LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 6 of total 6

Search options

  1. Article: High Platelet Count is a Potential Prognostic Factor of the Early Recurrence of Hepatocellular Carcinoma in the Presence of Circulating Tumor Cells.

    Lu, Zhan / Huang, Yiyue / Huang, Juntao / Ni, Hang-Hang / Luo, Tai / Wei, Xingyu / Bai, Xue / Qi, Lunnan / Xiang, Bangde

    Journal of hepatocellular carcinoma

    2023  Volume 10, Page(s) 57–68

    Abstract: Purpose: Recent studies indicated the vital role of platelet in enhancing the survival of circulating tumor cells (CTCs) in the blood, thereby stimulating the metastasis of tumors. CTCs have been considered an indicator of early tumor recurrence. ... ...

    Abstract Purpose: Recent studies indicated the vital role of platelet in enhancing the survival of circulating tumor cells (CTCs) in the blood, thereby stimulating the metastasis of tumors. CTCs have been considered an indicator of early tumor recurrence. Therefore, this study evaluated the prognostic potential of platelet count in predicting the early recurrence of hepatocellular carcinoma (HCC) in the presence of CTCs.
    Patients and methods: 127 patients, whose preoperative CTCs were detected, were enrolled in this study. Univariate analysis was performed to identify the significant association of factors with the early recurrence of HCC, followed by multivariate analysis to determine the independent prognostic indicators. The prediction potential was evaluated using receiver operating characteristic (ROC) curves.
    Results: A total of 81 (63.7%) patients showed early HCC recurrence. The platelet count ≥225×10
    Conclusion: The high platelet count was an independent factor of early HCC recurrence in the presence of CTCs. The combination of preoperative CTCs and platelet count could effectively predict the early recurrence of HCC. The subgroup analysis also showed similar results.
    Language English
    Publishing date 2023-01-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2780784-8
    ISSN 2253-5969
    ISSN 2253-5969
    DOI 10.2147/JHC.S398591
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Nomograms for postsurgical extrahepatic recurrence prediction of hepatocellular carcinoma based on presurgical circulating tumor cell status and clinicopathological factors.

    Wei, Hao-Wen / Qin, Shui-Ling / Xu, Jing-Xuan / Huang, Yi-Yue / Chen, Yuan-Yuan / Ma, Liang / Qi, Lu-Nan

    Cancer medicine

    2023  Volume 12, Issue 14, Page(s) 15065–15078

    Abstract: Background and aims: Extrahepatic recurrence (EHR) is one of the major reasons for the poor prognosis of hepatocellular carcinoma (HCC). The present study aimed to develop and assess the performance of predictive models by using a combination of ... ...

    Abstract Background and aims: Extrahepatic recurrence (EHR) is one of the major reasons for the poor prognosis of hepatocellular carcinoma (HCC). The present study aimed to develop and assess the performance of predictive models by using a combination of presurgical circulating tumor cell (CTCs) data and clinicopathological features to screen patients at high risk of EHR to achieve precise decision-making.
    Patients and methods: A total of 227 patients with recurrent HCC and preoperative CTC data from January 2014 to August 2019 were enrolled. All patients were randomly assigned to one of two cohorts: development or validation. Two preoperative and postoperative nomogram models for EHR prediction were developed and multi-dimensionally validated.
    Results: Patients with EHR had generally lower recurrence-free survival (p < 0.001), and overall survival (p < 0.001), and significantly higher CTC counts (epithelial CTCs, epithelial/mesenchymal hybrid CTCs, and mesenchymal CTCs count, all p < 0.05) than those without EHR. Univariate and multivariate analyses revealed that EHR was associated with four risk factors in the development cohort: total CTC count (p = 0.014), tumor size (p = 0.028), node number (p = 0.045), and microvascular invasion (p = 0.035). These factors were incorporated into two nomogram models (preoperative and postoperative), which reliably predicted EHR through multidimensional verification (e.g., calibration plot, receiver operating characteristic analysis, decision curve analysis, and clinical impact curve analysis) in the development and validation cohorts, respectively. With threshold of scores of 100.3 and 176.8 before and after surgery respectively, both nomograms were able to stratify patients into two distinct prognostic subgroups (all p < 0.05).
    Conclusion: The present study proposed two nomogram models integrating presurgical CTC counts and clinicopathological risks and showed relatively good predictive performance of EHR, which may be beneficial to the clinical practice of HCC recurrence. Further multicenter studies are needed to assess its general applicability.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/pathology ; Nomograms ; Liver Neoplasms/pathology ; Neoplastic Cells, Circulating ; Hepatectomy ; Prognosis ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.6178
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: The impact of the COVID-19 pandemic on undergraduate and postgraduate students: A cross-sectional survey.

    Zhu, Lu / Zhou, Ying / Huang, Yiyue / Lei, Xinxin / Guo, Haoran / Hu, Yibo / Wu, Songjiang / Lei, Li / Guo, Aiyuan

    Frontiers in psychiatry

    2023  Volume 14, Page(s) 1074597

    Abstract: Background: The COVID-19 pandemic has impacted many facets of life. This study focuses on undergraduate and postgraduate students in China to explore how the pandemic has affected health status, daily life, learning situations, graduation-related ... ...

    Abstract Background: The COVID-19 pandemic has impacted many facets of life. This study focuses on undergraduate and postgraduate students in China to explore how the pandemic has affected health status, daily life, learning situations, graduation-related situations, and their studies or work planning.
    Methods: This study sent online questionnaires to 2,395 participants to investigate the extent to which they were affected by the epidemic in the various aspects mentioned above and to understand what help they tend to get in the face of these effects.
    Results: A total of 2,000 valid questionnaires were collected. The physical health of 82.90% of the respondents was affected to varying degrees, with male students, non-medical students, and graduates being more affected than female students, students with medical majors, and non-graduates, respectively. The proportion of students affected by mental health, the total amount of physical exercise, emotional life, and interpersonal communication was 86.35, 88.65, 80.15, and 90.15%, respectively. Compared with medical students and non-graduates, non-medical students and graduates were more affected. In addition, students' learning and graduation conditions have also been affected to a certain extent: 13.07% of students may not be able to graduate on time, and the proportion of postgraduate students' graduations affected was higher than that of undergraduate students.
    Conclusion: The COVID-19 pandemic has affected the health status of students, their daily lives, learning situations, and so on to varying degrees. We need to pay attention to the issues, provide practical solutions, and provide a basis for better responses to similar epidemics in the future.
    Language English
    Publishing date 2023-02-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564218-2
    ISSN 1664-0640
    ISSN 1664-0640
    DOI 10.3389/fpsyt.2023.1074597
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Specific gut microbiome signature predicts hepatitis B virus-related hepatocellular carcinoma patients with microvascular invasion.

    Peng, Yu-Chong / Xu, Jing-Xuan / You, Xue-Mei / Huang, Yi-Yue / Ma, Liang / Li, Le-Qun / Qi, Lu-Nan

    Annals of medicine

    2023  Volume 55, Issue 2, Page(s) 2283160

    Abstract: Background: We aimed to assess differences in intestinal microflora between patients with operable hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) with microvascular invasion (MVI) and those without MVI. Additionally, we investigated the ... ...

    Abstract Background: We aimed to assess differences in intestinal microflora between patients with operable hepatitis B virus-related hepatocellular carcinoma (HBV-HCC) with microvascular invasion (MVI) and those without MVI. Additionally, we investigated the potential of the microbiome as a non-invasive biomarker for patients with MVI.
    Methods: We analyzed the preoperative gut microbiomes (GMs) of two groups, the MVI (
    Results: β diversity analysis, utilizing weighted UniFrac distances, revealed a significant difference between the MVI and non-MVI groups, as indicated by non-metric multidimensional scaling and principal coordinate analysis. We also observed a significant correlation between the characteristic intestinal microbial communities at the genus level and their main functions. Nine optimal microbial markers were identified, with an area under the curve of 79.76% between 46 MVI and 56 non-MVI samples and 79.80% in the independent verification group.
    Conclusion: This pioneering analysis of the GM in patients with operable HBV-HCC with and without MVI opens new avenues for treating HBV-HCC with MVI. We successfully established a diagnostic model and independently verified microbial markers for patients with MVI. As preoperative targeted biomarkers, GM holds potential as a non-invasive tool for patients with HBV-HCC with MVI.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/surgery ; Carcinoma, Hepatocellular/pathology ; Hepatitis B virus/genetics ; Liver Neoplasms/surgery ; Gastrointestinal Microbiome/genetics ; Retrospective Studies ; Neoplasm Invasiveness ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-12-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1004226-x
    ISSN 1365-2060 ; 1651-2219 ; 0785-3890 ; 1743-1387
    ISSN (online) 1365-2060 ; 1651-2219
    ISSN 0785-3890 ; 1743-1387
    DOI 10.1080/07853890.2023.2283160
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 680: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article: Crustacean Female Sex Hormone From the Mud Crab

    Liu, An / Liu, Jing / Liu, Fang / Huang, Yiyue / Wang, Guizhong / Ye, Haihui

    Frontiers in physiology

    2018  Volume 9, Page(s) 924

    Abstract: Recently, the crustacean female sex hormone (CFSH), which is considered a female-specific hormone, has been shown to play a crucial role in female phenotypes in crustaceans. In this study, two transcripts ( ...

    Abstract Recently, the crustacean female sex hormone (CFSH), which is considered a female-specific hormone, has been shown to play a crucial role in female phenotypes in crustaceans. In this study, two transcripts (
    Language English
    Publishing date 2018-07-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2018.00924
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Two beta-pigment-dispersing hormone (β-PDH) isoforms in the mud crab, Scylla paramamosain: implication for regulation of ovarian maturation and a photoperiod-related daily rhythmicity.

    Huang, Xiaoshuai / Ye, Haihui / Huang, Huiyang / Yu, Kun / Huang, Yiyue

    Animal reproduction science

    2014  Volume 150, Issue 3-4, Page(s) 139–147

    Abstract: In crustaceans, the neuropeptide pigment dispersing hormone (PDH), including α- and β-PDH, is mainly involved in color changes related to the dispersion of integumental pigments and shielding pigments in the compound eye. In this study, we cloned two β- ... ...

    Abstract In crustaceans, the neuropeptide pigment dispersing hormone (PDH), including α- and β-PDH, is mainly involved in color changes related to the dispersion of integumental pigments and shielding pigments in the compound eye. In this study, we cloned two β-PDH isoforms in the mud crab Scylla paramamosain (termed Sp-β-PDH-I and II, respectively). The tissue distribution analysis in the females showed that Sp-β-PDH-I was mainly expressed in the eyestalk and to a much lesser extent in the brain, thoracic ganglion and ovary; however, Sp-β-PDH-II was exclusively distributed in the eyestalk. From there, we detected Sp-β-PDHs expression levels in the eyestalks (for Sp-β-PDH-I and II) and ovaries (for Sp-β-PDH-I) at different stages of ovarian development. The expression of Sp-β-PDH-I was consistent between the eyestalk and ovary; it maintained high levels from the pre-vitellogenic stage to the vitellogenic stage and then decreased significantly during the mature stage. By contrast, Sp-β-PDH-II expression levels were high only during the vitellogenic stage and significantly lower during the pre-vitellogenic and mature stages. Additionally daily expression analysis of the first stage crabs during the 24-h period showed that the expression level of Sp-β-PDH-II had an obvious daily rhythmicity and bright light could inhibit Sp-β-PDHs expressions. Moreover, photoresponses of Sp-β-PDHs further indicated that the daily rhythmicity was closely regulated by photoperiods. The combined results suggested for the first time that PDH is involved in regulating ovarian maturation in crustaceans and that a photoperiod-related daily rhythmicity of PDH exists in the juvenile crabs.
    MeSH term(s) Animals ; Brachyura/metabolism ; Circadian Rhythm ; Female ; Ovary/growth & development ; Peptides/genetics ; Peptides/metabolism ; Photoperiod ; Protein Isoforms ; Sexual Maturation
    Chemical Substances Peptides ; Protein Isoforms ; melanophore-dispersing hormone (9046-72-4)
    Language English
    Publishing date 2014-11-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 429674-6
    ISSN 1873-2232 ; 0378-4320
    ISSN (online) 1873-2232
    ISSN 0378-4320
    DOI 10.1016/j.anireprosci.2014.09.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 3232: Show issues
    Z 80/707: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top