has been greatly improved. However, there are still some problems that urgently need to be solved, such as the unreasonable regional allocation of medical and scientific research resources, and the slow transition from basic science to clinical practice.
    Mesh-Begriff(e) Humans ; Aortic Dissection ; China ; Natural Science Disciplines ; Financial Management
    Sprache Englisch
    Erscheinungsdatum 2023-03-03
    Erscheinungsland China
    Dokumenttyp Journal Article
    ZDB-ID 2931065-9
    ISSN 2523-899X ; 2096-5230
    ISSN (online) 2523-899X
    ISSN 2096-5230
    DOI 10.1007/s11596-022-2662-9
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Patchouli alcohol induces G

    Liang, Chi-Yen / Chang, Kai-Fu / Huang, Ya-Chih / Huang, Xiao-Fan / Sheu, Gwo-Tarng / Kuo, Chia-Feng / Hsiao, Chih-Yen / Tsai, Nu-Man

    Thoracic cancer

    2023  Band 14, Heft 21, Seite(n) 2007–2017

    Abstract: Background: Lung cancer, especially non-small cell lung cancer (NSCLC), is one of the leading causes of cancer-related deaths worldwide. Vincristine (VCR) is a chemotherapeutic agent for lung cancers; however, its effectiveness is limited by side ... ...

    Abstract Background: Lung cancer, especially non-small cell lung cancer (NSCLC), is one of the leading causes of cancer-related deaths worldwide. Vincristine (VCR) is a chemotherapeutic agent for lung cancers; however, its effectiveness is limited by side effects and the development of drug resistance. Patchouli alcohol (PA), from Pogostemon cablin extract, is known to possess anti-inflammatory and anticancer properties. In this study, we investigated the role of PA in inducing reactive oxygen species (ROS)-mediated DNA damage in A549 and VCR-resistant A549/V16 NSCLC cells.
    Methods: The anticancer potential of PA was studied using the MTT assay, colony formation, flow cytometry analysis, western blotting, DCFDA staining, immunofluorescence staining, and TUNEL assay techniques.
    Results: The intracellular ROS levels were enhanced in PA-treated cells, activating the CHK1 and CHK2 signaling pathways. PA further inhibited proliferation and colony-forming abilities and induced cell cycle arrest at the G
    Conclusions: PA induced ROS-mediated DNA damage, triggered cell cycle arrest and apoptosis, attenuated drug resistance and cancer stem cell phenotypes, and synergistically inhibited proliferation in combination with cisplatin. These findings suggest that PA has the potential to be used for the treatment of NSCLC with or without VCR resistance.
    Mesh-Begriff(e) Humans ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/metabolism ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/metabolism ; Vincristine ; Reactive Oxygen Species/metabolism ; Cisplatin/therapeutic use ; Cell Line, Tumor ; Cell Cycle Checkpoints ; Apoptosis ; DNA Damage ; Cell Proliferation
    Chemische Substanzen Vincristine (5J49Q6B70F) ; patchouli alcohol (HHH8CPR1M2) ; Reactive Oxygen Species ; Cisplatin (Q20Q21Q62J)
    Sprache Englisch
    Erscheinungsdatum 2023-05-30
    Erscheinungsland Singapore
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.14982
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: Angelica sinensis

    Ma, Tsung-Liang / Chang, Kai-Fu / Huang, Xiao-Fan / Lai, Hung-Chih / Hsiao, Chih-Yen / Tsai, Nu-Man

    The Chinese journal of physiology

    2023  Band 66, Heft 3, Seite(n) 119–128

    Abstract: Glioblastoma (GB) is one of the most aggressive and malignant tumors of the central nervous system. Conventional treatment for GB requires surgical resection followed by radiotherapy combined with temozolomide chemotherapy; however, the median survival ... ...

    Abstract Glioblastoma (GB) is one of the most aggressive and malignant tumors of the central nervous system. Conventional treatment for GB requires surgical resection followed by radiotherapy combined with temozolomide chemotherapy; however, the median survival time is only 12-15 months. Angelica sinensis Radix (AS) is commonly used as a traditional medicinal herb or a food/dietary supplement in Asia, Europe, and North America. This study aimed to investigate the effect of AS-acetone extract (AS-A) on the progression of GB and the potential mechanisms underlying its effects. The results indicated that AS-A used in this study showed potency in growth inhibition of GB cells and reduction of telomerase activity. In addition, AS-A blocked the cell cycle at the G
    Mesh-Begriff(e) Humans ; Mice ; Animals ; Glioblastoma/drug therapy ; Glioblastoma/metabolism ; Glioblastoma/pathology ; Telomerase/metabolism ; Telomerase/pharmacology ; Telomerase/therapeutic use ; Apoptosis ; Cell Cycle Checkpoints ; Cell Cycle ; Cell Proliferation ; Telomere/metabolism ; Telomere/pathology ; Mitochondria ; Cell Line, Tumor
    Chemische Substanzen angelicae sinensis extract (B66F4574UG) ; Telomerase (EC 2.7.7.49)
    Sprache Englisch
    Erscheinungsdatum 2023-06-16
    Erscheinungsland India
    Dokumenttyp Journal Article
    ZDB-ID 966112-8
    ISSN 0304-4920 ; 0300-8525
    ISSN 0304-4920 ; 0300-8525
    DOI 10.4103/cjop.CJOP-D-23-00024
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The effects of patchouli alcohol and combination with cisplatin on proliferation, apoptosis and migration in B16F10 melanoma cells.

    Chang, Kai-Fu / Lai, Hung-Chih / Lee, Shan-Chih / Huang, Xiao-Fan / Huang, Ya-Chih / Chou, Tien-Erh / Hsiao, Chih-Yen / Tsai, Nu-Man

    Journal of cellular and molecular medicine

    2023  Band 27, Heft 10, Seite(n) 1423–1435

    Abstract: Melanoma is a highly metastatic cancer with a low incidence rate, but a high mortality rate. Patchouli alcohol (PA), a tricyclic sesquiterpene, is considered the main active component in Pogostemon cablin Benth, which improves wound healing and has anti- ... ...

    Abstract Melanoma is a highly metastatic cancer with a low incidence rate, but a high mortality rate. Patchouli alcohol (PA), a tricyclic sesquiterpene, is considered the main active component in Pogostemon cablin Benth, which improves wound healing and has anti-tumorigenic activity. However, the pharmacological action of PA on anti-melanoma remains unclear. Thus, the present study aimed to investigate the role of PA in the proliferation, cell cycle, apoptosis and migration of melanoma cells. These results indicated that PA selectively inhibited the proliferation of B16F10 cells in a dose- and time-dependent manner. It induced cell cycle arrest at the G
    Mesh-Begriff(e) Humans ; Cisplatin/pharmacology ; Sesquiterpenes/pharmacology ; Melanoma ; Cell Line, Tumor ; Apoptosis ; Cell Proliferation
    Chemische Substanzen Cisplatin (Q20Q21Q62J) ; patchouli alcohol (HHH8CPR1M2) ; Sesquiterpenes
    Sprache Englisch
    Erscheinungsdatum 2023-04-10
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17745
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel ; Online: Clinical risk score for postoperative pneumonia following heart valve surgery.

    Wang, Da-Shuai / Huang, Xiao-Fan / Wang, Hong-Fei / Le, Sheng / Du, Xin-Ling

    Chinese medical journal

    2021  Band 134, Heft 20, Seite(n) 2447–2456

    Abstract: Background: Postoperative pneumonia (POP) is one of the most common infections following heart valve surgery (HVS) and is associated with a significant increase in morbidity, mortality, and health care costs. This study aimed to identify the major risk ... ...

    Abstract Background: Postoperative pneumonia (POP) is one of the most common infections following heart valve surgery (HVS) and is associated with a significant increase in morbidity, mortality, and health care costs. This study aimed to identify the major risk factors associated with the occurrence of POP following HVS and to derive and validate a clinical risk score.
    Methods: Adults undergoing open HVS between January 2016 and December 2019 at a single institution were enrolled in this study. Patients were randomly assigned to the derivation and validation sets at 1:1 ratio. A prediction model was developed with multivariable logistic regression analysis in the derivation set. Points were assigned to independent risk factors based on their regression coefficients.
    Results: POP occurred in 316 of the 3853 patients (8.2%). Multivariable analysis identified ten significant predictors for POP in the derivation set, including older age, smoking history, chronic obstructive pulmonary disease, diabetes mellitus, renal insufficiency, poor cardiac function, heart surgery history, longer cardiopulmonary bypass, blood transfusion, and concomitant coronary and/or aortic surgery. A 22-point risk score based on the multivariable model was then generated, demonstrating good discrimination (C-statistic: 0.81), and calibration (Hosmer-Lemeshow χ2 = 8.234, P = 0.312). The prediction rule also showed adequate discriminative power (C-statistic: 0.83) and calibration (Hosmer-Lemeshow χ2 = 5.606, P = 0.691) in the validation set. Three risk intervals were defined as low-, medium-, and high-risk groups.
    Conclusion: We derived and validated a 22-point risk score for POP following HVS, which may be useful in preventive interventions and risk management.
    Trial registration: Chictr.org, ChiCTR1900028127; http://www.chictr.org.cn/showproj.aspx?proj=46932.
    Mesh-Begriff(e) Adult ; Aged ; Cardiac Surgical Procedures/adverse effects ; Cardiopulmonary Bypass ; Heart Valves ; Humans ; Pneumonia ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2021-09-15
    Erscheinungsland China
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000001715
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: Encapsulated

    Lin, Yu-Ling / Huang, Xiao-Fan / Chang, Kai-Fu / Liao, Kuang-Wen / Tsai, Nu-Man

    International journal of nanomedicine

    2020  Band 15, Seite(n) 749–760

    Abstract: Background: n-: Methods: DBTRG-05MG tumor bearing xenograft mice were treated with BP and BP/LPPC and then their tumor sizes, survival, drug biodistribution were measured. RG2 tumor bearing F344 rats also treated with BP and BP/LPPC and then their ... ...

    Abstract Background: n-
    Methods: DBTRG-05MG tumor bearing xenograft mice were treated with BP and BP/LPPC and then their tumor sizes, survival, drug biodistribution were measured. RG2 tumor bearing F344 rats also treated with BP and BP/LPPC and then their tumor sizes by magnetic resonance imaging for evaluation blood-brain barrier (BBB) across and drug therapeutic effects. After treated with BP/LPPC in vitro, cell uptake, cell cycle and apoptotic regulators were analyzed for evaluation the therapeutic mechanism.
    Results: In athymic mice, BP/LPPC could efficiently suppress tumor growth and prolong survival. In F334 rats, BP/LPPC crossed the BBB and led to tumor shrinkage. BP/LPPC promoted cell cycle arrest at the G
    Conclusion: BP/LPPC was rapidly and efficiently transported to the tumor area across the BBB and induced cell apoptosis, anti-angiogenetic and anti-metastatic effects in vitro and in vivo.
    Mesh-Begriff(e) Animals ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins ; Blood-Brain Barrier/metabolism ; Blood-Brain Barrier/pathology ; Brain Neoplasms/drug therapy ; Brain Neoplasms/pathology ; Cell Cycle/drug effects ; Cell Cycle Checkpoints/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Female ; Glioblastoma/drug therapy ; Glioblastoma/pathology ; Humans ; Liposomes/chemistry ; Mice ; Mice, Nude ; Phthalic Anhydrides/pharmacology ; Phthalic Anhydrides/therapeutic use ; Polyethylene Glycols/chemistry ; Polyethyleneimine/chemistry ; Rats, Inbred F344 ; Subcutaneous Tissue/drug effects ; Subcutaneous Tissue/pathology ; Tissue Distribution/drug effects
    Chemische Substanzen Antineoplastic Agents ; Apoptosis Regulatory Proteins ; Liposomes ; Phthalic Anhydrides ; Polyethylene Glycols (3WJQ0SDW1A) ; Polyethyleneimine (9002-98-6) ; butylidenephthalide (S9178G4B3F)
    Sprache Englisch
    Erscheinungsdatum 2020-01-31
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2364941-0
    ISSN 1178-2013 ; 1176-9114
    ISSN (online) 1178-2013
    ISSN 1176-9114
    DOI 10.2147/IJN.S235815
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Juniperus indica Bertol. extract synergized with cisplatin against melanoma cells via the suppression of AKT/mTOR and MAPK signaling and induction of cell apoptosis.

    Huang, Xiao-Fan / Gao, Hong-Wei / Lee, Shan-Chih / Chang, Kai-Fu / Tang, Li-Ting / Tsai, Nu-Man

    International journal of medical sciences

    2021  Band 18, Heft 1, Seite(n) 157–168

    Abstract: Juniperus ... ...

    Abstract Juniperus indica
    Mesh-Begriff(e) Animals ; Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Apoptosis/drug effects ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Cisplatin/pharmacology ; Cisplatin/therapeutic use ; Dogs ; Drug Synergism ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Juniperus/chemistry ; MAP Kinase Signaling System/drug effects ; Madin Darby Canine Kidney Cells ; Melanoma/drug therapy ; Melanoma/pathology ; Mice ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Skin Neoplasms/drug therapy ; TOR Serine-Threonine Kinases/metabolism
    Chemische Substanzen Plant Extracts ; TOR Serine-Threonine Kinases (EC 2.7.1.1) ; mTOR protein, mouse (EC 2.7.1.1) ; Akt1 protein, mouse (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Cisplatin (Q20Q21Q62J)
    Sprache Englisch
    Erscheinungsdatum 2021-01-01
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.49423
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Enhancement of cytotoxicity and induction of apoptosis by cationic nano-liposome formulation of

    Huang, Xiao-Fan / Chang, Kai-Fu / Lin, Yu-Ling / Liao, Kuang-Wen / Hsiao, Chih-Yen / Sheu, Gwo-Tarng / Tsai, Nu-Man

    International journal of medical sciences

    2021  Band 18, Heft 13, Seite(n) 2930–2942

    Abstract: Breast cancer is the second most common malignancy in women. Current clinical therapy for breast cancer has many disadvantages, including metastasis, recurrence, and poor quality of life. Furthermore, it is necessary to find a new therapeutic drug for ... ...

    Abstract Breast cancer is the second most common malignancy in women. Current clinical therapy for breast cancer has many disadvantages, including metastasis, recurrence, and poor quality of life. Furthermore, it is necessary to find a new therapeutic drug for breast cancer patients to meet clinical demand. n-Butylidenephthalide (BP) is a natural and hydrophobic compound that can inhibit several tumors. However, BP is unstable in aqueous or protein-rich environments, which reduces the activity of BP. Therefore, we used an LPPC (Lipo-PEG-PEI complex) that can encapsulate both hydrophobic and hydrophilic compounds to improve the limitation of BP. The purpose of this study is to investigate the anti-tumor mechanisms of BP and BP/LPPC and further test the efficacy of BP encapsulated by LPPC on SK-BR-3 cells. BP inhibited breast cancer cell growth, and LPPC encapsulation (BP/LPPC complex) enhanced the cytotoxicity on breast cancer by stabilizing the BP activity and offering endocytic pathways. Additionally, BP and LPPC-encapsulated BP induced cell cycle arrest at the G
    Mesh-Begriff(e) Apoptosis/drug effects ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Doxorubicin/administration & dosage ; Doxorubicin/pharmacokinetics ; Drug Combinations ; Drug Screening Assays, Antitumor ; Drug Synergism ; Female ; G1 Phase Cell Cycle Checkpoints/drug effects ; Humans ; Hydrophobic and Hydrophilic Interactions ; Liposomes ; Nanoparticles/chemistry ; Phthalic Anhydrides/administration & dosage ; Phthalic Anhydrides/pharmacokinetics ; Polyethylene Glycols/chemistry ; Polyethyleneimine/analogs & derivatives ; Polyethyleneimine/chemistry
    Chemische Substanzen Drug Combinations ; Liposomes ; Phthalic Anhydrides ; poly(ethylene glycol)-co-poly(ethyleneimine) ; Polyethylene Glycols (3WJQ0SDW1A) ; Doxorubicin (80168379AG) ; Polyethyleneimine (9002-98-6) ; butylidenephthalide (S9178G4B3F)
    Sprache Englisch
    Erscheinungsdatum 2021-06-05
    Erscheinungsland Australia
    Dokumenttyp Journal Article
    ZDB-ID 2151424-0
    ISSN 1449-1907 ; 1449-1907
    ISSN (online) 1449-1907
    ISSN 1449-1907
    DOI 10.7150/ijms.51439
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel ; Online: Evaluation of anticancer effects of Juniperus communis extract on hepatocellular carcinoma cells in vitro and in vivo.

    Huang, Nan-Chieh / Huang, Ru-Lai / Huang, Xiao-Fan / Chang, Kai-Fu / Lee, Chien-Ju / Hsiao, Chih-Yen / Lee, Shan-Chih / Tsai, Nu-Man

    Bioscience reports

    2021  Band 41, Heft 7

    Abstract: Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and accounts for the fourth leading cause of all cancer deaths. Scientific evidence has found that plant extracts seem to be a reliable choice due to their multitarget effects ...

    Abstract Hepatocellular carcinoma (HCC) is the most common type of primary liver cancer and accounts for the fourth leading cause of all cancer deaths. Scientific evidence has found that plant extracts seem to be a reliable choice due to their multitarget effects against HCC. Juniperus communis has been used for centuries in traditional medicine and its anticancer properties have been reported. As a result, the purpose of the study was to investigate the anticancer effect and mechanism of J. communis extract (JCo extract) on HCC in vitro and in vivo. In the present study, we found that JCo extract inhibited the growth of human HCC cells by inducing cell cycle arrest at the G0/G1 phase, extensive apoptosis and suppressing metastatic protein expressions in HCC cells. Moreover, the combinational treatment of JCo and VP-16 was found to enhance the anticancer effect, revealing that JCo extract might have the potential to be utilized as an adjuvant to promote HCC treatment. Furthermore, in vivo study, JCo extract significantly suppressed HCC tumor growth and extended the lifespan with no or low systemic and pathological toxicity. JCo extract significantly up-regulated the expression of pro-apoptotic proteins and tumor suppressor p53, suppressed VEGF/VEGFR autocrine signaling, down-regulated cell cycle regulatory proteins and MMP2/MMP9 proteins. Overall, our results provide a basis for exploiting JCo extract as a potential anticancer agent against HCC.
    Mesh-Begriff(e) Animals ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Cycle Checkpoints/drug effects ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Cell Movement/drug effects ; Cell Proliferation/drug effects ; Female ; Gene Expression Regulation, Neoplastic ; Hep G2 Cells ; Humans ; Juniperus/chemistry ; Liver Neoplasms/drug therapy ; Liver Neoplasms/genetics ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Mice, Inbred BALB C ; Mice, Nude ; Neoplasm Invasiveness ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology ; Signal Transduction ; Xenograft Model Antitumor Assays ; Mice
    Chemische Substanzen Antineoplastic Agents, Phytogenic ; Apoptosis Regulatory Proteins ; Cell Cycle Proteins ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2021-07-05
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20211143
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Positively Charged Nanoparticle Delivery of n-Butylidenephthalide Enhances Antitumor Effect in Hepatocellular Carcinoma.

    Chang, Kai-Fu / Huang, Xiao-Fan / Lin, Yu-Ling / Liao, Kuang-Wen / Hsieh, Ming-Chang / Chang, Jinghua Tsai / Tsai, Nu-Man

    BioMed research international

    2021  Band 2021, Seite(n) 8817875

    Abstract: Hepatocellular carcinoma (HCC) is the second and sixth leading cause of cancer death in men and woman in 185 countries statistics, respectively. n-Butylidenephthalide (BP) has shown anti-HCC activity, but it also has an unstable structure that decreases ... ...

    Abstract Hepatocellular carcinoma (HCC) is the second and sixth leading cause of cancer death in men and woman in 185 countries statistics, respectively. n-Butylidenephthalide (BP) has shown anti-HCC activity, but it also has an unstable structure that decreases its potential antitumor activity. The aim of this study was to investigate the cell uptake, activity protection, and antitumor mechanism of BP encapsulated in the novel liposome LPPC in HCC cells. BP/LPPC exhibited higher cell uptake and cytotoxicity than BP alone, and combined with clinical drug etoposide (VP-16), BP/LPPC showed a synergistic effect against HCC cells. Additionally, BP/LPPC increased cell cycle regulators (p53, p-p53, and p21) and decreased cell cycle-related proteins (Rb, p-Rb, CDK4, and cyclin D1), leading to cell cycle arrest at the G
    Mesh-Begriff(e) Animals ; Apoptosis/drug effects ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/metabolism ; Carcinoma, Hepatocellular/pathology ; Cell Cycle Checkpoints/drug effects ; Dogs ; Drug Carriers/chemistry ; Drug Carriers/pharmacology ; Hep G2 Cells ; Humans ; Liver Neoplasms/drug therapy ; Liver Neoplasms/metabolism ; Liver Neoplasms/pathology ; Madin Darby Canine Kidney Cells ; Nanoparticles/chemistry ; Nanoparticles/therapeutic use ; Neoplasm Proteins/metabolism ; Phthalic Anhydrides/chemistry ; Phthalic Anhydrides/pharmacology
    Chemische Substanzen Drug Carriers ; Neoplasm Proteins ; Phthalic Anhydrides ; butylidenephthalide (S9178G4B3F)
    Sprache Englisch
    Erscheinungsdatum 2021-03-19
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2021/8817875
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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