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  1. Article ; Online: The compensation effect of competence frustration and its behavioral manifestations.

    Meng, Liang / He, Linglan / Chen, Mingming / Huang, Yueting

    PsyCh journal

    2024  

    Abstract: The frustration of competence, one of the three basic psychological needs proposed by self-determination theory, has been widely demonstrated to negatively influence one's motivation and well-being in both work and life. However, research on the recovery ...

    Abstract The frustration of competence, one of the three basic psychological needs proposed by self-determination theory, has been widely demonstrated to negatively influence one's motivation and well-being in both work and life. However, research on the recovery mechanism of competence is still in the nascent stage. In this study, a two-stage behavioral experiment was conducted to examine the restoration of competence and the potential moderating role of resilience. Results showed that individuals who were asked to recall experience of competence frustration performed better on subsequent tasks, manifesting their behavioral efforts of competence restoration. However, resilience does not play a significant moderating role in competence restoration. Through convergent behavioral evidence, findings of this study demonstrate the compensation effect of competence frustration.
    Language English
    Publishing date 2024-03-26
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2717141-3
    ISSN 2046-0260 ; 2046-0252
    ISSN (online) 2046-0260
    ISSN 2046-0252
    DOI 10.1002/pchj.746
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    Zs.A 6992: Show issues Location:
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  2. Article ; Online: Relationship between incompetent perforator veins and pigmentation below the knee in patients with chronic venous disease.

    Huang, Yueting / Zhang, Jian / Wu, Haisheng / Zhao, Jun

    Journal of vascular surgery. Venous and lymphatic disorders

    2022  Volume 10, Issue 3, Page(s) 676–682.e2

    Abstract: Objective: The aim of the present study was to evaluate the correlation between incompetent perforator veins (PVs) and venous pigmentation.: Methods: A total of 203 limbs of patients with chronic venous disease were studied. The limbs were classified ...

    Abstract Objective: The aim of the present study was to evaluate the correlation between incompetent perforator veins (PVs) and venous pigmentation.
    Methods: A total of 203 limbs of patients with chronic venous disease were studied. The limbs were classified into two groups: C2 group (varicose veins) and C4a group (skin changes with pigmentation). The PVs of the lower legs were examined using Doppler ultrasound. The diameter, reflux duration, and peak velocities were measured and analyzed. The pigmentation area in the lower leg was also studied.
    Results: Pigmentation in the lower legs was significantly associated with venous insufficiency of the PVs. The prevalence of PVs insufficiency was higher for the C4a patients compared with the C2 patients (96 of 164 [58.3%] vs 4 of 39 [10.3%]; P < .001). The presence of incompetent PVs was associated with an increased risk of pigmentation (OR, 8.977; 95% CI, 2.824-28.537; P < .001). The higher the patients' pigmentation severity (higher VCSS), the greater the prevalence of perforator venous insufficiency (P < .001). The PVs in the areas of pigmentation were larger in diameter, required longer to reach peak velocity, and had higher peak velocities than the PVs in nonpigmented limbs (P < .01 for all). We found a linear relationship between the pigmentation area and the diameter of the PV, reflux time, and peak velocity (r = 0.272, r = 0.172, and r = 0.664, respectively; P < .05).
    Conclusions: Incompetent PVs are a significant risk factor for venous pigmentation and, therefore, are potentially suitable for surgical correction.
    MeSH term(s) Chronic Disease ; Humans ; Leg/blood supply ; Pigmentation ; Varicose Veins/complications ; Varicose Veins/diagnostic imaging ; Varicose Veins/epidemiology ; Veins/diagnostic imaging ; Venous Insufficiency/complications ; Venous Insufficiency/diagnostic imaging ; Venous Insufficiency/epidemiology
    Language English
    Publishing date 2022-01-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2213-3348
    ISSN (online) 2213-3348
    DOI 10.1016/j.jvsv.2021.12.085
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  3. Article ; Online: Prognostic implications of cGAS and STING gene expression in acute myeloid leukemia.

    Chen, Qiuling / Hong, Yan / Chen, WeiFeng / Lin, Feng / Zeng, Jiawei / Huang, Yueting / Zhang, Li / Yao, Jingwei / Xu, Bing

    Experimental biology and medicine (Maywood, N.J.)

    2024  Volume 249, Page(s) 10108

    Abstract: Acute myeloid leukemia (AML) is one of the most threatening hematological malignances. cGAS-STING pathway plays an important role in tumor immunity and development. However, the prognostic role of cGAS-STING pathway in AML remains unknown. Firstly, The ... ...

    Abstract Acute myeloid leukemia (AML) is one of the most threatening hematological malignances. cGAS-STING pathway plays an important role in tumor immunity and development. However, the prognostic role of cGAS-STING pathway in AML remains unknown. Firstly, The expression of cGAS and STING was analyzed by bioinformatics analysis. Subsequently, Bone marrow samples were collected from 120 AML patients and 15 healthy individuals in an independent cohort. The cGAS and STING expression was significantly elevated in AML patients compared with healthy controls. Patients with high cGAS and STING expression had a higher NRAS/KRAS mutation rate and lower complete remission (CR) rate. High cGAS and STING expression was significantly associated with lower overall survival (OS) and disease-free survival (DFS). Our findings revealed that the expression levels of cGAS and STING in AML are elevated. High expression of cGAS and STING correlated with worse OS and DFS and may be a useful biomarker for inferior prognosis in AML patients.
    MeSH term(s) Humans ; Prognosis ; Leukemia, Myeloid, Acute/metabolism ; Disease-Free Survival ; Gene Expression
    Language English
    Publishing date 2024-02-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 4015-0
    ISSN 1535-3699 ; 1525-1373 ; 0037-9727
    ISSN (online) 1535-3699 ; 1525-1373
    ISSN 0037-9727
    DOI 10.3389/ebm.2024.10108
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  4. Article ; Online: An investigation on 3-hydroxybenzaldehyde for exploring terahertz low-frequency vibration modes with quasi-harmonic approximation method.

    Chen, Tao / Tang, Zongqing / Liang, Dihan / Huang, Yueting / Yin, Xianhua

    Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

    2022  Volume 287, Issue Pt 1, Page(s) 122046

    Abstract: 3-Hydroxybenzaldehyde (3-HBA) was investigated in the range of 0.6-2.8 THz by terahertz time-domain spectroscopy (THz-TDS) and solid-state density functional theory (ss-DFT) with first-principles calculation. Four distinct peaks were found respectively, ... ...

    Abstract 3-Hydroxybenzaldehyde (3-HBA) was investigated in the range of 0.6-2.8 THz by terahertz time-domain spectroscopy (THz-TDS) and solid-state density functional theory (ss-DFT) with first-principles calculation. Four distinct peaks were found respectively, and among them, the intensity disparity between experiment and simulation spectra at 2.04 THz was recognized as the biggest inconsistency. Considering thermal behavior can be responsible for this, quasi-harmonic approximation (QHA) method was introduced to mimic the unit cell volume expansion. According to vibrational modes analysis, it was ascertained that the biggest vibrational modes discrepancy was also located at 2.04 THz. Molecules in 0% and 4% unit cell expansion exhibit an opposite rotational direction in a-b plane compared with 2% unit cell expansion. Noncovalent intermolecular interactions were investigated with independent gradient model (IGM), and the result indicates that hydrogen bonding is the dominating noncovalent interaction of 3-HBA. While calculating systematic potential energy to the displaced bonds stretching involving hydrogen atoms, it was found the anomalous potential energy variation to the bond stretching provides a possible explanation for the rotation direction divergence, that is, the rotation direction divergence can be related to some hydrogen atoms seeking lower overall potential energy around their equilibrium positions during bond stretching in response to the variational intermolecular van der Waals force. This research combined THz-TDS with the quasi-harmonic approximation method, elucidating the principle of vibrational characteristics in different volumes, which is beneficial to the investigation of the terahertz low-frequency vibration to thermal behavior as a reference in biochemistry and other fields.
    Language English
    Publishing date 2022-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 210413-1
    ISSN 1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
    ISSN (online) 1873-3557
    ISSN 0370-8322 ; 0584-8539 ; 1386-1425
    DOI 10.1016/j.saa.2022.122046
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  5. Article ; Online: Adverse events in lymphoma patients treated with phosphoinositide 3 kinase Inhibitor in clinical trials: a meta-analysis.

    Shan, Weihang / Wu, Guixiang / Huang, Yueting / Zeng, Hanyan / Xia, Weilin / Lin, Zhijuan / Xu, Bing

    Annals of hematology

    2022  Volume 101, Issue 8, Page(s) 1741–1753

    Abstract: Background: Malignant lymphomas are one of the most common cancers worldwide and with high biologic heterogeneity, while the phosphoinositide 3 kinase (PI3K)/mTOR pathway is crucial in maintaining cell growth and survival both in physiological and in ... ...

    Abstract Background: Malignant lymphomas are one of the most common cancers worldwide and with high biologic heterogeneity, while the phosphoinositide 3 kinase (PI3K)/mTOR pathway is crucial in maintaining cell growth and survival both in physiological and in pathological conditions (i.e., lymphoma). PI3K inhibitors have been proven to be effective in several subtypes of lymphomas. However, the high incidence of treatment-related adverse events as well as the special safety profile in PI3K inhibitors draws great attention. Thus, this meta-analysis was conducted to compare adverse events in PI3K inhibitors to conventional regimens in lymphoma patients.
    Methods: Articles were retrieved from PubMed, Cochrane, and Embase to identify randomized controlled trials and phase III clinical trials that used PI3K inhibitors comparing with non-PI3K inhibitors in lymphoma patients. To achieve the appropriate results, we calculated the risk ratio and 95% confidence intervals.
    Results: Four trials with 1399 patients that met our criteria were included. The PI3K inhibitors group significantly increased the risk of all-grade adverse events (AEs) (RR 0.95, 95% CI: 0.92-0.98) and high-grade AEs (RR 0.63, 95% CI: 0.57-0.70), compared with the non-PI3K inhibitors group. Besides, the incidence of neutropenia (RR 0.81, 95% CI: 0.74-0.90), pneumonia (RR 0.62, 95% CI: 0.46-0.83), and diarrhea (RR 0.40, 95% CI: 0.32-0.49) were significantly high in the PI3Ki group, while the incidence of anemia (RR 0.78, 95% CI: 0.50-1.20) and thrombocytopenia (RR 0.85, 95% CI: 0.51-1.42) had no statistic significant.
    Conclusion: PI3K inhibitors increased the risk of certain AEs in lymphoma patients.
    MeSH term(s) Humans ; Lymphoma/drug therapy ; Neoplasms ; Neutropenia ; Phosphatidylinositol 3-Kinases ; Phosphoinositide-3 Kinase Inhibitors
    Chemical Substances Phosphoinositide-3 Kinase Inhibitors
    Language English
    Publishing date 2022-06-11
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-022-04876-x
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  6. Article ; Online: CD4 T cells in chronic myeloid leukemia present MHC class II-dependent and IFN-γ-dependent cytotoxic capacity.

    Jiang, Yirong / Yao, Jingwei / Yao, Zhuoxin / Huang, Yueting / Li, Zhangkun / Fan, Ziying / Zhou, Yong / Li, Guowei / Li, Zhifeng / Xu, Bing

    Medical oncology (Northwood, London, England)

    2023  Volume 40, Issue 9, Page(s) 253

    Abstract: At present, many therapeutic schemes have been used to improve the prognosis of patients with chronic myeloid leukemia (CML), but response remains poor in a small group of patients. CD4 T cell-mediated cytotoxicity has been found in various autoimmune ... ...

    Abstract At present, many therapeutic schemes have been used to improve the prognosis of patients with chronic myeloid leukemia (CML), but response remains poor in a small group of patients. CD4 T cell-mediated cytotoxicity has been found in various autoimmune diseases. This study analyzed the characteristics of CD4 T cell mediated cytotoxicity in CML patients and healthy people. The cytotoxicity of CD4 T cells was tested in using two CML cell lines, including the MHC class II-deficient K562 cells and the MHC class II-expressing KU812 cells. CD4 T cell-mediated lysis was minimal in K562 cells but was much higher in KU812 cells. In CML patients, the level of CD4 T cell-mediated lysis was limited to a certain level. Interestingly, pre-treating KU812 cells with IFN-γ could significantly elevate the expression of MHC class II and elevate the level of CD4 T cell-mediated lysis. Overall, these data indicated CD4 T cells could become a potential candidate for cytotoxic elimination of CML cells.
    MeSH term(s) Humans ; CD4-Positive T-Lymphocytes ; Interferon-gamma ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive ; Antineoplastic Agents ; Cytotoxicity, Immunologic
    Chemical Substances Interferon-gamma (82115-62-6) ; Antineoplastic Agents
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1201189-7
    ISSN 1559-131X ; 0736-0118 ; 1357-0560
    ISSN (online) 1559-131X
    ISSN 0736-0118 ; 1357-0560
    DOI 10.1007/s12032-023-02123-5
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  7. Article ; Online: Ultrasound-based deep learning radiomics nomogram for risk stratification of testicular masses: a two-center study.

    Fang, Fuxiang / Sun, Yan / Huang, Hualin / Huang, Yueting / Luo, Xing / Yao, Wei / Wei, Liyan / Xie, Guiwu / Wu, Yongxian / Lu, Zheng / Zhao, Jiawen / Li, Chengyang

    Journal of cancer research and clinical oncology

    2024  Volume 150, Issue 1, Page(s) 18

    Abstract: Objective: To develop an ultrasound-driven clinical deep learning radiomics (CDLR) model for stratifying the risk of testicular masses, aiming to guide individualized treatment and minimize unnecessary procedures.: Methods: We retrospectively ... ...

    Abstract Objective: To develop an ultrasound-driven clinical deep learning radiomics (CDLR) model for stratifying the risk of testicular masses, aiming to guide individualized treatment and minimize unnecessary procedures.
    Methods: We retrospectively analyzed 275 patients with confirmed testicular lesions (January 2018 to April 2023) from two hospitals, split into training (158 cases), validation (68 cases), and external test cohorts (49 cases). Radiomics and deep learning (DL) features were extracted from preoperative ultrasound images. Following feature selection, we utilized logistic regression (LR) to establish a deep learning radiomics (DLR) model and subsequently derived its signature. Clinical data underwent univariate and multivariate LR analyses, forming the "clinic signature." By integrating the DLR and clinic signatures using multivariable LR, we formulated the CDLR nomogram for testicular mass risk stratification. The model's efficacy was gauged using the area under the receiver operating characteristic curve (AUC), while its clinical utility was appraised with decision curve analysis(DCA). Additionally, we compared these models with two radiologists' assessments (5-8 years of practice).
    Results: The CDLR nomogram showcased exceptional precision in distinguishing testicular tumors from non-tumorous lesions, registering AUCs of 0.909 (internal validation) and 0.835 (external validation). It also excelled in discerning malignant from benign testicular masses, posting AUCs of 0.851 (internal validation) and 0.834 (external validation). Notably, CDLR surpassed the clinical model, standalone DLR, and the evaluations of the two radiologists.
    Conclusion: The CDLR nomogram offers a reliable tool for differentiating risks associated with testicular masses. It augments radiological diagnoses, facilitates personalized treatment approaches, and curtails unwarranted medical procedures.
    MeSH term(s) Humans ; Deep Learning ; Nomograms ; Radiomics ; Retrospective Studies ; Risk Assessment
    Language English
    Publishing date 2024-01-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-05549-6
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    Uh III Zs.10: Show issues Location:
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  8. Article ; Online: Differentiation of testicular seminomas from nonseminomas based on multiphase CT radiomics combined with machine learning: A multicenter study.

    Fang, Fuxiang / Wu, Linfeng / Luo, Xing / Bu, Huiping / Huang, Yueting / Xian Wu, Yong / Lu, Zheng / Li, Tianyu / Yang, Guanglin / Zhao, Yutong / Weng, Hongchao / Zhao, Jiawen / Ma, Chenjun / Li, Chengyang

    European journal of radiology

    2024  Volume 175, Page(s) 111416

    Abstract: Background: Differentiating seminomas from nonseminomas is crucial for formulating optimal treatment strategies for testicular germ cell tumors (TGCTs). Therefore, our study aimed to develop and validate a clinical-radiomics model for this purpose.: ... ...

    Abstract Background: Differentiating seminomas from nonseminomas is crucial for formulating optimal treatment strategies for testicular germ cell tumors (TGCTs). Therefore, our study aimed to develop and validate a clinical-radiomics model for this purpose.
    Methods: In this study, 221 patients with TGCTs confirmed by pathology from four hospitals were enrolled and classified into training (n = 126), internal validation (n = 55) and external test (n = 40) cohorts. Radiomics features were extracted from the CT images. After feature selection, we constructed a clinical model, radiomics models and clinical-radiomics model with different machine learning algorithms. The top-performing model was chosen utilizing receiver operating characteristic (ROC) curve analysis. Decision curve analysis (DCA) was also conducted to assess its practical utility.
    Results: Compared with those of the clinical and radiomics models, the clinical-radiomics model demonstrated the highest discriminatory ability, with AUCs of 0.918 (95 % CI: 0.870 - 0.966), 0.909 (95 % CI: 0.829 - 0.988) and 0.839 (95 % CI: 0.709 - 0.968) in the training, validation and test cohorts, respectively. Moreover, DCA confirmed that the combined model had a greater net benefit in predicting seminomas and nonseminomas.
    Conclusion: The clinical-radiomics model serves as a potential tool for noninvasive differentiation between testicular seminomas and nonseminomas, offering valuable guidance for clinical treatment.
    MeSH term(s) Humans ; Male ; Machine Learning ; Testicular Neoplasms/diagnostic imaging ; Seminoma/diagnostic imaging ; Adult ; Diagnosis, Differential ; Middle Aged ; Neoplasms, Germ Cell and Embryonal/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Retrospective Studies ; Young Adult ; Reproducibility of Results ; Radiomics
    Language English
    Publishing date 2024-03-07
    Publishing country Ireland
    Document type Journal Article ; Multicenter Study
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2024.111416
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  9. Article ; Online: Lactate acid promotes PD-1

    Zhang, Yining / Huang, Yueting / Hong, Yan / Lin, Zhijuan / Zha, Jie / Zhu, Yuwen / Li, Zhifeng / Wang, Caiyan / Fang, Zhihong / Zhou, Ziwei / Peng, Yun / Yu, Xingxing / Liu, Long / Xu, Bing

    International immunopharmacology

    2024  Volume 130, Page(s) 111765

    Abstract: Background: Acute myeloid leukemia (AML) displayed poor response to programmed death-1 (PD-1) blockade therapy. Regulatory T cells (Tregs) was one of major immunosuppressive components in Tumor microenvironment and plays a vital role in the resistance ... ...

    Abstract Background: Acute myeloid leukemia (AML) displayed poor response to programmed death-1 (PD-1) blockade therapy. Regulatory T cells (Tregs) was one of major immunosuppressive components in Tumor microenvironment and plays a vital role in the resistance of immunotherapy. Coinhibitory receptors regulate function of regulatory Tregs and are associated with resistance of PD-1 blockade. However, the coinhibitory receptors expression and differentiated status of Tregs in AML patients remain to be unclear.
    Methods: Phenotypic determination of Tregs and CD8
    Results: More Tregs differentiated into effector subsets in AML patients. However, PD-1 and T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) expression on Tregs were comparable in healthy donors and AML patients. Further analysis showed that PD-1
    Conclusion: PD-1
    MeSH term(s) Humans ; Bone Marrow/pathology ; Programmed Cell Death 1 Receptor/metabolism ; CD8-Positive T-Lymphocytes/metabolism ; Lactic Acid ; Tumor Burden ; Leukemia, Myeloid, Acute/metabolism ; Tumor Microenvironment
    Chemical Substances Programmed Cell Death 1 Receptor ; Lactic Acid (33X04XA5AT)
    Language English
    Publishing date 2024-03-05
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2043785-7
    ISSN 1878-1705 ; 1567-5769
    ISSN (online) 1878-1705
    ISSN 1567-5769
    DOI 10.1016/j.intimp.2024.111765
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  10. Article ; Online: Secondary myeloma in patients with chronic lymphoblastic leukemia: A case report and analysis of data from SEER database.

    Lin, Zhijuan / Chen, Xing / Huang, Yueting / Zhao, Haijun / Li, Zhifeng / Xu, Bing

    Current problems in cancer

    2021  Volume 45, Issue 5, Page(s) 100728

    Abstract: Both chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are common hematological malignancies originating from mature B cells of different differentiation stage. However, it is quite rare that MM could develop after CLL diagnosed. We reported a ...

    Abstract Both chronic lymphocytic leukemia (CLL) and multiple myeloma (MM) are common hematological malignancies originating from mature B cells of different differentiation stage. However, it is quite rare that MM could develop after CLL diagnosed. We reported a 66-year-old female progressed forward myeloma 3 years after she was diagnosed as CLL and conducted an analysis to investigate the epidemiology and clinical features among these patients based on the Surveillance, Epidemiology, and End Results (SEER) database. Our data demonstrated that CLL patients were 19% less likely to develop myeloma than general U.S. population (standardized incidence ratio 0.81; 95% confidence interval 0.62-1.03), although without statistical difference. The median overall survival from CLL diagnosed was 90 (58.1-121.9) months, which was the same as general CLL patients according to historical data. But the outcomes of secondary MM was much poorer than general MM patients. Age and gender were independent factors that impact the survival among these patients.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell/pathology ; Male ; Middle Aged ; Multiple Myeloma/epidemiology ; Multiple Myeloma/secondary ; Risk Factors ; SEER Program ; Survival Rate ; United States/epidemiology
    Language English
    Publishing date 2021-03-06
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 441816-5
    ISSN 1535-6345 ; 0147-0272
    ISSN (online) 1535-6345
    ISSN 0147-0272
    DOI 10.1016/j.currproblcancer.2021.100728
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