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  1. Article ; Online: A highly diastereoselective (5+1) annulation of allenoates and pyrazolones catalyzed by CH

    Lai, Jingxiong / Huang, You

    Chemical communications (Cambridge, England)

    2024  Volume 60, Issue 15, Page(s) 2066–2069

    Abstract: The first (5+1) annulation of allenoates and pyrazolones catalyzed by ... ...

    Abstract The first (5+1) annulation of allenoates and pyrazolones catalyzed by CH
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc05751h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Phosphine-catalyzed formal Buchner [6+1] annulation:

    Lai, Jingxiong / Huang, You

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 88, Page(s) 13215–13218

    Abstract: An unprecedented phosphine-catalyzed formal Buchner [6+1] annulation of a newly designed allenoate has been developed, providing a series of cycloheptatriene derivatives in moderate to good yields (up to 99%). This reaction demonstrates that the ... ...

    Abstract An unprecedented phosphine-catalyzed formal Buchner [6+1] annulation of a newly designed allenoate has been developed, providing a series of cycloheptatriene derivatives in moderate to good yields (up to 99%). This reaction demonstrates that the introduction of an electrophilic allylic group to allenoates effectively extends the reaction scope of phosphine-catalyzed annulation, providing a concise route to cycloheptatrienes. Mechanistic study indicated that this reaction involves a [4+2] Diels-Alder reaction and ring expansion of the bicyclo[4.1.0] moiety, which is similar to the Buchner reaction. Notably, an enantioselective variant of this [6+1] annulation can also be performed using a chiral iminophosphine catalyst.
    Language English
    Publishing date 2023-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d3cc04905a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Design and Fabrication of Polymer Triboelectric Nanogenerators for Self-Powered Insole Applications.

    Huang, You-Jun / Chung, Chen-Kuei

    Polymers

    2023  Volume 15, Issue 20

    Abstract: Triboelectric nanogenerators (TENGs) are a kind of mechanical energy harvester with a larger force sensing range and good energy conversion, which is often applied to human kinetic energy collection and motion sensing devices. Polymer materials are the ... ...

    Abstract Triboelectric nanogenerators (TENGs) are a kind of mechanical energy harvester with a larger force sensing range and good energy conversion, which is often applied to human kinetic energy collection and motion sensing devices. Polymer materials are the most commonly used materials in TENGs' triboelectric layers due to their high plasticity and good performance. Regarding the application of TENGs in insoles, research has often used brittle Teflon for high output performance together with hard materials, such as springs, for the mechanism to maintain its stability. However, these combined materials increase the weight and hardness of the insoles. Here, we propose a polyethylene terephthalate (PET)-based TENG with a micro-needle polydimethylsiloxane (PDMS) elastomer, referred to as MN-PDMS-TENG, to enhance performance and maintain comfort flexibility, and structural stability. Compared with a flat PDMS, the TENG with a microstructure enhances the output open-circuit voltage (Voc) from 54.6 V to 129.2 V, short-circuit current (Isc) from 26.16 μA to 64.00 μA, power from 684 µW to 4.1 mW, and ability to light up from 70 to 120 LEDs. A special three-layer TENG insole mechanism fabricated with the MN-PDMS-TENG and elastic materials gives the TENG insole high stability and the ability to maintain sufficient flexibility to fit in a shoe. The three-layer TENG insole transforms human stepping force into electric energy of 87.2 V, which is used as a self-powered force sensor. Moreover, with the calibration curve between voltage and force, it has a sensitivity of 0.07734 V/N with a coefficient of determination of R
    Language English
    Publishing date 2023-10-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15204035
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Metal Free Dötz-Type Aminobenzannulation Reaction via 1,1-Dipoles Cross-Coupling.

    Cai, Wei / Huang, You

    Angewandte Chemie (International ed. in English)

    2023  Volume 62, Issue 41, Page(s) e202310133

    Abstract: Aryl amines are of constant interest in organic synthesis owing to their ubiquity in natural products, pharmaceuticals, and organic materials. However, C-H amination or pre-functionalization frequently results in uncontrollable site selectivity, over ... ...

    Abstract Aryl amines are of constant interest in organic synthesis owing to their ubiquity in natural products, pharmaceuticals, and organic materials. However, C-H amination or pre-functionalization frequently results in uncontrollable site selectivity, over activation and the generation of inseparable mixtures of regio-isomers. Here we present a novel metal free Dötz-type aminobenzannulation reaction that circumvents the selectivity issues inherent in aromatic chemistry, as well as the use of stoichiometric unstable organolithium reagents and toxic chromium complexes. The concept of utilizing readily available isocyanides and Morita-Baylis-Hillman (MBH) carbonates to achieve 1,1-dipoles cross-coupling to construct ketenimine is the key to success, which has been experimentally and computationally verified. The tandem 6π-electrocyclization/aromatization process offers a versatile method for synthesizing functionalized anilines, fused aryl amines and fused heteroaryl amines.
    Language English
    Publishing date 2023-09-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2011836-3
    ISSN 1521-3773 ; 1433-7851
    ISSN (online) 1521-3773
    ISSN 1433-7851
    DOI 10.1002/anie.202310133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Phosphine-Catalyzed Domino Annulation of γ-Vinyl Allenoates: Synthesis of Tetrahydrofuro[3,2-

    Ma, Mengmeng / Feng, Jiaxu / Cai, Wei / Huang, You

    Organic letters

    2024  Volume 26, Issue 19, Page(s) 4037–4042

    Abstract: A novel phosphine-catalyzed domino annulation reaction of γ-vinyl allenoates ... ...

    Abstract A novel phosphine-catalyzed domino annulation reaction of γ-vinyl allenoates and
    Language English
    Publishing date 2024-05-08
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.4c00656
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Lewis-Base-Catalyzed Enantioselective Formal [4 + 2] Annulations of Morita-Baylis-Hillman Carbonates: Access to Tetrahydroquinolines Derivatives.

    He, Yanlin / Cai, Wei / Huang, You

    Organic letters

    2023  Volume 25, Issue 19, Page(s) 3347–3351

    Abstract: The Lewis-base-catalyzed enantioselective formal [4 + 2] annulation reaction ... ...

    Abstract The Lewis-base-catalyzed enantioselective formal [4 + 2] annulation reaction of
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.3c00525
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: access to the synthesis of chromeno[4,3-

    Li, Xiaohu / Huang, You

    Chemical communications (Cambridge, England)

    2021  Volume 57, Issue 77, Page(s) 9934–9937

    Abstract: A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3- ...

    Abstract A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-
    Language English
    Publishing date 2021-09-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc04199a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: access to the synthesis of chromeno[4,3-b]pyrroles

    Li, Xiaohu / Huang, You

    Chemical communications. 2021 Sept. 28, v. 57, no. 77

    2021  

    Abstract: A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a ... ...

    Abstract A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.
    Keywords aldimines ; chemoselectivity ; cyclization reactions ; diastereoselectivity ; pyrroles
    Language English
    Dates of publication 2021-0928
    Size p. 9934-9937.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc04199a
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  9. Article ; Online: Isolation and genome characterization of Paenibacillus polymyxa 188, a potential biocontrol agent against fungi.

    Shih, Sra-Yh / Huang, You-Syu / Chou, Ker-Rui / Wu, Hung-Yi / Tsai, HsinYuan

    Journal of applied microbiology

    2024  Volume 135, Issue 4

    Abstract: Aims: In this work, we aimed to isolate marine bacteria that produce metabolites with antifungal properties.: Methods and results: Paenibacillus polymyxa 188 was isolated from a marine sediment sample, and it showed excellent antifungal activity ... ...

    Abstract Aims: In this work, we aimed to isolate marine bacteria that produce metabolites with antifungal properties.
    Methods and results: Paenibacillus polymyxa 188 was isolated from a marine sediment sample, and it showed excellent antifungal activity against many fungi pathogenic to plants (Fusarium tricinctum, Pestalotiopsis clavispora, Fusarium oxysporum, F. oxysporum f. sp. Cubense (Foc), Curvularia plantarum, and Talaromyces pinophilus) and to humans (Aspergillus terreus, Penicillium oxalicum, and Microsphaeropsis arundinis). The antifungal compounds produced by P. polymyxa 188 were extracted and analyzed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. The complete genome sequence and biosynthetic gene clusters of P. polymyxa 188 were characterized and compared with those of other strains. A total of 238 carbohydrate-active enzymes (CAZymes) were identified in P. polymyxa 188. Two antibiotic gene clusters, fusaricidin and tridecaptin, exist in P. polymyxa 188, which is different from other strains that typically have multiple antibiotic gene clusters.
    Conclusions: Paenibacilluspolymyxa 188 was identified with numerous biosynthetic gene clusters, and its antifungal ability against pathogenic fungi was verified.
    MeSH term(s) Humans ; Paenibacillus polymyxa/metabolism ; Antifungal Agents/chemistry ; Anti-Bacterial Agents/metabolism ; Paenibacillus/genetics
    Chemical Substances Antifungal Agents ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1358023-1
    ISSN 1365-2672 ; 1364-5072
    ISSN (online) 1365-2672
    ISSN 1364-5072
    DOI 10.1093/jambio/lxae075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Intermittent melena and refractory anemia due to jejunal cavernous lymphangioma: A case report.

    Liu, Kai-Rui / Zhang, Sheng / Chen, Wei-Run / Huang, You-Xing / Li, Xu-Guang

    World journal of gastrointestinal surgery

    2024  Volume 16, Issue 4, Page(s) 1208–1214

    Abstract: Background: Lymphangiomas in the gastrointestinal tract are extremely rare in adults. As a benign lesion, small intestine lymphangiomas often remain asymptomatic and pose challenges for definitive diagnosis. However, lymphangiomas can give rise to ... ...

    Abstract Background: Lymphangiomas in the gastrointestinal tract are extremely rare in adults. As a benign lesion, small intestine lymphangiomas often remain asymptomatic and pose challenges for definitive diagnosis. However, lymphangiomas can give rise to complications such as abdominal pain, bleeding, volvulus, and intussusception. Here, we report a case of jejunal cavernous lymphangioma that presented with intermittent melena and refractory anemia in a male adult.
    Case summary: A 66-year-old man presented with intermittent melena, fatigue and refractory anemia nine months prior. Esophagogastroduodenoscopy and colonoscopy were performed many times and revealed no apparent bleeding. Conservative management, including transfusion, hemostasis, gastric acid secretion inhibition and symptomatic treatment, was performed, but the lesions tended to recur shortly after surgery. Ultimately, the patient underwent capsule endoscopy, which revealed a more than 10 cm lesion accompanied by active bleeding. After single-balloon enteroscopy and biopsy, a diagnosis of jejunal cavernous lymphangioma was confirmed, and the patient underwent surgical resection. No complications or recurrences were observed postoperatively.
    Conclusion: Jejunal cavernous lymphangioma should be considered a cause of obscure gastrointestinal bleeding. Capsule endoscopy and single-balloon enteroscopy can facilitate diagnosis. Surgical resection is an effective management method.
    Language English
    Publishing date 2024-04-25
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2573700-4
    ISSN 1948-9366
    ISSN 1948-9366
    DOI 10.4240/wjgs.v16.i4.1208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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